DMSO - Science topic

Background The active metabolite of vitamin A (retinol) is retinoic acid (RA). RA is essential for developing several organs as a signaling molecule that is tightly regulated during embryogenesis. We explored the teratogenic effects of RA on forebrain and spinal cord development modified by cyclin-dependent kinase inhibitor 1B ( CDKN1B ), as the me...

Multi-walled carbon nanotubes co-doped with sulfur and nitrogen (S–N-MWCNTs) were produced onto silicon/silicon oxide by means of chemical vapor deposition (CVD) upon decomposition of dimethyl sulfoxide (DMSO) and acetonitrile (ACN) in the presence of ferrocene (FeCp2). The synthesized S–N-MWCNTs were characterized by means of scanning electron mic...

Five metal dithiocarbamate complexes [M(PTHIQDTC)2] [where PTHIQDTC is (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline dithiocarbamate anion and M is Ni(II) (1), Sn(II) (2), Hg(II) (3), Pb(II) (4) and Zn(II) (5)] were synthesized from the reaction of MX2 (X is Cl– for 1–3 and OAc– for 4–5) with ligand of triethylammonium (S)-1-phenyl-1,2,3,4-tetrahydro...

A number of bis(glycolato)borate (BGB) anion‐based salts, comprising Li⁺, Na⁺, K+, Mg²⁺ and Ca²⁺ cations, has been synthesized and characterized. Fluorine‐free electrolytes based on LiBGB and organic solvents, such as dimethyl sulfoxide (DMSO), triethyl phosphate (TEP), and trimethyl phosphate (TMP) have been created and their transport properties,...

Microplastics are one of the major pollutants with the ability to adsorb other pollutants such as triclosan. This potentially makes them vectors for the spread of triclosan in aquatic environments. This study analyses Oryzias javanicus embryo biomarkers that are sensitive for detecting the triclosan adsorbed on polypropylene microplastics. The trea...

The goal of this study is to develop a non-invasive approach for early detection of oral squamous cell carcinoma (OSCC) using our established mouse model that faithfully recapitulates the human disease. We present for the first time a comparative metabolomic profiling of saliva samples of the tobacco smoke constituent, dibenzo[def, p]pyrene, (DB[a,...

Nuclear spins in small molecules dissolved in stretched hydrogels typically have population‐averaged residual interactions. The nuclear magnetic resonance (NMR) spectra of these systems often show additional peaks and splittings compared with free solutions. Residual dipolar couplings (RDCs) and quadrupolar couplings (RQCs) are observed for guest ¹...

Optical filters are essential components for a variety of applicative fields, such as communications, chemical analysis and optical signal processing. This article describes the preparation and characterization of a new optical filter made of polyvinyl alcohol and incremental amounts of crystal violet. By using distinct solvents (H2O, dimethyl sulf...

Dicyanovinyl-modified uracil produces fluorescent molecular rotors (FMR) that display massively red-shifted emission and huge Stokes shifts. They are exemplified by DCVSU – an intrinsically fluorescent nucleobase analog (IFNA) with the longest emission wavelength of 592 nm (DMSO) reported thus far which also shows strong polarity sensitivity and la...

The pH effect on the photophysics of three push‐pull compounds bearing dimethoxytriphenylamine (TPA‐OMe) as electron donor and pyridine as electron acceptor, with different ortho‐functionalization (−H, −Br, and −TPA‐OMe), is assessed through steady‐state and time‐resolved spectroscopic techniques in DMSO/water mixed solutions and in water dispersio...

Cryopreservation of gametes offers significant potential for genetic diversity conservation and selective breeding in aquaculture. The blue mussel, Mytilus galloprovincialis , is a valuable resource for the aquaculture industry, but declining seed availability and the need for efficient hatchery production, especially outside its natural reproducti...

The present study explores the advantages of enriching the freezing medium with membrane lipids and antioxidants in improving the outcome of prepubertal testicular tissue cryopreservation. For the study, testicular tissue from Swiss albino mice of prepubertal age group (2 weeks) was cryopreserved by slow freezing method either in control freezing m...

Photoredox-catalyzed phosphonylation of bromo-substituted 1,10-phenanthrolines under visible light irradiation was studied. The reaction was shown to proceed under mild conditions with Eosin Y as a photocatalyst in DMSO under blue light irradiation. It is transition-metal-free and affords the target phosphonate-substituted 1,10-phenanthrolines in m...

Objective: More than 50% of human cancers show mutated TP53 gene. Reactivation or restoration of p53 mutations is viewed as a potential approach for treating cancer. The objective of the present study was to determine whether ursolic acid (UA) could effectively restore the p53 mutations to their wild type or normal state and upregulate its expressi...

Perovskite solar cells (PSCs) offer an efficient, inexpensive alternative to current photovoltaic technologies, with the potential for manufacture via high-throughput coating methods. However, challenges for commercial-scale solution-processing of metal-halide perovskites include the use of harmful solvents, the expense of maintaining controlled at...

Background: Ketamine HCl, an FDA-approved therapeutic, is administered through various routes, including intranasal delivery. Administering an adequate therapeutic dose of intranasal ketamine HCl is challenging due to the limited volume that can be delivered intranasally given the current commercially available concentrations. Objectives: This stud...

The aim of this study was to evaluate different transportation and incubation conditions to test the viability of adult Fasciola hepatica in order to propose a new cultivation workflow. The adult stage of F. hepatica was obtained from naturally infected cattle at a local slaughterhouse in Lima, Peru. Different transport and incubation conditions of...

This study focuses on the synthesis, characterization, and evaluation of NiBIDP and CuBIDP mixed‐ligand complexes. Synthesized with high yields in ethanol‐based solutions, these complexes demonstrate exceptional stability and non‐hygroscopic properties, with melting points exceeding 300°C. Solubility tests reveal compatibility with organic solvents...

This study aims to investigate the effect of estrogen hindrance, i.e., menopause in women for instance with rheumatoid arthritis on the brain hippocampal region by using collagen-induced arthritis (CIA) female rat model (RA). CIA was induced in female rats by injecting bovine type II collagen and incomplete Freund’s adjuvant. Estrogen receptor anta...

Aims No curative treatment is available for RASopathy‐associated childhood‐onset hypertrophic cardiomyopathy (RAS‐CM). Preclinical data and individual reports suggest a beneficial effect of small molecules targeting the RAS–mitogen‐activated protein (MAP) kinase (MAPK) pathway in severely affected RAS‐CM patients. The aim of this study was to evalu...

The biocompatibility of dental materials is critical for ensuring safety in clinical applications. However, standard in vitro cytotoxicity assays often rely on stiff tissue culture plastic (TCP), which does not accurately replicate the biomechanical properties of soft oral tissues. In this study, we compared human gingival fibroblasts (HGFs) cultur...

Fungal infections caused by dermatophytes and Candida species are becoming increasingly resistant to conventional treatments. This study evaluated phytochemicals and antifungal effects of the Tinospora cordifolia stem, Momordica charantia leaves, and Cardiospermum halicacabum leaves and their combined antifungal potential against Trichophyton menta...

Inkjet printing is a promising and scalable drop‐on‐demand deposition technique for cost‐effective mass production of thin film solar cells. However, the efficiency of inkjet‐printed Cu2ZnSn(S,Se)4 (CZTSSe) solar cells based on dimethyl sulfoxide (DMSO) precursor ink is inferior to state‐of‐the‐art spin‐coated devices. Therefore, it is crucial to i...

Purpose The glycolipid α-galactosylceramide (α-GalCer), when presented by CD1d, can modulate the immune system through the activation of natural killer T (NKT) cells. Previously, we synthesized over 30 analogs of α-GalCer and identified a compound, C34, which features two phenyl rings on the acyl chain. C34 exhibited the most potent NKT-stimulating...

The relevance of active research lies in the need to develop new technologies to improve drug delivery methods for the effective treatment of wound healing. Additionally, the potential application of organogels in other areas of biomedicine, such as creating medical patches with controlled drug delivery, indicates a wide range of possibilities for...

The structural rigidity of tetrakis(4‐pyridyl)porphyrin (TPyP) has been utilised to prepare a robust novel porous coordination polymer of composition Cd2(TPyP)(sez)2 (TPyP=5,10,15,20‐tetra(4‐pyridyl)porphyrin, sez=1,2,5‐benzoselenadiazole‐5‐carboxylate). The coordination polymer may be described as a hexagonal porphyrin nanotube (PNT) and has the p...

Reversible addition fragmentation chain transfer (RAFT) solution polymerisation of the bio-based lactone monomer γ-methyl-α-methylene-γ-butyrolactone (γMeMBL) has been demonstrated in DMSO and Cyrene. RAFT control was evidenced by control over molecular...

Ovarian tissue cryopreservation has been widely investigated for preserving female fertility. In the present study, we aimed to compare the effects of three concentrations (1, 1.5, and 3 M) of dimethylsulfoxide (DMSO) on the vitrification of ovarian tissue. The ovarian cortex was divided into control and vitrified groups: (i) 1 M-DMSO, (ii) 1.5 M-D...

Herein we report for the first time a sunlight‐driven, irreversible photocyclization reaction of indole‐linked trisubstituted thiazoles, for the synthesis of highly fluorescent thiazole‐fused benzo[a]carbazoles using a mixture of solvents (CH3CN: DMSO; 3 : 1). Ring opening of indole moiety was observed in the case of thiazole derivatives having 2‐m...

4‐Hydroxyisochroman‐1‐ones belong to the class of the secondary metabolite 3,4‐dihydroisocoumarins. They exhibit a wide range of biological activities. These compounds can be synthesized through halocyclization using hypervalent iodine species or N‐bromosuccinimide, followed by hydrolysis. Nonetheless, the reactions required specific conditions and...

A metal‐ and irradiation‐free approach for the direct arylation of secondary phosphines has been developed. The reaction employs diaryliodonium salts as electrophilic aryl‐transfer reagents, effecting the P−Ar bond‐formation in a single step, under mild conditions, using t‐BuOK as a base and DMSO as a solvent. The protocol furnishes expedient acces...

The recent discovery of highly conductive, solution‐processable, n‐doped poly(benzodifurandione) (n‐PBDF) marks a milestone in the development of conducting polymers. Currently, n‐PBDF is prepared by either duroquinone‐mediated or copper‐catalyzed polymerizations, where scalability and cost‐effectiveness may present challenges. Here, we report a ge...

The tightly bonded structure of polybenzimidazole (PBI) membrane is the origin of its poor proton conductivity, which severely hinders achieving a cost‐effective membrane for vanadium redox flow battery (VRFB). It desires a strategy to relax the membrane structure to significantly improve the proton conductivity and maintain its structure stability...

In the realm of organic synthesis, reagents can serve not only as solvents but also as synthons. Dimethyl sulfoxide (DMSO) is recognized for its efficiency in this dual capacity, enabling diverse chemical transformations. DMSO can generate various synthons, including methyl, methylene, methine, oxygen, and methyl sulfoxide, broadening the accessibl...

Oxidation of thirty-six monosubstituted benzaldehydes by 2-picoliniumchlorochromate (PICC) in dimethylsulphoxide (DMSO), leads to the formation of corresponding benzoic acids. A Michaelis-Menten type kinetics was observed with respect to the reactants. The reaction is promoted by hydrogen ions; the hydrogen-ion dependence has the form k obs = a + b...

Background and aims: The mitochondrial membrane permeability transition (mPT) pore is a critical event exploited in situations where apoptosis is dysregulated. Bioactive agents of plant origin induce mitochondrial-mediated apoptosis via the opening of the mitochondrial outer membrane permeabilization (MOMP). The fruit of Sarcocephalus latifolius is...

BACKGROUND Diabetic nephropathy (DN), affecting half of diabetic patients and contributing significantly to end-stage kidney disease, poses a substantial medical challenge requiring dialysis or transplantation. The nuanced onset and clinical progression of kidney disease in diabetes involve consistent renal function decline and persistent albuminur...

In this work new dispersion medium for positive electrode slurries for lithium-ion batteries, dimethyl sulfoxide (DMSO), is proposed, in combination with PEDOT:PSS conductive polymer as a binder. Dispersion of PEDOT:PSS in concentration of 2.5% w/w with anhydrous DMSO is prepared. The electrodes were prepared with NMC622 active material and prepare...

A BSTRACT Background and Objectives Dimethylsulfoxide(DMSO) is gold standard for cryopreservation of hematopoietic progenitor cells (HPC) to reconstitute hematopoiesis in autologous stem cell transplants (auto-HSCT). Higher DMSO-related adverse effects (AEs) are reported in pediatric patients due to lower body weight with the recommended maximal d...

The present study introduces polyvinyl cyanuric chloride (PVCC) as an efficient reagent for the selective catalyst/metal-free oxidation of primary and secondary alcohols to the corresponding aldehyde and ketones in the presence of dimethyl sulfoxide (DMSO) as a solvent and oxidant. PVCC was derived from polyvinyl alcohol (PVA) and synthesized simpl...

New uses of old drugs hold great promise for clinical translation. Flubendazole, an FDA‐approved antiparasitic drug, has been shown to target p53 and promote apoptosis in glioblastoma (GBM) cells. However, its damaging mechanism in GBM remains elusive. Herein, we explored the ferroptosis‐inducing ability of flubendazole on GBM cells. After treating...

The integrative implementation of multiple different components into metallosupramolecular self‐assemblies requires sophisticated strategies to avoid the formation of statistical mixtures. Previously, the key focus was set on thermodynamically driven reactions of simple homoleptic into complex heteroleptic structures. Using Pd2LA2LB2‐type coordinat...

Complexation between carnitine and acetylated or benzylated pyrogallol[4]arenes was studied in DMSO via dynamic NMR, UV-vis spectroscopy, and in the gas phase via electrospray ionization-mass spectrometry (ESI-MS). In the presence of benzylated tetra(phenyl)pyrogallol[4]arene, the interaction with carnitine via NMR was evident and was confirmed by...

Background and Purpose Current treatments for acute myocardial infarction (AMI) include pain relief and attempts to improve survival. This study investigated the effects of two new ligands of the adenosine receptor, LASSBio-1027 and LASSBio-1860, on cardiac function in an experimental model of AMI. Methods AMI was induced in Wistar rats by ligatin...

An asymmetric zinc phthalocyanine dye (ZnPcT3C), bearing three tetraethylene glycol donor groups and one carboxylic acid anchoring group, was synthesized as a photosensitizer dye for dye‐sensitized solar cells (DSSCs). The tetraethylene glycol (TEG), consisting of four ethoxy units, works as an amphiphilic long‐chain donor group that greatly helped...

An efficient, stable and reusable binaphthyl stabilized palladium nanoparticles (Pd‐BNP) catalyzed synthesis of 3‐acyl‐1‐indenone derivatives from oxidative cyclization of symmetrical and unsymmetrical aryldiynes using DMSO as a solvent as well as an oxidant has been established. The scope of the reaction has been studied with various aryldiynes ha...

Achieving high‐efficiency perovskite solar cells (PSCs) hinges on the precise control of the perovskite film crystallization process, often improved by the inclusion of additives. While dimethyl sulfoxide (DMSO) is traditionally used to manage this process, its removal from the films is problematic. In this work, methyl phenyl sulfoxide (MPSO) was...

Introduction Alzheimer’s disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and anxiety, and can reduce dementia risk, it is associated with increased risks of breast and uterine can...

Strategic installation of heteroatoms and modulation of porous hierarchy of polymers are significant approaches to obtain high-performance materials for practical applications. This study focuses on the syntheses of selenium-containing porous phenolic resin (Se-PR) using cheap raw materials, phenol and selenium dioxide. Two morphologically distinct...

Porphyrin derivatives serve as photocatalysts in reversible-deactivation radical polymerization and as photosensitizers in photodynamic therapy (PDT). Herein, a triple function porphyrin, ZnTPPC6Br, was synthesized as a photocatalyst and initiator for photoATRP. Oxygen-tolerant photoATRP produced fructose-based star-shaped glycopolymers as targeted...

Herein, we reported the straightforward synthesis of thiomethylnaphthalenes via the reaction of propargyl alcohols with dimethyl sulfoxide/thionyl chloride (DMSO/SOCl 2 ), which also provided easy access to deuterated thiomethyl and other thioalkyl scaffolds when deuterated dimethyl sulfoxide and dialkyl sulfoxides were used, respectively. In addit...

INTRODUCTION Glioblastoma (GBM), a primary brain malignancy with a median survival of 15-18 months, presents a pressing challenge in neuro-oncology. Patient-derived GBM cultures (PDGCs) exhibit spontaneous calcium (Ca2+) waves, which are thought to drive tumor growth and represent a therapeutic target. The mechanisms underlying the generation and t...

The new molecules piperidyl dillapiole and propyl ether dillapiole were evaluated in Aedes aegypti as an alternative for the control of populations of this mosquito. A total of 1,690 samples, comprising 780 eggs, 780 larvae and 130 adults, were treated with both substances for 4 h, 24 h and 90 min, respectively. The dillapiole (80 µg/mL), temephos...

Introduction Forkhead box E1 (FOXE1) is a transcription factor with a crucial role in thyroid morphogenesis and differentiation. Promoter hypermethylation downregulates FOXE1 expression in different tumor types; nevertheless, its expression and relationship with methylation status in differentiated thyroid cancer (DTC) remain unclear. Methods A to...

A base‐mediated cascade reaction of CF3‐imidoyl sulfoxonium ylides (TFISYs) and diimides has been developed for the preparation of functionalized amidines. In the transformation, a cascade nucleophilic addition and subsequent [2,3]‐sigmatropic rearrangement of sulfoxonium ylide occur to enable an intramolecular migration of dimethyl sulfoxide (DMSO...

The aim of this study is to prepare new cellulose derivatives that show good feasibility and processability. Accordingly, in this study, we demonstrate Michael addition to hydroxyalkyl acrylates, that is, 2-hydroxyethyl and 4-hydroxybutyl acrylates (HEA and HBA, respectively), to synthesize amorphous cellulose derivatives under alkaline conditions....