DMSO - Science topic

To expand industrial utilizations, membranes with fast transport of organic solvents and precision molecular separation, along with strong chemical stability, have great potential for minimizing energy consumption in separation processes. In this study, novel amino-cyclodextrin organic solvent nanofiltration (OSN) membranes containing P84 polymer w...

The purpose of this study is to determine the effects of proanthocyanidin (PA) on spermato-logical parameters and testicular toxicity in male rats exposed to glyphosate (GLP). In our study, four groups were formed out of 24 male rats, each group would include 6 rats. The rats in the PA group were given a dose of 400 mg/kg/day dissolved in DMSO via...

Water-lean solvents are thought to deliver promising benefits including enhanced mass transfer properties, increased absorption capacities, and lower solvent regeneration heat duties in the natural gas sweetening process. Acid gas (H 2 S and CO 2) removal is an essential piece of the natural gas value chain due to its corrosive effect on pipeline a...

Modern medicine delivery techniques like transdermal patches are vital for treating numerous disorders. With the aid of TDDS, first pass metabolism is prevented, which aids in achieving effective bioavailability. Drug molecules are also released into the systemic circulation at a controlled and predetermined rate. The objective of this study was cr...

The objective of this research was to isolate, characterize, and determine the effects of kafirins and procyanidins of brown sorghum, against different concentrations of superoxide anion radical (O2•−) chemically generated in an aprotic polar medium. Likewise (-)-epicatechin, which represents the most abundant monomer of sorghum procyanidins was in...

This article outlines a comprehensive procedure for conducting Transwell assays, a critical technique in cancer biology for assessing cell migration and invasion - key factors in cancer metastasis. The aim is to evaluate the migratory and invasive capabilities of cells, and the effectiveness of drugs influencing these processes. The experiment empl...

The flavanone glycoside naringin, which is abundant in the very immature pomelo peel cultivated in Vietnam, has been demonstrated to have potential use in semisynthesis into other flavonoid compounds, especially apigenin, which exhibits several biological properties and has a greater commercial value. In this study, we carried out an oxidation reac...

Pentaclethra macroloba (Willd.), whose common name is “pracaxi,” is naturally found in the Amazon region. The present study is aimed at analyzing the anatomy, seed histochemistry, and chemical composition in fatty acid profile of P. macroloba seed oils. Seeds were collected in the cities of Belém, Marituba, and São Domingos do Capim-PA. For the stu...

Background The family of Mycobacteriaceae contains hundreds of species, some causing diseases in humans. The most well-known is Mycobacterium tuberculosis (Mtb), the causative agent for tuberculosis. Approximately 2 billion people are infected with M. tuberculosis. Drug-resistant strains of M. tuberculosis have emerged in the last 30 years, making...

Organic dyes have shown a remarkable nonlinear optical (NLO) characteristics under low power laser regime because of chemical stability, large nonlinearity and high susceptibility. With this view in mind, herein we report the third-order NLO features of lissamine green dye using 5 mW power laser with operating wavelength of 650 nm. The lissamine gr...

A new chemo-dosimeter AK4 containing quinoline fluorophore has rationally been designed, synthesised and characterized using 1H and 13C NMR and mass spectral techniques. The probe senses explicitly CN− ion through a dramatic enhancement in fluorescence over other commonly coexistent anions in H2O:DMSO (9:1 v/v) medium over a broad pH range (4–10)....

Cabozantinib malate (CBZM), a new anticancer medication, has been studied for its solubility and thermodynamic properties in a variety of {dimethyl sulfoxide (DMSO) + water (H2O)} mixtures at 298.2–318.2 K and 101.1 kPa. Using the shake flask technique, the solubility of CBZM was assessed and the results were correlated to the van’t Hoff, Apelblat,...

Background Endometriosis is a common and complex syndrome characterized by the presence of endometrial-like tissue outside the uterus. Chinese medicine has been recently found to show good efficacy in treating endometriosis. Our previous results revealed that Maqian fruit essential oil (MQEO) could inhibit the proliferation and induce apoptosis of...

Lemon Suanggi (Citrus limon (L.) Burm. f.) banyak dibudidayakan di Kawasan Asia selatan berpotensi sebagai agen antibakteri. Lapisan bagian dalam kulit buah lemon suanggi terdiri atas glikosida, kumarin, dan flavonoid yang dapat berperan sebagai antibakteri, anti mikroba dan antioksidan alami. Penelitian ini bertujuan untuk mengetahui kandungan fit...

Background The present study pointed to evaluate the role of Triticum aestivum ethanolic extract (TAEE) in prophylactic and curative regimens on sodium oxalate (NaOx)-prompted lithiasis. Forty-eight rats were divided into the following regimen’s group (24 rats/regimen). Groups I, II, III, and IV served as prophylactic groups and divided as: group I...

Immune rejection is a significant concern in organ transplantation, as it can lead to damage to and failure of the transplanted organ. To prevent or treat immune rejection, transplant recipients are commonly administered immunosuppressive drugs. Tacrolimus (FK506) is a widely used immunosuppressive drug in organ transplantation. The excessive forma...

Few-layer MXene materials were obtained by etching Ti3AlC2 with HF and ultrasonically exfoliated with dimethyl sulfoxide (DMSO) intercalation. By compounding it with lithium iron phosphate (LFP) obtained using the solvothermal method, a cathode material LFP/M with excellent electrochemical properties was obtained. LFP/M exhibits ideal rate performa...

Puberulic acid, a tropolone compound, has antibacterial and antimalarial activities. In this study, we investigated the in vitro inhibitory effects of puberulic acid on three Babesia species and Theileria equi. Puberulic acid inhibited the growth of Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi with IC50 values of 1.79 ± 0.3,...

In recent years, organic-inorganic lead halide perovskites (OILHPs) have emerged as a promising photovoltaic material. These have very attractive optoelectronic properties such as high absorption coefficient, long carrier diffusion length and solution processability. However, the performance of OILHPs based solar cells is hampered by the imbalanced...

The present paper describes an efficient synthesis of a series of 4-aminopyrazolo[3,4-b]pyridine derivatives 11a–i in 69–81% yields by one-pot three-component domino reaction of phenylhydrazine and two different β-ketonitriles in DMSO. All the synthesized derivatives were screened in vitro for their antimicrobial potential against seven Gram-positi...

Polyanilines are a class of conductive polymers that have attracted significant interest in the field of organic electronics due to their unique properties. In this article, the fluorescence spectroscopy and photovoltaic properties of polyaniline-based thin films and copolymers are investigated. The study focuses on understanding the relationship b...

We show for the first time DMSO-free tin-based perovskite solar cells with a self-assembled hole selective contact (MeO-2PACz). Our method provides reproducible and hysteresis-free devices with MeO-2PACz, having the best device PCE of 5.8 % with a V OC of 638 mV. P erovskite solar cells (PSC) have attracted extensive research interest for next-gene...

Amphoteric PSF(polysulfone)-g-NaPSS(sodium p-styrene sulfonate)/PVP (polyvinylpyrrolidone) blended ion exchange membranes were prepared by simple solution casting method with dimethyl sulfoxide (DMSO) as solvent. The effect of the ratio of PSF-g-NaPSS to PVP on the properties of the membranes were studied and compared to that of Nafion 115 (DuPont)...

Accumulation of medicinally important flavones and acteoside was evaluated in Scutellaria lateriflora hairy root cultures subjected to different experimental strategies – feeding with precursors of phenolics biosynthesis (phenylalanine, cinnamic acid, and sodium cinnamate), addition of elicitors (chitosan, jasmonic acid) and Amberlite XAD-4 and XAD...

S100B, a homodimeric Ca2+-binding protein, is produced and secreted by astrocytes, and its extracellular levels have been used as a glial marker in brain damage and neurodegenerative and psychiatric diseases; however, its mechanism of secretion is elusive. We used primary astrocyte cultures and calcium measurements from real-time fluorescence micro...

Low‐dimensional organic–inorganic metal halides (OIMHs) have emerged as promising light emitters due to their broadband emission originating from self‐trapped excitons (STE), especially for Cu‐based OIMHs. Herein, Cu(I)‐based OIMH with a structure of (TPP)2Cu4I6·2DMSO (TPP stays for tetraphenylphosphonium, and DMSO – for dimethyl sulfoxide) has bee...

The investigation of the properties of aggregate materials is highly interesting because the process of aggregation can result in the disappearance of original properties and the emergence of new ones. Here, a novel fluorescent material (TPEIP), which synergistically combines aggregation-induced emission (AIE) and aggregation caused quenching (ACQ)...

Acute liver failure (ALF) is a disease accompanied by severe liver inflammation. No effective therapy is available yet apart from liver transplantation; therefore, developing novel treatments for ALF is urgently required. Inflammatory mediators released by NF-кB activation play an essential role in ALF. Proteasome inhibitors have many medical uses,...

In this work, we focused on the 3rd goal of the sustainable development plan: achieving good health and supporting well-being. Two redox-active hydrazo ligands namely, phenylcarbonohydrazonoyldicyanide (PCHD) and pyridin-4-ylcarbonohydrazonoyl-dicyanide (PyCHD), and their copper(I) complexes have been synthesized and characterized. The analytical d...

Replication Timing (RT) refers to the temporal order in which the genome is replicated during S phase. Early replicating regions correlate with the transcriptionally active, accessible euchromatin (A) compartment, while late replicating regions correlate with the heterochromatin (B) compartment and repressive histone marks. Previously, widespread A...

Pendahuan: Salmonella typhi (S. typhi) merupakan kuman patogen penyebab demam tifoid, yaitu suatu penyakit infeksi sistemik dengan gambaran demam yang berlangsung lama. Kandungan metabolit sekunder yang terdapat pada biji jintan hitam (Nigella Sativa) dapat digunakan sebagai antibakteri antara lain flavonoid, saponin, terpenoid, steroid dan alkaloi...

The synthesis of substituted 2,4,6,8,10,12-hexaazaisowurtzitane via direct condensation is challenging. The selection of starting ammonia derivatives is very limited. The important step in developing alternative synthetic routes to these compounds is to investigate their formation process in detail. Here, we examined an acid-catalyzed condensation...

Predictive models for the transport of volatile organic compounds in paper need to consider the complex interplay of diffusion, adsorption, desorption, or chemical reactions. The relative importance of each of these processes is determined by the polarity of the volatile. Hence, it is challenging to pick a valid theoretical model that correctly pre...

The introduction of plasmids into Agrobacterium cells is one of the key steps in the Agrobacterium-mediated transformation of plants for gene editing applications. Depending on chromosomal background, some Agrobacterium strains exhibit a very low transformation efficiency, which results in a low number of colonies for subsequent screening and thus...

Purpose Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic (dysfunction) associated fatty liver disease (MAFLD), is the most common chronic liver disease in the United States. Presently, there is an intense and ongoing effort to identify and develop novel therapeutics for this disease. In this study, we explored the anti-inflamma...

Background: Per- and polyfluoroalkyl substances (PFAS) are biopersistent, global pollutants. Although some in vitro and epidemiological studies have explored the neurotoxic potential of perfluorooctane sulfonate (PFOS), a prevalent PFAS congener, it is unknown how developmental PFOS exposure affects neuronal signaling, microglia development, and m...

A series of N -acylated 2-aminomethylenebenzo[ b ]thiophene-3(2 Н )-ones with a terminal phenanthroline receptor substituent was synthesized. Upon irradiation in CH 3 CN or DMSO with light of 436 nm, they undergo Z/E isomerization around the C=C bond followed by rapid N→O migration of the acyl group and the formation of non-emissive O -acylated iso...

Bilirubin is a toxicological biomarker for hemolysis and liver diseases. The current automated diazo method used in clinical chemistry has limited applicability in rodent models and cannot be used in small animals relevant to toxicology, microphysiological systems, cell cultures, and kinetic studies. Here, we present a versatile fluorometric method...

Schiff bases are an important class of organic compounds, which play an important role in medicinal and pharmaceutical applications. Metal complexes formed by the reactions of keto forms of Benzoic acid hydrazide (BAH) with Cu(II) and Fe(II) sulphate ions were prepared and characterized by X-ray Diffraction analysis (XRD), Fourier Transform Infrare...

Present work introduces an aggregation-induced emission (AIE) active Schiff base 4,4'-((1E,1'E)-([1,1'-biphenyl]-4,4'-diylbis(azaneylylidene))bis(methaneylylidene))bis(5-(hydroxymethyl)-2-methylpyridin-3-ol) (BNPY). Schiff base BNPY was synthesized by reacting benzidine with pyridoxal. The non-fluorescent BNPY in freely soluble DMSO medium showed a...

In this work, we investigate the vapor-assisted synthesis of the metal-organic framework MOF-74 starting from three metal oxides (ZnO, CoO, and MgO). Depending on the nature of the added vapor (H2O, DMF, DMSO), the metal oxide, and the temperature, the outcome of the reaction can be directed towards the desired porous phase. Ex situ and in situ XRD...

In this paper, the swelling effect of ionic liquid reverse micelle system on cotton fabric in supercritical CO2, and the influence of swelling on the dyeing of cotton fabric were studied. The results indicate that the ionic liquid reverse micelle system can cause swelling of cotton fabric. In the process of alkali free dyeing, swelling has a signif...

Introdução O Aedes aegypti é o vetor causador de diversas doenças como febre amarela, chikungunya, dengue e Zika, e por este motivo constitui um problema de saúde pública nas últimas décadas, principalmente nos centros urbanos brasileiros [1]. O método remanescente de controlar a propagação deste vetor é uso de inseticidas sintéticos tais como orga...

In this study, it was aimed to investigate the effects of berberine (BER) and curcumin (CUR) in the experimental model of cystitis induced by cyclophosphamide (CYP). A total of 36 Wistar‐Albino female rats were used in the study. Rats were randomly divided into six groups ( n = 6). Normal control group, dimethyl sulfoxide (DMSO) group, CYP group (7...

5‐hydroxymethylfurfural (5‐HMF) has been considered as an important biomass‐based platform chemical for its wide applications. Currently, the production of 5‐HMF from the catalytic dehydration of glucose is preferred, in which the Brønsted and Lewis acids in catalysts play an important role. Here, it was found that MIL‐53(Al) modified with tin was...

Backdround : By establishing the rat model of vascular dementia and observing the effects of low-dose Esketamine on cognitive function and related mechanisms in rats with vascular dementia, providing a new idea for clinical drug treatment of Vascular dementia (VD). Methods 100 rats were randomly divided into five groups: sham operation group, vasc...

3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) has broad-spectrum antitumor activity. However, its role in osteosarcoma (OS) remains unclear. Therefore, this study explored the effects of 3-AP on OS in vitro and in vivo using three human OS cell lines (MG-63, U2-OS, and 143B) and a nude mice model generated by transplanting 143B cells. T...

Graphene is a highly promising nanomaterial due to its unique properties, including high conductivity, which makes it an ideal material for constructing conductive textiles. However, current techniques for functionalizing conductive textiles with graphene face challenges such as low conductivity and the need for chemical modification to reduce grap...

The development of new substances with the ability to interact with a biological target is only the first stage in the process of the creation of new drugs. The 5-nitroisatin derivatives considered in this study are new inhibitors of cyclin-dependent kinase 2 (CDK2) intended for anticancer therapy. The research, carried out based on the ADMET (abso...

Vascular dementia is commonly associated with ischemic stroke. Moreso, satisfactory treatment options for dementia in stroke patients are lacking. However, therapeutic potentials of acetylcholinesterase (AChE) inhibitors have been reported. This study evaluated the therapeutic efficacy of Tetrapleura tetraptera phenolics (TTP) against memory and ch...

To further our understanding of the change in association between lignin and carbohydrates after kraft pulping, isotope-labeled kraft pulp (KP) was prepared using 13C and D double-isotope-labeled wheat straw, and it was subjected to enzymatic hydrolysis and ionic liquid treatment to explore the linkages between lignin and carbohydrate complexes in...

Patulin (PAT) is a major secondary metabolic mycotoxin produced by Penicillium that can contaminate food. Patulin forms an adduct when it interacts with amino acids that contain thiol groups; the creation of these adducts could represent the main toxic pathway of PAT. Catechins are a major component of green tea polyphenols. Polyphenols have many p...

Naphtho[1,8-de][1,2]oxazin-4-ol and its acyl or benzyl derivatives ring open to various 2,8-dihydroxy-1-naphthonitriles, that undergo methylation, reduction, demethylation and debenzylation reactions, to afford the target compound (E)-2-hydroxy-8-methoxy-1-naphthaldehyde. The best overall yield of the latter was 28.7%. This compound was converted t...

Background Accumulating evidence links the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangement to venous thromboembolism (VTE) in non-small cell lung cancer (NSCLC) patients. However, the corresponding mechanisms remain unclear. Method High-throughput sequencing analysis of H3122 human ALK-positiv...

Oxygen therapy is a crucial medical intervention, but it is undeniable that it can lead to lung damage. The mTOR pathway plays a pivotal role in governing cell survival, including autophagy and apoptosis, two phenomena deeply entwined with the evolution of diseases. However, it is unclarified whether the mTOR pathway is involved in hyperoxic acute...

We describe a robust one-pot cascade method for the synthesis of indole-3-carboxylic acids using isatins and DMSO via a one-carbon translocation involving in situ generation of α,β-unsaturated methylvinylsulfoxide followed by...

Ru( ii ) 1,2-azolylamidino-DMSO complexes are herein described. Their electrochemical behavior in CO 2 media is consistent with CO 2 electrocatalyzed reduction, whereas photocatalytic CO 2 reduction experiments lead to CO and trace amounts of formate.

Objective: The main objective of this present study is to conduct an experiment to analyze the variation of protonation-deprotonation equilibria with regards to the dielectric constants of an organic medium, influence of errors on protonation constants and effect of pH on the percentage of species. Methods: The present investigation was carried out...

Plants have been used in alternative medicine for centuries in the treatment of many diseases with the metabolites they contain. The goal of this work was to investigate the phenolic profile, antioxidant capacity and biological activity of I. helenium subsp. pseudohelenium extracts. Phe-nolic (HPLC) substances in leaf ethanol (L-EtOH), leaf pure wa...

The diverse uses of gold and its crucial role in the global economy are growing, particularly during cycles of economic crises. The broad use of cyanide by conventional gold-mining companies and mercury by artisanal miners poses environmental and health concerns for local communities. This article introduces an innovative gold-leaching process usin...

In this paper, a novel and facile method is reported for the synthesis of 2-thioxoquinazolinone. For the synthesis of the products, a reaction is introduced based on the molecular iodine catalyzed reaction of 2-aminobenzyl alcohol and isothiocyanates in DMSO. The reaction is simple and the products are obtained in good to excellent yields. FT-IR, ¹...

Tautomerism has a vital role in modern medicinal chemistry. An understanding of tautomerism is required to understand the mechanistic pathways of many biochemical processes, especially those involved in dynamic interplay with proteins, enzymes, and DNA. Spectroscopic techniques, X-ray diffraction, and quantum chemical methods help to explore tautom...

The UV/Vis absorption energies (νmax) of different solvatochromic probes measured in co-solvent/water mixtures are analysed as a function of the average molar concentration (Nav) of the solvent composition. Nav is discussed in terms of the underlying average molar mass (mol average or mass average) of the mixture. ET(30) of Reichardt`s dye B30 is t...