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Curcumin - Science topic

A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
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Publications related to Curcumin (10,000)
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This study aimed to evaluate the effect of curcumin on the inflammatory response during exercise-induced muscle damage (EIMD) is a literature review. The method applied to this article was a comprehensive strategy such as searching for articles in research journal databases. The databases were taken from Pubmed/MEDLINE, Scopus, Web of Science, and...
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In this study, polycaprolactone (PCL) nanoparticles were effectively synthesized as novel drug delivery systems by the electrospray method. Curcumin (Cur) was selected as the model drug with further enhanced stability of its composition with gluten (GLU). The physical-chemical characterization, including FTIR, UV-vis, and thermal analysis of PCL@Cu...
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Acute kidney injury (AKI) leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs. Here, a series of polyvinylpyrrolidone (PVP)-curcumin nanoparticles (PCurNP) are designed to meet the renal excretion threshold (∼45 kDa), presenting a controllable delivery nanosystem for...
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Alzheimer's disease (AD) is a neurodegenerative disorder that is a common form of dementia for the elderly. According to the world health organization (WHO), around 55 million older adults have dementia globally. The current medication for Alzheimer's disease is a human antibody or immunotherapy, which helps to reduce beta-amyloid plaques. However,...
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Spices have long been a part of human diets and commerce. Since the birth of human civilization, medicinal plants have yielded a wealth of information on treating and preventing illness. Still, the growing understanding of the connection between nutrition and health in the food business has increased its relevance and piqued researchers’ interest i...
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The development of effective carriers enabling combination cancer therapy is of practical importance due to its potential to enhance the effectiveness of cancer treatment. However, most of the reported carriers are monofunctional in nature. The carriers that can be applied to concomitantly mediate multiple treatment modalities are highly deficient....
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Recently, green synthesis of nanoparticles using plant has attracted much attention due to the environmental and economic benefits. The present work demonstrates an eco-friendly and low-cost method to study the antibacterial activity of the silver nanoparticles [AgNPs] biosynthesized from phenolic compounds of plant extracts (Raphanus sativus and C...
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Background Fructose-rich diets are linked to the epidemic of metabolic syndrome and co-morbidities including nephropathy. Phytochemicals are increasingly being used for medicinal purposes due to their perceived safety compared to conventional drugs. Although previously shown to beneficially programme metabolism, these phytochemicals might have a ne...
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Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery. However, cancers often develop resistance against drugs, leading to failure of treatment and recurrence of the disease. Polyphenols are a family of organic compounds with more than 10,000 members which have a three-membered flavan ring system in common. These n...
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Background A targeted co-administration system of docetaxel (DTX) and curcumin (CUR) using a PEG-modified RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated nanostructured lipid carrier (P/R-NLC) was constructed to exert synergistic anticancer effects against chemoresistant breast cancer. Results DTX- or CUR-loaded NLCs and P/R-NLCs were prepared using th...
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Abnormal iron metabolism, mitochondrial dysfunction and the derived oxidative damage are the main pathogeneses of Friedrich's ataxia (FRDA), a single-gene inherited recessive neurodegenerative disease characterized by progressive cerebellar and sensory ataxia. This disease is caused by frataxin ( FXN ) mutation, which reduces FXN expression and imp...
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Background: The enormous and irresponsible use of antibiotics has led to the emergence of resistant strains of bacteria globally. A new approach to combat this crisis has been nutritional immunity limiting the availability of nutrients to pathogens. Targeting the siderophore biosynthetic pathway that helps in iron acquisition, an essential microel...
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Objective The aim of this study was to investigate the pro-angiogenic potential of olfactory ensheathing cells (OECs) activated by curcumin (CCM) and lipopolysaccharide (LPS) and the possible underlying mechanisms. Methods Vascular endothelial cells or tissues were cultured and treated with conditioned medium (CM) extracted from activated OECs act...
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Objective The present study aimed to investigate the effects of nano-curcumin supplementation on adipokines levels and clinical signs in obese and overweight patients with migraine. Results Forty-four patients with episodic migraine participated in this clinical trial and were divided into two groups nano-curcumin (80 mg/day) and the control group...
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The identification of molecular targets of bioactive food components is important to understand the mechanistic aspect of their physiological functions. Here, we have developed a screening system that enables us to determine the activation of G protein-coupled receptors (GPCRs) by food components and have identified GPR55 as a target for curcumin....
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Background Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied with itchy and scaly rash. Compound traditional Chinese medicine dermatitis ointment (CTCMDO) consists of a mixture of extracts from five plants, which had been used in AD treatment due to good anti-inflammatory and anti-allergic effects. Materials and methods In...
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Background The purpose of the current study was to compare the antibacterial activity of silver nanoparticles AgNPs paste and silver nanoparticles AgNPs with curcumin paste as intracanal medications versus calcium hydroxide Ca(OH) 2 paste. Thirty extracted, human teeth with single roots were decoronated and mechanically prepared. After sterilizatio...
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Green colorimetric sensors based on the immobilization of catechin and curcumin nanoparticles (NPs) on macroporous starch cryogels were developed for the on-site detection of iron. Starch cryogels were synthesized from rice flour, while catechin and curcumin NPs were prepared from green tea and turmeric powder, respectively. Catechin and curcumin N...
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Solid tumors rely on pathological angiogenesis to meet their metabolic needs and facilitate their spread. Glioblastoma multiforme (GBM), an aggressive and deadliest brain malignancy, is represented by multi-mechanistic and exuberant angiogenic properties. Current treatment efforts to inhibit neovascularization using monoclonal antibodies (e.g., bev...
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Curcumin is a natural polyphenol with anti-inflammatory, anti-cancer, and emerging immunomodulatory effects through acting on a variety of targets including inflammasome. However, its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability; hence, the need for a novel formulation of curcumin nano-emuls...
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The present study was carried out in human schwannoma cells (HEI-193) to determine the combined anti-cancer effect of curcumin and dasatinib. Cells were treated with curcumin only, dasatinib only, or the combination of curcumin and dasatinib for 24 hours. Cellular toxicity, cell proliferation, and cell death were determined by LDH, MTT, and trypan...
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Cold-set egg white-bovine gelatin composite hydrogels were evaluated as potential delivery vehicles for the encapsulation and subsequent release of sucrose stearate–based niosomes loaded with curcumin. The effects of loading blank-niosome or curcumin-niosome and their content (6 and 12 mL) on physicochemical and rheological properties of composite...
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Preparation of porous starch (PS) from corn starch (NS) using enzymes amylase (AM) and amyloglucosidase (AMG) was standardized using two factorial experimental design in terms of surface area and pore size distribution. SEM micrographs confirmed the formation of porous structures in the granules. Based on surface area, pore size and statistical ana...
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Curcuma longa, also known as turmeric, is a Zingiberaceae plant whose rhizomes are used to make the spice. Curcumin is well known for its anti-inflammatory qualities and skin-protective characteristics. Curcumin has long been used to treat skin infections and inflammation in natural herbal medicines. The purpose of this project is to formulate a tu...
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Owing to its prevalent nature, diabetes mellitus has become one of the most serious endocrine illnesses affecting a patient's quality of life due to the manifestation of side effects such as cardiovascular diseases, retinopathy, neuropathy, and nephropathy. Curcumin ((1E, 6E) 21, 7‐bis (4‐hydroxy‐3‐methoxyphenyl)‐1,6‐heptadiene‐3,5‐dione), a major...
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COVID-19 is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) becoming a major threat worldwide due to its fast-spreading nature and more aggressive variants, such as the case of Omicron. The main interaction structure of the virus with the host cell is the spike region of the Spike protein calle...
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Bioactive compounds represent a broad class of dietary metabolites derived from fruits and vegetables, such as polyphenols, carotenoids and glucosinolates with potential for cancer prevention. Curcumin, resveratrol, quercetin, and β-carotene have been the most widely applied bioactive compounds in chemoprevention. Lately, many approaches to encapsu...
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The accelerating bone healing process is still a major challenge in clinical orthopedics, especially in critical-sized bone defects. Recently, Nanofiber membranes are showing increasing attention in the biomedical field due to their good biocompatibility, mechanical stability, and the ability to work as a drug carrier to achieve localized and susta...
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Background: Curcumin (CUR) displays the capability of suppressing the proliferation and metastasis of various cancer cells. However, the effects and underline mechanisms of CUR to treat triple-negative breast cancer (TNBC) have not been systematically elucidated with an appropriate method. Methods: In the present research, a combination method of n...
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Background: Diabetes is an increasingly prevalent global disease caused by the impairment in insulin production or insulin function. Diabetes in the long term causes both microvascular and macrovascular complications that may result in retinopathy, nephropathy, neuropathy, peripheral arterial disease, atherosclerotic cardiovascular disease, and cer...
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An active coating is one of the best ways to maintain the good quality and sensory properties of fruits. A new active coating was prepared by incorporating curcumin and phloretin into the konjac glucomannan matrix (KGM-Cur-Phl). The fourier infrared spectroscopy, rheology and differential scanning calorimetry confirmed the successful fabrication of...
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Electrospinning is a easy and versatile to synthesize the Nanofibers of different Polymers and compounds. The main merits of this process are we can get continuous and ultra thin fibers. Due to this we can use this process for mass production. This process overcome so many T limitations of otherT processes. Hence in this present work manufacturing...
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Medicinal plants contain numerous biologically active compounds which are helpful in improving the life and treatment of diseases and these are the primary source of synthetic and traditional herbal medicine. The presence of various life-sustaining constituents in plants made scientists investigate these plants for their uses. The objective of the...
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This study aimed to evaluate the potential of mesenchymal stem cell–derived exosomes loaded with curcumin (Curc-Exos) as an effective therapeutic strategy for rheumatoid arthritis through modulation of proliferation and inflammatory response in HIG-82 synovial cells. For this purpose, Exos were isolated and characterized with BCA protein assay, DLS...
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The aza-Michael polyaddition of L-arginine and N,N′-methylene-bis-acrylamide gives the biocompatible and easily cell-internalized polyamidoamine ARGO7. By controlled synthesis, two ARGO7 oligomers, namely a trimer and a pentamer, bearing acrylamide terminal units, were obtained as precursors of the β-cyclodextrin-end-terminated oligomers P3 and P5,...
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Alzheimer’s disease (AD) is a fatal neurodegenerative disorder associated with severe dementia, progressive cognitive decline, and irreversible memory loss. Although its etiopathogenesis is still unclear, the aggregation of amyloid-β (Aβ) peptides into supramolecular structures and their accumulation in the central nervous system play a critical ro...
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Background: Multiple sclerosis (MS) is characterized by a combination of inflammatory and demyelination processes in the spinal cord and brain. Conventional drugs generally target the autoimmune response, without any curative effect. For that reason, there is a great interest in identifying novel agents with anti-inflammatory and myelinating effect...
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The global health scenario in present times has raised human awareness about drug delivery strategies. Among colloidal drug delivery vehicles, vesicular nanocarriers such as liposomes and niosomes are popular. However, liposomes and niosomes get disrupted in the harsh environment of the gastrointestinal tract. In this context, the drug delivery com...
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Since the appearance of SARS-CoV-2 and the COVID-19 pandemic, the search for new approaches to treat this disease took place in the scientific community. The in silico approach has gained importance at this moment, once the methodologies used in this kind of study allow for the identification of specific protein–ligand interactions, which may serve...
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The main goal in periodontal treatment is to eradicate or at least reduce microbial population. Different wavelengths have been shown to be effective in reducing bacteria in this field. Among different laser procedures, antimicrobial photodynamic therapy (aPDT) has gained special attention due to its minimally invasive manner and safety. It uses li...
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Objectives: The objective of the present work is to formulate and evaluate lozenges of potassium salt of curcumin extract for the anticancer activity that delivers drug into buccal cavity. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidaemia. Curcumin lozenges were prepared...
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The copper oxide nanoparticles (CuO NPs) were synthesized by a simple method and then coated with the bovine serum albumin (BSA) to form CuO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug was loaded to the CuO@BSA NPs. The characterization of nanoparticles was carried out by Fourier-transport infrared (FT-IR), ultraviolet-visible (UV-vis),...
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Zebrafish larvae have been widely used in neuroscience and drug research and development. In the larval stage, zebrafish present a broad behavioral repertoire and physiological responses similar to adults. Curcumin (CUR), a major component of Curcuma longa L. (Zingiberaceae), has demonstrated the ability to modulate several neurobiological processe...
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The objective of the present study was to develop and characterize a new biodegradable film based on pistachio green hull pectin (PGHP)/poly vinyl alcohol (PVA) incorporated with different ratios of curcumin. With increase of curcumin concentration from 10 to 50 mg g⁻¹, tensile strength and water solubility of the films decreased significantly (p <...
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β-lactoglobulin(β-Lg)-polysaccharide soluble complexes formed in a specific pH range through electrostatic attraction have attracted a growing interest in the design of food-grade encapsulation systems for hydrophobic compounds, which is mainly ascribed to the ligand-binding properties of β-Lg. However, it remains unclear whether pH-induced conform...
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The Apoptosis is an intensely studied mechanism for cancer therapy. Various genes, drugs, and molecules have been combined to potentiate the apoptotic effect against tumor cells. Magnetic nanocomplexes with biopolymers have been proposed as nanocarriers for delivery of active molecules and improve apoptosis induction. To these purpose were formulat...
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Due to increasing antimicrobial resistance, studies where new treatment options are investigated along with the synergistic effects of natural products with antibiotics have arisen. Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen and infection with multi-drug resistant (MDR) P. aeruginosa poses a critical problem during treatmen...
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Objective To evaluate the randomized controlled trials (RCTs) of Curcumin and Curcuma longa Extract in the treatment of autoimmune diseases. Methods Databases such as Embase, Web of Science, PubMed and The Cochrane Library were searched from the database establishment to February 2022 to collect RCTs of Curcumin and Curcuma longa Extract in the tr...
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Polypharmacological targeting of lipid mediator networks offers potential for efficient and safe anti-inflammatory therapy. Because of the diversity of its biological targets, curcumin (1a) has been viewed as a privileged structure for bioactivity or, alternatively, as a pan-assay interference (PAIN) compound. Curcumin has actually few high-affinit...
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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment suggested to be induced by the accumulation of amyloid-β (Aβ) in the brain, especially in the hippocampus. Cerebral Aβ deposits may be detected through positron emission tomography (PET) as early as two decades before clinically diagnosed AD a...
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Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are becoming more frequent as the age increases. Contemporary therapies provide symptom resolution instead of targeting underlying pathological pathways. Consequently, there is considerable heterogeneity in response to treatment. Research has elucidated multip...