Science topic

Connective Tissue Cells - Science topic

A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
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Publications related to Connective Tissue Cells (1,595)
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Developing omasum of prenatal goat between 32 to 150 days of foetal life was taken for this study. The foeti were divided into three groups viz. Group I (age >50 days), Group II (age 51 > 100 days) and Group III (age 101 > 150 days). Staining was performed for PAS, AMPS, Bound lipid, Alkaline phosphatase, Acid phosphatase and DNA. Cells of basal zo...
Article
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Endoplasmic reticulum (ER) is a multifunctional membrane-enclosed organelle. One of the major ER functions is cotranslational transport and processing of secretory, lysosomal, and transmembrane proteins. Impaired protein processing caused by disturbances in the ER homeostasis results in the ER stress. Restoration of normal ER functioning requires a...
Article
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The use of light in the red and near-infrared light spectrum influences cell viability and proliferation in both cell and animal experimental models. In wounded models, photobiomodulation (PBM) at various laser parameters may stimulate or inhibit the tissue repair process by affecting cells important to healing. Connective tissue cells include oste...
Article
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Background/aim: Hoffa's disease is anterior knee pain presumably stemming from inflammatory fibrous hyperplasia of the infrapatellar fat pad (Hoffa's pad). The etiology and pathogenesis are unclear, however, and no genetic information about the disease has been published. We report the genetic findings in cells from the fat pad of a patient with H...
Article
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Kaposi’s sarcoma (KS) is an important health problem that develops with the proliferation of vascular endothelial and perivascular connective tissue cells and that holds many foci in the body. While involvement of skin and mucosa is at the forefront of human immunodeficiency virus (HIV)-associated Kaposi’s sarcoma, its symptoms may be asymptomatic...
Article
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Dysbiosis of the oral microbiome mediates chronic periodontal disease. Realignment of microbial dysbiosis towards health may prevent disease. Treatment with antibiotics and probiotics can modulate the microbial, immunological, and clinical landscape of periodontal disease with some success. Antibacterial peptides or bacteriocins, such as nisin, and...
Article
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Scarring, which develops due to fibroblast activation and excessive extracellular matrix deposition, can cause physical, psychological, and cosmetic problems. Fibroblasts are the main type of connective tissue cells and play important roles in wound healing. However, the underlying mechanisms of fibroblast in reaching scarless wound healing require...
Article
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Anatomically, the human tooth has structures both embedded within and forming part of the exterior surface of the human body. When a tooth is lost, it is often replaced by a dental implant, to facilitate the chewing of food and for esthetic purposes. For successful substitution of the lost tooth, hard tissue should be integrated into the implant su...
Article
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During amphibian metamorphosis which is triggered by thyroid hormone (TH), the small intestine is extensively remodeled from the larval to adult form. In the Xenopus laevis intestine, some of the larval epithelial cells dedifferentiate into adult stem cells, which newly form the adult epithelium similar to the mammalian one. We have previously show...
Article
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The aim of this study was to analyze and compare the immunohistochemical expression of plasminogen activator system (PAS) proteins (uPA, uPAR, and PAI-1) in ameloblastomas (AMBs), odontogenic keratocysts (OKCs), and dental follicles (DFs) representing normal odontogenic tissue, as well as to investigate possible correlations between these proteins....
Conference Paper
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ABSTRACT Placenta previa is defined as the condition when the cervix is completely or partially invaded by the placenta. Since this condition can cause postpartum hemorrhage, it is an important risk factor for maternal and fetal mortality and morbidity. Previous pregnancies and cesarean delivery, multiple pregnancy, and advanced maternal age are ri...
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Introduction:Morphological peculiarities of liver after dexamethazonne influence on the mother-placenta-fetus system is not well studied. Materials and Methods: The study included the livers of 144 white laboratory rats from 1 to 90 days of life. All animals were conditionally divided into 3 groups: Group I - intact animals, which were born from h...
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How distinct cell fates are manifested by direct lineage ancestry from bipotent progenitors, or by specification of individual cell types is a key question for understanding the emergence of tissues. The interplay between skeletal muscle progenitors and associated connective tissue cells provides a model for examining how muscle functional units ar...
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(1) Background: Lizard tail regeneration provides a unique model of blastema-based tissue regeneration for large-scale appendage replacement in amniotes. Green anole lizard (Anolis carolinensis) blastemas contain fibroblastic connective tissue cells (FCTCs), which respond to hedgehog signaling to create cartilage in vivo. However, an in vitro model...
Article
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Aldehyde dehydrogenase 1 (ALDH-1) is a marker of stem cells in a variety of diseases, but its role in individuals with chronic inflammatory periapical lesions remains unknown. The aim of this study was to investigate the presence of cells with a stem cell profile based on the immunoexpression of ALDH-1 in periapical granulomas (PGs) and radicular c...
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The present study was aimed at describing the anatomy of the nasal turbinates in adult Yankasa sheep using sectional anatomical planes and light microscopy. A total of 5 heads of Yankasa sheep obtained from the abattoir were used. The gross observations of the nasal turbinates were presented in midsagittal and serialized transverse sections. The na...
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Chondromas are tumors due to proliferation of cartilage cells. Most arise from residual cartilage in the bone and cause chondromas within the bone, they are called enchondromas. Rarely, a chondroma may develop from cartilage cells between the periosteum and the bone, they are called parosteal chondromas. Even less common are soft tissue chondromas...
Article
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The present study, conducted on the larynx of five adult Yankasa sheep was aimed at exploring its basic anatomy and histological features. The larynx consists of four cartilages; the unpaired epiglottis rostroventral, unpaired thyroid ventrally, dorsal paired arytenoid, and caudal unpaired cricoid. These cartilages presented distinct morphological...
Article
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The bones and joints in the skeletal system are composed of diverse cell types, including vascular niches, bone cells, connective tissue cells and mineral deposits and regulate whole-body homeostasis. The capacity of maintaining strength and generation of blood lineages lies within the skeletal system. Bone harbours blood and immune cells and their...
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The term “stromal cells” refers to a highly heterogeneous class of connective tissue cells that build the infrastructure of any organ and fulfill a variety of fundamental roles in health and disease [...]
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The uveal tract consists of the iris, the ciliary body and the choroid; these three distinct tissues form a continuous layer within the eye. Uveitis refers to inflammation of any region of the uveal tract. Despite being grouped together anatomically, the iris, ciliary body and choroid are distinct functionally, and inflammatory diseases may affect...
Research
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The prime mechanisms for the alteration or reshaping of common somatic gene cells into malignant tumor gene cells are transgenic or oncogene activation and tumor-suppresser gene cell dismission. Cancer genetic cells are the propulsion of growing and expansion. On the other side, they are incapable of developing them self. The wen microhabitat is th...
Article
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OBJECTIVE: To investigate the changes occurring in the umbilical cord of abnormally located placenta previa cases histopathologically and immunohistochemically, together with the clinical data of inflammation and angiogenetic process. STUDY DESIGN: Ten normotensive umbilical cords and 10 placenta previa umbilical cords (a total of 20 umbilical cord...
Article
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Purpose: Inflammation is associated with, and may be causal of, a variety of ophthalmic pathologies. These pathologies are currently difficult to model in vitro because they involve complex interactions between the innate immune system, stromal cells, and other cells that normally maintain ocular tissue homeostasis. Using transscleral drainage chan...
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Relevance. The results of five meta-analyzes of randomized controlled clinical trials indicate an association between genetic deficiency of the folate cycle (GDFC) and autism spectrum disorders (ASD) in children. Autoimmune mechanisms play a special role in the pathogenesis of encephalopathy in children with ASD associated with GDFC. Objective: to...
Article
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Matrix metalloproteinases (MMPs) play an important role in many physiological and pathological processes, including neoplastic processes. They belong to a group of enzymes called endopeptidases and have the ability to hydrolyze all proteins in the extracellular matrix (ECM). They are produced in most connective tissue cells, macrophages, leukocytes...
Article
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The present study was conducted on 18 young pigs of 8-10 months age of local mixed breed to determine the anatomical features of nasal commissures and alae. The gross anatomical studies revealed that external nares were round to oval in shape and bounded by dorsal and ventral commissures and medial and lateral alae. The histological studies reveale...
Article
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Orofacial clefts affect hundreds of thousands of children worldwide annually and are usually corrected by a series of surgeries extending to childhood. The underlying mechanisms that lead to clefts are still unknown, mainly because of the multifactorial etiology and the myriad of interactions between genes and environmental factors. In the present...
Conference Paper
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An extensive ameloblastic fibroma involving bilateral side of the mandible in a teenager Introduction Ameloblastic fibroma is a rare benign odontogenic tumor comprising of both epithelial and mesenchymal cells. It is commonly diagnosed in the first two decades of life and has slight male predilection. Case We report a case of ameloblastic fibroma...
Article
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It is widely believed that vascular endothelial growth factor (VEGF) induces angiogenesis by its direct mitogenic and motogenic actions on vascular endothelial cells. However, these activities are only detected when endothelial cells are cultured at very low (0.1%) serum concentrations and would not be expected to take place at the much higher seru...
Article
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The Mexican Axolotl is able to regenerate missing limb structures in any position along the limb axis throughout its life and serves as an excellent model to understand the basic mechanisms of endogenous regeneration. How the new pattern of the regenerating axolotl limb is established has not been completely resolved. An accumulating body of eviden...
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Epithelial, connective tissue and immune cells contribute in various ways to the pathophysiology of chronic rhinosinusitis (CRS). However, data of their distribution in upper airway mucosa are sparse. We aimed to provide quantitative, purely informative data on the distribution of these cell lineages and their coexpression patterns, which might hel...
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GDM is linked with overexpression of inflammatory cytokines and increased oxidative stress, leading to endothelial dysfunction and vascular disorder. Weaimed to examine the expression of ADAMTS13 and PCNA in the placentas of gestational diabetes mellitus (GDM) patients to investigate the effects of hypoxia, induced by GDM, on proliferation and extr...
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This study investigates the effect of graphene scaffold on morphology, viability, cytoskeleton, focal contacts, mitochondrial network morphology and activity in BALB/3T3 fibroblasts and provides new data on biocompatibility of the “graphene-family nanomaterials”. We used graphene monolayer applied onto glass cover slide by electrochemical delaminat...
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Fibrocytes, a distinct population of collagen-producing, monocyte-derived cells, are involved in wound healing as well as fibrotic diseases. Recently, fibrocytes have been revealed to play a role in the tumor microenvironment, particularly under antiangiogenic therapy. In addition, combination cancer immunotherapy with immune checkpoint inhibitor a...
Article
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Super enhancers (SEs) are large clusters of transcriptional activity enhancers, which drive and control the expression of cell identity genes, as well as differentiation of specific cell types. SEs have great application potential in pathogenic mechanism studies in developmental biology, cancer, and other diseases. However, the potential function a...
Article
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The human respiratory system appears as an outgrowth from the ventral wall of the primary foregut and its development includes a series of subsequent processes, dependent on the interactions between endothelial cells, respiratory epithelium and extracellular matrix (ECM). These interactions determine the acquisition of normal structural and functio...
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Cell dissociation has been an essential procedure for studies at the individual-cell level and/or at a cell-population level (e.g., single cell RNA sequencing and primary cell culture). Yielding viable, healthy cells in large quantities is critical, and the optimal conditions to do so are tissue dependent. Cell populations in the tongue epithelium...
Article
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Coronary arteries supply blood and nutrients to the heart. Coronary Artery Disease (CAD) develops by narrowing of the arteries. Once the inner walls of the arteries are damaged, fatty deposits made of cells, connective tissue elements , lipids and debris decrease their lumens which block blood flow to dis-tal tissues. This process is called arterio...
Article
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In recent years, the role of anti‐proliferative TOB proteins in the regulation of immune response by inhibiting T cell activation has been demonstrated. Nevertheless, no previous studies have explored their expression in patients with IBD. The aim of the study was to characterize the gene and protein expression of the TOB/BTG family in intestinal t...
Article
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In the Xenopus laevis intestine during metamorphosis, stem cells appear and generate the adult epithelium analogous to the mammalian one. We have previously shown that connective tissue cells surrounding the epithelium are essential for the stem cell development. To clarify whether such cells correspond to mammalian Foxl1-expressing mesenchymal cel...
Preprint
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The human adult hyaline cartilage is a unique and special tissue because not only lacks vasculature and innervation, but its nourishment is mainly by diffusion of glucose, which makes the chondrocytes one of the more pleiotropic cells in the organism, functioning in a medium practically anaerobic, and in one tissue which does not hurt when damaged....
Article
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Seminal plasma (SP) deposited in the porcine uterine tract at the time of mating is known to elicit an initial response that is beneficial for pregnancy outcome. However, whether SP has any long-term effect on alterations in endometrial molecular and cellular processes is not known. In this study, using microarray analyses, differential changes in...
Article
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Background: In periodontal connective tissue cells, the vitamin D pathway has been elucidated, and vitamin D3 in the main storage form, 25-hydroxy vitamin D3 (25[OH]D3 ), and the functional form, 1,25-dihydroxy vitamin D3 (1,25[OH]2 D3 ), have been found to induce the expression of human cationic antimicrobial protein (hCAP-18)/LL-37. Moreover, sy...
Article
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Cytomorphometry is used in the sampling of biological materials and diagnostic procedures. The use of cytological studies in periodontal diseases is not well described in the literature. Our study aimed to quantitatively assess the inflammation dynamics using cytomorphometric analysis of the periodontium before and after the use of fixed dental pro...
Article
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The aim of this study was to describe the most common forms of ovarian follicle atresia in large antral follicles of cows and quantify the occurrence of different cell structures in each form. Atresia of antral follicles in ovaries was determined on the basis of ultrastructural images acquired by electron microscopy of ultrathin sections contrasted...
Poster
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Hyaluronidases are enzymes that degrade hyaluronic acid (HA), a fundamental constituent of the extracellular matrix that can be injected subcutaneously for aesthetic purpose. Hyaluronic acid is a glycosaminoglycan (GAG), the main component of the extracellular matrix that links protein filaments, collagen fibers, and connective tissue cells. Hyalur...
Article
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Aims: This study was designed to evaluate the toxicity concern of Dr Iguedo Goko Cleanser® on kidney function parameters and histoarchitecture of the kidneys of exposed Wistar rats. Study Design: A 60-day subchronic toxicological assessment using animal model. Original Research Article Udom et al.; AJRIMPS, 9(1): 30-40, 2020; Article no.AJRIMPS.587...
Article
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The extracellular matrix (ECM) offers a structural basis for regulating cell functions while also acting as a collection point for bioactive molecules and connective tissue cells. To perform pathological functions under a pathological condition, the involved cells need to regulate the ECM to support their altered functions. This is particularly com...
Article
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Pelvic organ prolapse (POP) occurs when the pelvic organs (bladder, bowel or uterus) herniate into the vagina, causing incontinence, voiding, and bowel and sexual dysfunction, negatively impacting upon a woman's quality of life. Intermediate intermolecular cross-links and advanced glycation cross-links increase in prolapsed tissue. Stem cells are a...
Article
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Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds. The post-burn pruritus is a common and serious complication of burn injury, which severely lowers the quality of life of the patient. Many potential treatments are available for pruritus but there is no consensus of the best singl...
Article
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Background and Objective During cyclosporine‐induced gingival overgrowth, the homeostatic balance of gingival connective tissue is disrupted leading to fibrosis. Galectins are glycan‐binding proteins that can modulate a variety of cellular processes including fibrosis in several organs. Here, we study the role of galectin‐8 (Gal‐8) in the response...
Article
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Osteoblasts arise from bone-surrounding connective tissue containing tenocytes and fibroblasts. Lineages of these cell populations and mechanisms of their differentiation are not well understood. Screening enhancer-trap lines of zebrafish allowed us to identify Ebf3 as a transcription factor marking tenocytes and connective tissue cells in skeletal...
Article
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Systemic sclerosis (SSc) is a multi-system autoimmune disease with tissue fibrosis prominent in the skin and lung. In this review, we briefly describe the autoimmune features (mainly autoantibody production and cytokine profiles) and the potential pathogenic contributors including genetic/epigenetic predisposition, and environmental factors. We loo...
Article
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Skeletal muscle fibro-adipogenic progenitors (FAPs) are tissue-resident connective tissue cells and the main cellular source of pathological fibro-fatty scar associated with muscle disorders. Although our knowledge about skeletal muscle mesenchymal progenitor cells has exploded in the past decade, we still lack information about their origin, fate,...
Article
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Although the factors regulating muscle cell differentiation are well described, we know very little about how differentiating muscle fibers are organized into individual muscle tissue bundles. Disruption of these processes leads to muscle hypoplasia or dysplasia, and replicating these events is vital in tissue engineering approaches. We describe th...
Article
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Background. In the field of periodontal guided tissue regeneration, microperforated membranes have recently proved to be very promising periodontal regenerative tissue engineering tools. Regenerative periodontal approaches, employing gingival mesenchymal stem/progenitor cells in combination with these novel membranes, would occur mostly in inflamed...
Article
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Cardiac myxomas (CM) is by far the most common type of primary cardiac neoplasm that commonly arise within the left atria and is composed of primitive connective tissue cells and stroma. Despite the benign nature, the CMs are often surgically removed because they can lead to severe complications. Large, thin, and hypermobile forms are unusual. The...
Article
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Kaposi's sarcoma (KS) is the most common malignancy observed in patient with acquired immune deficiency syndrome (AIDS). It rarely causes upper airway obstruction. We report a 39-year-old gentleman, a former intravenous drug user with AIDS and Hepatitis C positive who developed progressive hoarseness with stidor. He underwent an emergency tracheost...
Article
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Limb regeneration is the outcome of a complex sequence of events that are mediated by interactions between cells derived from the tissues of the amputated stump. Early in regeneration, these interactions are mediated by growth factor/morphogen signaling associated with nerves and the wound epithelium. One shared property of these proregenerative si...
Article
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GBR has shown high long-term success rates (implant survival rates) that are similar to implant placement in pristine bone based on high evidence level publications. Moreover, it has been demonstrated that these success rates are achieved whether GBR is applied in a simultaneous or staged approach.[1] GBR is an alveolar ridge augmentation techni...