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Complementary Therapies - Science topic

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Let’s explore the growing impact of nutraceuticals on human health: their bioactive compounds are gaining recognition for their integrative roles in disease prevention, chronic condition management, and enhancing overall well-being.
A special issue of Nutrients MDPI (Nutrition and Public Health section) is open for manuscript submissions until July 20, 2025.
Guest editors Dr. Michele Antonelli and Dr. Davide Donelli encourage submissions that deepen our understanding of nutraceuticals’ efficacy, safety, and regulatory frameworks. Accepted papers will be published online with open access.
Let’s discuss how nutraceuticals are shaping the future of evidence-based medicine!
🧬🌿
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I believe it is important to understand and research the novel benefits of nutraceuticals and their bioactive compounds. Bioactive macromolecules such as polysaccharides, β-glucans, lectins, lovastatin, peptides, phenolics, and flavonoids exhibit nutraceutical properties including antioxidant activity, anti-cancer effects, and anti-diabetic benefits.
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Searching for articles pertaining to any alternative treatments or complementary therapies for monosymptomatic enuresis. specific powered analyses or even postulates
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Thank you. It is indeed difficult to locate the alternative therapies. The known modalitites of the alarms and training of parents and children are already well documented but the accupuncture , herbal and other modalitites lack concrete head to head evidence.
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Validating a psychological therapy involves a process similar to validating assessment tools, but with some differences given the dynamic nature of therapy. Here's a general outline of the steps involved:
  1. Theory and Rationale: Clearly define the theoretical framework underlying the therapy and articulate the rationale for how it is expected to work. This step involves synthesizing existing research and theory to establish the conceptual basis for the therapy.
  2. Manual Development: Develop a treatment manual that outlines the procedures, techniques, and protocols of the therapy. The manual should provide detailed instructions for therapists on how to deliver the intervention consistently.
  3. Pilot Testing: Conduct pilot testing of the therapy with a small sample of participants to assess its feasibility, acceptability, and initial efficacy. This step helps identify any logistical or practical issues with delivering the therapy and informs adjustments to the manual or procedures.
  4. Randomized Controlled Trials (RCTs): Conduct well-designed RCTs to evaluate the efficacy of the therapy compared to control conditions (e.g., waitlist, placebo, alternative therapy). Randomization helps ensure that any observed effects are due to the therapy itself rather than other factors.
  5. Outcome Measures: Select appropriate outcome measures to assess the effects of the therapy on relevant variables (e.g., symptoms, functioning, quality of life). These measures should have established reliability and validity and be sensitive to changes expected from the therapy.
  6. Assessment Points: Determine the timing of assessments to capture changes in outcomes over the course of therapy and follow-up periods. Multiple assessment points allow for the examination of both short-term and long-term effects.
  7. Statistical Analysis: Analyze the data using appropriate statistical methods to compare outcomes between the therapy and control groups. This may involve techniques such as analysis of covariance (ANCOVA), mixed-effects modeling, or survival analysis, depending on the study design and outcome variables.
  8. Clinical Significance: Assess the clinical significance of treatment effects by considering not only statistical significance but also the magnitude of change and its practical relevance for patients' lives.
  9. Mediation and Moderation Analysis: Explore potential mechanisms of change (mediators) and factors that influence treatment outcomes (moderators) through mediation and moderation analyses. Understanding these processes can inform refinements to the therapy and help personalize treatment approaches.
  10. Replication and Extension: Replicate findings in independent samples and settings to establish the generalizability of the therapy's effects. Additionally, conduct studies to examine the effectiveness of the therapy when delivered in real-world clinical settings and by community providers.
  11. Meta-Analysis: Synthesize findings from multiple studies using meta-analysis to provide a comprehensive overview of the therapy's efficacy across diverse populations and contexts.
  12. Dissemination and Implementation: Disseminate the findings through publication in peer-reviewed journals, presentations at conferences, and outreach to clinicians and policymakers. Provide training and support for clinicians interested in implementing the therapy in their practice.
By following these steps, researchers can rigorously evaluate the efficacy of psychological therapies and contribute to the evidence base supporting their use in clinical practice.
To give reference
Singha, R. (2024).How to validate a psychological therapy? Retrieved from https://www.researchgate.net/post/How_to_validate_a_psychological_therapy
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Thanks, this is a clear and very well laid out set of steps.
I do feel that for non-pharmaceutical studies that removing or minimising the placebo effect may be a disservice to the methodology that is studied.
I believe that the placebo and nocebo effects are integral to understanding treatment outcomes. Some treatments derive their efficacy from enhancing the placebo effect, which is a well-documented and beneficial phenomenon. Conversely, the nocebo effect can exacerbate perceptions of danger and elicit exaggerated responses to perceived threats. The challenge lies in isolating and accurately recording these cognitive influences.
There is a crucial intersection between science and innovation where research should focus on understanding why certain treatments yield positive results, rather than solely aiming to disprove hypotheses through traditional falsifiability methods. Both approaches—proving a treatment's efficacy and attempting to disprove it—can introduce bias.
In my own research, I have found that excluding placebo and nocebo effects might be counterproductive. Instead, we should explore ways to harness and enhance these natural healing phenomena to alleviate chronic pain. Investigating the mechanisms behind treatment efficacy can accelerate the development of effective cures more efficiently than traditional hypothesis testing.
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TMJ arthroscientesis alternatives therapy.
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In 20 years of practice I've never seen this done. Most of the time temporomandibular disorders are a conservative musculoskeletal problem that should be managed by a properly trained physiotherapist. Needles are rarely required.
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Since antibacterial resistance is becoming a fast-rising crisis in the field of healthcare, I would like to know how where do these known and existing therapies stand as secondary methods of treatment for these drug resistant bacteria, and how affective are these methods compared to standard antibiotics.
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Depending upon the evidence base for their effectiveness, as well as the placebo response, alternative and complementary therapies may build immune system resistance. RCT trials will be needed to evaluate effectiveness against standard antibiotics and other treatment methods.
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Dear research family, my kind greetings. How can we address AMR by avoiding use of antimicrobials? i.e. using alternative therapies. What alternative therapies and strategies are available?
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Dear Dr Manal Hadi Kanaan , thank you very much for your encouraging contributions. Much appreciated Manal Hadi Kanaan
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in HIV / AIDS research, Could fecal microbiota transplantation be considered as an alternative therapy to antiretrovirals?
What treatment (FMT and ART) for people with HIV do you think is the most appropriate?
If the FMT has been around for many years, why do you think it has not been implemented as yet another alternative against HIV?
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FMT has some studies treating intestinal disbiosis caused by chronic inflammation in HIV, not as an alternative to ART to control the viremia.
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Hi,
I am looking for a scale to determine if participants are more prone to accept scientific or 'transcendental explanations to alternative therapies. My hypothesis is that if expectancies/beliefs and explanations provided are coherent, the alternative therapy will have a bigger effect.
Is there any validated tool to measure a similar construct? I am thinking about some scale containing items like 'science cannot explain everything', 'if a therapy is not scientifically tested, it should not be used', or 'some phenomena are beyond our understanding'.
Thanks!
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Maybe it's not 100% what you're looking for - but i think the 10-item Belief in Science Scale by Farias et al., 2013 is really close to what you're trying to measure ( ).
It measures the extent to which people believe in the superiority of science and the extent to which people believe science is an important and valuable social institution (Some items sound like the one you were talking in your question: “Science provides us with a better understanding of the universe than does religion”).
Maybe you can check out all of the "Bullshit receptivity" stream of research as well (e.g. "On the reception and detection of pseudo-profound bullshit, by Pennycook et al. 2015" - http://journal.sjdm.org/15/15923a/jdm15923a.pdf ).
There's a nice debate around religiosity, spirituality and receptivity to pseudo-profound claims, we talk about it in our working paper ( )
Hope it's useful!
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prolonged use of conventional anti-rheumatoid is detrimental hence need for alternative therapy
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Dear Mwihia Stephen,
Propolis has a complex composition. Many of its pharmacological affects are believed to be related to phenolic compounds. Caffeic acid phenethyl ester (CAPE) is among the most active compounds with antiinflammatory activity. Here we have reviewed of the pharmacology of CAPE and clinical trials: https://www.academia.edu/40588958
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Urotherapy is an established practice. Urotherapy has been practiced for treating piles, Atheletics foot, prevention from wetting the bed and skin care. The safety of urotherapy has not been established by scientific studies.
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Specially using music, binaural beats and solfeggio?
I am looking for recent studies.
Thanks,
Iara
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TRD (Treatment Resistant Depression) is the subject of my research. However, I will let you know as soon as I have it ready to announce here. Thanks for your interest.
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It would be a small-scale pilot study using myself as the provider and volunteers as clients.  I'm fascinated by reflexology and it's charted indications of active health conditions in clients upon subjective palpation review.  I believe the mechanisms of reflexology are similar to that of acupuncture.  I'd like to research even elementary connections between the two disciplines.  Any constructive advice appreciated.
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The "Gold Standard" is fMRI imaging.  Eg, if you stimulate a point near the 5th toe, areas in the occipital lobe "light up",  or stimulate a point on the ventral wrist between flexor carpi radialis and palmaris longus, near where your wrist watch might sit, and multiple centres in the cerebellum "light up". You need large sums of money, even in a small pilot study. Costs range from a low of AUD$360 per 1/2 hour at University of Melbourne, Australia through USD$621 per hour at University of Michigan to up to USD$800 per 1/2 hour at Indiana University.
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I am looking for freely available research tools to measure burnout among health care workers and teachers
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Practice of yoga improves the physical health. There are a number of studies available that prove the efficacy of yoga as therapy. Can someone practice it during spinal cord injury?
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Any injury can be treated with yoga and CAM effectively. Time and nature of intervention, would depend on the type of injury. Divine association can also make the patient feel comfortable.  Yoga and Asanas may be correctly practiced with concurrent use of other CAM medicines also. Surgery may be an aided requirement. Diseases may be treated with multidisciplinary approach, all that is required is a perfect coordination between them.
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Several medicines as well as complementary therapies promises that their use can improve the bowel movement. How can anyone understand whether the medicine is working or not?
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Meant to add that the letter we published can be found at:
Constipation: patient perceptions compared to diagnostic tools.
Liz Brown, Iain Lawrie, Viv Barros D'Sa, Sarah Wilcox, Mike Bennett
Palliative Medicine 11/2006; 20(7):717-8.
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Cupping therapy with drugs or drugs alone.
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Dear Samira,
Cupping therapy is good for many diseases and it is Sunnah. However one has to be very careful in this. Certified and recognized clinics should be approached for this. The relevant physicians should also be consulted. To my knowledge its an effective treatment for so many known and unknown diseases in human body. Do read about articles on this. Its called as Hijama also. Please visit Al-hudaI International website.
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Supportive measures like psychotherapy, diet advice, creative activities and massage therapy may be equally rewarding in complicated cases like cancer etc.,
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I think integrative method is the best