Clomiphene - Science topic

DFT calculations were used to investigate the reaction mechanism and guide the optimization of selective O‐alkylation conditions, minimizing side reactions and hazardous waste. The O‐alkylation of 4‐hydroxybenzophenone and 4‐bromophenol was studied to synthesize intermediates for Clomiphene and Tamoxifen. DFT studies revealed that C‐alkylation is t...

Clomiphene citrate (CC) is commonly used for infertility treatments, particularly in intrauterine insemination (IUI) and in vitro fertilization (IVF) programs. Despite its effectiveness in inducing ovulation, it is reported to have a low pregnancy rate compared to letrozole. Further, risks of ectopic pregnancy, miscarriage, and fetal malformations...

Background: Epithelial ovarian tumors are among the most lethal gynecologic malignancies, often presenting at an advanced stage due to vague symptoms and lack of early detection strategies. These tumors account for the majority of ovarian cancer cases worldwide and pose a significant burden in low-resource settings. Identifying key risk factors in...

Background Obesity has been implicated in reproductive problems, particularly in male functionality disorder while the therapeutic effects of ginger have been owing to its pharmacological activities. Aim The study compares ginger-inclusive diet effects on fertility parameters in obese rats. Methods Rats were given a high-cholesterol diet to induc...

While some studies have implicated the histone 3 lysine 4 demethylase KDM5A in tumorigenesis and promotion of metastasis, KDM5A has also been shown to boost immunotherapy responses in melanoma. The distinct functional role of KDM5A in the context of immunotherapy and the underlying mechanisms remain largely unknown. Here, we report that higher KDM5...

Purpose To investigate the association between fertility drug use and non-Hodgkin lymphoma. Methods This cohort study utilized data from the extensive Danish Infertility Cohort, comprising 148,036 women with fertility problems residing in Denmark between January 1, 1995 and December 31, 2017. The study cohort was linked to national registers to ga...

Purpose The aim of this research is to assess the development potential of oocytes and zygotes obtained from Natural cycle IVF (NC-IVF), different minimal stimulation IVF (Min stim-IVF) and conventionally stimulated IVF (cIVF) treatment protocols. Methods International multi-centre retrospective cohort study including 1483 NC-IVF, 1208 Min stim-IV...

Letrozole, an aromatase inhibitor, is commonly used for ovulation induction in patients with polycystic ovary syndrome (PCOS). However, the effect of different doses of letrozole on pregnancy outcomes remains controversial. This systematic review and network meta‑analysis aims to compare the effects of different doses of letrozole on pregnancy outc...

Objective: We aimed to compare the efficacy and safety of letrozole and clomiphene versus letrozole alone for ovulation induction in patients with Polycystic Ovary Syndrome (PCOS). Data Sources: We systematically searched EMBASE, PubMed, and Cochrane databases on October 31, 2024. Study selection: We included studies of women with PCOS treated wi...

Context Polycystic ovary syndrome (PCOS) affects up to one-in-five reproductive-aged women and its global healthcare-related economic burden is substantial. The aim of this review was to summarise evidence of the cost-effectiveness of interventions related to the treatment of women with PCOS. Evidence Acquisition Six academic databases were system...

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder prevalent in women of reproductive age. Treatment or management of this syndrome includes several pharmacological and non-pharmacological treatment approaches for different manifestations of the disease that vary with the patient’s age, symptoms, requirements, and geographical lo...

Objectives The literature indicates that there is no clear consensus on the effectiveness of assisted reproductive techniques (ART) in women with thyroid disorders. In this study, we aimed to compare the reproductive outcomes of patients taking clomiphene citrate (CC), focusing on those with normo-thyroid TSH concentrations (<2.5 µIU/ml) and those...

Introduction: Polycystic ovarian syndrome (PCOS) is often accompanied by anovulatory infertility in women and contributes to lower pregnancy rates and an increased risk of miscarriage. While clomiphene citrate (CC) is the first line treatment for ovulation induction, CC resistance develops in 15 to 40% of women with PCOS. Emerging studies suggest t...

Clomiphene citrate is a well-established treatment for Polycystic Ovarian Syndrome (PCOS) but has poor efficacy and adverse effects. Coenzyme Q10 supplementation improves mitochondrial function. Letrozole has been reported to be effective with fewer adverse effects but is not approved for PCOS by the USFDA. This is a retrospective study in women di...

This study aimed to investigate the effects of probiotic Bifidobacterium longum subsp. longum BL21 on reproductive health in zebrafish (Danio rerio), focusing on hormonal modulation, sperm vitality, and overall reproductive function improvement. Adult male zebrafish of the wild-type AB strain were divided into four groups: control (CTL), model cont...

Polycystic ovary syndrome (PCOS) is a common gynaecological complication with alarmingly high incidence of 6–20% in women of reproductive age and leads to multifaceted symptoms such as menstrual irregularities, hyperandrogenism, polycystic ovaries, and insulin resistance. Several therapeutic methods have been recommended for PCOS including lifestyl...

HIGHLIGHTS Polycystic ovarian syndrome (PCOS) is a hyperandrogenous state with oligo-anovulation. Letrozole is more efficient than CC in promoting ovulation and facilitating pregnancy in women with PCOS who are overweight or obese. ABSTRACT Objective: Indonesia has a higher prevalence of PCOS, a common endocrine disorder that affects 4% to 8% of wo...

This study was conducted to determination the effects of fertility drugs on some sex hormones and the histological changes of the ovary. Forty-two of female rats were used, it divided into sevsn groups, each group containing 6 rats. The first group was fed with distilled water and feed as control group. The second and third groups were received Clo...

Azanza garckeana (Gorun Tula) is a commonly consumed edible plant, in parts of Nigeria, with claims by many that it possesses several medicinal potencies like aphrodisiac effects and more. Thus, the present study investigated the effects of the Azanza garckeana hydromethanolic seed extract (AgSE) on percentage body weight changes, reproductive horm...

Case Description A 35-year-old woman with a history of intrauterine device use for family planning presented with a spontaneously conceived heterotopic pregnancy. Clinical Findings The patient developed a ruptured cornual ectopic pregnancy, leading to hemodynamic instability and an acute abdomen, while concurrently carrying a viable intrauterine p...

Ethmocephaly is the most severe form of holoprosencephaly, which results from incomplete cleavage of the forebrain during embryogenesis. It is incompatible with life. Here we reported a case of ethmocephaly in a clomiphene citrate induced pregnancy. Hereby we reported a 32-year-old woman, gravida 6, at a gestational age of 23 weeks, presented for r...

Infertility remains a significant challenge in women’s reproductive health, necessitating the development of innovative therapeutic strategies. Advances in pharmacological interventions, including hormonal therapies like clomiphene citrate, gonadotropins, and letrozole, have improved ovulatory function and pregnancy rates. Assisted reproductive...

Background Clomiphene citrate effectively suppressed the negative feedback of estrogen on the hypothalamus and induces premature luteinizing hormone (LH) surge during controlled ovulation stimulation, while obese women often have impaired hypothalamic-pituitary function. This study aimed to investigate whether the utilization of clomiphene citrate...

This study examined the impact of Phyllanthus muellerianus root extracts on lipid profiles in rats with letrozole-induced polycystic ovary syndrome (PCOS). Aqueous and ethanolic extracts of P. muellerianus were prepared using maceration and infusion methods. Forty-two adult female Wistar rats were divided into groups and treated for 21 days with le...

Background The term post-cycle therapy (PCT) often appears in bodybuilding forums in the context of anabolic-androgenic steroids (AAS) cessation. To reduce the negative impact of AAS on the hormonal system, unapproved PCT is used, which consist of medications that help restore hormonal balance. The most used medicinal products are selective estroge...

Osteoarthritis (OA) is a progressive degenerative joint disease that significantly impairs mobility and quality of life, particularly in aging populations. Current therapeutic approaches primarily focus on symptom relief, but fail to address the underlying mechanisms of cartilage degeneration. In recent years, epigenetic reprogramming has emerged a...

Previous epidemiological studies have suggested that green tea catechins, including Epigallocatechin‐3‐gallate (EGCG), the most abundant polyphenol in green tea, may be associated with reduced serum folate levels. This is of particular interest as women of childbearing age may be consuming EGCG from tea, dietary supplements, or involved in active c...

Due to healthcare shortages and high infertility costs, medicinal plants and herbal preparations with fertility properties are gaining popularity in developing countries. In this study, female wistar rats were treated with n-hexane (nHE), dichloromethane (DCM), and aqueous ethanol (Aq. Eth) extracts of Cucurbita pepo seed to investigate its effect...

Objective: To evaluate the effects of Corchorus olitorius leaf extract on induced polycystic ovarian syndrome (PCOS) rats. Materials and Methods: 36 female Wistar rats were divided into six groups (n=6) including Sham, PCOS + vehicle (Dimethyl sulfoxide), PCOS + Clomiphene citrate, PCOS + 200, 400, and 600 mg/kg Corchorus olitorius. The Sham group...

Abstract Introduction Ovarian hyperstimulation syndrome (OHSS) is a potentially severe complication of ovulation induction. Although less common than with gonadotropin treatment, OHSS can occur secondary to an excessive dose of clomiphene citrate, a first-line ovulation induction agent. A serious complication of OHSS is ovarian torsion, which deman...

Due to healthcare shortages and high infertility costs, medicinal plants and herbal preparations with fertility properties are gaining popularity in developing countries. In this study, female wistar rats were treated with n-hexane (nHE), dichloromethane (DCM), and aqueous ethanol (Aq. Eth) extracts of Cucurbita pepo seed to investigate its effect...

Heterotopic pregnancy (HTP) is a rare, life‐threatening condition in which both extrauterine and intrauterine gestation co‐occur. It presents diagnostic and therapeutic challenges for physicians, often being missed or overlooked. A heterotopic pregnancy must always be considered if a patient presents with pelvic pain, especially when pregnancy is a...

Aim: Polycystic ovary syndrome is a very common endocrine and metabolic disease in clinical practice. Most polycystic ovary syndrome patients are complicated with obesity, a condition associated with an elevated risk of long-term complications such as diabetes, hypertension, and endometrial cancer, seriously threatening the health of patients. The...

CASE HISTORY: A 49-year-old male and a 41-year-old female with a seven-year history of infertility presented to Urology. Despite a successful IVF in 2021, natural conception remained elusive. The male reported fatigue, lethargy, low libido, and unexplained weight gain. A prior scrotal ultrasound detected bilateral varicocele with reverse flow. Both...

Polycystic Ovarian Syndrome is a complex, gynecological disorder. Being multifactorial, the most common risk associated with it is infertility. Hyperandrogenism is the major hallmark feature in distinguishing PCOS. CYP17, an enzyme essential for the androgen synthesis, when overexpressed, leads to hyperandrogenism. Inhibiting this overexpression wo...

Psidium guajava, also known as guava, is a tropical fruit known for its nutritional and medicinal benefits. It contains bioactive substances like flavonoids, phenolic acids, and essential oils, which have antioxidant activity, aiding in reducing oxidative stress and reducing the risk of chronic illnesses. Guava's fiber content and laxative properti...

Influential guidelines have supported the role of metformin in the management of polycystic ovary syndrome (PCOS) for a number of years. However, regulatory approvals for this therapeutic indication are still exceptional and exist only in a few countries, including for the originator, Glucophage®. PCOS is an insulin-resistant state, which drives hy...

Objective: To assess the efficacy and safety of drugs used for infertility with respect to ovulation induction and conception. Methods: A prospective observational study was conducted in gynaecology Out Patient Department (OPD) of a tertiary care hospital from June 2019 to November 2019. 45 women who presented with history of infertility were inclu...

Infertility is a chronic illness that causes not only medical but also creates social, mental and financial burden on the couples and their families. Infertility is defined as failure to conceive within one or more years of regular unprotected coitus (intercourse). Infertility is a global problem in the field of reproductive health. It affects appr...

Purpose Clomiphene citrate (CC) is often utilized as an adjunct in in vitro fertilization (IVF) protocols during the first 5 days of stimulation for endogenous FSH release. However, due to its antiestrogenic mechanism of action, CC may also effectively prevent the LH surge, and hence premature ovulation, if continued until the day of trigger. The o...

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by subfertility, insulin resistance and metabolic dysfunction, commonly associated with nonalcoholic fatty liver disease (NAFLD). Letrozole is a first line ovulation induction agent, superior to clomiphene citrate but liver effects in PCOS patients with and...

Fertility stimulants are medications used to enhance reproductive fertility in both men and women. Clomiphene citrate (Clomid), Duphaston, and Procreation V are commonly used fertility drugs. However, their prolonged use has been associatd with adverse effects, including histological and biochemical changes in the liver and kidney. This study aimed...

Introduction & Purpose of Research: Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder affecting women of reproductive age. Given the high prevalence of PCOS and its impact on infertility, this research explores strategies to stimulate ovulation and improve pregnancy outcomes. To address this issue comprehensively, we specifically selec...

Purpose Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, often leading to anovulatory infertility. Obesity exacerbates the reproductive, metabolic and psychological features of PCOS, making fertility treatment and patient satisfaction difficult. Despite guidelines from the European Society of Human Repro...

Gynecology surrounds a roomy range of medical environments and physiologic states specific to the female generative order, necessitating miscellaneous pharmacological attacks. This review surveys the classifications, mechanisms of operation, and dispassionate applications of drugs secondhand in gynecology. Hormonal medicines, including spoken contr...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age and requires better treatment. N-acetylcysteine (NAC) is known to be beneficial under such conditions owing to its antioxidant potential and insulin-sensitizing properties. The effect of NAC on the reproductive outcomes of PCOS patient...

Clomiphene (CL) is a widely used antiestrogenic drug for inducing ovulation. The drug is marketed as a mixture of two geometric isomers, E-CL (62%) and Z-CL (38%), with opposing actions and low water solubility. Chemical separation and enhanced solubility can be achieved through cyclodextrin (CD) association. Recent ¹H NMR titration experiments hav...

Clomiphene Citrate (CC), a selective estrogen receptor modulator, represents a valuable therapeutic option for addressing male hypogonadism and infertility. This article reviews practical approaches to CC prescription, emphasizing its use both as monotherapy and in combination with other treatments. Clinical evidence consistently demonstrates that...

Aim: The study aimed to evaluate whether the CYP3A4 mutation was associated with the response of Iraqi women to clomiphene citrate. Patients, Materials, and Methods: in this cohort study, 80 women with polycystic ovarian syndrome received monotherapy with clomiphene citrate (100 mg/day). We evaluated the cytochrome P450 3A4*18 genotypes in these wo...

Objective Male infertility is a common issue that affects people worldwide and presents challenges in terms of treatment. In recent times, there has been significant interest in the use of herbal remedies as a potential solution for male infertility. In this study, we aimed to assess and compare the effects of clomiphene, carrot seed, and education...

A 62-year-old female patient, in menopause since the age of 47, presented with severe and virilizing hyperandrogenism condition that had been progressing for 10 years, with plasma testosterone levels above 500 ng/dL. Medical history included Cushing 's disease in remission since hypophysectomy in 2014 and obesity. On imaging tests, there was an ade...

A 62-year-old female patient, in menopause since the age of 47, presented with severe and virilizing hyperandrogenism condition that had been progressing for 10 years, with plasma testos-terone levels above 500 ng/dL. Medical history included Cushing 's disease in remission since hypophysectomy in 2014 and obesity. On imaging tests, there was an ad...

Introduction Infertility is the inability to achieve pregnancy after one year of unprotected intercourse. However, over 50% of couples undergoing infertility evaluations will conceive within 2 to 3 years, either naturally or with the help of interventions such as intrauterine insemination or in vitro fertilization, leading to a successful pregnancy...

Clomiphene citrate (CC) has emerged as a safe and effective therapy for male hypogonadism and infertility, particularly for men seeking to preserve fertility. However, clinical responses remain variable, and identifying pre-treatment predictors of therapeutic success or failure is crucial to guide patient selection and optimize outcomes. This lette...

Clomiphene Citrate (CC) has been widely used in medicine since the 1970s, primarily as a Selective Estrogen Receptor Modulator (SERM) for female ovulation induction. However, its off-label use in men has gained traction, particularly for the treatment of hypogonadotropic hypogonadism and idiopathic infertility. CC’s mechanism of action, which incre...

Purpose To evaluate the effect of transvaginal ovarian drilling (TVOD) on IVF outcomes in subjects with clomiphene-resistant PCOS and a history of IVF failure. Methods Between 2008 and 2011, 19 subjects with sonographically PCOS and a history of failure to ovulate to high-dose clomiphene citrate were prospectively followed and underwent TVOD at a...

Background: In women of reproductive age, polycystic ovary syndrome or PCOS has become themost frequent cause of anovulatory infertility. Although CC has been used in the past as the firstline treatment for ovulation induction, recent challenges such as antiestrogen city of the drug andpoor response in certain patients have seen use of the like of...

Objective To explore whether acupuncture combined with clomiphene can reduce the luteinizing hormone-to follicle-stimulating hormone ratio and impact the gut microbiota in patients with obese polycystic ovary syndrome. Methods This open-label, randomized, parallel-group controlled trial included 86 women aged 20–40 years with obese polycystic ovar...

Background: Laparoscopic ovarian drilling (LOD) is superior to gonadotropins as it induces mono-ovulation, hence eliminating the potential risks linked to multiple pregnancies or ovarian hyperstimulation syndrome. Aim: To contrast the efficiency of unilateral laparoscopic ovarian drilling (ULOD) and bilateral ovarian drilling (BLOD) in treating clo...

Objectives On the first line of polycystic ovary syndrome (PCOS) treatment, ovulation with clomiphene citrate (CC) is induced. However, 25% of patients need alternative therapy. Laparoscopic ovarian drilling (LOD) can result in successive ovulations and is not linked to ovarian hyperstimulation. In this systematic review and meta-analysis, we aimed...

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hormonal imbalances, metabolic disturbances, and ovarian dysfunction. This study aimed to investigate the therapeutic potential of methanol extract from Psidium guajava leaves as a natural remedy for alleviating PCOS symptoms in female albino rats. The experimental a...

Objectives: This study investigated the potential ameliorative effects of Albizia ferruginea leaves on letrozole-induced PCOS in Wistar rats. Methods: PCOS was induced in 25 female Wistar rats by administering letrozole (1 mg/kg), followed by treatment with 100 and 250 mg/kg body weight A. ferruginea leaf methanolic extract, as well as 1 mg/kg body...

Introduction Ovarian torsion during pregnancy is a rare condition that requires prompt diagnosis and repositioning to preserve ovarian function. Case Report A 32-year-old woman underwent a successful pregnancy after FET, but was hospitalized for observation because of a threatened abortion. During the 8th week of pregnancy, a transvaginal ultrasou...

Objective: This study utilized shear wave elastography (SWE) to evaluate endometrial receptivity (ER) in cases of unexplained infertility (UI) following treatment with clomiphene citrate (CC). The aim was to establish a reliable imaging reference for clinical treatment. Methods: This investigation encompassed 68 patients with UI who attended our ho...

Background Anabolic androgenic steroids (AAS) are synthetic forms of testosterone frequently used as performance enhancing drugs among gay, bisexual, and queer (GBQ) men. Despite widespread use, associated harms, and the likely existence of an AAS use disorder, there is no medical consensus on standards of care for people who use AAS, with most med...

Background The role of laparoscopy and hysteroscopy in managing unexplained infertility (UI) is debatable because of the improved success rate of assisted reproductive technologies (ART). This study aims to assess the findings of laparoscopy and hysteroscopy in selected women diagnosed with UI to determine the frequency of such pathological conditi...

Hypogonadism in men is a clinical condition characterized by insufficient production of testosterone leading to infertility.The aim of this study is to investigate the combined effects of varying clomiphene citrate (CC) dosages and different exercise modalities (aerobic vs. resistance training) on sperm quality parameters, including sperm count, mo...

Background: Clomiphene citrate (CC) is one of the first and commonest drug management for treating ovulatory dysfunction in polycystic ovary syndrome (PCOS) patients as it is cheap, has minimum adverse effects, and needs less monitoring. There is a common difference concerning ovulation and pregnancy rates due to antiestrogenic properties y that in...

Benign prostatic hyperplasia (BPH) is known to negatively impact male fertility. This can occur via various mechanisms. It can be due to the intrinsic enlargement of the prostate gland, inflammation of the prostate gland and its contiguous structures, as well as the treatment modalities of BPH. Most of the treatment options for LUTS due to BPH, bot...

Objective: Polycystic Ovarian Syndrome (PCOS) is a common cause of ovulatory dysfunction and infertility, often requiring patients to undergo hormonal treatments to induce ovulation and achieve pregnancy. Despite numerous studies, no meta-analysis has yet evaluated the role of letrozole combined with human menopausal gonadotropin (HMG) in treating...

Introduction: Infertility related to polycystic ovary syndrome (PCOS) represents a significant challenge for women of reproductive age. Over the last few years, evidence-based medicine has driven new approaches for treating infertility in patients with PCOS, changing rapidly and deeply the clinical practice. Areas covered: The authors provide an...

Background: Poor Ovarian Response (POR) to ovarian stimulation is a challenging factor in Assisted Reproduction Technology (ART). This study aimed to compare the efficacy of a conventional antagonist with high doses of gonadotropin protocol with double stimulation protocol in females with POR. Methods: This randomized clinical trial study was condu...

Drug repositioning is an efficient strategy to search for new treatment alternatives that is especially valuable for neglected parasitic diseases such as leishmaniasis. Tamoxifen and raloxifene are selective estrogen receptor modulators (SERMs) that have shown antileishmanial activity. Clomiphene is a SERM structurally similar to tamoxifen, whose a...

Objective This study aimed to assess the effect of sildenafil citrate and estradiol valerate as adjuvant therapy during ovarian stimulation cycles with clomiphene citrate in patients with unexplained infertility in Kisangani. Method A double-blind, randomized controlled trial was conducted for two years at two specialized health facilities in Kisa...

Objectives: To determine the effect of short-term metformin administration on follicular fluid (FF) total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and nuclear factor kappa B (NF-kB) in women with clomiphene citrate-resistant polycystic ovary syndrome (PCOS). Methods: Fifty-eight patients aged 23–34 who were...

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder and a leading cause of infertility among women of reproductive age. This study examines the diagnostic challenges, clinical features, and treatment outcomes for women with PCOS in Niger State, Nigeria. A prospective analysis of 47 women diagnosed using the Rotterdam criteria reveale...

Infertility is a stigmatized and emotionally challenging issue for affected individuals, often compounded by the high costs of conventional fertility treatments. This study investigated the prophylactic and therapeutic effects of an ethanolic extract of Tamarindus indica fruit pulp on sodium fluoride-induced sexual and reproductive dysfunction in W...

Clomiphene citrate is a selective estrogen receptor modulator commonly used off-label for male infertility despite being approved only for female infertility. Clomiphene is generally safe, and serious adverse effects such as venous thrombosis are rarely reported. This report presents the case of a 32-year-old man who developed portal vein thrombosi...

Infertility is a significant global health issue often exacerbated by environmental toxins like sodium fluoride (NaF), which induces oxidative stress and reproductive dysfunction. Medicinal plants, such as Tamarindus indica, known for their antioxidant properties, offer potential natural remedies. This study evaluates the antioxidant potential of t...

Objective: To compare the effect of two ovulation induction drugs on anti-Mullerian hormone level in polycystic women. Method: The experimental cohort study was done at the infertility outpatient clinics of Al-Yarmouk Teaching Hospital, Baghdad, Iraq, from May 2020 to April 2021, and comprised infertile women aged 18-35 years with confirmed diagnos...

Polycystic ovarian syndrome affects 7 to 10% of women. To manage PCOS in women without lowering the likelihood of becoming pregnant, researchers are looking for botanicals with antioxidant potential, optimum bioavailability, efficacy, and safety. Therefore, this research investigated the effect of Mormodica charantia leaves on PCOS in rats. The tox...

Background: Approximately 13-36% of ovarian stimulation and intrauterine insemination cycles are complicated by premature luteinizing hormone (LH) surge. Gonadotropin releasing hormone (GnRH) agonist or antagonist has been traditionally used to prevent a premature LH surge and premature luteinization in ovarian stimulation cycles. Clomiphene citrat...

Aim: To quantify Clomiphene and Orlistat in pharmaceutical formulations simultaneously, this study is set out to create a sensitive, fast, and accurate stability-indicating RP-HPLC method. Materials and Methods: The isocratic method was used to achieve the chromatographic separation of the Clomiphene and Orlistat mixture. A mobile phase was prepare...

Successful ovulation induction can overcome the common condition of infertility associated with ovulatory dysfunction. Monotherapy of clomiphene citrate (CC) or combined with gonadotrophins are the best treatment modalities for ovulation induction with a successful outcome. We concentrated on evaluating the effects of 100 mg Clomiphene Citrate, bot...