Questions related to Clinical Studies
Hi all academics,
What do you think about the need of melanogenesis research in humans?
Why there is a lack of melanogenesis research in humans?
Recently, using honey 10 ml every 5 minutes po for immediate preoperative protection of the esophagus in children with an esophageal button battery has been proposed and added to guidelines [Mubarak A et al. J Pediatr Gastroenterol Nutr. 2021]. There is one experimental study that looked at the mitigating, pH-neutralizing effects of a variety of agents, including fruit juices, maple syrup, honey and sucralfate suspentsion, which I guess these recommendations are based upon [Anfang RR et al. Laryngoscope. 2019]. The approach is intriguing but I wonder if anyone has clinical experience the application of honey in this setting, and/or working on clinical studies.
Dear Sir/Madam, my question is that as we know we use PICO model in Systematic Literature Review (SLR) mostly for Randomize Clinical Studies. so what model or approach should we use for Observational cohort studies, or case studies or in qualitative research or any other study design? Thank you in advance for kind guidance
As all know, in successful pre clinical cancer experimental studies, only 8% could be successful as well in human studies and clinical trials.
Can you reverse the previous statement, expecting successful data in clinical trials although of failure in pre clinical studies?
Hello! I'm looking for anyone who has had any kind of experience with The Fisher Wallace Stimulator. Please specify whether you have tried the device or know someone who has. Any information would be greatly appreciated. I'm also interested in any clinical studies and which diagnosis in particular has a better efficacy rate.
If we observe, apart from pre-clinical and clinical studies, researcher in health research usually write Review articles. What's you think regarding contribution/impact of review articles in Research field?
I am writing a synopsis for my dissertation on a topic in which I'm comparing 2 endodontic sealers clinically (RCT). there are no clinical studies for their comparison in literature till now. I am having difficulty in calculating sample size. I need guidance.
The concept of angiogenic therapy emerged in the early 1990s. The method employs genes that encode growth factors to promote formation of new vessels and remodeling of collateral vessels. Since the procedure involved in this therapy usually only consists of local injections of vectors, the process is minimally invasive, quick, and simple to perform. However, since the first clinical evidence of the effects of gene therapy with vascular endothelial growth factor (VEGF) was observed in patients with peripheral artery disease, to date only two angiogenic therapy drugs have been approved, one in Russia and another in Japan, which seem a very small number, in view of the large volume of investment made in pre-clinical and clinical studies. After all, can we conclude that angiogenic therapy is a reality?
Keywords: gene therapy; atherosclerosis; peripheral artery disease; limb ischemia.
I would like to conduct the systematic review of stroke studies. I found that the GRADE-CERQual tool is useful to evaluate the strength of qualitative evidence. It is possible if I use this approach for my review?
Thanks for your help
I have seen from some review articles which used the EPHPP or the Newcastle Ottawa Scale (NOS), but I can imagine that these are mainly used for clinical studies (cohort studies, case-control studies, etc.). I did a check on the keys used for the assessment to confirm it.
My systematic review however is not related to clinical studies. I am working on a review in the field of environmental pollution, particularly PAH pollution (which reports on the analytical techniques and the PAH concentrations in the different media), and I need to assess the quality of the already selected list of papers (after using PRISMA guidelines or checklist).
I have conducted a Interventional study with pre-post design where outcomes are measure before and after the intervention. In my study, I also have control group (so study design is "Mult-arm pre-post study). I selected patients through block randomization. I have an argument in scientific community that randomization can only be used for Clinical Trials. My study is not clinical trial, its just prospective intervention study. Is randomization in this study appropriate?
Please help me to find out the recent clinical studies on effect of Pollution on human body and various body systems.Also what parameters/ scoring pattern can be applied in research.
Is a scenario possible wherein the drug exposure achieved in clinical studies surpass or exceed than the exposure achieved in nonclinical toxicity studies conducted of appropriate duration?
And if so, is the dose selection flawed in that particular clinical study?
And to address that kind of a situation, should more nonclinical toxicity studies be performed that test a higher exposure than what is expected in humans?
Does any clinical studies in canine proves that an increase in serum calcium level can be correlated with the occurrence of Mammary tumor in canine patients.
I want to also know whether increased serum calcium level is seen in any other tumor conditions in canines...?
I want to find a database in which i can draw the chemical structure of the core ring and it will give me all the published structures with their biological activity. For example, the benzimidazole ring can be found in different drugs or compounds under clinical study, so which website can give me all compounds containing benzimidazole associated with its biological activity or target protein.
I've just started my masters on a clinical trial (n=36) involving supplementation with different fatty acids .My project is looking into if SNPs can influence certain lipid metabolites. I'm wondering what the advantages/disadvantages are for using whole genome sequencing versus a targeted approach.
Any input is much appreciated!
My name is Amandine HUFSCHMITT, I am a sixth-grade dentistry student from the university of Strasbourg (France). With another dentistry student, we would like to realise a research thesis about the using of carisolv and Papacarie for caring axious patient (adult or children). This thesis will be based on actual articles but also based on a clinical study that we would like to realise in our dentistry clinic of the University of Strasbourg. In that way we need some carisolv and papacarie syringe however there is no carisolv and papacarie distributor in France. That is the reason why we contact you to know how collecting some carisolv and papacarie products for our study. This carisolv study will be the first in France and we wish our work will be published. Thank you for your precious help, if anyone have an idea who can I contact for this sample.
I have been researching about using dichoptic video games for binocular treatment of amblyopia. We have developed various video games prototypes with the anaglyph technique; but we have not been able to do clinical studies.
Are you interested in to do clinical studies about binocular treatment of amblyopia?
CPVT is related to an RyR2 mutation which is a calcium channel. Flecainide is a type 1c antiarrhythmic which acts on the sodium channel. There is controversy as to how this is of benefit but it is clear from clinical studies that flecainide can reduce both atrial and ventricular arrhythmias in CPVT. What is the mechanism and what is the evidence for this?
I conducted a clinical study in which the outcome rate was 26 /200 i.e. 13%. I wanted to do a logistic regression analysis to detect important predictors of this outcome.
Univariate analysis showed that 19 variables had p<0.1, so can be included in the analysis.
My questions are:
1) I was told that in a multivariate logistic analysis, I can only include 1 variable for every 10 events. So, in this case, I should only include 3 variables in every logistic analysis. Is this correct? If so, do I have to repeat the logistic analysis several times in order to enter 3 variables at a time? And which variables should be entered together? Should I choose variable that are related to each other some how? or it doesn't matter, and I can choose any 3 variables that have nothing in common!! Moreover, in the paper, do I write that I performed logistic regression 6 times separately !! I have never seen such a thing in any paper that I read including megatrials !!
2) When I did logistic regression for every 3 variables, I found S.E. was high for some of them, which signals high collinearity. Should I omit one variable with high SE at a time and repeat after replacing it with another variable from the 19?
3) Some variables had high correlations with the constant (p around 0.8 and 0.85), do I omit them too?
Condylus tertius (also known as third occipital condyle,median occipital condyle, or basilar tubercle) is an extremelyrare condition, named by Merkel in 1815.1 There are veryfew clinical studies of prevalence of condylus tertius in theliterature. In humans it is found in approximately 0.5% ofthe population and may exist as a discrete condyle or an isolated osseous element.
The power or sensitivity of a binary hypothesis test is the probability that the test correctly rejects the null hypothesis (H0) when the alternative hypothesis (H1) is true. should this be addressed before every clinical studies?
In a block randomisation clinical study, the block length was 10 which was decided and known only by the biostatician. Random allocation sequence was done with a computerized random-number generator. The allocation numbers were random four-digit numbers which were in non-consecutive order in the allocation list.
Question - If the biostatician is aware of the block length, is this of any significance? Does it bring in any bias?
Preclinical studies suggest carnitine and ALCAR should have antidepressant efficacy, but (to my knowledge) there is a paucity of clinical trials.
i am hoping my RESEARCHGATE colleagues know of clinical studies/reports.
I would like to know if and how it is possible to use Bland-Altmann graph to quantify interobserver variability of measurements done by 3 reseachers. Could you suggest otherwise any alternative statistic methods?
Thank you in advance!
What is/are validated or widely used and accepted tests to score anxiety/depression/stress in clinical studies? (I see HADS, PHQ9, Hamilton in literature)
I'm trying to compare research data received from an experimental model of HF with known facts from clinical studies.
can anybody share checklist for retrospective & prospective study documents needs to be submitted for approval of clinical trials to conduct study with reference.
Are there certain factors could make the statistical significant ( p value less than 0.05) clinically important as larger sample size or randomized controlled clinical studies?
Is that true that there are many clinical studies showing the efficacy of an anticancer treatment with high-dose vitamin C with total remission and pharmaceutical industries have blocked these clinical trials ?
I am in problem in analysis of two studies. a) In an RCT with 50 patients in each group need three followup at day 0, 28 and 90 days. In every follow up there are missing of some patients. Intension to treat basis analysis I need to apply here(Is it oK?) but I want to know the procedure in SPSS-20. b) In another analytic study with 60 patients with convulsion and 60 patients with headache without convulsion, where TSH, fT3 and fT4( to observe sub clinical hypothyroidism) levels are needed to measure at week o, 12 and 24. Here also there are some patients not coming to follow up. Intention to treat analysis is still applicable here with missing values?
Can anyone tell what is the ASTM standard protocol for hydrogel synthesis? And where its used mostly like if you are performing the clinical studies etc. or in general in vitro type of work also you need ASTM standard protocol. Please help?
I am the first author of a group responsible for updating a Cochrane systematic review that needs the cooperation of a Chinese co-author. We are looking for a partner for data extraction and evaluation of some clinical studies and we are not able to partner a few months ago. Do you know someone who can help us?
I don't have any experience in using urine LH ovulation detection strips and wondered if anyone could recommend a particular brand that I ought to consider Or NOT use? I need a testing strip that will reliably measure the LH peak in women. Thank you.
As far as I know, most of the case studies are based on clinical cases. I wonder whether it is acceptable to do a case study with a supernormal participant. I searched it with Google, but found nothing. Have you seen some studies related to supernormal cases?
I found out the optimal version for my experiment would be ABBA/BAAB/AABB/BBAA, but it only made sense just to do a ABBA/BAAB.
My question is what properties of the optimum get lost through this reduction of test groups?
is it still uniform and strongly balanced? If yes, what's the disadvantage of this reduction of groups?
At https://onlinecourses.science.psu.edu/stat509/book/export/html/123 are some definitions, but I'm not sure about whether or not these properties also match with my cross over design...
I am looking for individuals who are evaluating information provided from patients during either specific treatments or during clinical trials....My goal is to somehow obtain quality data and then evaluate that information in a quantitative manner.
We are conducting research on whether a computer-based training simulation can be used to educate clinical staff on the benefits of applying correctly the clinical safety checklist developed by WHO, and how it must be applied. To measure changes in what are the effects of this training approach, we must measure somehow "frequency of application of the safety checklist" and "correctness of application of the safety checklist". As far as we know, there are no validated tools for this.
Any suggestion? Any related work we should be aware of? I'd like to see, for example, if someone knows of anyone that had tried to improve application of a specific protocol/tool/piece of equipment etc. in the OR and had the same need to repeatedly measure correctness on the application of the target element being studied.
Does anyone have any suggestions (pros/cons) with regards to choosing a primary endpoint in a randomized clinical controlled trial with an expected inclusion of 100 patients with pulmonary embolism (intermediate risk, not hemodynamic affected, but with either/or RV involvement an increase in troponins).