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Clinical Nutrition - Science topic

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Questions related to Clinical Nutrition
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Can anyone suggest a SCIE/ Scopus indexed (IF 0.5 - 2.5 preferred) journal in Food Nutrition/ Functional Foods/ Clinical Nutrition categories that accept Reviews?
Especial requirement is the higher number of volumes per annum and lower review time.
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Dear Dr. Madhura Jayasinghe these two journals in food science, kindly check their links that may be useful to what you want.
Functional Foods in Health and Disease
Current Research in Nutrition and Food Science
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Except for the heart failure and the renal disease edema cases
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Thank you very much. It will be easier to choose the right instrument now
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What are the conceptual bases for personalised nutrition?
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Agree with Deshmukh
I would include some othre ideas related to: reponses, intraindividual variabilitiy, taste, enjoyable, pleasure
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Dear All, 
I hope you are doing well 
I wanted to use R to calculate the healthy eating index (2015) based on the NHANES 2018/2018. However, I was unable to locate a guide or r script that demonstrates how to compute the healthy eating index using NHANES 2018/2018. I'm hoping that if anyone knows how to calculate the healthy eating index in R or has an r script that they could share, it would be greatly appreciated.I eagerly await your response.
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I am looking for potential collaboration in research about clinical nutrition of patients with liver disease
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Please have look on our(Eminent Biosciences (EMBS)) collaborations.. and let me know if interested to associate with us
Our recent publications In collaborations with industries and academia in India and world wide.
EMBS publication In association with Universidad Tecnológica Metropolitana, Santiago, Chile. Publication Link: https://pubmed.ncbi.nlm.nih.gov/33397265/
EMBS publication In association with Moscow State University , Russia. Publication Link: https://pubmed.ncbi.nlm.nih.gov/32967475/
EMBS publication In association with Icahn Institute of Genomics and Multiscale Biology,, Mount Sinai Health System, Manhattan, NY, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918
EMBS publication In association with University of Missouri, St. Louis, MO, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30457050
EMBS publication In association with Virginia Commonwealth University, Richmond, Virginia, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211
EMBS publication In association with ICMR- NIN(National Institute of Nutrition), Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611
EMBS publication In association with University of Minnesota Duluth, Duluth MN 55811 USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211
EMBS publication In association with University of Yaounde I, PO Box 812, Yaoundé, Cameroon. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30950335
EMBS publication In association with Federal University of Paraíba, João Pessoa, PB, Brazil. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30693065
Eminent Biosciences(EMBS) and University of Yaoundé I, Yaoundé, Cameroon. Publication Link: https://pubmed.ncbi.nlm.nih.gov/31210847/
Eminent Biosciences(EMBS) and University of the Basque Country UPV/EHU, 48080, Leioa, Spain. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852204
Eminent Biosciences(EMBS) and King Saud University, Riyadh, Saudi Arabia. Publication Link: http://www.eurekaselect.com/135585
Eminent Biosciences(EMBS) and NIPER , Hyderabad, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29053759
Eminent Biosciences(EMBS) and Alagappa University, Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30950335
Eminent Biosciences(EMBS) and Jawaharlal Nehru Technological University, Hyderabad , India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/28472910
Eminent Biosciences(EMBS) and C.S.I.R – CRISAT, Karaikudi, Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237676
Eminent Biosciences(EMBS) and Karpagam academy of higher education, Eachinary, Coimbatore , Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237672
Eminent Biosciences(EMBS) and Ballets Olaeta Kalea, 4, 48014 Bilbao, Bizkaia, Spain. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918
Eminent Biosciences(EMBS) and Hospital for Genetic Diseases, Osmania University, Hyderabad - 500 016, Telangana, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/28472910
Eminent Biosciences(EMBS) and School of Ocean Science and Technology, Kerala University of Fisheries and Ocean Studies, Panangad-682 506, Cochin, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27964704
Eminent Biosciences(EMBS) and CODEWEL Nireekshana-ACET, Hyderabad, Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/26770024
Eminent Biosciences(EMBS) and Bharathiyar University, Coimbatore-641046, Tamilnadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27919211
Eminent Biosciences(EMBS) and LPU University, Phagwara, Punjab, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/31030499
Eminent Biosciences(EMBS) and Department of Bioinformatics, Kerala University, Kerala. Publication Link: http://www.eurekaselect.com/135585
Eminent Biosciences(EMBS) and Gandhi Medical College and Osmania Medical College, Hyderabad 500 038, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27450915
Eminent Biosciences(EMBS) and National College (Affiliated to Bharathidasan University), Tiruchirapalli, 620 001 Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27266485
Eminent Biosciences(EMBS) and University of Calicut - 673635, Kerala, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611
Eminent Biosciences(EMBS) and NIPER, Hyderabad, India. ) Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29053759
Eminent Biosciences(EMBS) and King George's Medical University, (Erstwhile C.S.M. Medical University), Lucknow-226 003, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25579575
Eminent Biosciences(EMBS) and School of Chemical & Biotechnology, SASTRA University, Thanjavur, India Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25579569
Eminent Biosciences(EMBS) and Safi center for scientific research, Malappuram, Kerala, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237672
Eminent Biosciences(EMBS) and Dept of Genetics, Osmania University, Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25248957
EMBS publication In association with Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/26229292
Sincerely,
Dr. Anuraj Nayarisseri
Principal Scientist & Director,
Eminent Biosciences.
Mob :+91 97522 95342
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Dietitians all over the world strive to help fight obesity and other food related diseases. I am sure that most hospitals turn a sharp eye on healthy food according to contemporary knowledge. There are databases covering this topic, e.g. USDA. On the other hand, different patients have different needs relating their diets.
Which software and applications can you recommend for use in a hospital food planning system that takes into account nutritional data for creating healthy diets?
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Nutritionist Pro is so good
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There is some misinformation and myths about the benefits of eating figs and olives, do you have information about studies dealing with this topic?
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Yes, I believe in the Holy Qur’an and what is mentioned in the Holy Qur’an is a tribute to these two plants, but with regard to mixing one fig with 7 olives, it is not mentioned in the Holy Qur’an. The site I mentioned did not mention the source of this information, and I searched for its source and did not find it. If I knew the source of the information or research, please send it to me.
And thank you very much Chinaza Godswill Awuchi
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Dear all
In this situations of carona pandemic what would be the role of Nutrition and nutritionists to combat this ?? Plz enlight if some approches can be made??
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may be the nutritionist can be help to formulated best formula for optimize the immune system.
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Where does the oxidation of the sd LDL take place, Given the high dietary intake of polyunsaturated oils and sugar these days in the face of limited exogenous antioxidants such as vitamin E, lycopene, flavonoids and Coenzyme Q10 which would normally protect the lipoprotein, it would appear that diet may be the major source of oxidised lipids and glycated Apo B in this cardiovascular risk factor.
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This is an area of active research and the rationale for the oxLDL test offered by commercial laboratory companies. Unfortunately, the aspect of LDL oxidation attributable to PUFA oxidation is under emphasized, understudied, and under-appreciated. My work involves collating and synthesizing information in this area.
See section on Atherosclerosis on this page
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I have not found specific bibliography on the subject.
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Prolong total parenteral feeding (nutrients only via IV) causes gut atrophy, which reduces hunger. However, parenteral nutrition with small oral feeding ameliorates gut atrophy and hunger for a certain extend. Parents experienced hunger on short term administration of TPN.
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Dear all.
Please share the materials and views on canine and feline feeding. In recent times owners prefer to consult doctors more frequently regarding dog foods, quantity to be offered ingredients etc. And many myths are also associated like salt feeding sugar feeding even people dont like to offer milk to dogs. Please put some light and share your experiences in pet feeding.
Please suggest a balanced feedung schedule for dogs and cats.?
Thanks and regards
Partha
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@
Dogs should eat at least two meals each day, about 12 hours apart. But a breakfast, lunch, and dinner schedule is an equally great option. If more than 12 hours elapses between meals, the stomach can become hyperacidic causing nausea.
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Hello,
Many protein shake powder mixes contain digestive enzymes such as protease, lipase, and cellulase. However, the products do not detail from which organism the proteins are produced or which protein homolog is used. I would imagine that the enzymes are produced in yeast or fungi. I am am curious regarding which organisms are used. Also, is the native form of the protein harvested from these organisms, or are they made to produce a recombinant human version? In the case of cellulase, there is no human homolog, so it must be from another organism. Regardless, should not the host species be listed on the product? Additionally, if the protein is not naturally occurring in humans, is it ever a good idea to consume it in high quantities?
Thank you!
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Digestive enzymes are extracted from animals,plants and microorganisms. Pancreatic enzymes for digestion are extracted in the Middle East from Camel, Cattle and Cheeps.Also yeasts are an important sources in our country as a source of huge enzymes.Lactic acid bacteria are used as lactase source for treatment of lactose-intolerant people.
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I was wondering whether high-fat diet or high-sugar-high-fat diets are more commonly used for diet induced obesity in rodents?  And the reasoning behind using one or the other.
When i do a pub-med search i see more hits for 'high-fat diet' for rodents, although there are many different terms for a high-sugar-high fat diet, so its hard to say.  I would have expected that HFHS would be more effective.
I'm interested in which is the most effective at inducing obesity, and in particular i'm interested in the effect of the quality of the diet on inducing overeating behaviour.  (i'm not planning on conducting experiments, rather looking at the findings in the literature).    In general, I'm hoping to get impressions of 'experts in the field' as to what researchers generally use and why...  
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Hi,
always used only high-fat diet, or high- proten or high -fiber ,according to experimental models from previous studies. But usually we use one or the other.
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Robert John Wolff Yes! Please write this paper and send it to me when you're done. I'd appreciate reading more on this topic and seeing more articles and papers published on this topic.
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Many studies reported an association between nutrition and human hearing loss. These studies showed the incidence of hearing loss was increased with the lack of micro-nutrients such as vitamins A, B, C, E, zinc, magnesium, selenium and iron.Moreover, high carbohydrate, fat, and cholesterol intake, or lower protein intake, are responsible for poor hearing status.
Dear colleagues, Any more studies or experience about the relation between nutrition and hearing loss?
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I think the following article will be useful
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Coffee is a simple beverage, but it’s full of complex compounds with health benefits. It contains hundreds of bioactive components including vitamins, minerals, and anti-inflammatory polyphenols such as flavonoids. The amount of caffeine in a cup of coffee can vary, depending on factors ranging from the type of bean used. So, What about the healthy daily amount of caffeine was recommended to be healthy with no risk?
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Does anyone have papers of human trials suggesting polyphenols act as synbiotics?
Thanks
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I would like to analyse epigenetic changes in response to dietary phytochemical supplementation in humans.
Can anyone explain if this is feasible and how would such analysis be conducted?
Thanks.
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This article will help you to conduct epigenetic analysis in a clinical nutrition
from a randomized controlled trial. Good luck!!
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The Health Technology Assessment (HTA) unit of the CHU de Québec – Université Laval is currently working to get data on integrated early rehabilitation interventions in pediatric intensive care unit.
We define «integrated early rehabilitation interventions» as physical, functional, nutritional, psychological, communicational, social or spiritual rehabilitation activities initiated during the first days of admission of a patient in the pediatric intensive care unit and delivered by each professional according to an intervention plan that has been developed beforehand as a team by these same professionals.
Are early interdisciplinary rehabilitation interventions an established practice in the pediatric intensive care unit of your hospital?
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Currently I am living in Bolivia and most of the Hospital don´t count with those services in ICU.
In Brazil there is a law that determine the presence of some of those professional (PT for example) 24/7. But that doesn´t translate into practice.
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How do you Control and manage your mood swings without drug therapy ?
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Exercise, yoga, and meditation are the best ways for the control and management of mood swings.
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Emotional nutrition could be defined as constantly giving you a positive mindset and keeping yourself away from negativity. So, what is the most important for a healthy emotional nutrition ?
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  • Express your feelings in appropriate ways. ...
  • Think before you act. ...
  • Manage stress. ...
  • Strive for balance. ...
  • Take care of your physical health. ...
  • Connect with others. ...
  • Find purpose and meaning. ...
  • Stay positive. Focus on the good things in your life.
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Hello there, how are you? I do have a friend working a clinical Nutrition research which is rare to our country and specifically localized to Neonatal ICU. There are a few articles which is directly related to what his is working on but as the result of most of these articles are an observational study he couldn’t get the raw data of exposed and unexposed group or two by two table or something like that to calculate the sample size by using double population formula. He is ask you for your suggestion or ideas what should he do to get a minimum sample size from those papers in reach of these problem.
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You might consider using Harvard's online sample size calculator which, as I understand, was created with support from NIH General Clinical Research Program. Available at following address: http://hegwig.mgh.harvard.edu/sample_size/size.html. Several design options available in this calculator. Suspect that "parallel trial where the outcome is a measurement" would be appropriate for cohort study as opposed to "study of the effect of one variable on another" which seems appropriate for randomized trial.
@
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I have genotype of 400 people, only 102 SNPs. There were target for genetics lifestyle report. They are divided between Brazilians and Swiss.  
My research now is to look at few SNPd and calculate a GRS score then to check the differences among these 2 group populations. 
From the 102 genes I have selected only 20. We have another data, life BMI, physical activity,  age, nationality, and place of residence.
Do you have an ideia, besides basics Statistics and alleles frequency how I can create the GRS scores and calculate more advanced parameters?  I have been reading lots of papers, however my background is more clinical nutrition.
Thank you in advance
Viviane
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The way I interpret is you have genetic profiling data (some sequencing ? or using other techniques like micro-array? or multiplexing pcrs?) whatever and you want to associate your 102 polymorphisms identified between two groups based upon races. The comparison of the identified polymophisms probably will be done by genetic risk scoring.
Few question:
1- Type of genetic data source?
2- Will you do genotype-phenotype (lifestyle) comparison for GRS?
3- Your exact OBJECTIVE
Regards
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The ketogenic diet has gained popularity as a natural way to lose weight and improve health. The diet is very low in carbohydrates, high in fat and moderate in protein. While the diet is considered safe for most people, it’s associated with some unpleasant side effects.
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Keto flu can be avoided by consuming more electrolytes and fats, adding more salt to diet, drinking chicken broths, doing moderate exercise and staying hydrated. Moreover, addition of prebiotics and probiotics to diet are also helpful in avoiding the keto flu.
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Would anyone have knowledge or literature references to share on which vitamins or minerals would be beneficial as markers of a healthy diet? The method used is a 48-hour dietary recall and the nutrients used in the analysis should be fairly reliable in a study population of approx. 300.
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The healthy food system helps maintain and develop public health and is intended to improve the health of the individual. This system is based on supplying the body with essential nutrients such as fluids and "major nutrients", which the body needs in large quantities to survive and grow with. The "micronutrients" needed by the body in small quantities to promote growth, and improve, in addition to sufficient calories for the body. There are many innovative diets, the owners of which are diverse, but they are not based on science. These systems create confusion about what health food is, and give unnecessary false impressions about what can be unhealthy. These systems are fiercely promoted. For healthy people, a healthy diet is not as complex as some think; it contains mostly fruits and vegetables, while minimizing or preventing total processed foods and sweetened beverages. The requirements of this system can be obtained from several plant or animal sources, but those who follow A vegetarian diet that requires vitamin B-12 from an animal source. There are many guidelines published by medical and government food organizations to educate people about what they need to eat in order to be healthy. In addition, the labeling of food information on products is compulsory in several countries to allow the consumer to choose from the following: based on which of them has healthier ingredients. Healthy diet, along with healthy nutrition, involves daily exercise, and this method can reduce the risk of diseases such as obesity, heart disease, diabetes, hypertension and cancer.] There are dedicated diets called "therapeutic diets"; It is a system for people with different diseases and symptoms. There are ideas about these systems that existed before the current scientific development, as in traditional Chinese medicine. Other WHO recommendations include that the food chosen by the individual should have sufficient vitamin and mineral content and avoid direct toxicity such as Heavy metals, carcinogens and avoid foods contaminated with human pathogens, and the replacement of saturated fats, polyunsaturated fats in the diet, can reduce the risk of coronary heart disease, diabetes. Food guidelines for Americans provided by the United States Department of Agriculture recommend three types of diets, summarized in the table below, for a diet containing 2000 calories. These systems give importance to human health and environmental sustainability with a flexible approach. The great discovery of a sustainable diet is that the system rich in food from plant sources (such as vegetables, fruits, whole grains, legumes, nuts, and seeds), low in calories and food of animal origin, Healthier, and is also less harmful to the environment than the current American diet. This type of food can be achieved through many dietary patterns, as follows: Food groups - SubcategoryHealth style of the AmericasPeaceful vegetarian variety Mediterranean fruit2 (equivalent cup) 2 cups equivalent 2.5 cups Vegetables 2.5 cups equivalent 2.5 cups (Equivalent to 1.5 cups) equivalent weekly (1.5) cups equivalent weekly (red oranges) 5.5 cups equivalent weekly (5.5) cups equivalent weekly (5.5) cups weekly equivalent (Weekly cup) (5) weekly equivalent (5) cups weekly equivalent (legumes 1.5) cups equivalent weekly (3) k B) Equivalent weekly (1.5) cups weekly equivalent (other 4) weekly equivalent cup (4) weekly equivalent cup (4) cup equivalent weekly (cereals 6) equivalent ounce (6.5) ounce equivalent (6) Milk (3 oz equivalent) 3 oz equivalent (2 oz equivalent) protein food 3.5 oz equivalent (6.5) oz equivalent (meat) red and processed 12.5 (weekly equivalent) - 12. (weekly equivalent) poultry 10. 5 cups weekly equivalent (10 cups daily equivalent) 10 cups daily equivalent (3 cups) weekly (3 cups) weekly (3 cups) (Weekly) (4 cups weekly equivalent (processed soy)) tofu (0.5) cups equivalent weekly (8) cups equivalent weekly (0.5) cups equivalent weekly (oils 27 grams 27 grams 27 grams fat (Maximum) per gram (21) Maximum in grams (17) Maximum in grams (added sugar 30) Maximum in grams (36) Maximum in grams (29) Maximum in grams (American Heart Association, American Fund for Cancer Research, They recommend food that is mostly based on an untreated vegetable source, with a grain focus Whole, legumes, vegetables, and non-roasted fruits. This herbal food system contains a wide range of vegetables, and non-roasted fruits, which offer different colors such as red, green, yellow, purple, and orange. They noticed that the tomatoes cooked with oil and garlic, planted with cruciferous vegetables such as cauliflower, provide some protection against cancer, and this low-calorie health system, which can protect against the increase
 
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Off-seasons vegetable offers the higher prices to the farmers. Instead of high price, people preferred off-season fruits and vegetables. It is a general perception that such fruits and vegetables are not good for health. There is any such studies proving the various negative health effects?
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Growing of off season vegetables in my knowledge don't have any negative effect on health, instead of any negative effect on health it provides the required vegetable to the consumer, although at some higher price. Such vegetables are not harmful unless some excessive chemicals used during its course of production. Growing of offseasons is very useful to marginal farmer, as it ensures their livelihood security.
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Portions of five food groups per day for adults & type 2 diabetics, is there any difference?
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I wanted to add question actually. Me and my team go through 60 journals on DM and found similarity of this illnesses consequences. My question is despite all these medical review/examination, however, there is no sign the DM disease Diabetes Mellitus slowing down or reduced rate of number of DM patient. In Fact, the trend is alarming both in developing or developed countries. I myself can get 'hypertension' readings the result presented by the medical/ GPs :D.
The 'genuine' way of preventing DM has not yet available in most countries if we evaluate it from research/academic trend.
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some athletes follow the paleolithic diet. paleolithic diet also known as caveman diet. in this diet you have to eat like of a caveman. what is your idea about this diet? can this diet increase the athletic performance? can anyone explain about the aspect of health of this diet?
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Pitt CE. Cutting through the Paleo hype: The evidence for the Palaeolithic diet. Aust Fam Physician. 2016;45(1):35-8. https://www.racgp.org.au/download/Documents/AFP/2016/January/February/Clinical-Pitt.pdf
Popp CJ, Bohan Brown MM, Bridges WC, Jesch ED. The Effectiveness of MyPlate and Paleolithic-based Diet Recommendations, both with and without Exercise, on Aerobic Fitness, Muscular Strength and Anaerobic Power in Young Women: A Randomized Clinical Trial. Int J Exerc Sci 2018;11(2):921-933. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179430/pdf/ijes-11-2-921.pdf
Manousou S, Stål M, Larsson C, Mellberg C, Lindahl B, Eggertsen R, Hulthén L, Olsson T, Ryberg M, Sandberg S, Nyström HF. A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women. Eur J Clin Nutr. 2018;72(1):124-129. https://www.nature.com/articles/ejcn2017134
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My clinical study measured the blood biomakers (glucose, insulin, glucagon, GLP-1, GIP, amino acids, etc) at baseline before an intervention meal and at multiple time points after an intervention meal.
We did this measure three times using three different intervention meals at three different days. My main objective is to compare whether there is any difference in the change in blood biomarkers after different intervention meals.
There are several AUC calculation methods to do this, such as the total AUC, incremental AUC (ignore the area under baseline) and net incremental AUC (subtract the area under baseline). How to determine which one to use and what is the rationale?
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iAUC (incremental ...) is the most recommended and approved method. Follow iAUC
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If someone supplements himself with zinc at a daily dose of 11 mg, does he need to watch out for his dietary sources for zinc content? Or this no upper tolerable with regard to dietary sources? I.E, if someone ingest 11 mg of zinc (supplement form) along with other zinc rich food, will he suffer adverse effects or not?
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Zinc toxicity is a medical condition involving an overdose on, or toxic overexposure to, zinc. Such toxicity levels have been seen to occur at ingestion of greater than 225 mg of zinc [unreliable medical source?] Excessive absorption of zinc can suppress copper and iron absorption. The free zinc ion in solution is highly toxic to bacteria, plants, invertebrates, and even vertebrate fish.[ Zinc is an essential trace metal with very low toxicity in humans.
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People these days are becoming sick because of overeating and junk foods and bad food additives, and healthy people are those who eat small amounts. Most people are dying because of diseases linked to food consumption and their number is more than those who are dying of hunger.
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Over heating is not much problem is Sub-Saharan countries but mostly countries in this area which are all developing are facing double burden of malnutrition. That is obesity in cities and towns and under-nutrition in rural areas.
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Paleo diet method is one of the successful diet method for diabetic, obesity, HT. The main concept of this food method is simple as avoid glucose completely. And there is no restriction for the natural lipid and protein intake.
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We can base on the literature to see why and how Paleo diet is developed. From the original publication ( ), Paleolithic diet was decided to capture the diet characteristics of our remote ancestors at Stone Age, with high intake and variety of fruit and vegetables, large amount of lean meat and no grains and dairy products. The reason why Paleo diet is developed is due to the evolutionary discordance hypothesis, which suggests the high prevalence of chronic diseases in the modern society is due to the changes of diet and physical activity patterns from our ancestors at Stone Age. Hence the focus of the diet is to minic the diet pattern of our ancestor instead of just avoiding glucose. Apart from the food groups I have mentioned, Paleo diet do not suggest processed food such as processed meat, soft drinks, etc.
Regarding to the efficacy of Paleo diet, a meta-analysis of randomized controlled trial concluded that Paleo diet may result in statistically significant short-term improvement in waist circumference and triglycerides ( ). However, it is important to note that the emerged sample size in the meta-analysis is still quite low (n = 159) and some studies warrant the long-term compliance to Paleo diet and its consequence (e.g. ). Hence according to the current limited evidence, I would not suggest people to follow Paleo diet for obesity, diabetes and hypertension, as more studies are needed to clarify its long term relationship and safety.
For your question about Food4Me and Paleo diet, Food4Me is a study on personalized nutrition, which considers the interaction between genes and nutrition (http://www.food4me.org/about/aims-and-objectives). Hence it is not related to Paleo diet.
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There are several molecular forms of Cholecystokinin (CCK), of which CCK-8 and CCK-33 are the two frequently used molecular forms in pharmaceutical infusion studies to induce fullness and reduce hunger in human/animals.
However, in dietary studies, which involve participants to consume a test meal, which molecular form of postprandial plasma CCK should we assess? What are the methods available? What are the advantages and disadvantages?
Many dietary studies have not been explicitly stating the molecular form of CCK analysed, although some did mentioned CCK-8, CCK-33 or total CCK being measured.
So how should be make decision around which form of postprandial plasma CCK should be analysed in appetite studies?
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Cholecystokinin-8 regulates hepatic glucose production through a CNS-dependent CCKAR mechanism which may be defective in the setting of obesity.
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which countries in europe are the exporting?
which countries in europe already consuming insects for human use?
which countries are already using insects for animal feed?
how much protein can be supplied by insects in broiler feed?
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Canada, South Africa.
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Ferulic and Vanillic acids are secondary metabolites of anthocyanins. Both can be obtained as food-grade.
Does anyone know what the maximal doses of ferulic and vanillic acids can be given to humans.
Does anyone have know of papers which have provided ferulic and vanillic acid in human intervention studies for cardiometabolic health?
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Ferulic and vanillic acids are important dietary antioxidant phenolic acids, but under certain conditions, might exert pro-oxidant effects.
Some in vitro studies described that higher dose of vanillic acid (2 ug/mL) might damage DNA in human lymphocytes
see link
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Some studies recommend to add oil to salad dressing to help fat soluble vitamins to be absorbed. Other studies indicate to the dense calories from oils and recommend low or free fat salad dressing  and mention to the diets already have fat that help these vitamins to be absorbed and as a healthy nutritional strategy to prevent adding more direct source of oil to foods to avoid weight problems. Other studies and recommendations indicate to add little healthy oil sources to salad dressing  such as flaxseed and other source of oil seeds to salad dressing instead of direct adding oils as they seen adding direct oils is a bad strategy to learn children healthy options and to reduce redundant use of oils; also recommend healthy ingredients such as different sources of vinegar and mustard instead of using direct oils in salad dressing.  I would like to listen to your opinions.
Best regards
Aly 
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Respected Aly R Abdel-Moemin!
Its not good to add oil in raw form on salads. But if good one oil like virgin olive oil or extra virgin olive oil or any first cold processed oil is used in measured quantity then its good for health. Along with health benefits it would add some taste to the salads also making them delicious.
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Energy requirement of Albino rats
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Please look into national academy  for the care and use of  laboratory animals manual. You will find the answer. 
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Sucralose (known as Splenda) is a sweetener from  sucrose that was approved by the FDA. It is recommended from many doctors to patients who have sugar problem. It said to be safer and healthy product compared to sugar. However, although my grandparents (85 years old) consumes a lot amount of sugar, they not have any health problem. I am wondering what medical experts think about consuming splenda. We should consume splenda or sugar?
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There is a tendency for people to have mistrust in substances that have been chemically altered. Regarding your question, this alteration is from sucrose to sucralose. People place too much trust in the “appeal to nature” which is the rhetorical tactic which proposes that something is good because it is ‘natural’ or bad because it is ‘unnatural.’ However, there are plenty of things occurring naturally which are poisonous (i.e., arsenic, strychnine, curare alkaloids, etc.). With this in mind, it is inconsequential whether or not sucralose is chemically altered from sucrose.
The over consumption of sugar is much more detrimental than the over consumption of sucralose. From an epidemiological stance, there is enough evidence to link the consumption of sugared beverages (and essentially increased sugar consumption) to the causation of obesity. This evidence includes a consistent positive association between sugar intake and long-term weight gain in both prospective cohort studies and randomized controlled trials (RCTs). Additionally, there is enough evidence to indicate that sugar intake is a causal link to obesity as indicated through temporality and a dose-response relationship (Hu, 2013). Furthermore, meta-analyses have provided evidence linking sugared beverages to the risk of diabetes, metabolic syndrome, and cardiovascular disease (Bray & Popkin, 2014).
In regards to sucralose, the study cited by the above researcher (Abou-Donia et al., 2008) which suggested that sucralose alters intestinal microflora and potentially alters p-glycoprotein and cytochrome p-450 was reported to be flawed. An Expert Panel undertook a rigorous investigation of the study and found that, the study was deficient in “several critical areas” and the results were “not consistent with published literature and not supported by the data presented” (Brusick et al., 2009). A review of the current literature on sucralose reported that the substance is safe for its intended use as a non-caloric sugar alternative (Magnuson, Roberts & Nestmann, 2017).
While it is most likely true that excessive consumption of sucralose would have negative health effects, these would pale in comparison to those experienced from excessive consumption of sucrose. Your anecdotal evidence that your grandparents consume vast quantities of sugar with no ill effect should not dictate that sugar is safer than sucralose. Sucralose is safer, but as with everything, moderation is the key.
References:
Abou-Donia MB, El-Masry EM, Abdel-Rahman AA< McLendon RE, Schiffman SS. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A. 2008;71(21):1415-29. doi:10.1080/15287390802328630.
Bray GA, Popkin BM. Dietary sugary and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar. Diabetes Care. 2014;37(4):950-6. doi:10.2337/dc13-2085.
Brusick D, Borzelleca JF, Gallo M, et al. Expert panel report on a study of Splenda in male rats. Regul Toxicol Pharmacol. 2009;55(1):6-12. doi:10.1016/j.yrtph.2009.06.013.
Hu FB. Resolved: There is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. Obes Rev. 2013;14(8):606-19. doi:10.1111/obr.12040.
Magnuson BA, Roberts A, Nestmann ER. Critical review of the current literature on the safety of sucralose. Food Chem Toxicol. 2017;106(Pt A):324-55. doi:10.1016/j/fct.2017.05.047
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I need to know the effect of cabbage  on hyperthyrodism to this parameters lipid -protiens -thyroid hormon-testesteron-liver and kidney function 
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Cabbages are restricted for hypothyroid patients.
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Anyone know of observational studies of vegetarian / vegan dialysis patients - albumin levels, other clinical outcomes?
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Thank you both! Those were helpful!
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I am working on the development of functional yogurt by GABA supplementation. Can you tell me, what is the maximum dose of GABA for not producing any side effect (or toxicity)? And how can we determine that what quantity of oral intake has beneficial effects on CNS?
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To convert dosage from animal to human or vice versa please look over my ppt in slideshow website.
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Smoking cigarette, consuming lots of saturated fatty acids with lots of fruits, vegetables and red wine can lower the incidence of heart disease? so how much of that is true/untrue?
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But, in general, the French are not fat.  It is the over consumption of refined carbohydrate  which in addition to calories is pro inflammatory.  That combination leads to the plaque.
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Dear Dietitians and nutritionists what is best diet for rheumatoid arthritis patients?
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Low intake of food which provides omega-6 fatty acids (mainly arachidonic acid). So try to avoid meat and meat products since they are rich in arachidonic acid. On the other hand increase intake of food rich in EPA and DHA, such as fish and in particular fatty sea fish. EPA is the presursor of eicosanoids which are less inflammatory and a type of thromboxane which is less likely to aggregate. On the other hand, eicosanoids coming from arachidonic acid are pro-inflammatory, which is negative for rheumatoid arthrithis since this disease is based on pro-inflammatory events. Many studies have also shown that the intake of Omega-3 fatty acid supplements improve the symptoms of RA, typical amounts are between 1-3 g of fish oil. However, be also áware that a very high amount of Omega-3 fatty acids could lead to oxidation, which means you have to have a look to your intake of antioxidants. So increase the intake of vegetables and also fruits. 
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In a splendid review published in Pediatr Nephrol (2017) 32:921-931 (attached below as pdf) the authors are stressing the pathophysiological mechanisms and the role of gut microbiota in triggering and progressing the CKD among other pathologies as DM or Hypertension.
As possible therapeutic tolls probiotics, synbiotics as well as fecal transplantaton are listed.
Do you have expereince with these therapies and what results did you obtain? Thanks in advance. Kind regards, Michaela
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Dear Pat
  • thank you for your answer. I will take a look at the website of the company and also try to get in touch with them.I will also get a close look to Nutriose.
  • I will let you know about the progress. Cheers and best regards, Michaela
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Should we supplement diet with phytosterols, or modify diet, adding nutrition products rich in phytosterols? What products should we enrich diet to provide the right amount of phytosterols per day?
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And what do you think; Can we accept that example Benecol, both margarine and drink, contain enough phytosterols to make lower cholesterol? The producer ensures in the advertisements?
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There are many publications on dietary or nutritional risk factors for developing cancer or carcinoma. But there are only few recommendations for post-treatment nutrition, mostly in colorectal cancer. But I didn't find specific recommendations for post-treatment nutrition for people with diabetes mellitus and pancreatic carcinoma.
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Dear Gautam Ray, many thanks for this information. I did not know the articles from Gilliland [1] and Phillips [2] before. They are very helpful. Best wishes, Michael
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I thought it is the glycemic index of cooked food that will give a clue for the potential contribution of a given food for the hypoglycemic effect upon ingestion.What is the relevance of estimating the glycemic index of raw food(like uncooked legume grain??)
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Dear Dr. Endale,
Thank you. It gives sense that way and I raised the issue to have a common consensus with professional with the area like you. 
Regards,
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Nutraceuticals 
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I follow closely Dr.Greger and I have doubt. There are some nutraceuticals "the more the better", so the waiter should not ask and bring them, However, presenting as balanced plates as possible would be the key. E.g. serve a piece of sweet potatoes with every meal in order to supply vit.A. Otherwise waiter has to have long questionnaire to find out what previous meals were. In terms of herbal teas and spices the general rule would be: use those which match with the type of food (turmeric with kari, oregano with pasta)
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I would be  interested  especially  in  mineral  deficiencies / natural  treatment  through  diet 
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Hello Margaret 
Nice  hearing  from  you  and   , Thanks once  again  for  great  input !
The  most  frequent  deficiencies  I encountered  during  my  observations  here  are those  in   zinc , iron ,  and  will  try  to  follow  up  especially  on  these .  
Another  interesting  fact  that  I  came  across  with  is  that  those  observed  as  having  zinc  deficiency  are  always  as  well  kids  giving  headaches  to  the  teachers  in  terms  of  behavior (  so , I  really  want  to  follow  up  on  this too  hahahehe  ) .  The  main focus  of  the  study  will  still remain  the  academic  performance ...  and ,  definitely  my  biggest  and  hardest  challenge  in  will  be  the  health  education  of  both  students and  families ,  in  order  to make  them  shift  towards  healthy  dietary  patterns !    Really  hard !  
Thanks  once  again !
All  the  best  in  your  research  work  too !     
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I want to know deep about satiety index and structure index for better balancing of TMR in dairy cow.
Thank You In Advance!!!!
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attached files may be useful.
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Dear colleague:
we have come up with a simple, inexpensive drug formulation that reverses insulin-dependent diabetes. There is opposition to this finding for two reasons: the formulation contains the nutritional supplement pyrroloquinoline quinone (PQQ) which we show to have vitamin character, a designation journal editors object to. 
If taken preventatively, one would expect it to prevent the development of insulin-dependent diabetes. The head of the American Medical Association does not want this information to become public as he fears people would no longer undergo blood glucose testing.
How can I overcome the resistance of journal editors to accept a communication?
Thank you for looking into this
Best regards,
Rudolf Fluckiger, Ph.D
Independent biomedical researcher
Novacule, LLC/ founder and president
2587 Albany ave.
West Hartford, CT 06117
860-519-1621
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Dear Rudolf,
you might want to implement a robust and focused study design, conducted according to clinical trial standards,  in order to ascertain the  applicability of Novapyrin in diabetes, obesity or else. 
First, upon reading your report, you make strong conclusion based on anecdotal evidence. The sensation of improvement from a single patient study is difficult to use to establish a proof-of-concept, a proof-of-mechanism or to suggest its addition in the therapeutic arsenal against a condition. The decrease of 6mM systolic blood pressure in one individual is not an evidence of any atheroprotective properties of your molecule. And so on.. 
Moreover, you don't provide the background required to support the rationale of your studies and thus, it is difficult to see why you would propose the usage of Novapyrin for many of the conditions you tested. 
Lastly, I doubt that any of your ''trials'' were approved by the Institutional Review Board of an academic institution or any similar entity.  
In short, the resistance that you are experiencing might be based on the lack of a clear rationale, absent study design, abysmal ethical consideration and cookie-cutter conclusion drawn from an inconclusive set of data.
So, if you want to distinguish your ''natural product'' company from the mass, it would be advisable to take a step back and reflect on how you can design your study to prove or refute your hypothesis using the established and accepted scientific standards. 
Best,
Nicolas
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There are many factors which affect anthocyanin bioavailability.
However in terms of comparing healthy and disease-state patients, would bioavailability be expected to be greater in healthy subjects post-ingestion of dietary sources rich in anthocyanins?
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I need to run offline experimentation about user's daily dietary activity and find a way to classify them based on their adherence.
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There are some great examples on here too :) http://dapa-toolkit.mrc.ac.uk/
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When having a patient recieving enteral nutrition we reduce the fluid from the IV line of the 24 hour. But do we need to substract the total of the enteral feeding of the total fluids even thought the enteral feed is not a whole sum of fluid because there are solutes, and i sometimes have to go and talk to the nutrition department that the increase the enteral load to fast on a critical patient that needs the IV line for fluid intake regarding specific cases?
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Ok, According to A.S.P.E.N guideline in determination of required fluid in ml/ day by multiply % water in formula times daily formula in mL to determine water contribution of EN.
Subtract formula water from total fluid requirements to determine water flushes.
For example,
Patient needs 2200 ml fluid
2000 ml formula * 84% water = 1680 ml
So, 2200 - 1680 = 520 ml of additional water ( by IV or medication dilution).
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there is Harris–Benedict equations with its revised version by mifflin, i m confused which one to use ?
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Dear Munib,
Although established around 100 years ago, our students still use the Harris–Benedict prediction in the physical activity lab. Due to changes in lifestyle, new predictions such as the Mifflin St Jeor equation are more accurate. Working with obese patients (BMI 30 or more) the Broca-Index correction makes sense.
All these measurements simply rely on bodyweight, height, age and gender.
If you are able to measure lean body mass by bioelectrical impedance analysis you can predict the daily resting energy expenditure by Katch-McArdle and Cunningham formula, respectively.
Concerning you question, the difference between Harris–Benedict and Mifflin St Jeor equations is around 5 %, with higher accuracy of the later one.
Best wishes
Marc
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If any, which combination of nutrients can provoke rapid weight gain? Which kind of nutrient supplementation can be combined to achieve this?
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Callisthenics is a good form of exercises that helps to stimulate lean muscle growth, results can be moderately rapid if put in combination with a healthy diet and sufficient sleep, as it allows the body to recover.
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Unhealthy diets that contain bacterial lipopolysaccharides (LPS) promote amyloid beta aggregation and healthy diets in the developing world are encouraged to reduce the toxic amyloid beta speices by release of a number of proteins to prevent amyloid beta aggregation.
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The answer appears to be yes.  Researchers found Candida yeast in the brains of 11 AD who diet but not in the brains of those who died of other causes. (Pisa D et al. Scientific Reports, 5, 2015). 
AB proteins thought to cause AD but now found to block the growth of C. albicans & other brain infections.  Therefore, AB is a symptom--not the cause of AD.
Dr. Mark Stengler (Health Revelations 2016) recommends a low glycemic diet, protein, vegetables, pre/probiotic food & multi-strain PBs, S. Boulardii  (and antifungal drugs when needed) to help eradicate and keep low C. albicans--therefore preventing the buildup of AB.
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Magnesium is important to lower cholesterol and maintain the peripheral clearance to toxic amyloid beta. Active lifestyles with exercise reduce magnesium levels with increase risk for Type 3 diabetes. Diets with magnesium supplementation may be important to increase fat metabolism in diabetes.
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low blood and brain levels of magnesium have been reported in patients with Alzheimer’s disease and some evidence from preclinical animal model studies suggests that magnesium may disrupt some Alzheimer’s disease pathways
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I am interested in the relationship between diet and FTO gene expression. Most studies have been performed on FTO expression changes in hypothalamus. But as we know, FTO is expressed ubiquitous. We are going to do a research on this subject in adolescents in Iran and I look forward to hearing from everybody that can help us.
Thank you
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Thank you for you response
Studies in recent years has been shown the FTO role in cell metabolism through mTOR pathway. so we expect the FTO gene expression can influenced by many dietary factors such as calorie intake, dietary protein, dietary fat and so on.
But about The gene expression changes in blood cell, we don't know anything...
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The major risk of overconsumption of a high fibre diet will lead to excessive intake of phytosterols that lead to neurodegeneration. Diets that are high in fibre in the developing world may also contain toxic xenobiotics that may lead to insulin resistance, NAFLD cardiovascular disease and brain damage.
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 What we see in the US is very poor and very low fiber diet. NAFLD and NASH, obesity and even cardiovascular disease tend to associate rather with obesity, high fat and low fiber diet. I would not change my clinical recommendation of healthy fiber intake in the US unless I would find compelling studies done in industrialized countries showing a detrimental effect of fiber intake. At this point as far as I am aware a plant based diet containing at least 20-25 grams of fiber per day is the healthiest for most people in the industrialized world.
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In general, dietary salt intake was found to be in correlation with arterial hypertension and increased prevalence of cardiovascular diseases, which is endorsed in guidelines of cardiovascular societies and WHO. 
On the other hand, decrease of salt intake in patients with heart failure, especially those with hyponatremia was found to increase the mortality, and lower quality of life. 
Are there any studies (controlled would be the most desirable), reporting on the effects of sodium diet uptake depending on age, existence of renal disease, COPD, liver failure, diabetes, obesity, or others. 
What if you double the water intake, would it not decrease sodium concentration.
Could there be a "salt paradox" similarly to the obesity paradox. 
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Dear Dr.Boban,
As far as I can see the cited studies have not assessed potassium intake and sodium-potassium balance. There were numerous studies (although mostly the preclinical ones, such as the works of Prof. Dr. S. Yu. Shtrygol’ and co-authors, Eksp Klin Farmakol. 2006 May-Jun;69(3):32-4. PMID: 16878496; Eksp Klin Farmakol. 2002 May-Jun;65(3):22-4, PMID: 16878496; Eksp Klin Farmakol. 2002 Jan-Feb;65(1):37-40, PMID: 12025783 etc.) providing the strong evidence of salt substitutes efficacy and supporting their hypotensive, antiedema, diuretic, hypoglycemic effect, protective activity in the disorders of cerebral blood flow, improvement of trophic processes in tissues and rheological properties of blood as well as such effects as anticonvulsive and antidepressive.
In clinics it has been shown that the patients with IHD and atherosclerotic changes in blood lipoproteins benefit significantly from hypocholesterolemic effect of the salt substitute hyposol (summarized in SYu Shtrygol’. Pharmacological Effects Modulation by Different Salt Regimens, Avista-VLT, Kharkiv, 2007). Unfortunately, the work on salt substitutes is scarce now (although there are some products on the markets) and surely there is a certain opposing of food industry interests.
Regards,
Dr. Olga Tovchiga
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Diets that are calorie sensitive have become important with activation of anti-aging genes that lower glucose levels with the prevention of the induction of NAFLD and diabetes.
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Once we know a little more about the immortality gene cluster, perhaps all the rest will become redundant.  
Mario, thank your parents!  ;)
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Overeating can be controlled by the food restriction procedures that may prevent the consumption of various xenobiotics that may disrupt astrocyte-neuron interactions in the hypothalamus that are responsible for appetite control.
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I don't think that this issue is that simple. In fact most research in weight loss in humans supports the idea that energy deprivation results in a state were there is a loss of appetite control, specifically disturbed responses of appetite related hormones to food intake, alterations in adipose tissue physiology and overall increase in food craving. 
An interesting review has been published recently...!
Anastasiou, C.A., Karfopoulou, E., Yannakoulia, M. Weight regaining: from statistics and behaviors to physiology and metabolism. Metabolism 64: 1395-407, 2015
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The blood sugar for some diabetics patients may disturb during fasting Ramadan although the take there medication in regular  manner, dose change of diet time has a role ?  
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Actually if we see the diet pattern and their food type during fasting Ramadan, it is quite obvious that it is different than daily pattern of diet they take whole of the year. Other reason that our biological clock of the body (For releasing enzyme and harmone that keep body equilibrium) is adopted for the life style pattern of rest of year wise (11 month) but when we start fasting in whole day and diet at evening and early morning with late night party, less sleep, it will mismatched with biological clock. Other many reason that may be associated are their sleep disturbance, whole day fasting of diabetic patient, tension for managing fast etc. Main strong reason is also very practical that they usually take heavy food to counter whole day fast. so all these factors collectively impact the health of diabetic patients adversely. Also the anti-diabetic drugs that are administered are generally following regular diet pattern so it may be advised that patients should be change their schedule of taking anti-diabetic drug. 
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I have a number of items that I need converting from grams per day to serving per day. Indeed, how much is a serving per day potato as grams per day?
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Hi Milad,
This would be dependant on what your country (or country where analysis was conducted) classifies as a serving. In the UK, for example, a serving of vegetables is commonly defined as 80g. Therefore if an individual consumed 160g carrots per daily this would equate to 2 servings. Alternatively, you could look at nationally representative nutrition surveys that detail dietary habits of a certain population (average servings sizes etc) and work things out that way.
Hope this information begins to help a little.
Thanks,
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Is anyone aware of a commercially available "nutraceuticals" - compound library for screening in the cell lines?
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Dear Maria, did you find information about such library? Please share if you got.
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Dear colleagues, during a recent hypothesis-driven study of type 2 diabetes my research group confirmed our prediction that HbA1c and FBG levels are related to two different early pathophysiological subtypes of type 2 diabetes that may be partly overlapping in later stages. In this case HbA1c and FBG should be considered as independent predictors of different pathologies, but not as interchangeable alternatives as suggested by expert committees in diabetes. Outcome may be different protection management and protecting treatment against the disease development.
Editors of Diabetes and Diabetes Care considered that our finding "does not contain sufficient new or novel information" for sending our submission to external peer review. On behalf of my co-authors I myself would like to reach external peers and appeal for your opinion on this forum. I would appreciate very much if anybody on this forum could help us with a reference to similar finding (i.e., with respect to different pathophysiological subtypes associated with HbA1c and FBG), because I could not find such during my literature search.
FYI: Our pathophysiological subtypes are not among rare subtypes like MODY, LADA and hemochromatosis-related diabetes, as well as are not related to pathophysiological (insulinopenic, hyperinsulinemic, or classic) forms developing later in type 2 diabetes.
Unfortunately, I cannot say more about our findings, because do not lose hope to publish them. Your suggestions in a journal that does not use a modern editorial politics for restricting peer reviewing of submissions like in Diabetes and Diabetes Care are very appreciated.
Thank you.
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The paper was accepted and is already on-line (the link below). I thank all people, who have replied.
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According to the research of T.Colin Campbell, PHD, cancerous tumors can be nutritionally manipulated. Animal protein promotes tumor growth, while sustaining from animal protein turns the cancer "off".
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I looked at correlations between many different foods and 8 major cancers. The highest correlation in 5 of the cancers was with sugar. Fructose encourages production of DNA for tumour growth and metastasis. So the main thing I tell my cancer patients is to avoid sugar, high fructose corn syrup, and fruit juice. Eat vegetables rather than sweet fruit. Do eat avocado for the vitamin E.
Glucose feeds cancer cells like other cells, and glucose comes in sugar, fruit and milk. Human anti-cow milk fat globule membrane antibodies bind to natural killer cells, which are thought to suppress tumour growth. So that is another reason to avoid milk.
Do have flax seed or flax seed oil, as the alpha linolenic acid in them appears to act against cancer.
Avoid supplements containing vitamin B1, as it also enhances DNA production, via transketolase.
I suggest it is not animal protein you should avoid, but sugar, and also milk, because of the glucose in it, and the membrane round the milk fat globules
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in case of using parenteral nutrition (central or peripheral) is there any contraindication or any recommendation  of using proton pump inhibitors( PPI) or H2- blocker in ICU patients?? 
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Proton pump inhibitors (PPI) regulate gastric hypersecretion & prevent peptic ulcer disease, but long-term acid suppression from proton pump inhibitors PPI or H2- blocker increase intestinal PH & may result in small intestinal bacterial overgrowth , may reduce the absorption of important vitamins and nutrients, increased risk of fractures with high-doses by affecting calcium absorption, so the risk benefit ratio should be applied.
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Load bearing activities increase the calcium absorption as it prescribed in all osteoporosis cases. Is there any reliable test to measure the absorption after load bearing exercise? Any supportive articles are appreciated.
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Both increased net Ca absorption and increased net bone mineral formation will cause the Ca isotope composition of blood and urine (d44Ca) to shift in a positive direction. This is the natural Ca isotope composition, not anything involving tracers. See, for example:
Channon M, Gordon GW, Morgan JLL, Skulan, JL, Smith, SM, Anbar AD. Using natural, stable calcium isotopes of human blood to detect and monitor changes in bone mineral balance. Bone 2015; 77: 69-74; DOI: 10.1016/j.bone.2015.04.023.
I think this article is available here.
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Kindly, explain your answer. Thanks in advance.
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The golden method to measure the percentage of calcium absorptions is to meaure calcium intake and fecal calcium excretion associated or not with calcium stable isotope intake. However, one can have a rapid idea about calcium absorption (comparative) by measuring 24 hours urinary calcium after ca intake.
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At 2003, the Project Human Genome was finished and many fields of science like nutrigenomics appear but it seems no very practical to use to promote personalized nutrition. have we any papers about this question? i really like to know more about this issue.
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Dear Ricardo,
<<At 2003, the Project Human Genome was finished and many fields of science like nutrigenomics appear but it seems no very practical to use to promote personalized nutrition.>> Yes, I agree. The area of nutrigenomics has proliferated after it mushroomed. However, the possibility of furnishing personalized dietary counseling and advise has not shown a marked and decisive pace.
The concept of personalized nutrition/medicine (in connection with the fashionable label, nutrigenomics) is nothing new! It stems from the idea of "biochemical individuality", a concept popularized by Roger Williams in 956 [Williams, R. Biochemical Individuality, 1st ed.; McGraw-Hill: New York, NY, USA, 1998].
Dr Roger J Williams, "Biochemical Individuality".
Landmarks in personalized nutrition/medicine:
Garrod AE. The incidence of alkaptonuria: a study in chemical individuality.
Lancet. 1902;160(4137):1616-1620.
Linus Pauling used the term, “molecular medicine” in 1949, in his epoch-making paper on the mechanism of production of sickle cell anemia.  published in 1949. This article formulated that the origin of disease was influenced by specific mutations of genes, which could manifest an altered "molecular environment". Consequently, modified physiological functions find an association with specific diseases. Pauling L, Itano HA. Sickle cell anemia: a molecular disease. Science 1949; 110:543-548:
Roger Williams postulated that requirements for nutrients differ widely in different individuals, and that some persons may require much higher amounts of certain nutrients than others for appropriate and optimal functioning based upon their unique biochemistry. He wrote, “Individuality in nutritional needs is the basis for the genetotrophic approach and for the belief that nutrition applied with due concern for individual genetic variations, which may be large, offers the solution to many baffling health problems.
 You will find several articles focusing on nutrigenomics in the journal, Journal of Nutrigenetics and Nutrigenomics.
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We recently acquired a tetrapolar bioimpedanciometry device and our results in terms os body composition percentuals differ a lot from our clinical perception. We understand that clinical perception is not the best way to evaluate body composition, but our results are so unexpected that we'd like to hear from the coleagues theirs experiences and difficulties in this kind of method, in hospitalized clinical ward patiens.
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It is true that for these sort of subjects BIA is the most practical/applicable technique currently available,  however one should be aware of potential issue with BIA. I suggest that you also look at these papers for a more in-depth look at BIA.especially in those subjects with atypical fluid status and/or body geometry:
Evolution of bioimpedance: a circuitous journey from estimation
of physiological function to assessment of body composition and a
return to clinical research. HC Lukaski. European Journal of Clinical Nutrition (2013) 67, S2–S9
Bioimpedance at the Bedside: Current Applications,
Limitations, and Opportunities Urvashi Mulasi, MS, RD1; Adam J. Kuchnia, MS, RD, LD, CNSC1;Abigail J. Cole, BS1; and Carrie P. Earthman, PhD, RD, LD1. Nutrition in Clinical Practice, 2015  30:180–193
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Parents of children with ASD are frequently asking me about Nutrition Therapy for their children. I need some evidences about the topic. Do you agree using Nutrition Therapy for autism? is there any evidence about it?
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Yes, autistic children tested either had poor sulphate production, or poor sulphate transport. Sulphate deals with amines produced by the nervous system. Dietary amines and phenols are sulphated, and autistic children should not have too much amine or phenol in their diets. Relevant supplements are molybdenum, omega 3 fatty acids, and vitamins B2, B5 and B6. Poor sulphation in the gut may make it too permeable, in which case avoiding casein and gluten makes sense. Boron is excreted with vitamin B2, and so foods high in boron are best avoided. Often there have been many courses of antibiotics, and replenishing beneficial bacteria is relevant. Chlorella and vitamin C may help remove harmful minerals like mercury and aluminium.  Butter and coconut provide fatty acids to reduce gut permeability.
If possible, test plasma elements, red cell magnesium and functional B vitamins.
Relevant articles include:
Murch SH, MacDonald TT, Walker-Smith JA, Levin M, Lionetti P, Klein NJ. Disruption of sulphated  glycosaminoglycans in intestinal inflammation. Lancet 1993; 341: 711-4.
Waring RH, Klovrza LV. Sulphur metabolism in autism. J Nutritional & Environmental Medicine 2000; 10: 25-32.
Whiteley P, Shattock P. Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention. Expert Opin Ther Targets 2002; 6(2):175-183.
Harris RM, Waring RH. Dietary modulation of human platelet phenolsulphotransferase activity. Xenobiotica 1996; 26: 1241-7.
Moss M. Effects of Molybdenum on Pain and General Health: A Pilot Study. J Nutr Env Med 1995; 5: 55-61.
Moss M. Purines, Alcohol and Boron in the Diets of People with Chronic Digestive Problems. J Nutr Env Med 2001; 11: 23-32.
Moss M, Waring RH. The Plasma Cysteine/Sulphate Ratio: a Possible Clinical Biomarker. J Nutr Env Med 2003; 13(4): 215-229.
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I have found red cell sodium values (calculated values only unfortunately) to be 'low' - sometimes 'undetectable'. I am guessing that a value around mmol/Litre
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I ' m glad I could help you.