Chlamydia - Science topic

Coxiella burnetii and Chlamydia spp. are known to have a wide range of hosts, e.g., mammals, birds, reptiles, including free-living animals, which serve as vectors for its transmission to human and animal population. The aim of this study was to verify the occurrence of Coxiella burnetii and Chlamydiaceae in samples collected from red deers, roe de...

Chlamydia trachomatis, the most prevalent bacterial agent of sexually transmitted infections , poses a significant threat to reproductive health. The release of progeny through the orchestrated lysis of host cells plays a crucial role for the development of new infections, though the underlying molecular mechanisms remaining largely unexplored. In...

Introduction The application value of metagenomic next-generation sequencing (mNGS) in detecting pathogenic bacteria was evaluated to promote the rational and accurate use of antibiotics. A total of 180 patients with severe infections were included in this study. Methods Based on their different symptoms, bronchoalveolar lavage fluid (BALF) or blo...

Venous thromboembolism (VTE) is a serious yet often overlooked disorder with numerous contributing risk factors. Pulmonary embolism (PE) and deep vein thrombosis (DVT) together constitute VTE. Both PE and DVT are highly prevalent and present a significant global burden in terms of morbidity and mortality. There are various reported underlying cause...

Background With this study, we aimed to explore the clinical features, laboratory examinations, imaging features, and severe predictors of Chlamydia psittaci pneumonia to identify the disease early, shorten the course of illness, and improve prognosis. Methods We retrospectively reviewed the clinical data of 39 patients diagnosed with Chlamydia ps...

Study of the links of prostatitis immunogenesis, including against the background of chronic infections, which is accompanied by resistance to therapy and deterioration in the quality of life of patients, is relevant for the determination of prognostic markers of the course and the development of modern effective individualized approaches to therap...

Wild ruminants often harbor pathogens transmissible to other animals and humans, but their epidemiological role is not always defined for all microorganisms. In this survey, spleens, kidneys, and hearts sampled from 162 fallow deer (Dama dama) were subjected to molecular analyses to detect bacterial (Anaplasma phagocytophilum, Borrelia burgdorferi...

Objective Cervical cancer remains a significant health concern, particularly in low-income and middle-income countries (LMICs). This study aims to compare the efficacy and suitability of a self-collected tampon for the detection of human papillomavirus (HPV) and sexually transmitted infections (STIs) using qualitative TMA-based assays (Transcriptio...

Introduction Sexually transmitted infections (STI) are highly prevalent among women of reproductive age (WRA) and increase the risk of HIV acquisition and transmission. However, the burden of extragenital STIs is understudied among WRA in the US. Estimates of disease are urgently needed among women living with (WWH) and without HIV (WWOH), to infor...

Background Psittacosis is a global and underappreciated zoonosis, with increasing reported cases in many countries. There have been several outbreaks and even deaths of psittacosis reported in China. Understanding its epidemiological characteristics and dimensions is crucial for formulating precise prevention and control strategies. This study aime...

Background Antibiotics are frequently used to treat infections caused by Chlamydia pneumoniae; an obligate intracellular gram-negative bacterium commonly associated with respiratory diseases. However, improper or overuse of these drugs has raised concerns about the development of antibiotic resistance, which poses a significant global health challe...

Objective The objective of this study was to characterize new HIV diagnoses in key Ontario cities, in order to understand current drivers of continued HIV transmission to inform HIV testing and prevention efforts. Methods Chart reviews were carried out at four clinical sites in Ontario, Canada. The study population included individuals who were di...

To explore the clinical utility and optimal timing of metagenomic next-generation sequencing (mNGS) in diagnosing pathogens in patients with diabetes complicated by community-acquired pneumonia (CAP). The study included 50 hospitalized patients diagnosed with diabetes complicated by CAP who underwent conventional microbiological testing (CMT) and m...

Background We examined characteristics associated with mpox vaccine uptake among gay, bisexual, queer and other men who have sex with men and non-binary people (GBQ+ people), the primary target group for Australian vaccination programs following the mid-2022 outbreak. Methods Vaccine uptake was assessed using cross-sectional surveys of GBQ+ people...

Psittacosis is caused by Chlamydophila psittaci (Chlamydia psittaci), it is a zoonotic bacterial pathogen with wide range of hosts, that includes birds, humans and other mammals. Psittacosis is derived from the Greek word ‘psittakos’ means parrot (first used in 19th century). Chlamydia psittaci primarily affects birds – tamed (pet birds like parrot...

Background Eliminating infectious diseases epidemics requires resources for testing, prevention, and treatment in jails. The 2022 Centers for Diseases Control and Prevention guidelines recommend offering hepatitis C virus (HCV), HIV, and STI testing at jail intake. Currently, the impact of offering testing at intake in jails has only been analyzed...

Introduction Serious respiratory infections can occur in both in-hospital and out-of-hospital settings. These infections are known as community-acquired pneumonias (CAPs). Streptococcus pneumoniae and other microorganisms commonly cause atypical pneumonia. This study examined the clinical features, medication therapy, and prognosis of 85 cases of c...

The order Holosporales is a broad and ancient lineage of bacteria obligatorily associated with eukaryotic hosts, mostly protists. Significantly, this is similar to other evolutionary distinct bacterial lineages (e.g. Rickettsiales and Chlamydiae). Here, we provide a detailed and comprehensive account on the current knowledge on the Holosporales. Fi...

Background Female sex workers (FSWs) are at high risk of chlamydia infection, yet the seroprevalence among FSWs in China remains unclear. This study aimed to determine the seroprevalence of Chlamydia trachomatis and associated factors among FSWs in Guangdong Province, China. Methods A cross-sectional study was conducted among FSWs in two cities in...

Objectives The objective of this study was to retrospectively assess the pathogens associated with feline ocular and respiratory diseases in routine diagnostic samples submitted to Georgia Veterinary Diagnostic Laboratories. Furthermore, pathogens detected by the respiratory PCR panel in the upper vs lower respiratory tract were compared (specimen...

Despite a high prevalence of sexually transmitted and blood-borne infections (STBBIs) among patients with substance use disorders, screening rates in addiction medicine settings are often low. At baseline in our addiction clinic, only 65% of patients were offered screening and only 6% completed screening blood work. This quality improvement project...

Background Performance of a 16S rRNA analysis of the cervicovaginal microbiome of 220 participants recruited into the T Cell Response against Chlamydia (TRAC) cohort between February 2011 and August 2014 in Allegheny County, Pennsylvania USA detected DNA encoding chlamydial 16S rRNA in samples from seven participants whose tests were negative for C...

Chlamydia trachomatis is an obligate intracellular bacterial pathogen that if left untreated can cause reproductive harm. Failure of natural adaptive immunity results in chronic and repeat infections. In efforts to understand the failure of adaptive immunity, we have previously discovered that CD8⁺ T cells, normally integral for controlling intrace...

Background Persistent trachoma is increasingly recognized as a serious concern for the global trachoma program. Persistent trachoma is defined as those districts that have had two or more trachoma impact surveys in which the trachomatous inflammation—follicular (TF) prevalence has never been <5%, the elimination threshold for TF. Enhanced tools suc...

Background Pneumonia caused by Chlamydia abortus (C. abortus) is uncommon, particularly when complicated by severe acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS). Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disease characterized by the uncontrolled activation and non-malignant...

Chlamydia trachomatis (Ct) is an obligate, intracellular Gram-negative bacteria and the leading bacterial sexually transmitted infection in the United States. Chlamydia manipulates the host cell biology using various secreted bacterial effectors during its intracellular development. The early effector translocated actin-recruiting phosphoprotein (T...

Introduction: Men’s health, particularly for those involved in sex work, is frequently overlooked, resulting in higher mortality rates and significant public policy challenges. This is especially critical given the specific risks faced by sex workers. Objective: The sexual health of men was investigated to identify which aspects of their clinical h...

Lower respiratory tract microbiome constitutes a unique immune microenvironment for advanced non-small cell lung cancer as one of dominant localized microbial components. However, there exists little knowledge on the associations between this regional microbiome and clinical responses to anti-PD-1 immunotherapy from clinical perspectives. Here, we...

Chlamydia pecorum is a significant cause of morbidity and mortality in koalas and a major contributor to population decline. Due to its crucial role in vaccine development and use as a strain typing tool, multiple studies have investigated the prevalence and diversity of the C. pecorum outer membrane protein A (MOMP), encoded by ompA. This prior wo...

Aim: This study reports structural modeling, and molecular dynamics profiling of hypothetical proteins in Chlamydia pneumoniae genome database. Methodology: The hypothetical protein sequences were extracted from Genome Database of Chlamydia pneumoniae for functional elucidation using computational approaches. Results: Host-pathogen interactions are...

Background Whether ambient air pollutants affect the transmission of respiratory pathogens in central Wuhan is unknown. So, we conducted a series of statistical analyses to discover the correlation between the two. Methods We enrolled a total of 47,668 outpatient and hospitalized patients who underwent IgM antibody tests for nine types of respirat...

Objective Chlamydia psittaci is a zoonotic pathogen that causes an acute disease known as psittacosis. To establish infection in host cells, Chlamydia manipulates the host cell’s membrane trafficking pathways. Methods In this study, using fluorescently labeled C. psittaci and screening a human membrane trafficking small interfering RNA (siRNA) lib...

Introduction International travel is a significant contributor to the acquisition of sexually transmissible infections (STIs). Despite the high volume of outbound travel from Australia, peaking at 10.8 million travellers in 2023, limited data exist on the burden of overseas-acquired STIs. This study aims to investigate the burden and trends of over...

Background In recent years there has been an increase in the diagnoses of sexually transmitted infections (STI) among men who have sex with men (MSM) using human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP); however, data on PrEP users in Austria are limited. Patients, material and methods In June 2020, we initiated a prospective o...

Objectives: To explore the role of phenomenological research in public health, highlighting its contributions, challenges, and practical implications. Study design: A narrative review informed by studies employing phenomenological methodologies published in the journals Public Health and Public Health in Practice. Methods: Using the search keywords...

Background: Since 2020, there has been a significant increase in sexually transmitted infections (STIs), especially in young people, and these include syphilis, gonorrhea, chlamydia, and lymphogranuloma venereum, which are often asymptomatic but with the potential for transmission. In addition, certain risk behaviors, such as the use of dating apps...

Chlamydia trachomatis (Ct) is a leading cause of sexually transmitted infections globally, often resulting in inflammatory disorders, ectopic pregnancies, and infertility. Studying Ct’s pathogenesis remains challenging due to its unique life cycle and host-specific interactions, which require diverse experimental models. Animal studies using mouse,...

Women's health is extensively impacted by diverse infections that can have profound consequences on each physical and mental well-being. This summary explores the prevalence, causes, and outcomes of infections specific to women's, inclusive of urinary tract infections (UTIs), sexually transmitted infections (STIs), and reproductive tract infections...

Introduction Psittacosis pneumonia, as a zoonotic infection, is induced by the pathogen Chlamydia psittaci. In the present study, we sought to characterize the clinical manifestations and prognosticate the severity of psittacosis pneumonia. Methods We retrospectively verified instances of psittacosis pneumonia in Zhejiang province, China, from Jan...

The genetic consequences of population isolation include inbreeding, genetic diversity loss and loss of adaptive potential. Koalas across south-western Sydney (New South Wales, Australia) may be vulnerable to isolation due to major roads and cleared forest. A few sites within south-western Sydney are some of the last chlamydia-free sites for koalas...

Mistreatment and unsanitary conditions to which trafficked animals are subjected provide an environment conducive to the proliferation and dissemination of pathogens. The Centros de Triagem de Animais Silvestres (CETAS - Wild Animal Screening Centers), which receive trafficked animals, aim to release them back into the wild, thus making the investi...

Objectives: To analyse the occurrence of Sexually Transmitted Infections (STIs) and risk behaviours among those attending the only state-run genitourinary clinic in Malta between 2017-2020. Method: The demographics, STI diagnoses and risk behaviours of all patients were analysed. Results: In the past four years, 12,132 individuals between 10 and 85...

Background/Objectives: Chlamydia trachomatis (Ct) is a common pathogen causing urogenital, anal, oral, and ocular infections. Although extensive vaccine efforts have been underway for decades, there is no licensed vaccine available to prevent human Ct infection. Polymorphic membrane protein D (PmpD) is a highly conserved protein present on the surf...

Deep vein thrombosis (DVT) of the legs is a rare but clinically important complication of Chlamydia psittaci pneumonia. We report a case of a 51-year-old man who was admitted to the hospital with fever, cough, and dyspnea. Next-generation sequencing confirmed the diagnosis of Chlamydia psittaci pneumonia. His D-dimer level was elevated on admission...

Background Sexually transmitted infections (STIs) continue to be a significant public health challenge and have an impact on sexual and reproductive health. European Union and European Economic Area (EU/EEA) countries report data annually on the number of cases of syphilis, gonorrhoea, chlamydia, and lymphogranuloma venereum (LGV) to the European C...

Many causative pathogens can cause pneumonia. Atypical pathogens such as Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila pneumoniae and Chlamydia psittaci are important known agents of atypical pneumonia. Viruses can cause pneumonia in both immunocompetent and immunocompromised patients. As causative pathogens, Adenovirus (AV), Meta-pn...

Background The COVID-19 pandemic impact on sexually transmitted infections in countries practicing syndromic management remains unknown. We conducted cross-sectional surveys in Fiji to assess increases and risk factors for Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) infections pre- and post-pandemic. Methods We enrolled women, men wh...

Chlamydia comprises a diverse group of obligate intracellular bacteria that cause infections in animals, including humans. These organisms share fascinating biology, including distinct developmental stages, non-canonical cell surface structures, and adaptations to intracellular parasitism. Chlamydia trachomatis is of particular interest due to its...

Purpose of Review Doxycycline post-exposure prophylaxis (doxy PEP) has proven to be highly effective in reducing the incidence of sexually transmitted infections (STIs) among men who have sex with men (MSM) and transgender women. In response, the US Centers for Disease Control and Prevention (CDC) issued official clinical guidance on the use of dox...

Background Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality throughout the world. COPD is often accompanied by acute exacerbations [AECOPD] where 70% of it is caused by aerobic bacteria, 30% due to viruses and 5-10 % by atypical bacteria,most commonly Mycoplasma pneumoniae ( M. pneumoniae ), Chlamydia pneumon...

Background/Objectives: Chlamydia (C.) psittaci is an avian respiratory pathogen that regularly infects budgerigars (Melopsittacus undulatus) and is a known zoonosis. This study aimed to evaluate the efficacy of a nucleoside-modified mRNA vaccine formulated in lipid nanoparticles (LNPs), either with (mRNA Galsomes) or without (mRNA LNPs) the glycoli...

Chlamydia psittaci is one of the primary pathogens responsible for community-acquired atypical pneumonia. If not treated promptly, it can progress to severe pneumonia and may lead to multiple organ dysfunction as well as secondary infections with multi-drug-resistant (MDR) bacteria. Omadacycline, a novel aminomethylcycline antibiotic derived from t...

Women's health is extensively impacted by diverse infections that can have profound consequences on each physical and mental well-being. This summary explores the prevalence, causes, and outcomes of infections specific to women's, inclusive of urinary tract infections (UTIs), sexually transmitted infections (STIs), and reproductive tract infections...

Background Rates of bacterial sexually transmitted infections (STIs) have risen dramatically over the past decades. Doxycycline postexposure prophylaxis (DP) is a novel intervention to prevent bacterial STIs. Recent randomized controlled clinical trials reported high DP efficacy at preventing syphilis and chlamydia in cisgender men who have sex wit...

Chlamydia species represent a paradigm for understanding successful obligate intracellular parasitism. Despite limited genetic malleability, development of genetic tools has facilitated the elucidation of molecular mechanisms governing infectivity. Random mutagenesis approaches provide one of the most powerful strategies available to accomplish unt...

Recent outbreaks of highly pathogenic avian influenza in Europe have raised questions regarding the epidemiological role of commensal wild birds on free-range poultry farms. This study aimed to assess the prevalence of avian influenza viruses (AIV), avulaviruses, coronaviruses and Chlamydia sp. in commensal wild birds on a free-range duck farm in s...

The virulence plasmid of the obligate intracellular bacterium Chlamydia encodes eight proteins. Among these, Pgp3 is crucial for pathogenicity, and Pgp4 functions as a transcriptional regulator of both plasmid and chromosomal genes. The remaining proteins, Pgp1, Pgp5, Pgp6, Pgp7, and Pgp8, are predicted to play various roles in plasmid replication...

Background Respiratory tract infections (RTIs) pose a significant global health burden, caused by various pathogens. The COVID-19 pandemic and non-pharmaceutical interventions (NPIs) have created unprecedented challenges for public health systems, inadvertently altering the dynamics of other respiratory pathogens. This study aims to illustrate chan...

Objectives This study aimed to investigate the epidemiological characteristics and risk factors associated with human psittacosis in Hangzhou city, eastern China. Methods The human psittacosis data from 2021 to 2024 were obtained from the China information system for diseases control and prevention infectious disease surveillance system. Epidemiol...

Chlamydia are obligate intracellular bacterial pathogens affecting humans and animals, causing miscarriage, stillbirth, or weak fetuses in the late stages of pregnancy of goats and sheep. Because there is no commercial vaccine for chlamydia in animals, drug treatment has become the most effective curative method. Natural products, also known as sec...

Vaccination is the most effective measure to prevent Chlamydia infection. However, to date, no vaccine has successfully completed the rigorous clinical trial process and gained regulatory approval for use in clinical practice. Scholars have been working on a safe and effective Chlamydia vaccine. In order to better grasp, the global frontiers and de...

CCR2, a member of the G protein-coupled receptor (GPCR) superfamily, is widely expressed on monocytes, macrophages, activated T cells, and other cell types, and plays a critical role in coordinating the immune response to various infections. Here we demonstrate that CCR2 expression is significantly elevated during Chlamydia muridarum (C. muridarum)...

Objectives There is a growing body of evidence that in the absence of Chlamydia trachomatis and/or Neisseria gonorrhoeae, Mycoplasma genitalium and bacterial vaginosis (BV) are associated with cervicitis. We aimed to describe infections detected among cervicitis cases over a decade and establish how commonly M. genitalium and BV were detected among...

Abstract: Introduction: The health of men, including those who engage in sex work, is often neglected, resulting in higher mortality rates and challenges for public policies, especially considering the specific risks faced by sex workers. Objective: We investigated the sexual health of men, seeking to identify which information in the clinical hist...

Background: Chlamydia trachomatis is an obligate intracellular bacterial pathogen that has been implicated in a wide spectrum of human reproductive diseases including infertility. Many studies have confirmed the association of Chlamydia trachomatis with tubal infertility. However, there is a paucity of information on its contribution to various oth...

The aim of this study was to investigate the prevalence of Tropheryma whipplei, Chlamydia psittaci, Chlamydia pneumoniae, Legionella, Brucella, and Francisella tularensis in valve samples from endocarditis patients using the real-time PCR method at a major referral heart hospital in Iran. In this study, 146 paraffin-embedded tissue samples from the...

Chlamydia trachomatis and Candida albicans are common inhabitants of the female genital tract. C. albicans can impact viability and pathogenesis of some bacteria. Previously, we investigated physical interactions between C. trachomatis elementary bodies (EB) and C. albicans. This work indicated that EB bind to C. albicans and become noninfectious b...

Background: Sexually transmitted infections (STIs) remain a significant global health challenge, affecting millions of individuals daily. This study aimed to investigate the prevalence and causative organisms of common STIs in women aged 18-49 years who presented with symptomatic vaginal discharge at a tertiary care hospital in India. The primary o...

The cultivation of Chlamydia gallinacea, a recently identified species, is challenging due to the lack of an optimized protocol. In this study, several infection protocols were tested, including different cell lines, incubation temperatures, centrifugation methods and culture media. However, none were successful in field samples. The only exception...

Keywords: ABSTRACT prevalence, chlamydia trachomatis antibodies, infertile, pregnant women Chlamydia trachomatis (C. trachomatis) is one of the most common sexually transmitted bacterial infections associated with reproductive and gynecologic consequences of pelvic inflammatory disease, infertility and ectopic pregnancy. Most of these patients are...

Objective This study aims to evaluate the utility of targeted next-generation sequencing (tNGS) in bronchoalveolar lavage fluid (BALF) for hospitalized patients with pulmonary infections. Methods A cohort of 358 patients who received diagnosis and treatment for respiratory infections in the department of Respiratory Medicine at Wenzhou People’s ho...

Background The prognostic value of Chlamydia pneumoniae (Cpn) infection in postoperative lung cancer patients remains unclear. This study aimed to evaluate the association between Cpn infection and survival in lung cancer patients. Methods This study included 309 newly diagnosed primary lung cancer patients from three hospitals in Fuzhou, China. C...

Background/Objectives: We generated a novel recombinant Vibrio cholerae ghost (rVCG)-based subunit vaccine incorporating the A1 subunit of cholera toxin (CTA1) and a multiepitope Chlamydia trachomatis (CT) antigen (MECA) derived from five chlamydial outer membrane proteins (rVCG-MECA). The ability of this vaccine to protect against a CT transcervic...

Background The rapidly evolving nature of eHealth necessitates regular optimization and subsequent evaluation. Within the Dutch sexual health intervention Sense.info, we utilized a mixed-methods cyclic evaluation process to assess and optimize the potential impact of the chlamydia page. This paper reports on the page's optimization through the deve...

Chlamydia trachomatis (Ct) is an obligate intracellular pathogen that causes the most commonly diagnosed bacterial sexually transmitted infection (STI) and is a leading cause of preventable blindness globally. Ct infections can generate a strong pro-inflammatory immune response, leading to immune-mediated pathology in infected tissues. Neutrophils...

Nucleic acid amplification tests (NAATs) are the method of choice for Chlamydia trachomatis diagnosis, but these strategies are susceptible to target site mutations. C. trachomatis variants escaping detection with the Aptima Combo 2 (AC2) assay on the Hologic Panther instrument from 23S rRNA mutations have been reported in Nordic countries, England...