Science topic

Central Nervous System - Science topic

The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
Filters
All publications are displayed by default. Use this filter to view only publications with full-texts.
Publications related to Central Nervous System (10,000)
Sorted by most recent
Article
Full-text available
Background: Health Locus of Control (HLOC) is the degree to which individuals believe that their health outcomes are controlled by 'external' factors - environmental forces, chance, fate, other people, or some higher power - or by 'internal' factors - their own behavior or action. Most of the literature on HLOC associates an Internal Health Locus o...
Article
Full-text available
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in which many processes are detected including (neuro)inflammation. Many drugs have been tested for ALS in clinical trials but most have failed to reach their primary endpoints. The development and inclusion of different types of biomarkers in diagnosis and clinical tria...
Article
Full-text available
Glioma is considered to be the most common brain malignancy in the central nervous system. At present, the aetiology of glioma is not clear. Due to its rapidly growth and easily recurrence, the prognosis of patients with glioma is very poor. N6-methyladenosine (m6A) methylation is an internal reversible modification in most RNAs, including messenge...
Article
Full-text available
Currently, most CNS tumors require tissue sampling to discern their molecular/genomic landscape. However, growing research has shown the powerful role imaging can play in non-invasively and accurately detecting the molecular signature of these tumors. The overarching theme of this review article is to provide neuroradiologists and neurooncologists...
Article
Full-text available
Pain and itch are recognized as antagonistic sensations; pain suppresses itch and inhibition of pain generates itch. There is still a lack of evidence about the neural mechanism of the interaction between pain and itch in the central nervous system. In this study, we focused on the orexin (ORX) neurons in the lateral hypothalamus (LH), which mediat...
Article
Full-text available
Introduction Despite the increased number of novel immunotherapy (IO) agents under current development, their toxicity profile remains to be fully elucidated. Methods An IO risk stratification model was developed based on 5 different variables: treatment-related deaths; rate of grade ≥3 treatment-related adverse events or treatment-emergent advers...
Article
Full-text available
Hemangioblastomas are rare and benign tumors of the central nervous system. They account for 1.5%-2.5% of all intracranial tumors and have an incidence of 3.2%. The resemblance of hemangioblastomas to other tumors renders preoperative diagnosis and management challenging. Herein, we report a case of a supratentorial hemangioblastoma accompanied by...
Conference Paper
Full-text available
Melanom predstavlja maligni tumor porekla melanocita. Koža je najčešće mesto pojave melanoma, verovatno zbog gustine melanocita u njoj. Ostala predilekciona mesta su mukozne membrane i oko. Incidenca melanoma je neujednačene geografske distribucije, krećući se od 3-5/100.000 u mediteranskim zemljama, preko 20-35/100.000 u zemljama Severne Evrope, d...
Article
Full-text available
ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. However, radiological findings of this disease have...
Research Proposal
Full-text available
Parkinson’s disease (PD) is a multi-systemic neurodegenerative disorder with a broad spectrum of motor and non-motor symptoms (NMS). Atypical Parkinsonism is a rare group of neurodegenerative diseases of the central nervous system, but more severe than PD. It is essential that practitioners address the NMS in order to improve quality of life for th...
Article
Full-text available
Coagulase-negative Staphylococci have emerged as a major group of pathogens in mastitis of dairy animals. The present work was performed to investigate the spatial distribution of milk-associated CNS pathogens in parts of Bundelkhand and to understand its relevance to the incidence of subclinical mastitis during the period 2016-2019. Etablished met...
Preprint
Full-text available
Lgr4/5/6 have been identified as stem cell markers and canonical Wnt signalling enhancers via complexing with R-spondin and Rnf43/Znrf3. Lgr4/5/6 have been reported to interact with Norrin, a cystine-knot growth factor that activates Wnt signalling via binding to Frizzled4 cysteine-rich domain (Fz4CRD). Norrin–Fz4 signalling axis regulates central...
Article
Full-text available
Neurodegenerative diseases are a heterogeneous group of disorders characterized by gradual progressive neuronal loss in the central nervous system [...]
Article
Full-text available
Background: OPG accounts for 3–5% of childhood central nervous system (CNS) tumors and about 2% of pediatric glial lesions. Methods: Article selection was performed by searching PubMed, Web of Science, and Cochrane databases. Results: The pooled mortality rate was 0.12 (95%CI 0.09–0.14). Due to the unrepresentative data, improved and not changed ou...
Preprint
Full-text available
Background: Passive blood-brain barrier permeability (BBB Pe), fraction bound to brain tissue (fb,brain) and efflux by transport proteins MDR-1 and BCRP are essential determinants for the brain uptake and disposition of drugs. Methods: The main objective of the study was to use the software ANDROMEDA by Prosilico to predict passive BBB Pe- and fb,b...
Article
Full-text available
RESUMO Introdução: A esquizofrenia é uma doença com causas multifatoriais, dentre elas alterações neuroquímicas, em que a suplementação de ômega-3 surge como adjuvante ao tratamento, na busca da remielinização dos neurônios do sistema nervoso central. Objetivo: Sintetizar os principais resultados e benefícios da suplementação de ômega-3 nas diferen...
Article
Full-text available
Background Recently, with the rapid progress of metagenomic next-generation sequencing (mNGS), inconsistency between mNGS results and clinical diagnoses has become more common. There is currently no reasonable explanation for this, and the interpretation of mNGS reports still needs to be standardised. Methods A retrospective analysis was conducted...
Article
Full-text available
Silent information regulators, sirtuins (SIRTs), are a family of enzymes which take part in major posttranslational modifications of proteins and contribute to multiple cellular processes, including metabolic and energetic transformations, as well as regulation of the cell cycle. Recently, SIRTs have gained increased attention as the object of rese...
Article
Full-text available
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative disorders of the central nervous system (CNS). Increasing evidence supports the view that dysfunction of innate immune cells initiated by accumulated and misfolded proteins plays essential roles in the pathogenesis and progression of these diseases. The TLR...
Research
Full-text available
Generic Pharmaceuticals Global Market 2022 Opportunities And Strategies To 2030: By Therapy: (CNS; Cardiovascular; Dermatology; Genitourinary/Harmonal; Respiratory; Rheumatology; Diabetes; Oncology; Biosimilars); By Distribution Channel; By Type
Article
Full-text available
Background and Objectives: To describe preliminary results upon the application of the “Cube Navigation System” (CNS) for computed tomography (CT)-guided splanchnic nerve radiofrequency neurolysis. Materials and Methods: CT-guided splanchnic nerve neurolysis was performed in five patients; in all cases, neurolysis was performed under CT guidance us...
Article
Full-text available
Multiple sclerosis (MS) is a degenerative disease of the central nervous system in which auto-immunity-induced demyelination occurs. MS is thought to be caused by a complex interplay of environmental and genetic risk factors. While most genetic studies have focused on identifying common genetic variants for MS through genome-wide association studie...
Preprint
Full-text available
To understand the clinical significance of the tumor microenvironment (TME), it is essential to study the interactions between malignant and non-malignant cells in clinical specimens. Here, we established a computational framework for a multiplex imaging system to comprehensively characterize spatial contexts of the TME at multiple scales, includin...
Article
Full-text available
Neural stem cells (NSCs) are self-renewing, multipotent cells which give rise to all components of the central nervous system (CNS) during embryogenesis, but also activate in response to injury and disease and maintain a certain level of neurogenic activity throughout adulthood. This activity takes place in specialized regions of the brain, the neu...
Article
Full-text available
The indications for fetal body MRI are amplifying because of the expanding possibilities of fetal and perinatal therapy. However, huge heterogeneity regarding the indications for fetal body MRI is seen among different European countries that is mostly related to local use of US, but also to local fetal MRI expertise and legislation on pregnancy ter...
Article
Full-text available
Every year in Poland there are approximately 1200 new cases of malignant tumours in children and adolescents. Leukaemia, CNS tumours, and lymphomas are the most frequently diagnosed cancers. Coping with a child’s illness is challenging, which is why many parents suffer from anxiety, depression disorders, and even PTSD (post-traumatic stress disorde...
Article
Full-text available
Background: Rosette-forming glioneuronal tumor (RGNT) is an extremely rare entity described for the first time in the WHO classification of tumors of the central nervous system in 2007. Predominantly, single case reports of RGNT in the pineal region have been published, and specific therapy concepts are pending. Methods: The study group comprised a...
Preprint
Full-text available
Metric perturbations are deviations from a homogeneous spacetime background. In this paper, the authors extend an earlier investigation by using high precision computer simulations and show that there is definite impact of metric perturbations, that is, gravitational radiation, on the time-coded information conducted by a tract of neural axons as f...
Article
Full-text available
Resumo Introdução O pronto-socorro (PS) tornou-se a principal porta para o início da assistência a pacientes graves. A inserção do fisioterapeuta nesses setores está em processo de consolidação no Brasil. Objetivo Carac-terizar a abordagem fisioterapêutica e o perfil clínico-funcional dos pacientes na unidade cirúrgica PS de um hospital terciário....
Article
Full-text available
Purpose Immune checkpoint inhibitors (ICIs) markedly improve the clinical outcomes of advanced non-small-cell lung cancer (NSCLC). However, the intracranial efficacy of ICI is not well elucidated, and previous studies showed discordant outcomes of ICI between intracranial and extracranial diseases. We aimed to evaluate the clinical outcomes and the...
Article
Full-text available
The presence of aneurysmal subarachnoid hemorrhage (aSAH) is usually accompanied by excessive inflammatory response leading to damage of the central nervous system, and the sialic acid-binding Ig-like lectin 10 (Siglec-10) is a recognized factor being able to modify the inflammatory reaction. To investigate the potential role of Siglec-10 in aSAH,...
Article
Full-text available
Opinion statement Referring to any central nervous system (CNS) involvement with preceding or concurrent systemic disease, secondary CNS lymphoma (SCNSL) lacks a clear standard of care and historically carries a very poor prognosis. Aggressive histologies predominate, most notably diffuse large B cell lymphoma (DLBCL), with higher relative frequenc...
Article
Full-text available
Many arboviruses, including viruses of the Flavivirus genera, are known to cause severe neurological disease in humans, often with long-lasting, debilitating sequalae in surviving patients. These emerging pathogens impact millions of people worldwide, yet still relatively little is known about the exact mechanisms by which they gain access to the h...
Article
Full-text available
The diagnosis of primary vitreoretinal lymphoma and central nervous system lymphoma is challenging. In cases with intraocular involvement, vitreous biopsy plays a pivotal role. Several diagnostic tests are employed to confirm a diagnosis and include cytologic evaluation, immunohistochemistry, flow cytometry, and cytokine analysis. The limitations o...
Article
Full-text available
Migraine is a common neurological disorder impairing the quality of life of patients. The condi-tion requires, as an acute or prophylactic line of intervention, the frequent use of drugs acting on the central nervous system (CNS). The long-term impact of these medications on cognition and neurodegeneration has never been consistently assessed. The...
Article
Full-text available
Spontaneous synaptic activity is a hallmark of biological neural networks. A thorough description of these synaptic signals is essential for understanding neurotransmitter release and the generation of a postsynaptic response. However, the complexity of synaptic current trajectories has either precluded an in-depth analysis or it has forced human o...
Article
Full-text available
Background Regularly updated epidemiological data on the burden of brain and central nervous system (CNS) cancers are important in the prioritization of research and the allocation of resources. This study aimed to investigate incidence, mortality, disability, and trends in brain and CNS cancers between 1990 and 2019. Methods Epidemiological data,...
Conference Paper
Full-text available
The present paper is designed to develop a central nervous system tumours diagnosis using machine learning methods based on multiple biomarkers. We used five supervised machine learning for classification; such as Support Vector Machine (SVM), Naive Bayes (NB), K Nearest Neighbours (KNN), Decision Tree for Classification (DTC), and Linear Discrimin...
Preprint
Full-text available
The morphology of the neural system has not been previous addressed at the level of detail in this work. Section 10.1 addresses the ground rules for any comprehensive review of morphology. Section 10.2 reviews the cytoarchitecture of the human brain, with specific focus on the prefrontal cortex; and addresses whether all human brains are identical....
Article
Full-text available
Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources allocated to the understanding and development of AD treatments, setbacks have been more prominent than suc...
Article
Full-text available
An autonomous navigation method based on the fusion of INS (inertial navigation system) measurements with the line-of-sight (LOS) observations of space targets is presented for unmanned aircrafts. INS/GNSS (global navigation satellite system) integration is the conventional approach to achieving the long-term and high-precision navigation of unmann...
Article
Full-text available
In recent years, with the current access in techniques, studies have significantly advanced the knowledge on meningeal immunity, revealing that the central nervous system (CNS) border acts as an immune landscape. The latest concept of meningeal immune system is a tertiary structure, which is a comprehensive overview of the meningeal immune system f...
Article
Full-text available
The transient receptor potential (TRP) channel is a type of channel protein widely distributed in peripheral and central nervous systems. Genes encoding TRP can be regulated by natural aromatic substances and serve as a therapeutic target for many diseases. However, the role of TRP-related genes in lung adenocarcinoma (LUAD) remains unclear. In thi...
Article
Full-text available
Purpose To validate the diagnostic performance of commercially available, deep learning-based automatic white matter hyperintensity (WMH) segmentation algorithm for classifying the grades of the Fazekas scale and differentiating subcortical vascular dementia. Methods This retrospective, observational, single-institution study investigated the diag...
Preprint
Full-text available
Chapter 17 presents the details of the memory storage mechanism in the cerebellum of humans, and most Primates for the first time. The cerebellum of the human contains 50 billion neurons, roughly half the neurons in the central nervous system, yet it is essentially unexplored except for its anatomy. It has been reported that only seven neuron types...
Article
Full-text available
Background The age of glioma plays a unique role in prognosis. We hypothesized that age is not positively correlated with survival prognosis and explored its exact relationship. Methods Glioma was identified from the SEER database (between 2000 and 2018). A multivariate Cox proportional regression model and restricted cubic spline (RCS) plot were...
Article
Full-text available
Glioma is the most common malignant tumor of the central nervous system and resistance is easily developed to chemotherapy drugs during the treatment process, resulting in high mortality and short survival in glioma patients. Novel therapeutic approaches are urgently needed to improve the therapeutic efficacy of chemotherapeutic drugs and to improv...
Article
Full-text available
Giant congenital melanocytic naevi (CMN) are large melanocytic lesions commonly associated with neurologic abnormalities. Patients diagnosed with giant melanocytic naevi are at an increased risk of developing melanoma compared to patients with smaller congenital naevi. If patients develop central nervous system (CNS) lesions and exhibit certain cha...
Article
Full-text available
Background: Reaction time is a reliable indicator of rate of processing of sensory stimuli by central nervous system and its execution in the form of motor response. It is found to be affected by factors like physiological stress, mood and diseases like neuropathy & nerve injury. Various relaxation interventions have shown to reduce stress, but the...
Article
Full-text available
Due to the high clinical heterogeneity of neuronal intranuclear inclusion disease (NIID), it is easy to misdiagnose this condition and is considered to be a rare progressive neurodegenerative disease. More evidence demonstrates that NIID involves not only the central nervous system but also multiple systems of the body and shows a variety of sympto...
Article
Full-text available
As resident component of the innate immunity in the central nervous system (CNS), microglia are key players in pathology. However, they also exert fundamental roles in brain development and homeostasis maintenance. They are extremely sensitive and plastic, as they assiduously monitor the environment, adapting their function in response to stimuli....
Article
Full-text available
Glioblastoma (GBM) is the primary brain tumor of the central nervous system which is most common and the most aggressive of all other types of tumors. Current therapy for GBM involves surgical removal (excision) of the tumor followed by radiotherapy with concomitant and adjuvant therapy with temozolomide. Despite the improvement in therapy for GBM,...
Article
Full-text available
Night shift work impairs vigilance performance, reduces the ability to stay awake, and compromises brain health. To investigate if the magnitude of these adverse night shift work effects differs between sexes and weight groups, 47 men and women with either normal weight or obesity participated in one night of sleep and one night of total sleep loss...
Article
Full-text available
Study aim : The most important psychological mechanisms that are responsible for sports activity are arousal and attention. Study aim the relationships between the level of arousal and the level of attention, an attempt has been made to explain the mechanisms responsible for sportsman activity. Material and method : The study was conducted in a gro...
Article
Full-text available
According to the evidence, neuroimmune activation plays a crucial role in neurological disorders such as stroke and Parkinson’s disease (1). Clarifying immunity is the initial step in properly investigating neuroimmune activation (2). The immune system is a complex information processing system that protects the body against infectious disease...