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Can flood paths be identified in mountainous areas? What is the solution? And what solutions can be offered to prevent flooding in human settlements in cities and villages?
like incessant rain, increased hydrostatic pressure, and rapid ice melt, a large amount of lake water can be suddenly released. This leads to dam instability and eventual breach, triggering a GLOF (number . Similarly, LLOFs also involve breaching dams. However, LLOFs dams are formed by earthquakes or rainfall-induced landslides blocking streams and rivers. The landslide carries soil, debris, and other materials blocking streams and rivers to form landslide dams .which in turn create dammed lakes. Rising lake levels and erosion of the dam’s sidewall can destabilize its structural integrity. If the dam fails, it can suddenly release large volumes of water downstream, triggering an LLOF (number .Overall, climate conditions interact with cryospheric and geological environments, collectively driving the occurrence and development of GLOFs and LLOFs. Y. Bai et al. Science Bulletin Our analysis shows that humans and infrastructure in HMA have been exposed to increased risk from various floods in the past seven decades. PFs have the broadest impact, causing at least 23,900 deaths and displacing 105 million people from 1950 to 2023. The PFs triggered by monsoon rains are particularly concerning due to their widespread impact, prolonged duration, and tendency to cause severe casualties and displacements (Fig. S11 online). Additionally, our statistical analysis reveals a significant positive correlation between the number of fatalities and rainfall intensity . Unlike PFs, SFs often mobilize large ice blocks and meltwater, potentially transforming or cascading into debris flows and landslides. On average, each SF in HMA has caused 18 fatalities, affected approximately 128,000 people, damaged 3,378 ha of crops and killed 553 livestock . GLOFs on the other hand have far-reaching impacts, also causing devastating damage to settlements and infrastructure downstream. For instance, over 6,000 fatalities were reported in June 2013 due to the Chorabari glacial lake outburst in the western Himalayas . Like GLOFs, when LLOFs occur, they release a huge volume of water, generating extremely high peak flows and catastrophic floods. Meanwhile, we observe a marked population growth and expansion of infrastructure (e.g., hydropower, buildings, and transportation) in HMA (Fig. S13 online), with an average annual growth rate of 1.53% and 7.11%, respectively. This growth trend is expected to continue under various socio-economic development scenarios .and the exposure to flood risks may further intensify in the future. Besides their direct impact on population and infrastructure, floods can trigger a series of environmental issues and landscape instabilities . Very extreme floods can transport large amounts of sediment and pollutants which could accumulate in downstream river channels and floodplains. These pose serious threats to human health and environmental safety and even delay postflood recovery efforts. For instance, in 1975, spring SFs in Xinjiang, China, washed a large amount of sediment into channels, resulting in 70,000 m3 of sediment accumulation and delaying channel discharge for several months (Fid16 in Table S2 online). Extreme floods can also alter river morphology, resulting in riverbed elevation changes, channel widening, or even river avulsion . For instance, such processes were observed when the Kosi River was flooding in 2008. . Additionally, floods may transport long buried soil organic carbon .and mercury, affecting the regional carbon cycle and drinking water quality. Our state-of-the-art flood inventory is comprehensively compiled from public databases, flood yearbooks, media reports, and literature, and highlights the changes of flood complexity over the past seven decades. We highlight the flood complexity and increasing flood exposure risks due to the growth of infrastructure and population in HMA. The complex trends in flooding frequency arise from the interplay between climate warming, shifted precipitation patterns, rapid melting of glaciers, snow cover, and permafrost, as well as more research and public attention (Supplementary Text S6 online). In a warming future accompanied by accelerating glacier melting, snowfall-rainfall shift, more frequent rainfall extremes, and growing human activities, flooding risk in HMA is expected to further increase without effective adaptive measures. We emphasize that identifying risk-sensitive areas and adjusting the spatial distribution of population and socio-economic activities are essential in the future. Additionally, international data sharing and encouraging indigenous people, especially the youth, to participate in local flood mitigation efforts are vital for creating further awareness and addressing climate challenges in HMA.
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Las áreas propensas a inundaciones en regiones montañosas se pueden reconocer utilizando mapas de riesgo y técnicas de mapeo. Para evitar inundaciones en comunidades, se utilizan métodos tanto estructurales como no estructurales.
Las soluciones estructurales comprenden estructuras como muros de contención, presas, embalses y la desviación de cursos de ríos. Las opciones no estructurales incluyen sistemas de alerta anticipada, planificación del uso de la tierra y reforestación.
La integración de estas tácticas, adaptadas a cada región particular, es fundamental para una prevención eficaz de inundaciones en zonas montañosas pobladas.
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Hi, I have established a bioreactor parameters mammalian cell process with the following parameters:
Setpoint Deadband PID settings
1) pH- 7.0 0.1 1.0,5.0,1.0
2) DO- 60% 1 1.0,1.0,1.0
3) Stirer- 127 0
4) PO2 cascade with oxygen at (10ml/min)
5) pH cascade with base and (acid CO2 at 10ml/min)
The issue here is still the oxygen doesn't stop at the given setpoint and reaches around 120-180 % DO.
what can I do to maintain the DO to the specific setpoint. The total volume of reactor is 250ml and WV is 100ml.
The other issue here is the stirrer speed at what rpm I should be keeping it. Can we calculate the rpm of the stirrer according to the volume of the working volume of the reactor. Tip speed was calculated as- 0.0376m/s.
please let me know if more information are needed.
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Kaushik Shandilya thank you for the great explanation. I need help regarding cell growth issue of CHO cells in bioreactor. Here's the summary:
Help! My CHO Cells Aren't Growing in the Bioreactor!
I'm running a fed-batch process for CHO cells in a 250mL Biostream bioreactor with a working volume of 80mL. The key parameters are:
Impeller diameter: 6mm
Target tip speed: 0.5 m/s (achieved at 323rpm)
Air flow: 10 mL/min
DO: 60%
pH control: CO2 and 100mM sodium bicarbonate
Cells: Adapted to CD media Dynamis
Seeding density: 0.5 million cells/mL (viability >98%)
Temperature: 37°C
The Problem:
Cells aren't growing well in the bioreactor. Even at a higher tip speed (1.0 m/s, 640rpm), there's no improvement. Compared to shake flasks (130rpm) where cell counts reach 38 million/mL, the bioreactor only reaches 5 million/mL.
Question:
What could be causing the low cell growth in the bioreactor? How can I optimize the next batch?
Additional Information:
kLa is within the recommended range for CHO cells.
I'm looking for troubleshooting tips, especially simple or overlooked issues.
Expert Advice Needed:
Can you help me identify the root cause of the problem and suggest the best impeller rpm for the next batch?
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Hi,
I am new to research in the field of medicine. What would be the best way or method to find the prescribing cascade ? Should I have excel file and check it against the patient pharmacy record ?
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Dear Doctor
Go To
Prescribing Cascades: How to Detect Them, Prevent Them, and Use Them Appropriately
Tobias Dreischulte, Faiza Shahid, Christiane Muth, Sven Schmiedl, and Walter Emil Haefeli
Dtsch Arztebl Int. 2022 Nov; 119(44): 745–752.
Published online 2022 Nov 4. doi: 10.3238/arztebl.m2022.0306
"Conclusions
Implications for clinical practice
Numerous prescribing cascades have already been described in the literature. A differentiated consideration of these shows, on the one hand, that unintentional and avoidable prescription cascades must be prevented more effectively in order to reduce unnecessary polypharmacy and its associated risks. On the other hand, prescribing cascades may be part of good prescribing practice and necessary for a positive benefit–risk balance in the overall treatment approach. One can also assume that many prescribing cascades have yet to be detected and that with the use of novel drugs, new ADR profiles will emerge (for example, checkpoint inhibitors) that lead to new prescribing cascades.
Implications for research
It has been shown that it is important to further develop current approaches for the systematic identification of previously undetected prescribing cascades and enable a better distinction between clinically relevant prescription cascades and spurious signals in which the prescription of a second drug has no causal relationship to the prescription of the precipitating drug. A systematic review compiles currently known prescribing cascades (40).
The extended classification system for prescribing cascades proposed here can provide a theoretical framework to classify the identified prescribing cascades into appropriate, necessary, and potentially inappropriate prescribing cascades. This can be used to develop practically implementable, potentially electronic instruments, aiming to alert physicians to both potentially inappropriate and potentially omitted prescribing cascades."
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We've got a problem with OD600 after overnight growth in bioreactor namely after
12 h we've reached 8 ,
7 and 6 during three day respectively . We want to establish DO cascade by means of glucose dosage by pump , but maybe this is wrong solution we've no enough experience in this subject ( maybe 'll be better we have to set up pH in cascade instead of DO )
Thank you for your suggestions
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is your DO cascade linked to nutrition pump? or just gas flow, propeller etc.? if your OD600 was decreasing, that means there are some restriction factors in the cell growth, if DO is not the restricting factor, it could be carbon source, nitrogen source, or pH etc. You need to first find out this restricting factor, and then adjust this during the fermentation run. https://plygenind.com/how-to-control-dissolved-oxygen-do-in-bioreactor/
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We've got a problem with OD600 after overnight growth in bioreactor namely after
12 h we've reached 8 ,
7 and 6 during three day respectively . We want to establish DO cascade by means of glucose dosage by pump , but maybe this is wrong solution we've no enoug experience in this subject ( maybe 'll be better we have to set up ph in cascade instead of DO )
Thank you for your suggestions
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Do you mean when you see a DO spike you turn on the glucose pump? that could work, but you also need to make sure that the DO is high enough that it won't impede the bacteria growth. otherwise DO is usually controlled with gas flow rate and agitation speed, and possibly the use of pure oxygen. The following article has more detailed information:
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The topics should have to do with two or more induction motors cascaded and be used as drives.
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try for reducing the weight without compromising the efficiency for aerospace application
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I would like to ask for small help regarding the Automation/Robotics of hand manufacturing prism solution.
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Automating the hand manufacturing chamfering process with traditional robotics is a good approach to achieve precise and consistent results. The use of a vision system to scan the chamfering tool and the prism can help to determine the roundness and position of the tool and the prism, which is crucial for achieving parallelism between them. The use of a laser displacement sensor to verify the position of the prism is also a good approach for ensuring that the prism is correctly positioned.
The cascaded servo loop approach you suggested is a good way to maintain a constant force on the prism and to ensure that the pressure is evenly exerted along the entire edge. However, it is important to make sure that the force applied is not too high, as this could cause the prism to break or run off the edge of the disk. To prevent a runaway condition, you can add logic to detect when the force exceeds a certain threshold and to stop the process if this happens.
Regarding the system block diagram and the cascade force feedback control loop, they look good and provide a clear representation of the process. However, it would be helpful to include more details about the specific sensors and actuators used in the system, as well as any software or control algorithms used to control them. Additionally, it may be helpful to include a description of how the system will be calibrated and validated to ensure that it produces accurate and consistent results.
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Does anyone have an example of a parasite species where the non-parasitic life stage(s) hold a key location in the ecosystem, not related to the host, where elimination of the parasite could cause an ecological cascade?
I know that, theoretically, elimination of a parasite might cause a host population to increase unchecked, which in turn could have cascading effects on other trophic levels, competitors of the host, etc. And there might actually be real-world examples of this.
BUT, what I am looking for is an example where elimination of the parasite causes an unrelated cascading effect (for example, if elimination of screwworms (Diptera: Calliphoridae) might cause a plant species to decline because adult screwworms were no longer present to pollinate the plants.)
The only example I've seen so far is Wyeomyia smithii mosquitoes in North American pitcher plants. They function as a key member of the tiny, close-knit intra-pitcher plant community, where they feed on organic detritus left by the Metriocnemus knabi midges, making nitrogen available to the plants. But there are also many other microorganisms (rotifers, bacteria, protozoa) present that could potentially fill the niche left if Wyeomyia were eliminated. Plus, Wyeomyia adults are only facultatively parasitic.
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Yes, Sunday J Kekrula , agreed, but those are secondary effects of the parasite as a result of it parasitizing its host. What I am asking is examples of a parasitic species NOT acting as a parasite and effecting all the downstream ecosystem services because of that trophic role, but as a different trophic level - AND where it functions in a more-or-less keystone fashion where its presence/absence would make a significant ecological difference.
See my example in the question: Wyeomyia mosquito larvae function as filter-feeders (not as parasites) in the pitcher plant community; their absence alters the rotifer, bacteria, and protozoan communities, and it is unknown if it affects the nutrition of the pitcher plants. Although adult Wyeomyia can function as parasites, the larvae are not functioning as parasites but still hold a significant position in the community.
I'm looking for examples like that one.
What I am NOT looking for:
  • Parasites affect their hosts, which in turn affects predation or herbivory or pollination services by the hosts, which in turn affects lower trophic levels through reduced mortality, higher trophic levels through feedback mechanisms, or the same trophic level through reduced competition. These are all secondary effects of being parasites.
  • Parasites like mosquito larvae are fed upon by other organisms. True, but they are generally redundant with chironomids, chaoborids, corixids, etc., So their absence would probably not make a significant ecological difference.
By the way, I did find another possible example: Horse guard wasps in the genus Stictia (Hymenoptera: Crabronidae) prey preferentially on tabanids, which are parasites. They seem to do a good job at controlling horse fly populations, so I wonder if removing horse flies would have an effect on the Stictia population or if they would switch to preying on other flies (as they already do facultatively).
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There was a problem with gel electrophoresis. I don't really understand what's going on. Every time I act according to the protocol, but every time it turns out to no avail. I need a hint. Chemically synthesized single-stranded DNA is used for quantitative determination. I use 2% agar per 100 ml of TAE buffer (1x) with the addition of 10 µl of ethidium bromide. I prepare samples in a ratio of 1:1 each. Сell C contains DNA labeled with TAMRA fluorophore with 60% glycerin. In the D cell - DNA (Dz1e) with a size of 30 b.p. In the cell E, a mixture of TAMRA-DNA and Dz1e - in theory, there should be 46 p.o. In cells F and G, a mixture of several DNA samples of sizes 88 and 231 b.p., respectively. The voltage in the system was 60V. The samples were run for 1 hour. 6x loading Dye was used as a buffer for samples. But unfortunately, looking at the picture, it is hardly possible to identify the resulting DNA cascades. Who can tell you how to change the conditions
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as you mentioned that I follow proper protocol but cont get results. based on this there may be problem in PCR reaction weather it occur or not and to trace this just add on positive control to your sample and then run the gel. also check the nature of agarose sometime it happened when there is problem in agarose i also face the same problem but once change the agarose now i am doing it successfully.
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The Mandelbrot set is related to the Feigenbaum cascades, which are found in lots of mathematical models of real-life phenomena. But does the Mandelbrot set have have any real-world use, either on its own or in connection with Feigenbaum cascades? Or is it purely aesthetic?
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you can look below this source for your question:
My regards,
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Diabetes is a multifactorial disease characterised by chronic hyperglycemia as the baseline symptom. However, specific dietary components have been implicated as classic independent risk factors. Scientific investigations of these on-switches with respect to the pathogenesis of types I and II diabetes is very vital in preventive clinical practice. What is the distinguished "nutritional sword of Damocles" that usually precipitate insulin deficiency/pancreatic beta cell destruction as well as insulin resistance? How do these dietary agents instigate molecular cascades to initiate and also sustain lifelong hyperglycemia?
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Type 1 Diabetes Mellitus is almost purely genetic but type DM pathogenesis is involved considerably with diet related almost all excessive carbohydrates taken by the person.
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Different cascaded fiber structures such as single-multi-single (SMS) mode, multi-single-multi (MSM) etc. have unique spectral features due to the multimode interference (MMI) phenomena. The transmission spectrum depends on the sensing fiber length i.e., SMF and MMF for MSM and SMS, respectively at the time of fabrication (ignoring the effect of external perturbations).
How does the group dispersion phenomenon affect these spectral features?
The spectrum of one of such cascaded fiber structures (here MSM) has been attached for the reference that occurs due to the MMI phenomena.
#fiber #SMS #MSM #Groupdispersion #opticalfiber
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Thank you so much Jawher Makhlouf for sharing the article. I will go through it.
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Pls provide some relevant research paper for reference.
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I agree with Mike, this is the exact process happening inside two cascaded FBG. part of spectrum will be reflected from the first FBG and the remaining transmitted signal will observe the reflection under cavity same as FP filter.
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Fs=?; %Sampling frequency ?KHz
Flp=?;
Fls=?0;
Wp=2*Flp/Fs;
Ws=2*Fls/Fs;
Rp=?; %(unit:dB)
Rs=?; %(unit:dB)
[N,Wn]=cheb1ord(Wp,Ws,Rp,Rs);
[b,a]=cheby1(N,Rp,Wn); %
[hw,w]=freqz(b,a);
subplot(2,1,1);
plot(w/pi,20*log10(abs(hw)));grid on;
xlabel('ω/π');ylabel('amplitude(dB)')
title('BM filter');
subplot(2,1,2);plot(w/pi,abs(hw));
grid on;
xlabel('ω/π');ylabel('amplitude(H)');
This is for matlab use.
Can you please give me some advice on this?
I knew that The basement membrane model consists of 108 or 54 second-order low-pass filters cascaded in decreasing order of cut-off frequency.
Just wanna a simple model of cochlear.
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Thank you very much for providing this article!
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Hello,
I have been trying to research to develop a cascade CS CS Low noise amplifier on keysight ADS. I haven't been able to find a direct reference for such LNA.
I would appreciate your assistance
Thank you
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See this paper in MTT Transactions:
A Graphic Design Method for Matched Low-Noise Amplifiers, Feb 1990
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So this really is a discussion about something I am just curious about: should we redefine the oxygenation target in COVID0-19 patients, and aim to individualize it instead?
Current guidelines recommend a target SpO2 of 90-96%. Improved oxygenation has been linked with avoidance of a hypoxia stimulated inflammatory cascade.
I am going to link a few studies down here as well which discuss this oxygenation criteria in more detail.
Personally, however, I have this lingering afterthought that baseline oxygen saturation of patients should be used as a guide for determining target goal for oxygenation. A setpoint can be researched and identified, and we can aim for a goal of 20-30 %, or even 50% greater target saturation than baseline saturation in COVID-19 patients. This might potentially mean that we aim for a lower PaO2, using a more conservative approach towards oxygenation, and focusing more on correcting underlying pathology than simply driving loads of oxygen in decompensating lungs. There is a clinical trial currently going on as well about conservative versus aggressive oxygenation in COVID patients (https://clinicaltrials.gov/ct2/show/NCT04425031)
I have no idea if this notion is correct or not. Nor have I tried it on any patients in clinical practice because there is no proper clinical trial protocol that I have for this. But I am just interested hypothetically in how this works, and if maybe it makes sense.
If anyone has any experience/advice/literature/thoughts to share on this, please do!
Here are some interesting articles on this too:
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Target is set to spo2 of 90 so that oxygen hb dissociation curve reaches the flat portion.
Below that po2 falls drastically and o2 delivery to tissues is hampered
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I have a molecule which according to my kinase data analysis activates several putative pathways. Is there a way to visualize these e.g. the RAGE, VEGFR2, TCR, TLR (and others) signalling cascades and showing their overlap and interaction? I would like to find common parts of these cascades to identify the "core" affected signalling pathways.
Thanks in advance!
Cheers,
Niko
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Dear Prof. Dr. Kanegasaki,
thank you very much for these suggestions, will have a close look at the publications.
Kind regards,
Nikolas
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Comprehensive ground water management requires suitable tools that consider the groundwater balance as well as the variety of potential risks that might impact groundwater recharge and chemistry. Due to cascading anthropogenic effects, particularly in urban areas this forms a challenge. Which simulation and management tools (both, freeware or licensed software) do already exist?
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Water Security is one of the most (if not the most) nagging issues in water-scarce countries, particularly as it is exacerbated by Climate Change concerns. Perspectives for sustainable development in the arid region are given in the following discussions:
(2) Adaptation and Resilience to Climate Change: "Temporal Paradox" versus "Chronology Protection Conjecture". (researchgate.net)
(2) On Water Scarcity Indicators (researchgate.net)
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dear researchers, having a cluster of islanded DC-Microgrids supplied by PV- Battery- Supercapacitor, besides supported by backup diesel generator, how to control the diesel generator when compensating power unbalace of microgrids? Is it uaing dual loop cascaded structre, or using single current loop control.
Noting that the battery and supercapacitor are controlled with dual loop structrue considering the Dc bus voltage deviations.
Thank you for your reply and feedbacks.
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The following steps: 1, the system load status detection step: When the system load during normal operation of the island grid system changes, it is transferred to the next step; 2. Diesel generator starts stopping control processing step: If the diesel generator is working The energy storage has been added to the high state, and the diesel generator is processed. If the diesel generator is added to the energy storage, the diesel generator is stopped; if the diesel generator is started to stop control processing After the island grid system still cannot operate stably, then it is transferred to the next step; Machine, energy storage and other equipment for flexible examination, charge, extending the service life of the equipment.
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I would highly appreciate if you can comment down below some leading works on ICA in the context of cascading disasters (disasters whose effects spread through space and time).
I prefer numerical modeling works.
Many thanks!
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I am looking for some new ideas to cascade these two reactions together. I used glycosidase to catalyze the first transglycosylation and Novozyme 435 to catalyze the esterification reaction.
The problem is the first step reaction needs 10% of water, but, there shouldn't have any water in the second step. Anyone who can provide useful ideas, I will add your name as a coauthor when I publish this work.
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Mirosław Grzesik, the first step reaction achieved 8.3g/L/H product from the transglycosylation reaction. I am still working on the esterification product determination. Since I used commercial lipase, I think the second step reaction is much faster than the first one.
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When measuring gamma spectra from the decay of a radioactive nucleus, I observe 3 peaks in the spectrum. The databases indicate that during the decay of this nucleus, there are only 2 lines that lie in a cascade. The third observed peak is cumulative and is approximately 10% of the first or second peak. What is the possibility of dividing the third peak into contributions from the first and second transitions?
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I guess you talking about something like Co-60 1.17+1.33 = 2.5 MeV.
That comes to probability of detecting both gammas. E.g if you bring the detector closer the fraction of the events in combined line will relatively grow . Note that there might be or is (at least in case of Co-60) angular correlation/anti-correlation of emitted gammas.
So in simple case if you detect first gamma (as photopeak not Compton partial event) with probability a1, the second one with a2 the fraction of of combined line over total photopeak events will be simply a1*a2 /(a1+a2+ a1*a2). Note that some 'pot' or 'well' type gamma detectors may have a1,a2 approaching one for some cases.
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Hello friends,
I am working on a control strategy of a grid connected 7 Level cascaded H-bridge(CHB) with independent Maximum Power point tracking (MPPT) PV System, according to the enclosed reference papers ( they have nearly the same control strategy).
Each H-bridge is connected to a single PV module with Vmpp= 75V, and Impp= 1.4 A. The PV modules voltages and currents are not getting stable and even they are not changing although I tried to adjust the DC link capacitors and the PI voltage and current controller gains, so I thought maybe there is an issue in the Control strategy implementation. A PLL is used for synchronisation and a Phase shifted PWM (PSPWM) is implemented in this Matlab Simulink model.
Important to notice, that the model and my MPPT algorithm (P&O) is working perfectly fine with a single H-bridge, I also tried to adjust it with 7 level CHB, but no changes in the results.
Is the implementation of the control strategy right? and do you have an idea where can the issue be? I can convert and send you the file if you can help me with this.
Enclosed you find the reference papers, Control strategy scheme and the Simulation results.
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Hello, please explain more if possible. Thank you
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For cascade refrigeration system, when we want to calculate the compressor discharge temperature (T2) of lower temperature circuit. İ know it is calculated depending on evaporator temperature of lower temperature circuit. but i dont know how to calculate the compressor discharge temperature (T6) of high temperature circuit. On their articles of some researchers, it seems that they calculated depending on evaporator temperature(T1). İ think it is wrong because of the fact that compressor discharge temperature of high temperature circuit depends on evaporator temperature of high temperature circuit.
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Discharge temperature is the function of suction temperature, suction pressure, discharge pressure, and the ratio of specific heats of the particular circuit.
it might be helful: ,
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Dear Researchers, does anyone know already applied cascaded fuzzy PI-PI (i.e. Fuzzy PI speed controller + Fuzzy PI current controllers) control scheme to regulate speed of Permanent magnet synchronous machines (PMSM)? I could not see any published studies on combined fuzzy PI speed and fuzzy PI current controllers in the web. If any available, could you please share the papers or studies about this issue?
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Dear Jüri Joller , thank you for your answer.
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I am designing a 3-stage inverter TIA. The first stage in my design is capable of voltage gain 5x at the maximum(14 dB). I wanted to increase this gain, so I cascaded it with two similar stages. For a first stage alone, the phase margin of the system from stb analysis in cadence is about 96 degree. The three stage cascade on the otherhand has a phase margin of -130 degree indicating unstable system. To tackle this issue, while having the cascade; what is the best way to approach towards bettering my phase margin?
It seems like by varying the feedback capacitor and resistor alone, the phase margin is not improving. So how to get over the low phase margin; any parameters that I need to check/adjust? The figures for the phase and gain (For Phase margin calculation) single stage and 3 stage TIA are attached here.
-Rakesh.
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welcome!
By inspecting your stage amplifier i notice that the DC operating point of the inverter is not defined. There is something foul with this circuit. You have to connect a high resistance between the drain and gate of the inverter.
At first we have to resolve this issue and then we speak about the stability of the amplifier.
Best wishes
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I am currently working on prevention of cascading failure using Q-learning in a power network. I don’t have a very good expertise in MATLAB. Could someone please assist me how should I carry out the experiment using SIMULINK?
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I have created a three-phase cascaded h-bridge inverter at Simulink with the SHE-PWM technique, and I want to test it in the DVR applications. How can I design a controller for that in the DVR application?
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The problem is that SHE-PWM is usually a low frequency modulation technique. It can be used in high frequency but it won't be as effective. For DVR applications high frequency modulations and conventional three level inverters are used. Therefore, u have two options;
(1) use a hybrid SHEPWM technique that is effective in high-frequency. The following papers can be useful;
(2) You have to use higher level inverter instead of conventional three level inverters so that u can remove high number of low order harmonics and improve the overall harmonic profile. But bear in mind it can make the system a little bit complicated.
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I am working with a two output single input system using a cascaded PI control strategy. But that is not effective in rejecting the disturbances in the system. As a result I was looking at the application of 2dof PID for the outer loop to reject the disturbances and have a better control. Can someone help me with the tuning procedure of this type of PID controller? Also is it that 2dof PID is applicable only for systems with time delay? Please give specific suggestions in this regard.
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Dear Chandra,
If you can write an appropriate objective function. You can adjust and tune Cascade PID parameters with lots of metaheuristic algorithms. I can recommend you to examine the following studies. Best. Hasan.
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Hi
This is Ravi. i am trying to create a separation bubble on a flat plate using a contoured upper wall. I want to apply same pressure distribution of a given blade on the flat plate. I have read few paper and they mentioned something like this:
" The shape of the contoured wall is designed using a simple one-dimensional continuity argument to match the pressure distribution measured on the flat plate to that measured on the T106 LP turbine cascade."
It would be helpful if some one tell me the procedure or related derivation.
The simple schematic of the contour wall is attached
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Hi Ravi,
the presence of a separation at the contoured wall also depends on the slope and curvature of this wall. To adjust the pressure gradient you have do adjust the area-ratio h(x)/h_1 (Conti- and Bernoulli-Equation, as Dragan Kozulovic said).
This means: By reducing the duct height h_1 at the inlet, you will need less aggressive slope angles at the contoured wall and you may avoid or minimize the separation at the upper wall. Also, the pressure distribution will come closer to you 1D-prediction.
However, you have to take care, that you do not force an interaction of several separation regions in your duct. Once the boundary-layer at the contoured wall separates, the boundary-layer at the flat plate will maintain attached and vice versa; this system may become unstable.
I think it is a good advice from Dragan Kozulovic to use active or passive flow control (trip wires, little dents or wings etc.) to keep the boundary-layer at the contoured wall permanently attached.
Best regards,
Christoph
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Dear all,
I have a basic biology question, but have yet to come across a satisfactory answer.
Many signalling cascades downstream of specific receptors occurs through intermediates such cAMP, which is used across various other specific signalling cascades.
My question is, how does the signal maintain specificity further down-stream if a common intermediate is used? How to signals not get crossed within the cell?
Many thanks,
Sam
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Dear Sam,
The answer to your question worths a Nobel prize :-) In my opinion, this is one of the very important open questions in biology. You very clearly described the core of the problem: there can be dozens of thousand cellular outcomes as responses to several dozens of thousand extracellular/environmental stimuli - transmitted by a few second messengers. Certainly, there might be several different mechanisms in maintaining specificity. Compartmentalization and other ways of localized production of second messengers very likely contribute, but I think these classic biological processes are, by far, not enough. The missing information might be encoded into the spatio-temporal dynamics of second messenger levels, or other, as yet not identified biophysical/biochemical features of the complex interaction network in cellular signaling. So, there must be a lot to discover :-)
Cheers, Karoly
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As there have been identified numerous tipping points in the climate system that might trigger a domino effect or hidden feedback loops [1], I wonder how much more CO2 we can emmit until the system is beyond human control. Or is it possibly already too late?[2]
The IPCC reports indicate, that the risks and impacts increase a lot between a global mean surface temperature of 1.5°C to 2°C. But they are quite far from a statistically significant CO2 budget calculation of p < 0,05.
Therefore I would like to know how much time we have left for a statistically safe pathway with a CO2 budget that is not based on any 50:50 probabilities.
[1]
RESEARCH ARTICLE
Cascading regime shifts within and across scales
Science  21 Dec 2018: Vol. 362, Issue 6421, pp. 1379-1383 DOI: 10.1126/science.aat7850
[2]
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The scientists say that “estimates of where an Amazon tipping point could lie range from 40% deforestation to just 20% forest-cover loss”.
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The Output buffer consists of a source follower cascaded with two CMOS Inverters and uses a self biased CMOS inverter to set the bias current for the source follower and bias point for the two inverters.
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The DC operating point of this circuit is driven by DC potentials of its inputs. One can only say that it looks like two bottom NMOSFET are current mirror - like repeaters driven by potential of resistor R. RC time constant must >> 1/f therefore R does not interfere with RF signal, only defines DC operating point.
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Hi everyone, I hope you are well today, OK, let me go straight forward, I really like to implement the cascade control technique to stabilize the frequency of the Power system. But I'm having too much problem in the concepts of which combinations of cascade control (PI-PD, PI-PID, etc.,)is suitable for the application and how to tune the parameters of the cascade controller. So I will be really thankful if you can share me some idead, whether you wrote it or you see them somewhere else. Thanks a lot, Sincerely, Andrew Control Theory Optimal Control Optimal Control Theory
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Dear Andrew,
Please check the attached files
Article Procedure for Cascade Control Systems Design: Choice of Suitable PID Tunings September 2008 International Journal of Computers, Communications & Control (IJCCC) 3(3
  • DOI:10.15837/ijccc.2008.3.2392
  • Orlando Arrieta Ramon Vilanova P. Balaguer
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Hi guys,
Can someone guide on how can i create a detector to auto detect both sides of human cheeks from large number of dataset using viola jones? basically my project is on detecting cheeks from sequential image frames from low cost webcam. It is an obligation to use Viola jones here. Preferably using Matlab. Do share your inputs. Thank you in advance.
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I suggest that you can use the library of OpenCV for python or C and we use hare cascade that applies the algorithms of Viola Jone . We can check this site OpenCV by you give the examples.
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The use of cascaded neural networks for the reverse design of metamaterials and nanophotons can effectively alleviate the problems caused by one-to-many mapping, but the intermediate layer of the cascaded network is unsupervised learning, and an effective method is needed to limit output range of the intermediate layer.
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Multi-layer networks can't and don't alleviate the problems caused by one-to-many mappings. What they do is allow the representation of associations that aren't linearly separable.
Since the output of any unit of an intermediate layer becomes an input to the next layer, the range of input/output values is determined by the activation function of each unit. So it's simple to limit the range-just specify that the activation function.
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I have a physical system G=Q*D (composed of 2 systems in cascade). I have created a controller with an LQG controller, but not directly for complete system G. I created 2 LQG controllers, that means, "LQG controller for Q" and "LQG controller for D" and use these controllers in cascade to control the physical system. The problem is the disturbances and noise. The physical system has a "process disturbance : N(0,w) "and "output noise = N(0,v)". My question is:
How I can separate the disturbance and noise for each LQG controller?
Thanks a lot for comments and answers
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Thank you for the papers
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because all steps need ATP. while prolonging the process, more ATP will be used.
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I think MAP-kinases can regulate multiple pathways and different downstream kinases have specificity to activate different pathways differentially depending on the cellular availability of substrates. A cascade also allows differential inhibition of each component. These are like safety valves in the system at multiple places in the circuit to have better control of the cellular system.
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what are the drawbacks of using R744 in cascade refrigeration systems compared to R41?
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Dear Nicholas,
That is true., By taking care of R41 which is flammable , performance value can be increased.
Ashish
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Cascaded DAB dc dc Converter Circuit Design is Required , I have to simulate that in Matlab
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Dear Daniel,
welcome,
What is the primary input and the final output voltage. If one also knows the voltage step up ratio that can be realized for one stage, then one can get the number of the sages provided that all will have the same voltage step up ratio.
One may give more share if you show a circuit configuration. You can start with one stage and then determine its maximum gain and then repeat until the output voltage is achieved.
Best wishges
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The typical approach to designing flight control systems is to design an inner control loop to stabilize vehicle attitude and angular rates, while an outer loop tracks vehicle position. The reason given for the above is that attitude dynamics is "faster" than the translational dynamics. The theory of time scale separation in dynamic systems seems provides an answer to this question but What is the physical intuition behind this argument? Also, Is it possible to design a controller that does not consist of multiple cascading loops?
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Hi Adhithya,
Dynamical systems often involve faster and slower transients. Longitudinal dynamics vary much slower in comparison to lateral dynamics, for example. Therefore we can construct models for lateral dynamics alone by assuming velocity to be constant in a finite time horizon, which is true for a fraction of a second. These engineering assumptions are there to make the analytical descriptions to be simpler. I don't know if these are sufficient for a physical intuition?
Yes it should be possible to design a single controller to achieve both stability and performance. I believe classical design techniques would be too simple for such a performance requirement. I would start with LQR design to achieve the control objectives. The solution of course depends on the specific problem at hand.
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In the context of MBSE approaches, how do you use model(s) to replace textual requirements depending on the requirement type considered (functional, non-functional, constrains...)? Including requirements links, cascades, attributes (like rationales, owners...) and their links to V&V.
Thanks a lot for your answers
Best regards
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Now in problem analysis you have to define requirements and than model. But sometimes you apply the model to interpret the requirements and make recommendations like in teaching
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I was simulating a cascade cooling system in HYSYS and when I activated the dynamic mode of HYSYS, even after controlling a few parameters(to not change much and remain the same as in static mode) by the PID controller. The other parameters changed by itself and continued to do so till stabilization is reached. I didn't get this result displayed by HYSYS. Did anyone face the same issue?
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Thank you Mr. Tanvi, for your reply over the post.
So, if I come back to my cooling system design question, the system will not produce the desired resultant temperatures in real-time as indicated by dynamic simulation?
Is this one of the reasons why dynamic simulation is important as the results produced in the steady-state simulation may not comply over a run(after stabilization).
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please sent to me some codes of exergy analysis.(with article)
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Please refer to my book in the same directory
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I have made 2 dumbbell shaped DGS along with T stub and microstrip line but I am not getting correct simulation results
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S21 should be less than 0.1dB in pass band and greater than 20dB in stob band
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Is it possible to separate dust aerosol from total aerosol to study the optical properties? I would like to quantify the scattering coefficient of dust from different regions. Basically the variation in scattering property when it gets transported, by comparing the samples from source regions and receptor regions. I know we can use cascade impactors to separate particles of different sizes but still, I believe that the dust getting transported will be mixed and of smaller in size. If I collect samples using cascade impactor, what would be the best analysis methods? Thanks in advance.
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There are some methods that you can use to associate your samples with different types of aerosol. You can put your experimental data in a graphical framework based on scattering vs absorption Angstrom exponent, as performed in Cappa et al 2010 or in our study (Romano S et al, 2019 in Atmospheric Environment). Different areas of the graphical framework correspond to different types of aerosol.
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Agitation was normalized by power input but I am looking to understand how to normalize air sparge, overlay, CO2 cascade settings for pH control and O2 sparge settings for DO control.
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dear Tosin,
Your question is not very informative, but can be answered in general terms. In general it is not possible to scale down a process if transport processes are involved. Already by choosing P/V as scale down criterium, several transport processes will change.
Important is to know your aim. Do you want to mimic the large scale physically, and making a model as preparation? Or do you want to study and improve the large scale using small scale model/experiments?
In our opinion scale down is meant for the last. Then you will have to perform a regime analysis to find the rate-determining subprocess (such as oxygen transfer). Next design your small scale as much as possible to study that subprocess, meaning creating the same oxygen level at the same kinetics using sensible (cor)relations for oxygen transfer and medium control. Study the effect of oxygen transfer (and DO) on microorganism behaviour, without losing a lot of broth per experiment.
Realise that mixing at large scale is different from small scale, and that you have to model/design the small scale accordingly if limiting.
Study our lecture notes if you want to have more information, esp page 4.4, at this site ( Lecture Notes on Scale up / Scale down).
Success, Rob
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Dear All
I am wondering if someone has an good explanation for the "nanobuffering" behavior of pH responsive polymers. Here is some literature on the topic:
In brief, the phenomenon is explained as due to a negatively charged polyelectrolyte attracting protons as counterions, thereby lowering the pH locally in its vicinity. My problem with this explanation is that the concentration of other cations is much higher than that of protons. For instance, the research paper above appears to achieve nanobuffering at a bulk pH of 7 and physiological ionic strength. At pH 7 we have [H+] = 10^-7 M, which is more than 6 orders of magnitude less than the concentration of other cations (Na+, K+ etc). So less than one in a million of the negative charges on the polyelectrolyte will attract a proton, meaning that there couldn't possibly be any significant change in pH (even if we are talking small volumes).
I'm not questioning the results of any published work, just trying to understand what is going on.
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I found this paper about interfacial pH for lipid membranes. They use a bulk salt of 400 mM, even more than physiological! Yet they claim protons are attracted by the negatively charged head groups in the membrane (or repelled by positive ones). The strength of the work is that they acknowledge that the pKa of the probe is different depending on its environment and that this is another effect than the local pH change (free proton concentration). They calculate the actual interfacial pH by going through two different previous papers, one on the role of permittivity for probe pKa and one on how to estimate permittivity from spectral peak wavelength.
I will not comment on how precise this method is, but even if it is correct that the interfacial pH is shifted from the bulk by more than one unit, I see no good explanation. Again, why cannot Na+ act as counterions?
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how can i support the diode switched multilevel inverter which requires 12 switches with 4 DC sources to produce 27 level with cascaded trinary configuration which uses same 12 switches and 3 DC sources to produce the same amount of 27 levels
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Blessingh,
I would like to introduce you my multi level inverter called the stepped sinawave in inverter. It is implemented with fully controlled transistor switches.
You may extend it and use it in your research.
To get the work please follow the link:
Bestwishes
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I need to employ hysteresis band current control method for the inverter (CHB) used in my STATCOM, however, I am unable to do it.there are several papers within this topic, However they are not well-written or comprehensive. How should I calculate the bands and other characteristic? I need to use this method for a CHB with more than 21 levels.
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You can refer to following paper.
A. Shukla, A. Ghosh and A. Joshi, "Hysteresis Modulation of Multilevel Inverters," in IEEE Transactions on Power Electronics, vol. 26, no. 5, pp. 1396-1409, May 2011. doi: 10.1109/TPEL.2010.2082001
The paper is well written, comprehensive and suggests no. of methods for hysteresis modulation of MLI. These method have been successfully applied to DSTATCOM application.
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To design control algorithm for 3 phase inveter with unbalanced load using Cascade control (Voltage - outer, Current -inner). And also which safety protection must be carried out for testing in test bench?
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Finding such a paper is difficult and also easy! You can hardly find the "cascade control" as the main subject of a paper. But there are many papers that use this conventional control as their basic control strategy.
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Hi
I want to reduce insertion loss of cascade 1:2 Wilkinson divider for 110GHz.
How can I design arc with given width at CST?
Can someone post video file of an example?
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Dear Uri,
watch following video. it may help you.
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Heparin does affect INR when larger bolus doses are given due to INR thromboplastin reagent inhibition, but is has minimal effect when smaller doses are used. Whatever the dose, is seems that INR should be affected since it inhibits the final common pathway.
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Because PT reagents have heparin neutralizers in them that are usually able to neutralize from 0.6 to 1 unit of heparin. It will prolong the PT and INR if there is a massive amount of heparin in sample.
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I am looking into cross talk between 2 GPCRs and I wanted to understand how does GPCR dimerization occurs in order to activate downstream cascade?
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Thank you for sharing the paper Saleh Alkarim . I will definitely take a look at it
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can i help me, EES code for cascade Refrigeration system
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See following file. It may help you.
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For example
I have a cascade model of three enzymes and my reaction is as follows:
(please see the attached file)
In the reaction, I added three enzymes, the first substrate (glucose acetate) and the last substrate OPD and measured the last product (DAP). I ran the reaction in two different conditions:
1) I used various amount of 6-o-Acetyl glucose and kept OPD concentration fixed.
2) ) I kept 6-o-Acetyl glucose concentration fixed but varied OPD concentration.
In both cases I measured 3rd enzyme activity (by measuring the DAP production).
Now how can I calculate km for the last enzyme?
Thanks in advanced
Sharifun
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It is meaningless to speak of the Km and Vmax for a cascade of three reactions. Each enzyme has its own Km and Vmax. These can be determined by using the individual enzymes and performing the reactions free in solution, following the requirements of Michaelis-Menten kinetics.
If you use enzymes 2 and 3 as coupling enzymes to detect the product formed by enzyme 1, and set up the system so that the rate of enzyme 1 is limiting (i.e enzymes 2 and 3 are faster than enzyme 1), then you can use that coupled system to measure the Km and Vmax of enzyme 1 free in solution.
Since you have attached your enzymes to a scaffold of some sort so that they are not free in solution, then I don't think any Michaelis-Menten kinetic analysis is appropriate.
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I am planning to work on the effect of operating temperatures on the secondary flows in low pressure turbines, specifically the T106 cascade. I am unable to find any temperature range.
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dear collegue. realy I am not sure if i understood your question. the tempearture range of operation in gas turbine depende on what kind of cycle you are trying to simulate. is not the same a simple cycle than a regenerative cycle. At the same time the pressure ratio for the gar turbine engine is another important thing. generally when higher pressure ratio are used higher inlet temperature are provided. the upper limit for inlet temperature is decided by metal constrains and cooling system used in the blades. The outlet temperature of gas turbine before the regenerator (if used) at full load are ranging from 450-600 degree centigrade.
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Hi! I'm little new on this signaling pathway, but I'd like to test if certain compounds can activate Notch signaling on HUVECs. As a positive control I'm thinking on using Jagged1. Which downstream genes could be indicative of Notch activation on this cells? Any protein on the signaling cascade that could be measured too? Many thanks in advance!
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Dear Dr.Shanmugam,
The above chapter is really informative and could answer your question; if you can not access it, please send me your contact email and I will send it to you
regards,
Essam
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I realized a system connected to an electricity grid and I would like to know what level of voltage should I produce to inject renewable energy into the grid? would it be an cascaded H-bridge inverter 5-levels, 7-levels, 9-levels or even 15 or 21-levels? On what criteria will my choice be based?
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Jorel,
The multilevel inverter is characterized by much less harmonic content than the two level inverter. In fact with multilevels output waveform one synthesizes the sine wave.This also reduce the filter size since it will operate on a harmonic frequencies much greater than the second harmonic.
As the number of levels increases the harmonics decreases but the complexity of the inverter increases. So, one has to make a compromise between the number of levels and the complexity and thereby the cost and reliability. Since as the number of elements in a component increases its reliability decreases.
I studied this issue in the paper at the link:
Best wishes
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Enstrophy is the integral of vorticity square over the flow domain/surface of interest. The unit dimensions of enstrophy is m^2/s^2. The enstrophy flux has been used in several studies to investigate the characteristics of turbulence cascade. However, there is no consensus on the basic physical mean of enstrophy in time/frequency/wavenumber domains. I would like your opinion on this.
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I agree that the fundamental quantities are based on physical govening laws, based on the Reynolds transport theorem (mass, momentum, total energy) and that other fields are introduced on mathematical basis.
However, concerning enstrophy I don't think its meaning is other than what based on its definition, it is a scalar field that intrinsicly measures the strenght of the vorticity field without a vector implication (that is directionality). Therefore, based only in the scalar value, we can attribute only partially the meaning of intensity of vortical structures as vorticity is possible in a simple strain field with no structures.
More interesting is the discussion about the governing equation of the enstrophy that has several interesting terms.
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It would really help to find candidate genes in an easy to handle internet platform which are transcribed by specific transcription factors (e.g. NFAT) to dissect signal transduction cascades from the plasma membrane to the nucleus and to cell function.
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Thank you so much. That's a great tool!
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I'm reading a paper about CRISPR and they say: "To investigate whether the CasE subunit is sufficient for pre-crRNA cleavage activity, it was overproduced as a fusion with the E. coli maltose binding protein (MalE). Like the complete Cascade, the CasE fusion protein cleaved only the K12-type precrRNA (Fig. 2D), showing that CasE is an unusual endoribonuclease that does not require the other Cascade subunits."
I don't understand why they fuse the CasE to the maltose binding protein of E. coli (MalE). Is it because this MalE is naturally over produced?
Thanks
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They had to purify the overexpressed protein for use in the cleavage assay (see supplemental materials and methods). Maltose binding protein (MalE) binds to amylose resin, thus purification of the fusion protein is a lot easier than purification of the native protein.
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I just read your article about Trihydroxy-10E-octadecanoate generation as a fungizide on GIT-Labor.de from 2016 (https://www.git-labor.de/forschung/lebensmittel/trihydroxyfettsaeure)
Are there any recent publications focusing on the (chemo-)enzymatic reaction cascade for the production of those TriOHs?
I would like to present this topic to my students in a lecture about industrial biocatalysis.
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Forgot to mention this one, more related to what you seek:
Best wishes,
Rogelio
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Viruses such as Epstein Barr, cause stress to the CNS, which then activates mMC that begin an unending inflammatory cascade resulting in activation of Th-17 pathogenic lymphocytes, oxidative stress, oligodendrocyte cessation, and recruitment of B-cell plasma.
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Agreed, any form of toxic stress can trigger mutated mast cells (mMC) into an inflammatory cascade. Mast cells are on all cutaneous tissue. In MS, the mMC find molecular mimicry on the optic nerve, two areas of the brain and the cervical spine. PGD2 increases histemic inflammation up to 1000 times, allowing for violation of both the BBB and lymphatic vasculature in the CNS.
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I am going to design a multilevel inverter, for this how i set the values of L and C
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OK Thank u :)
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Hi
I have a two-loop control system (cascade control system). The outer loop aims at generating the inner loop reference input so that the global system output tracks its reference input. Each loop has a controller which needs to be designed. First, I used two PID controllers and I got a good response for ramp and sine for both loops, but when applied a step as the desired trajectory, the inner loop did not result in a good response.
What to do in designing controllers for two loop controllers?
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Dear Armin,
The easiest way to design a two-loop control system is to use the PI as a controller, and there you have many examples in the literature. However if you want to complicate your control structure and get more performance there is also a know-how for this. I propose you to see the links and the references for the one and the other method.
-Designing Cascade Control System with PI Controllers - MATLAB ...
https://www.mathworks.com › ... › PID Controller Tuning
-Double-loop PI controller design of the... - ResearchGate
-Two Feedback Loops are Better Than One | Machine Design
-Two-loop Design for Dual-rate Cascade System - ScienceDirect
-Decoupling Double-Loop Control System... (PDF Download Available)
-Robust design of cascade control - IEEE Control Systems Society
Best regards
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The phenomenon of infection, infectious processes and infectious diseases is very complicated and interesting. Scientific research of the infection cannot be reduced to the creation of vaccines for humans and domestic animals. In the manifestation of infection and the periodic spread of infection (epidemics and epizootics), many connections are manifested. They are often not registered. Climate change carries new infectious threats. This is a very typical manifestation of how changes in the environment may lead to a cascade of consequences. Including infectious nature. In the discussion, it is necessary to focus on theoretical and methodological issues. They are key. Important interpretation of various cases of manifestations of infectious diseases among humans and animals. The purpose of discussion is to develop effective scientific positions on the study of the natural phenomenon of infection. Infectious ecology allows to go beyond the very limited approach of modern epidemiology and veterinary medicine. We are trying to reach a new level of understanding of relationships in nature.
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The answer to the question:
"Please define" infectious ecology "in the context of global warming or cooling.
For a correct understanding of what can happen during climate change and changes in the manifestation of the pathogenic properties of microorganisms, the following should be considered:
• Refuse the human perception of climate change. Probably 99% of what is said on the subject, is connected with human perception. We are talking about microorganisms that were "always" and who saw a lot of changes.
• Do not look for a direct and simple connection. These connections are complex. In addition, nature plays infectious jazz in various parts of the world. The geography of manifestations of infectious diseases is changing.
• Including, microorganisms have seen 6 mass extinctions of biological species. The role of the infectious factor in them is not considered. In my opinion it is done absolutely in vain. An infectious factor can be an integral part of changes in the biodiversity of planet Earth.
• Warming - cooling. Usually the set of characteristics for their evaluation is purely anthropocentric. For microorganisms, the link "climate - vegetation - insects - soil" is important. It is clear that everything is much more complicated. Well, let it be so for now. Between climate change and changes in soils, a complex relationship. It should be studied. It is not easy to do.
• Another aspect of the warming - cooling. Reservoirs. In particular, freshwater reservoirs. They begin to change from an ecological point of view. This will affect the microorganisms associated with them. An example is water reservoirs in Ukraine (the Dnieper River). Warming the water gives a cascade of effects. Including, infectious nature. Fresh water changes. Its quality. We can say that the "African standard" of fresh water is being formed.
• For a correct answer to the question about the relationship between climate and infections, new taxonomic units need to be developed. Landscapes, geosystems, ecosystems and other terms are not entirely acceptable when studying the process in infectious ecology.
• A typological analysis of the soil is necessary from the point of view of infectious ecology. I can recognize about 200 types of soil environment. These types are defined precisely in the context of infectious ecology. They will behave differently depending on the geographical area of the world.
• It is necessary to take into account the new connections. Example. Habitual use of herbicides in the new environment can give is not quite the usual result. There are many examples with pathogens. Let's say tularemia. The problem is that the adaptive properties of microorganisms are not investigated. Meanwhile, the discrete activation of pathogens is likely to be an adaptive response to the environment.
• There is no reason to believe that adaptive reactions also do not change. Virulence and many other characteristics will change.
• And 35 - 45 more points.
The general conclusion - we need to deal with this subject. In epidemiology and veterinary medicine, only try to treat infected warm-blooded. They consider a tiny segment of connections. They do not want to hear about anything else. A failure in the fundamental understanding of how exactly the activation of pathogenic properties of microorganisms takes place. As a consequence of the limited position of epidemiology and veterinary science, it is not understanding why the infectious process begins and for what it ends.
Do you remember the ebola of 2014?
This is the ebola report for June 5, 2018. Ebola is back in the Congo. 13 pages of the report for one day. And all about the consequences. And not a word about the study of the environment. On this basis, it is impossible to understand the links between climate change and the changes in the manifestation of infectious diseases.
In the infectious ecology the object can be explored in a fundamentally different way.
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I need PATC code in any language preferably matlab.
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Dear Aamir,
I suggest you to see links and attached file in topic.
-An SLP Filter Algorithm for Probabilistic Analytical Target Cascading
-Structural Design Optimization Considering Uncertainties: Structures ...
-Sequential probabilistic analytical target cascading method for ...
-Introduction to LS-OPT 5.1 - DYNAmore
-Sequential Linear Programming Coordination Strategy for ... - CiteSeerX
Best regards
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Hi everyone,
I currently make nanostructures on single crystal gallium oxide with Ne+ bombardment. I am interested to know how the surface and bulk compositions are being affected during the process. At the lab I have access to EDX, Raman and XPS but I have no experience with any of them.
Usually my structures consist of having a narrow pillar (radius 100nm or less) surrounded by a trench (width 400nm or more). Although the beam does not go on the pillar, there might also be a change in its composition due to cascade effects. Therefore ideally I would like to measure the surface/bulk compositions of (1) the pillar; (2) the surface where atoms were sputtered; (3) somewhere else on the sample where no radiation occurred as a reference. I'm expecting a higher concentration of Ga at the surface than originally, but that might not be the case.
How would you recommend to proceed? I understand that the size of the structures might be a limitation, so I thought that I could obtain a qualitative measurement of the pillar using EDX, while I could do bigger trenches for Raman and XPS regarding the sputtered surface. I read that XPS has a lateral resolution of 60µm, which is way bigger than my structures! Is that so? I could do bigger structures, but not that big (10µm at most I suppose).
Thank you very much in advance for your suggestions.
Julien.
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The results from XPS and EDX will not be comparable because the former probes depths of 1 - 10 nm while the latter probes depths of 1 - 3 microns. I truly do not have any confidence in EDX as anything but a semi-quantiative tool for composition analysis because an assumption has to be made about the homogeneity of the sample over the probe depth and because, as I understand, the composition analysis may also depend on the structure of the material.
The question of whether the statistics of one XPS spectrum is a reasonable representation of an entire sample arises with small spot analysis (curious that few seem to consider the same issue with analysis from just one EDS spectrum where the spot size is sub-micron). First, with one spot analysis at normal take-off of electrons, the spectrum will carry a ratio of 4:1 of valley to surface composition (based on the dimensions you give for your trenches versus pillars). When the columns are high enough, you will correspondingly loose information from the valleys because the scattered electrons will be shadowed. So call the ratio 4 f_s : 1, where f_s represents a "shadow factor" between 1 (flat films) to 0 ("infinitely tall" pillars). The value of f_s will depend on take-off angle. As you go to glancing, f_s will be reduced approximately as f_s*sin(theta), where theta is take-off angle (angle relative to the surface ... 90o is perpendicular take off).
--> To maximize the fraction of composition from the tops of pillars, go to glancing angle. To maximize the fraction of composition from the trenches, use 90o take off angle.
--> A clever set of experiments would be to measure spectra where you vary the width of the trenches and then extrapolate composition values to a point of zero trench width.
--> Another clever set of experiments would be to vary the height of the pillars from nearly zero to micron sizes. The former would give the closest to 4:1 in trench to pillar composition, the latter would be closer to just the top of the pillars.
Continuing on the question of statistics for the small spot size, I would suggest analysis over at least three spots on any given sample with both XPS and EDS. The more regions, the better. Of course, the more samples (replicants in statistics), the better as well.
I recommend that you calibrate the XPS and EDS analysis against samples of pure Ga and stoichiometric Ga2O3 as well as the suboxide Ga2O when possible.
This is an interesting sample configuration to do serious XPS analysis when you truly need to define pillar to trench composition. At the end of the day, I would however still push to do SIMS analysis (and I would ignore EDS as being too ambiguous).
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This connected potentials can accurately describe the displacement cascades in graphite. I would like any suggestions about how to connect AIREBO and ZBL potentials using a Fermi function or spline function. Thanks.
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Thank you for your answer. The hybrid command just superposes hybrid potentials in an additive way instead of connecting them using a Fermi function or spline function.
I wonder if anyone has some experience in connecting airebo and zbl potentials?
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Could anyone possibly tell me about similarity parameters in experimental set up in the annular cascade test rigs? I would be grateful if you could tell me what kind of non-dimensional parameters needs for aerodynamic similarity between experiments and real operations conditions in annular cascade tests for axial compressors? "Corrected mass flow", "pressure ratio", "Reynolds", "Mach number", which parameter (or parameters) is necessary? I want to use surface oil flow visitation on last stators in incompressible flow in annular cascade test rig.
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From aerodynamic point of view the most important are: velocity triangles between stages (i.e. tip speed ratio) and Reynolds numer.
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Dear all,
With access to high-speed time-synchronized data provided by phasor measurement units (PMUs), real-time state estimation becomes possible for power system monitoring, protection
and control. While most of PMU-based research work focuses on real-time state estimation or filtering including static and dynamic states in power systems, my questions are:
1. How can these processed PMU data be used for detection and identification of abnormal system state?
2. How can this knowledge (real-time state, detection and identification of abnormal system state) be used to improve resilience of power systems? (such as loading shedding, isolation schemes and generation tripping under cascading failures)
Thanks very much and appreciate your reply.
Regards,
Hehong
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Dear Hehong,
Regarding the first point of your questions, you can have a look on our recent works on fault detection in an electric grid:
Regards,
Mohamed
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I am working on the geochemistry of a pluton in the Cascades. It ranges in chemistry from diorite to granite, and whole rock major element harker diagrams indicate they share a common parent source. However, the behavior of Th is confusing me. I've never seen an inverse relationship between Zr/Th vs Th. Any comments would be much appreciated!
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Dear Ms. Karyn Ann Patridge:
Agree with the view by Dr. Jan. The key is to establish the field relationship of the granitoid suite via geological mapping aided by geochronolgy. Then, using different models, e.g., fractional crystallization, partial melting, to test the geochemical data set, may give you clues to which petrogenitc process best fitting the data.
Regards,
Xue-Ming
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usage of goals cascade properly according to stakeholder needs is the most important issue in effective COBIT-5 application. usage and application of procesess should be primarily laid on needs of stakeholders. therefore requirements analysis is the core. your project can help ISACA in issuing another version of COBIT X.
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I will be glad to see your views and experiences. good luck!
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There are hormonal replacement options but why not drugs to bypass the coagulation cascade altogether?
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Thank you for the answers. Dr. Sivakumaran, ofcourse replacement options are the reason haemophiliacs are suffering a little less, no denying their importance, I was just curious about chemical drugs rather than their biological counterparts.
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fine and ultrafine aerosol sampling
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Thank you Mr Brink for the questions, our air is to exclude PM>=2.5 i.e to exclude collection at stage A of the sioutas cascade impactor. We are only interested in Stages B, C, D and after filter for which we are using quartz filters. So can we use glass filter paper at stage A i.e top most stage and quartz filters at lower stages B,C,D and after filter.
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DVT is mostly observed in patients of mitral stenosis....I have read that when blood passes through stenotic valve it activates clotting cascade leading to hypercoagulable state that is responsible for DVT..Please explain is it true? Is there any reference 
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We have got patient...If this DVT is caused  by some pooling issues then Inferior vena cava and common illiac veins should have shown involvement first but its not that what we observed in our patient.The DVT involved saphenous and popliteal veins bilaterally that made me ponder something else has got role in this DVT.
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So I need to model a single phase inverter, through function blocks and mathematical equation. I have a real time simulator D-space, through which I can add on the close loop functions and complete my system. Can anyone has some references for this kind of system..?
/Anup
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You can use the user defined block.
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PS is phospholipid cell membrane and in contact with TF Tissue factor involved in the initiation of coagulation (enhances the effect of the cofactor). Does PS - do the same factors can bind and activate a cascade of plasma clotting?
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The detection of antibodies against phosphatidic acid is an important aid in the diagnosis of the antiphospholipid syndrome (APS).
Phosphatidic acid antibodies appear almost exclusively together with anticardiolipin antibodies and / or phospatidylserine antibodies. Its detection is compatible with a diagnosis of antiphospholipid syndrome (APS) and helps in the assessment of the risk of thrombosis in patients with systemic lupus erythematosus (SLE) ) And lupus-like diseases. AFLs are a heterogeneous group of autoantibodies directed to various compounds such as negatively charged phospholipids, plasma proteins, membrane proteins of endothelial cells or platelets, with which they can form complexes of high affinity for the surfaces of anionic phospholipids; The major antigens against which the antibodies are targeted are β-2 glycoprotein I, prothrombin, prothrombin phosphatidylserine, vimentin / cardiolipin, annexin A5, annexin A2, protein C, protein S, oxidized low density lipoproteins (LDL), acid Lysophosphate (LBPA) and sulfatide levels. The prevalence in the general population of aFL is between 5%; However, only a minority will develop the disease, acute myocardial infarction , deep venous thrombosis , and morbidity in pregnancy
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If there are two resonant circuit inductively or capacitively coupled, then how to design the small signal model of  one-only (i.e, for only the transmitter side LC series resonant circuit), while considering the effect of another(transmitter)?
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Your question is not as clear as desirable ...
You have a resonant transmitter - receiver setup (wireless energy transfer ?) and want to evaluate another driver on the transmitter side ?
If it is still operating at the same frequency: simply swap it in.
If not:
  1. make the receiver a well-defined load (eg. a simple resistor of adequate value)
  2. adapt the receiver side LC - rectifier circuit to exhibit the same losses as the previous setup
  3. adapt the transmitting side and start the new simulation.
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Iam using a basic cascade voltage multiplier to boost and rectify the 0.3v ac signal. The circuit rectifies but the boost is very less. So I thought of using LTC3105 after this stage to get a regulated dc output voltage. Problem in simulation is it is taking really long time to simulate moreover LTC3105 is not boosting up below 0.5 v but according to datasheet LTC3105 starts up at 0.25 v. Can you please help me out with this?
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Dear Pritha,
The output voltage value of multiplier circuit  depends on these criteria:
1. Type of the diodes.. hence that the schottky diodes have a good performance comparing to the normal diode. if you keep the same design and you changed just the diodes into schottky diode .. you will notice that there will be increasing in the output voltage of the multiplier circuit. 
2. Number of the stages also important issue to increase the output voltage of the circuit.. more stages that means more output voltage.
3. Values of the capacitors depends on the range of frequency of the source...for example.. if the frequency range is MHz.. the range of the capacitors value will be in pF.
You can find some useful steps in designing criteria in these articles. I designed several types of rectification circuits which I hope will be useful for you.
Good luck in your research.
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Just wanting to know since I know only about tank cascades in India.
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Prairie potholes are depressional wetlands found most often in the upper Midwest, especially North Dakota, South Dakota, Wisconsin and Minnesota. These formerly landscapes are pocket marked with an immense number of potholes, which fill with snowmelt and rain in spring.
The landscape of southern India is dotted by about 140,000 tanks that have backbone of irrigation system for centuries. These are called as tank cascades. However, due to modernization most of the tanks have gone into disuse.
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I am trying to find THD of 2 H-Bridge cascade Multilevel inverter. THD calculated using THD Formula and the THD in FFT analysis are different for a particular case, in all other cases it matches exactly. so which one is accurate THD in MATLAB or THD by formula?
Please find the THD formula which  have used attached
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Hello,
From the simulated waveform itself you understand that matched one gives accuracy.
So you take that THD in FFT for your analysis
All the best
by
R.Suresh Babu
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The exsting system has a cascaded control with volume flow rate as quantity of major interest, being controlled in primary loop and controller in secondary loop controlls the valve position. Both are PI controllers. I want to design optimal controller for this system, so can I just replace outer(primary) PI controller with optimal controller with inner PI controller still controlling valve position or I should redesign whole as one optimal controller?
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In cascade control each control loop has its own controller no matter of which type. Cascade control is mainly used in process control but also in other industrial control applications like industrial robots. The respective outer loops deliver the setpoints for the inner control loops. A common rule is that the inner loops handle the faster subprocesses of the total process and the outer loops the slower subprocesses. That's why the sample rates of the inner loops should be higher than those of the outer loops. An example can be found in robot control where the most inner loop is responsible for the current control of the actuator. The next loop is responsible for the speed control and the next for the position control. In a well structured cascade control system the respective inner control loops can be handled as a closed stable system with a specific time constant. This assumption makes the design of the control parameters of every control loop easier to handle.
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Is there any publication on vane cascades with heterogeneous outlet angle. This is, the outlet angle varying from vane to vane?
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I'm not aware of any publications on vanes with non-uniform outlet angle, but I wrote a few papers many years ago on vanes with non uniform pitch, which also results in non-uniform flow angles.
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I need to reproduce the bifurcation diagram of the Rossler attractor while varying the parameter C (period-doubling cascade) using MatCont.
I have been reading tutorials and trying on my own with no succes.
Could anyone give me some help on this topic? I would really appreciate it.
Thanks in advance.
Bruno Rango.
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i think you can use several loops in matlab,plot and show that...i have a code about bifurcation of logistic map...it is usefull for you...i can send you that...
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I'm running ANSYS FLUENT simulation on a compressor cascade, and I wonder if the growth of the separated flow regions could affect the number of iterations required to reach convergence, and why is this the case? Thanks in advance Ahmed.
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Surely, this expected. A separation bubble could well be unsteady even under  a steady mainstream flow with low momentum and high turbulence levels.
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I am designing shunt Active power filter with cascaded h-bridge 5 level MLI.how to derive capacitance, should i take capacitance value for each bridge and should i require seperate reference voltage for each phase,PI controllers?
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Matlab 2009b, its for 3phase
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I need how to set the timing in one complete full cycle of sine wave output will get using H-bridge configuration(i.e., 16 IGBT switch) (or) I need control circuit diagram...
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Dear Krish,
if you're familiar with generating pulses for a 2-Level-Converter using sine-triangle comparison, the next step is quite simple in theory:
Instead of comparing the desired sine to a single triangle function, you would have to stack 8 triangles and do 8 comparisons.
Generally, for a n-Level converter, you'd need (n-1) triangle-sequences to compare to.
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I need to know how the timing in one complete full cycle of sine wave output will get to use the 4 H-bridge configuration (i.e., 16 IGBT switches) (or) I need the model control circuit diagram.
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Dear Radhakrishnan, for modelling of  control circuit in power electronics I have the best experience with modified Petri-Nets. A model library and run time environment are implemented in system simulators Simplorer and Portunus. However with this system simulators you can not directly generate C-Code for your hardware.
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Wnt, Hh, Bmp's etc. Gene-expression/ protein changes marking stages in normal colon development
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Hello Marin, you can start to read these 4 reviews, Pascal
1/ The intestinal epithelium tuft cells: specification and function.
Gerbe F, Legraverend C, Jay P.
Cell Mol Life Sci. 2012 Sep;69(17):2907-17. doi: 10.1007/s00018-012-0984-7. Epub 2012 Apr 19. Review.
2/ The role of the visceral mesoderm in the development of the gastrointestinal tract.
McLin VA, Henning SJ, Jamrich M.
Gastroenterology. 2009 Jun;136(7):2074-91. doi: 10.1053/j.gastro.2009.03.001. Epub 2009 Mar 17. Review.
3/ Hedgehog signaling in development and homeostasis of the gastrointestinal tract.
van den Brink GR.
Physiol Rev. 2007 Oct;87(4):1343-75. Review.
PMID: 17928586 [PubMed - indexed for MEDLINE] Free Article
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Select item 12943221
4/ Development and differentiation of the intestinal epithelium.
de Santa Barbara P, van den Brink GR, Roberts DJ.
Cell Mol Life Sci. 2003 Jul;60(7):1322-32. Review.
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I am working on Space Vector Pulse Width Modulation Technique. I wanted to determine the switching sequence of switches of Cascaded Multilevel Inverter. 
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you can read the same procedure on 2-level inverter and extend it to a multilevel. at first draw the hexagon and determine which switches are required to generate associate voltage vectors.
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I am designing a control technique for three Phase rectifier in MATLAB. 
Using two PI controller block, outer for voltage control and inner for current control connected in cascade. I tried to tune the model using trial and error method and got output assigning DC voltage reference. Output voltage is following the reference voltage but when I change the voltage reference value the resultant voltage is not changing according to reference value. e.g.  If I set reference value as 400 and use trial and error method, output will follow the reference value and settled to 400 but when ref value is changed, say it is now 200 then output voltage is pulsating from 0 to 400 instead of following 200 reference value. Can anyone please suggest a solution?
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It seems you used of train-error method, and didn't use smart method such as fuzzy or GA, I think it emanates your method.  you should change it.
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I am doing my thesis on compressible turbulence. In case of incompressible 2D turbulence, in the usual study materials, the energy is shown to be an eulerian invariant and the enstrophy as a lagrangian invariant. The existence of an inverse cascade of energy cascade is then argued to exist thanks to these two conservations. In fact for incompressible turbulence the lagrangian and eulerian invariance in this case are equivalent. But for compressible turbulence we have the square of vorticity/density which is a lagrangian invariant but not an eulerian one. On the other hand total energy is an eulerian invariant. Can these two conservations make some possibilities of an inverse cascade too?
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Dear Diego,
Thank you very much for your answer. The compressible variable is theoretically justified in our PRL (Galtier & Banerjee, 2011). My question is a bit different ! It is about the case where there is a possibility of dual cascade or not in compressible case ! May we extend the Kraichnann formalism (1968) for compressible turbulence too (keeping in mind the new density weighted velocity of course) ! In any case Fleck(1996) can be interesting too ! I shall go through and I shall let you know !
Regards,
SB