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Cardiovascular Disease - Science topic

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Background Postprandial dysmetabolism, an important cardiovascular disease risk factor, can be improved by exercise. Further systematic review and meta-analysis is needed to compare the effects of accumulated exercise with a single session of energy-matched continuous exercise on postprandial glucose (PPG), insulin, and triglycerides in adults with...
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Hypertension is a well-recognized risk factor for the development of cardiovascular disease, and the early detection of cardiac changes from hypertension can allow reversing these. Hypertensive heart diseases (HHD) refer to the complex and diverse change of the cardiac structure and function secondary to hypertension. Although conventional echocard...
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Calcific aortic valve disease (CAVD) is the most common valvular disease in the developed world with currently no effective pharmacological treatment available. CAVD results from a complex, multifactorial process, in which valvular inflammation and fibro-calcific remodelling lead to valve thickening and cardiac outflow obstruction. The exact underl...
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Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is...
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Background Despite the growing utility of cardiovascular magnetic resonance (CMR) for cardiac morphology and function, sex and age-specific normal reference values derived from large, multi-ethnic data sets are lacking. Furthermore, most available studies use a simplified tracing methodology. Using a large cohort of participants without history of...
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Objective To determine the prevalence of incidental findings (IFs) on coronary computed tomography (CCT) in women aged 45–55 years and previously diagnosed with reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI) or preeclampsia (PE). Methods A total of 486 middle-aged women with PCOS ( n = 101),...
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Background One fifth of the global burden of cardiovascular diseases (CVDs) in 2017 was attributable to excessive salt intake. As a member of the World Health Organization (WHO), Iran has committed itself to a 30% reduction in salt intake by 2025. Evidence on the amount and trend of salt intake among the Iranian population at national and sub-natio...
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Background It is now well established that atherosclerosis begins in childhood and evolves through adolescence and young adulthood, ultimately resulting in myocardial infarction and stroke in adults. Main test Childhood is a critical phase during which atherosclerosis may begin to develop; in the presence of familial hypercholesterolemia, lifelong...
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PM2.5 can bring serious harm to people's health and life because it easily causes cardiovascular disease and increases the risk of cancer. Hence, monitoring PM2.5 real‐timely becomes a key problem in environmental protection. Towards this end, this paper proposes an improved picture‐based prediction method of PM2.5 concentration using artificial ne...
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Background and aims: Hypertension (HTN) is a common comorbidity in non-alcoholic fatty liver disease (NAFLD) affecting up to 40% of individuals. However, the impact of HTN and its control on outcomes in NAFLD remains unclear. Therefore, we aimed to examine the impact of HTN on survival outcomes in a longitudinal cohort of NAFLD patients. Methods: T...
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Background: Hypertension is becoming an important Public Health problem in World wide. Several Cardiovascular risk factors increase the mortality of coronary heart disease. Hyperuricemia is accompanied by many cardiovascular risk factors. However the relationship between them especially with hypertension has not been confirmed. Objective: To evalua...
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Background: This systematic review and meta-analysis focuses on PCSK9 changes in obese patients following bariatric surgery. Methods: A systematic literature search in four databases was performed. Comprehensive Meta-Analysis (CMA) V2 software used to conduct the meta-analysis. Studies were evaluated regarding heterogeneity in design, populations...
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Present study was done to assess the effectiveness of planned teaching programme on knowledge regarding netiquettes among the students studying in nursing colleges of Sangli, Miraj, Kupwad corporation area. The objective are 1) To assess the existing knowledge score regarding netiquettes.2) To assess the post test knowledge score regarding netiquet...
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Background Nighttime physical activity (PA) has significant effects on human health. Whether excessive nighttime PA is associated with adverse long-term prognosis remains unknown. Methods Three thousand six hundred ninety adults from the US National Health and Nutrition Examination Survey (NHANES) 2003–2006 with accelerometer monitor recording PA...
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Purpose of Review To summarize the prevalence, correlates, and health consequences of poor mental health in the increasingly sizable population of survivors of Sudden cardiac arrest (CA) and to describe current intervention research in this area. Recent Findings After CA many patients report high psychological distress, including depression, gener...
Chapter
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Heart disease is considered one of the calamitous diseases which eventually leads to the death of a human, if not diagnosed earlier. Manually, detecting heart disease needs doing several tests. By analyzing the result of tests, it can be assured whether the patient got heart disease or not. It is time consuming and costly to predict heart disease i...
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Prenatal heart disease, generally known as cardiac problems (CHDs), is a group of ailments that damage the heartbeat and has recently now become top deaths worldwide. It connects a plethora of cardiovascular diseases risks to the urgent in need of accurate, trustworthy, and effective approaches for early recognition. Data preprocessing is a common...
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Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and succe...
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Objective: Women with a history of pre-eclampsia have an elevated lifetime risk of cardiovascular disease that may be partly attributed to an adverse cardiovascular risk factor profile, the etiology of which is unclear. Hypothesizing that this adverse risk profile may begin to arise over time in the years before pregnancy, we sought to evaluate th...
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Introduction Serum albumin levels at a single time point have been shown to predict mortality in peritoneal dialysis (PD) patients. However, we believe that the dynamic change in albumin after PD may be more significant. In this study, we investigated the relationship between dynamic serum albumin and the clinical outcome of patients undergoing con...
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Purpose of Review Hypertension prevention and cardiovascular risk reduction are cornerstones in the prevention and treatment of cardiovascular diseases. Potential applicability of nontraditional cardiovascular risk reduction methods, such as pet ownership, raises a growing interest. Recent Findings Studies show that having pets may reduce the risk...
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Cardiovascular diseases cause approximately 17 million deaths each year and 31% of deaths worldwide. These diseases generally occur as myocardial infarction and heart failure. The survival status, which we used as a target in our classification study, indicates that the patient died or survived before the end of the follow-up period, which is a mea...
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Purpose of Review Cardiovascular disease remains the leading cause of morbidity and mortality in women. Women were historically underrepresented in landmark trials for which cardiovascular guidelines are based on and are prone to gender-specific risk factors that predispose to coronary heart disease. Recent Findings More attention has been made on...
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Background The relationship between joint changes in physical activity and adiposity with mortality is not well understood. We examined the association of changes in these two established risk factors with all-cause (ACM), cardiovascular disease (CVD), and cancer mortality. Methods We used longitudinal data from Taiwan’s MJ Cohort, comprising 116,...
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Background The status of hypertension in patients with atrial fibrillation (AF) remains unknown in China. Methods This study used data from patients hospitalized with AF recruited by the Improving Care for Cardiovascular Disease in China-AF (CCC-AF) project from 236 hospitals enrolled by geographic-economic level in China from 2015 to 2019. The pr...
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Purpose Adipokines have been associated with increased risk of cardiovascular disease. Our aim was to determine if adipokine levels are associated with coronary artery calcification (CAC) as well as all-cause mortality in incident dialysis patients. Methods In patients new to dialysis, we prospectively investigated the association of adiponectin,...
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The coronavirus disease-2019 (COVID-19) pandemic has become a major global health problem. COVID-19 is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and exhibits pulmonary and extrapulmonary effects, including cardiovascular involvement. There are several attempts to identify drugs that could treat COVID-19. Moreover, many...
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Purpose During the COVID-19 pandemic, widespread public health measures were implemented to control community transmission. The association between these measures and health-related quality of life (HRQOL) among patients following percutaneous coronary intervention has not been studied. Methods We included consecutive patients undergoing percutane...
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Ferroptosis is a new programmed cell death characterized by the accumulation of lipid peroxidation mediated by iron and inflammation. Since the transcentury realization of ferroptosis as an iron-dependent modality of nonapoptotic cell death in 2012, there has been growing interest in the function of ferroptosis and its relationship to clinical dise...
Preprint
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Studies show that Studies that cardiovascular diseases (CVDs) are malignant for human health. Thus, it is important to have an efficient way of CVD prognosis. In response to this, the healthcare industry has adopted machine learning-based smart solutions to alleviate the manual process of CVD prognosis. Thus, this work proposes an information fusio...
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Automatic diagnosis of arrhythmia by electrocardiogram has a significant role to play in preventing and detecting cardiovascular disease at an early stage. In this study, a deep neural network model based on Harris hawks optimization is presented to arrive at a temporal and spatial fusion of information from ECG signals. Compared with the initial m...
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The new version of the hydro-electro-mechanical system (HEMS) is modeled via 14 serially connected electrical equivalent circuits resulting in an integrated equivalent circuit. The new model accepts a group of variables and even examines the interaction between them. This paper introduces an improved integrated new model of the heart by replacing t...
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Segmentation of retinal blood vessels is crucial in the automated diagnosis of many retinal and cardiovascular diseases. The process of precise vessel extraction using fundus images is still a challenge due to spatially varying vessel-width and non-homogeneous retinal backgrounds. This work targets the challenges mentioned above with an adaptive mu...
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Introdução: Considerando a importância crescente da qualidade de vida da pessoa, a comunidade científica debruça-se incessantemente sobre os melhores instrumentos de medição, que a permitam caracterizar. A este respeito, um dos pontos da investigação atual reside nas doenças cardiovasculares, onde integramos o enfarte agudo do miocárdio. Objetivo:...
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Background Hypertension is the biggest contributor to the global cardiovascular burden with evidence for ethnic differences in treatment response and outcomes. Under-representation of ethnic minorities in clinical research is well known, and despite wide-ranging public engagement events by the Glasgow Blood Pressure Clinic team, there was a lack of...
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The article presents the current understanding of the problem of radiation therapy (RT)-induced heart diseases. The paper is based on a clinical case of restrictive cardiomyopathy in a female previously cured of Hodgkin's lymphoma with RT. The importance of using modern imaging technologies aimed at verifying pathomorphological changes in the myoca...
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Objective To explore the prevalence and clinical significance of newly diagnosed diabetes mellitus (DM) in patients with primary aldosteronism (PA). Investigating the risk factors for cardiocerebrovascular disease (CCVD) will guide strategies for reducing CCVD in patients with PA. Methods We retrospectively included 729 PA patients without DM and...
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Purpose: To demonstrate that retinal microvasculature per se is a reliable biomarker for Diabetic Retinopathy (DR) and, by extension, cardiovascular diseases. Methods: Deep Learning Convolutional Neural Networks (CNN) applied to color fundus images for semantic segmentation of the blood vessels and severity classification on both vascular and full...
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Introdução: A hipertensão arterial sistêmica é uma doença causadora de grandes impactos na saúde individual e coletiva. A reabilitação cardíaca é reconhecida como um método eficaz para tratar e controlar a doença. Objetivo: Avaliar os efeitos da reabilitação cardíaca em pacientes hipertensos. Material e Método: Foi desenvolvido um estudo transversa...
Chapter
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Detection of blood microbiota in patients with cardiovascular diseases
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It is unclear whether the dose–response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean ag...
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Background: Chronic Obstructive Pulmonary Disease (COPD) has considerable effects on cardiac functions primarily affecting the pulmonary vasculature and then right ventricle along with left ventricle. These cardiac effects complicate the clinical course of COPD and correlate inversely with survival.
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Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat ca...
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Purpose of Review To report on recent data about PCSK9 monoclonal antibodies and to evaluate their relevance in a nucleic acid–based therapy era for lipid lowering and prevention of cardiovascular disease. Recent Findings New methods of PCSK9 inhibition based on nucleic acid therapeutics such as antisense oligonucleotides, small interfering RNAs,...
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Background: Polycystic Ovary Syndrome (PCOS) represents one of the major causes of infertility in women. Various criteria are set to diagnose PCOS, some over diagnose and some underdiagnose it. The objective of the study was to compare the various criteria used for the diagnosis of PCOS: NIH 1990 criteria, Rotterdam 2003 criteria and AE-PCOS Societ...
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Although the epidemiology—as well as the morbidity and mortality—of cardiovascular diseases (CVD) is a subject of constant change, nevertheless, CVDs are still the primary (or secondary at best after neoplasms) cause of deaths in developed countries [...]
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Chronic kidney disease (CKD) is associated with an increased risk for cardiovascular disease (CVD), major adverse CVD events, and cardiovascular mortality. Low levels of physical activity and reduced cardiorespiratory fitness further compound the health consequences in this patient population. Aerobic exercise alone and the combination of aerobic a...
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Cardiovascular diseases seriously endanger human physical and mental health and life safety, to investigate correlation between miR-let-7b and miR-29b and coronary artery calcification of various patients. At present, real-time fluorescence quantitative PCR (qRT-PCR) was used to detect the expression levels of plasma miR-let-7b and miR-29b in patie...
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In the 21 st century, cardiovascular diseases (CVDs) constitute the leading cause of death. It is difficult for potential CVD therapies to be successful since CVDs cannot be effectively or cheaply treated with existing therapy. To formulate and transport therapeutically active molecules to treat a variety of ailments, innovative drug delivery carri...
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To determine the prevalence of osteoarthritis and its associated factors in populations from Russia. The population-based Ural Eye and Medical Study (UEMS) and the population-based Ural Very Old Study (UVOS) were conducted in a rural and urban region in Bashkortostan/Russia and included participants aged 40+ and 85+ years, respectively. As part of...
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Radiomics is an emerging technique for the quantification of imaging data that has recently shown great promise for deeper phenotyping of cardiovascular disease. Thus far, the technique has been mostly applied in single-centre studies. However, one of the main difficulties in multi-centre imaging studies is the inherent variability of image charact...
Preprint
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Cardiovascular diseases (CVDs) are a group of heart and blood vessel disorders that is one of the most serious dangers to human health, and the number of such patients is still growing. Early and accurate detection plays a key role in successful treatment and intervention. Electrocardiogram (ECG) is the gold standard for identifying a variety of ca...
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Five new chloro-azaphilones, chaetofanixins A–E (1–5), and five known analogs (6–10) were isolated and identified from the hadal trench-derived fungus Chaetomium globosum YP-106. The structure of chaetofanixin E (5) is unique and interesting, bearing a highly rigid 6/6/5/3/5 penta-cyclic ring system, which is first encountered in natural products....
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Compared with normal people, patients with intellectual disability have poor cardiopulmonary and muscle fitness levels, and their daily physical activity generally cannot reach the “guideline-recommended amount,” which increases the risk of obesity and cardiovascular disease in this group. From the perspective of six elements of exercise prescripti...
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Background Elevated blood pressure is associated with cardiovascular disease, stroke and chronic kidney disease. In this study, we examined the socioeconomic inequality and its related factors in prevalence, Awareness, Treatment and Control (ATC) of hypertension (HTN) in Iran. Method The study used data from the recruitment phase of The Prospectiv...
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Introduction: Combustible cigarette use is associated with an increased risk of several cardiovascular diseases; however, less is known about associations between these cardiovascular conditions and electronic cigarette use. Methods: This study investigated relationships between electronic and/or combustible cigarette use and diagnoses of cardio...