Cardiovascular - Science topic

Hi frds,

Looking for a monthly updated database for cardiac, cerebrovascular, and multisystemic events. No success as of yet to find one in Europe.

It should correspond to the monthly data of the CDC Wonder database in the USA:

Cherish your feedback.

Is a GWAS study of LVH genetic predisposition of 500 samples be considered low powered study? If so how to justify a small sample size ? Is there research conducted with small n size with GWAS ?

Hello everyone

I Load apolipoprotein on extracellular vesicles (EVs).

After centrifuging, I have EVs, apolipoprotein, and also loaded apolipoprotein. How I can separate them?

And also confirm that?

Thanks for your suggestions.

Hi frds,

What calculation formula and hypotheses do actuaries currently use for the assessment of the impact of Covid and Long Covid on life expectancy in years?

How long does it historically take to integrate new diseases in formulas? 2 years? 5 years? 15 years?

Cherish your feedback.

I recorded the ECG of rats using Adinstrument Powerlab device with 3 electrodes, and started to analyze the recorded ECG manually. I want to identify the abnormality in R wave that seems to be fluctuating with low and high amplitudes alternatively. I suggested that could be a Poor (slow) R Wave Progression but all explanation data regarding this was with 12 lead ECG not 3 leads ECG. is there any suggestions to explain this abnormal change in R wave amplitudes.

I want to work on the effect of nitrate fertilizer on toad (Bufo bufo)

2017 ACDC CMR dataset is widely used in segmentation, classification and other CV studies. And to my knowledge, there were many other open cardiovascular imaging dataset(including ECG, CT, MR) but I can't find their exact name and get access to their website. Can anyone help? thanks!

Plaques form due to a self-healing mechanism of blood vessels and will increase over time. When entering blood vessels, they block blood flow, lead to hypertension and decrease blood flow to organs such as the heart. To get rid of these plaques, we need to boost the good cholesterol such as HDL or improve health of liver to produce enzymes that move these plaques. So, what other ways to get rid of these plaques without using invasive methods?

Thanks and best regards.

I'm wondering if there is less stress on the mom's cardiovascular system during a pre-term delivery than a full-term delivery. This is outside my wheelhouse, but smaller baby = smaller cardiovascular stress is my hypothesis. Anesthesia-free data would be ideal. Thanks in advance!

Has anyone seen any interesting gaps in the literature related to cardiovascular exercise physiology and could suggest any potential topic? Would be greatly appreciated

Many Studies have now shown benefit of SGLT2 inhibitors in heart failure. The outcome measures often include composite cardiac outcome measures that include Ischaemic Heart Disease [IHD] outcomes.

Is the benefit limited to Heart failure alone?

Anybody aware of any study that shows true benefit for Ischaemic Heart Disease alone?

Can SGLT2 inhibitors be safely used in Non-Diabetics, as diuretic therapy?

Do they have other beneficial pleiotropic effects in general, eg in endotheleal function and vascular tone

Dear Colleagues,

Below I copy a call for help in our meta-analytical work. In brief, if you have any data (published or unpublished) that is not on the list of paper below, please let us know!

Thank you RG community!

Call for meta-analysis data: The Undoing Effect of Positive Emotions.

We looking for unpublished data/manuscripts regarding the undoing effect of positive emotions for the purpose of a meta-analysis. We are a team of researcher from Adam Mickiewicz University, Stanford University, and University of Amsterdam.

Specifically, we are looking for studies with the following characteristics:

- Experimental studies that induced positive emotions vs a neutral control following experimentally induced negative emotions or stress.

- Autonomous Nervous System recovery was measured during elicitation of positive emotions and during the neutral conditions.

If you have any unpublished work on this topic, we would like to include it in our analyses. We would be very grateful if you might either send your study information or data at your earliest convenience (deadline: 15th of October), or contact us with any questions you may have to the following address: macbeh@amu.edu.pl.

Additionally, we are interested if you know of any additional unpublished or ongoing studies (by yourselves or other authors) that might be relevant. We would also appreciate it if you would forward our request to any researchers in your network that may be doing relevant work in these areas.

Please find the list of studies that we identified by the literature search. If you cannot find your papers that can contribute to our meta-analysis on this list, please let us know about your work. There have been relatively few studies published about this phenomenon, thus every contribution is highly appreciated

Best regards,

Maciej Behnke & Łukasz D. Kaczmarek

Adam Mickiewicz University

James J. Gross; Stanford University

Mark Assink; University of Amsterdam

List of identified studies:

*Fredrickson, B. L., & Levenson, R. W. (1998). Positive emotions speed recovery from the cardiovascular sequelae of negative emotions. Cognition & Emotion, 12(2), 191–220. https://doi.org/10.1080/026999398379718.

*Fredrickson, B. L., Mancuso, R. A., Branigan, C., & Tugade, M. M. (2000). The undoing effect of positive emotions. Motivation and Emotion, 24(4), 237–258. https://doi.org/10.1023/A:1010796329158

*Gilbert, K. E., Gruber, J., & Nolen-Hoeksema, S. N. (2016). I don't want to come back down: Undoing versus maintaining of reward recovery in older adolescents. Emotion, 16(2), 214–225. https://doi.org/10.1037/emo0000128.

*Hannesdóttir, D. K. (2007). Reduction of fear arousal in young adults with speech anxiety through elicitation of positive emotions (Doctoral dissertation). Retrieved from, https://vtechworks.lib.vt.edu/bitsteam/handle/10919/28941/dissertation.pdf?sequences=2&isAllowed=y.

*Kaczmarek, K. (2009). Resiliency, stress appraisal, positive affect, and cardiovascular activity. Polish Psychological Bulletin, 40(1), 46–53. https://doi.org/10.2478/s10059-009-0007-1.

*Kaczmarek, L. D., Behnke, M., Kosakowski, M., Enko, J., Dziekan, M., Piskorski, J., ... & Guzik, P. (2019). High-approach and low-approach positive affect influence physiological responses to threat and anger. International Journal of Psychophysiology, 138, 27-37. https://doi.org/10.1016/j.ijpsycho.2019.01.008

*Medvedev, O., Shepherd, D., & Hautua, M. J. (2015). The restorative potential of soundscapes: A physiological perspective. Applied Acoustics, 96, 20–26. https://doi.org/10.1016/j.apacoust.2015.03.004.

*Qin, Y., Lü, W., Hughes, B. M., & Kaczmarek, L. D. (2019). Trait and state approach-motivated positive affects interactively influence stress cardiovascular recovery. International Journal of Psychophysiology, 146, 261-269. https://doi.org/10.1016/j.ijpsycho.2019.08.011

*Radstaak, M., Geurts, S. A., Brosschot, J. F., Cillessen, A. H., & Kompier, M. A. (2011). The role of affect and rumination in cardiovascular recovery from stress. International Journal of Psychophysiology, 81(3), 237-244. https://doi.org/10.1016/j.ijpsycho.2011.06.017

*Soenke, M. (2014). The role of positive emotion eliciting activities at promoting physiological recovery from sadness (Doctoral Dissertation). Retrieved from, http://arizona.openrepository.com/arizona/bitstream/10150/325214/1/azu_etd_13407_sip1_m.pdf.

*Sokhadze, E. M. (2007). Effects of music on the recovery of autonomic and electrocortial activity after stress induced by aversive visual stimuli. Applied Psychophysiology and Biofeedback, 32(1), 31–50. https://doi.org/10.1007/s10484-007-9033-y.

Dear All,

Hope you are doing well.

How to draw a line in center of the artery fluid volume domain. The problem is that, the line/plane couldn't fall properly at center of artery. When i use the option "LINE command from Location in ANSYS Fluent post processor.

The geometry or model was extracted from patient CT scan data so which is not in a single plane.

Thanking you in anticipation.

&

Regards,

I conducted a Mendelian randomisation study for assessing the association between X (exposure) on Y (outcome or case). But, I am not sure whether our outcome (cases) are valid. My question is, how can I check the validity of my outcome using genetic data? For example, is there any reasonable method for checking genetic correlation between our outcome and previously published GWAS including gold standard case ascertainment?

There seems to be a lot of controversy about the validity of HRV as a measure of vagal tone. Specifically, Marmerstein, McCallum, & Durand (2021) published a paper suggesting the lack of correlation between HRV and vagal tone. Are there better, non-invasive ways to clearly and accurately measure vagal tone? So much of the literature over the past few decades focuses entirely on HRV in some way or another. Is this still an accurate way to measure vagal tone?

I'm looking for an excel sheet to calculate the STS Score. From the website http://riskcalc.sts.org/stswebriskcalc/calculate. Does anyone have a worksheet to calculate the STS Score?

I want use the zebrafish to study heart and vessel development, as well as adult heart regeneration.

I've heard garlic and high nitrate foods like arugula or beets typically occupy high ranking here. What others do you know of or recommend? What's your top 10 list, based on what research? Thanks.

As we know,the pulse propagates in wave form and the velocity of wave propagation depends on the propagation medium features. So,Is it possible to use the measurment of velocity of pulse propagation in the body to diagnose cardiovascular problems such as hypertension and hypotension?

Chronic kidney disease (CKD) is commonly defined as reduction in eGFR value < 90 ml/min/1.73 sq. m. Several studies have reported a significant association between CKD and cardiovascular events. Oxidative stress, inflammation, and endothelial dysfunction are important phenomenons in atherosclerotic CVD. Oxidative stress is also observed in patients with CKD. Thus, it further related to atherosclerosis and CVD events.

While doing a CVD risk assessment, I am curious about using the CKD as a surrogate endpoint of CVD events. Can we do that? Is it possible to use CKD as a surrogate biomarker of CVD and other vascular comorbidities including stroke?

Paper that shows the association between CKD and CVD is available at:

DOI: 10.1056/NEJMoa041031

What are the functional criteria of the cardiovascular, respiratory and autonomic nervous systems predict the severity of the disease, the presence of complications and mortality?

Any ideas/suggestions related to re-opening of fitness centra and personal training and safety measures and/or risk factors related to covid-19?

What about material?

What about training machines?

Risk of spread with breathing, with higher-intensity training?

What kind of safety measures would you suggest?

Any science about this related to sars-covid from before?

Over the past two years, our understanding of anti-hyperglycemic medications used to treat patients with type 2 diabetes (T2D) has fundamentally changed. Before the EMPA-REG OUTCOME trial, agents used to lower blood glucose were felt to prevent or delay the development of microvascular complications, but were not known to definitively reduce cardiovascular risk or mortality. Previous studies with then novel sodium-glucose cotransport-2 (SGLT2) inhibitors demonstrated improvements in several cardiovascular and renal risk factors, including HbA1c, blood pressure, weight, renal hyperfiltration, and albuminuria. However, as with other antihyperglycemic drugs, it could not be known if these salutary effects would translate into improved cardiorenal outcomes. In the EMPA-REG OUTCOME trial, SGLT2 inhibition with empagliflozin reduced the primary outcome of major adverse cardiovascular events (MACE), while also reducing mortality, hospitalization for heart failure, and progression of diabetic kidney disease. In the CANVAS Program trials using canagliflozin, the rates of the 3-point MACE endpoint, the risk of heart failure and the renal composite endpoint were also reduced, albeit with an increased risk of lower extremity amputation and fracture. As a result, clinical practice guidelines recommend the consideration of SGLT2 inhibition in high-risk patient subgroups for cardiovascular risk reduction. Ongoing primary renal endpoint trials will inform the cardio-metabolic-renal community about how to optimally treat patients with chronic kidney disease – including those with and without diabetes.

Does the accuracy of the cardiac flow analysis vary when analysis is done using 2D Cine -3 directional velocity encoded MRI and when it is done using 4D flow MRI with volumetric coverage and 3 directional velocity encoding?

In the clinical world, GLP1 agonists and SGLT2 inhibitors are not commonly co-prescribed, though given the benefit of weight loss, cardiovascular benefits, and blood glucose control in patients with insulin resistance as well as obesity, should this be more commonly used? Thank you!

I have 2D PC MRI velocity data in a square matrix. I want to calculate the pressure differences at different points between the inlet and outlet of left atrium from this data. I have calculated using Bernoulli equation where I could calculate the pressure differences along a particular streamline only. I want to know how can I calculate pressure difference in the whole flow?

Research gate is continually sending me research on bio stuff (cardiovascular) I am not interested in. I mark it as not interesting but research gate insists. It is a bit frustrating that in teh era of artificial intelligence nothing better can be done.

I am doing a review work on the cardiovascular conditions of patients living with diabetes Miletus. I wish to know where to look for very recent resources. Apart from published literatures, will the government hospitals be of help?

What do you think that Noise Pollutant affects you the most?

o Effect on hearing

o Other health issues

o Disturb sleep

o Result in deafness

o Mental health disorders

o Any other, please mention

o Reduce Working Efficiency

o Interfere with communication

o Cause annoyance

o Any other, please mention

(Other health issues may include like High Blood Pressure, Hypertension, cardiovascular effects, Heart Disease, Stress

I have only x and y directional blood flow velocity data obtained from MRI. I have no z-directional velocity data . I have learnt that the vortex detection methods like q-criterion, lambda2 method needs velocity data for all three directions (x,y and z) to identify vortex core locations. Is there any method that i can apply for identifying vortex core locations for my two directional data?

We are working with an industry partner who has developed screening kiosks for general population assessment of physical and mental health. They are measuring HRV, and I want to know if the objective HRV data at an individual level might add predictive variance over and above self-report measures (e.g., K10) in the prediction of high prevalence mental disorders.

HRV is also a predictor of bad cardiovascular outcomes. As a secondary question, are there holistic models predicting multimorbidity (which might use HRV, blood pressure, self-reported anxiey, etc. as a screen for multimorbidity risk)

Is there anyone who would like to this literature review with me?

Our experience in cardiovascular ischemic heart disease is very promising using TPA in carotid sonography for very large population!!!! Dont you think to use any cardiovascular subrrogate?

This method is easy, in 2d sonography, with very low variability in inter an intra observer variation!!

Dear colleagues

Have a good day!

Is there any relationship between lipid profile parameters and cholesterol in patients treated with MTX?

Regards

I have some MRI images and 2D phase contrast blood flow velocity data of healthy patients obtained from MRI. I need to obtain the vortex lines of blood flow inside the heart from the data. So to clean the data, I have applied Gaussian and wiener filters of certain radius. Still I think proper vortex lines are not coming. I am really in a fix. Any help or suggestion will be accepted with gratitude.

I want to develop a material for a cardiovascular stent application. Therefore, I want to know about the pressure which a stent will bear in the artery.

I have ran a study comparing the Daily Mile and HIIT in children to see which is best for improving cardiovascular endurance (Beep test) and anaerobic power (20m sprint).

Scores on both test were measured before and after the interventions so it is a differences in the change in the mean of the scores post both interventions to see which is greatest.

Which is the correct statistical analysis to run on SPSS? I thought a one-way repeated ANOVA but I am now doubting myself.

Any help is appreciated.

Currently I am working on the formulation and development of microsphere formulation for cardiovascular drug, where i am not getting standard references for estimation of drug from same formulation. So I have decide to develop my own method for the estimation of drug from microsphere formulation.

Since I am not getting any related research articles therefor i am not sure to proceed.Please guide me on this..

Thank you all..

Currently, physical exercise programs are being developed for elderly people who perform at home and are offering very advantageous results for the prevention of cardiovascular, rheumatic and musculoskeletal diseases. It is interesting to conduct studies aimed at evaluating the effectiveness of these programs, as well as adherence to them.

How significant is OSA in your practice and how aggressively do you manage it?

Apart from CPAP therapy, should weight loss strategies be vigorously followed?- Bariatric surgery/ Liraglutide/other?

CPAP doesnt improve mortality

https://www.uptodate.com/contents/management-of-obstructive-sleep-apnea-in-adults UpToDate : available on open source, Google

Do any physicians, researchers and scientisays among us ever wonder how it is that while researching and standing as proponents of advancing the health of the general population —we often fail to acknowledge our own health — and may even put others’ health before our own personal health?

“Doctor health thy self” may not just be a cute anecdote. Seriously. The path to becoming a doctor and the hours invested in treating others, long and arduous, may be killing us. What say you?

The objective of the position is to develop a PhD work on the subject “cardiovascular stent design and analysis”. The aim of the work will be to analyze the expansion of the stent and the contact with the artery to simulate thrombectomy technique. The developments will have to be carried out within the Kratos framework.

More info:

In an experimental study we tested various breathing exercises and monitored respiratory flow, beat-to-beat blood pressure, and heart rate. We developed MATLAB script for baroreflex analysis based on the sequence method and the result was interesting.

Now, we want to compare breathing exercises regarding the magnitude and phase of transfer between respiration -> blood pressure, respiration -> heart rate, and blood pressure -> heart rate using transfer function analysis.

I appreciate if someone with experience in such analysis can help us with a MATLAB script.

Statins reduce further deposition of lipid and in some cases with very high dose statin, some marginal reduction in atheroma may be seen.

In patients with substantial atheroma, one wants appreciable reversal and removal of lipid. Statins cannot do this

Initial studies with HDL infusions have shown promising results, but problems exist with immunogenicity .

Can HDL be rendered less immunogenic and is it a potential game changer in the world of cardiovascular disease and death?

Can we one day 'clean out' the atheroma from our arteries with this intervention?

Nano-contribution for cardiovascular disease is quite vast. So, search for marketable nano-medicine for Cardiovascular treatment.

I use Lagendorff ischemia-reperfusion for rat hears 30 min ischemia then 90 min reprfusion. Half of the hearts did not come back (died) after ischemia. Any reasons for that?

Dear Colleagues, we have been collecting data for a meta-analysis regarding positive emotions and responses in peripheral physiology. If you wished to contribute please contact us (mansape@stanford.edu)

A team of researchers from Stanford University and Adam Mickiewicz University is conducting a meta-analysis on autonomic nervous system activity in positive emotions. We are looking for unpublished data/manuscripts.

Specifically, we are looking for studies with the following characteristics:

·  Experimental studies that induce positive emotions.

· ANS measures were assessed during baseline and emotional responding

If you have any unpublished work on this topic, we would like include it in our analyses. Please either send your study information or data at your earliest convenience, or feel free to contact us with any questions you may have to the following address: mansape@stanford.edu

Additionally, we are interested if you know of any additional unpublished or ongoing studies (by yourselves or other authors) that might be relevant. We would also appreciate it if you would forward our request to any researchers in your network that may be doing relevant work in these areas.

You will find a list of already included studies attached.

Thank you!

I am looking for antibodies against the protein Puromycin N-acetyltransferase.

Colleagues,

A bit of a puzzle, I am reviewing the effect of an intervention against coronary heart disease (CHD) in a large population (at least 250 000 subjects drawn from North American (USA and Canada), Western Europe (UK, Germany, Netherlands), Southern Europe / The Mediterranean, India, Taiwan and Japan). The challenge is that some of the studies state RR values while others use OR values. Is there a concise way to convert RR values to OR values?

I ran into an argument that was raised in Grant (2014) Converting an odds ratio to a range of plausible relative risks for better communication of research findings, BMJ, 2014, doi: 10.1136/bmj.f7450. The author argues that one can convert OR values to RR, the converse can be true - one can convert RR values to OR?

RR = OR / (1 - p + (p x OR)) (Grant, 2014)

To use the equation, how can one determine the baseline risk of CHD (p) for each of the populations above (North American (USA and Canada), Western Europe (UK, Germany, Netherlands), Southern Europe / The Mediterranean, India, Taiwan and Japan)? Can we assume that baseline risk of such study populations is zero (0) since the subjects recruited into each study were CHD free (obviously there is always a baseline risk greater than 0!)?

Can someone suggest a way to treat such data (RR / OR)?

Thank you in advance. 

The carotid shunt is made up of a tube on the extremities of which the balloons are glued during the manufacturing process. Quality control (functionality test) are carried out in order to ensure that the product is conform. It has to be ensured that the balloons suffer no leaks.

What are the possible quality control test (non-destructive) that can be put in place after the assembly process to ensure conformity of the product ?

Could cardio lead to a mitochondrial reshape and higher MPS such as in resistance training and remoddeling of contractile elements?

GLP-1 agonists improved treatment of DM, mainly due to improvement of the complications rate. Numerous of those are cardiovascular related.

rct

We have data from Finapress NIBP system recorded through the bitscope easy software for 30 min. We wish to perform an ultra short term blood pressure variability. Could anyone suggest possible tools/methods/literature about the same?

There are contradictory data, two references are attached. What would be your decision ? Recommend it or not ?

We have EKG and respiration data recorded using ADinstruments. Could anyone suggest the steps to assess the cardiorespiratory synchronization ratio?

Very low sodium diet

Control of hypertension in first trimester of pregnancy is critical. most of traditional drugs such as betablockers, ACEI. ARB, potassium channel opener and diuretics potentially have teratogenic effects. In addition clinician concern about hypertension crisis result in cardiovascular and brain damages. It claims that methyl-dopa is safe and useful without any potential of fetus malformation. Sometimes the therapeutic effects of this agent is not adequate. management of these patients is a dilemma.

Does stroke volume and diastolic BP have a positive linear correlation?

Given greater pre-load and thus end-diastolic volume is it expected that diastolic BP would be reduced?

are there different ways that hba1c is analysed to support its association to cardiovascular complications in diabetic patients?

Please suggest some relevant articles.

As it is seen most of the heart failure is from lack of energy source in the heart muscles, but it is hypothetizing that D-ribose is essential component for energy replenishing instead of glucose, dextrose and other sugar sources, it is practice going on practically for cardiovascular problems. Any proofs available

Hi,

I want to create a cardiovascular search engine and I need to download cardio related meta data, where can I get it?

Thanks

I need to evauate if variability of an inipendent variable can partially explain a risk of cardiovascular events.

Since standard deviation and coefficient of variation both are considered to be too closer to mean value, I found that a parameter called VIM is poorly influenced by mean value.

Anyone can suggest me how to calculate it from a pool of data?

Thanks.

Guido

I have some doubts about the possibility that intravitreal avastin injections are a safe alternative to Eylea in some cases of essudative maculopathy. I'like to know your opinion about its potential role in favouring cardiovascular problems. Thanks.

I have 300+ participants to analyze in Kubios for heart rate variability. Currently, the only option I know of, is to save each data file one by one, which is very time consuming. Is there a way to run a batch in Kubios, or MATLAB scripts to speed the process up?

Would anyone know how I can test this question. Patients with Cardiovascular disease complete the DASS - depression scale and also the Cognitive Emotional Regulations Strategies scale which has 9 predictors (strategies). I want to know if Cognitive reappraisal  (CRA) moderates the relationship of depressive symptoms in men and women with Cardiovascular patients? Does anyone know how I would analysis this? Depression is the DV, gender dichtomous variable and CRA continuous IV.

Or should I be saying gender moderate the relationship between CRA and Deperssion?

thank you

I am performing a propensity score analysis with weights on different medications.  I'm obtaining a very low misclassification rate based on the fact that these medicines were introduced at different times and, the data seem to say, were most often prescribed right after their introduction to the market.  By including when the patient first got their prescription I'm able to predict with a fairly high degree on certainty what drug she got.

The problem is that other variables pivotal to the clinical outcomes, such as measures of cardiovascular or overall health, are not as predictive and so remain unbalanced after propensity score weighting.

Since it seems to me that the outcomes (stroke and adverse bleeding) are not dependent upon when the drug was prescribed am I right in thinking that I can exclude the date of the first script as a predictor, settle for a much higher misclassification rate and conduct a more rigorous propensity score analysis with only those confounders included that I think will have an effect on the clinical outcomes?

I am not sure if this is possible or not. I am aware that greater than 100 ms is generally considered to be "good" hrv. 

If you are interested to be a part of the Quality and Patient Safety in Cardio Vascular practice specific to Nursing and Allied Health Profession, Kindly let me know. 

How could I have information about blood flow restriction training and cardiovascular function adaptations?

katso training

There are a few papers that discuss what the Compensatory reserve index (CRI) is, and its relevance during simulated hemorrhage. These papers only elude that the CRI is calculated using a unique algorithm. How exactly then, is it calculated. i.e which parameters does one need to calculate (MAP, HR, SV, TRP, etc)? Also, can one calculate the CRI retrospectively?

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We are seeing some sex-specific differences in cardiovascular variables with aging. These differences might be explained by changes in the concentration of sex steroids with aging.