Questions related to Cancer Treatment
"Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment" in Oncology Research.
Discover how nanotechnology and phytochemicals are changing the game in cancer therapy.
Read it here:https://techscience.com/or/online/detail/19431
With the aim of better loading of gold nanoparticles in drug delivery and cancer treatment.
The question is whether clinical trials have been conducted on the use of vitamin B17, also known as amygdalin or laetrile, in metabolic therapy for breast cancer to kill tumor cells. Vitamin B17 is a natural substance found in many plants, particularly in the seeds of the rosaceous fruits such as apricot kernels and other bitter nuts. It has been promoted by some as a potential cancer treatment, with claims that it can kill cancer cells while leaving healthy cells unharmed. Breast cancer is one of the most common types of cancer, affecting millions of people around the world. Treatment options for breast cancer include surgery, radiation therapy, chemotherapy, and hormone therapy. These treatments can be effective in killing cancer cells, but they also come with a range of side effects and are not always successful in completely eliminating the cancer. Metabolic therapy is an alternative approach to cancer treatment that involves using diet and nutrition to boost the body's natural defenses against cancer. Proponents of metabolic therapy claim that it can help to improve the body's immune system and make it better able to fight cancer cells. Vitamin B17 is often used in metabolic therapy as a way to supplement the body's natural defenses and help to kill cancer cells.
Modern cancer treatments and immunotherapies costs can easily top $1,000,000 per patient because of cumbersome, expensive manufacturing and patents. The success rate of, say, CAR-T cell therapies is about 20% and often relapse occurs due to evolution of cancer on cell level. The cancer incidence is on the rise mainly due to the ageing population. Do you think that sooner or later, government-funded cancer treatments would become unavailable due to their burden on the economy and euthanasia would become the only option for patients who cannot afford private healthcare? I do not want to sound pessimistic, but how likely would that situation become real?
I am looking for datasets containing ECG signals collected from patients undergoing cancer treatments (such as anthracyclines) aiming to stratify cardiomyopathy risk
Establishing non-inferiority margin in indirect comparison of cancer treatments.
Assume a cancer patient that has just received a specific procedure A. Is it possible to know the probability to be referred to a following procedure B? Like in a network of procedures?
I have found some characterization studies for specific cancer populations of patients, but I'm looking for a more quantitative and modelling approach.
We are trying to design Mesoporous Silica Nanoparticles for breast cancer treatment by PhotoDynamic Therapy.
And we are challenging with a question that Which ligand should we add onto the particle for attaching only breast cancer cells when the particles are added into the tumor cells directly by the vaccine (intra-tumoral injection).
Our ligand choice is Anti-HER2 antibody, HA.
We try to research that it is a good choice for us.
#Ligand #HyaluronicAcid #DrugDelivery #BreastCancer #PhotodynamicTherapy #SilicaNanoParticles #Ligand #Antibody #IntraTumoralInjection
There is a serious need to improve research in the field of metastatic cancer treatment. Being a non-medical person, but being a researcher (also a son of a cancer warrior, but unfortunately lost the whole game), I am feeling that there is a serious need to float fund in the area of cancer research.
When I used to look back in the past I am not finding any reason of occurance of metastatic pancreatic cancer of my father but he had diagnosed with this health ailment, so there was really any root cause of occurance of cancer. Being a student of Environmental Engineering I know there is a significant impact of environmental pollution for cancer disorder and apart from that some studies also shown food habits may be the reason for this deadliest disease.
So, what needs to be done?
How one can win this war?
My serious and sincere questions to all my fellow researchers in the field of cancer cells research, medical practioners and related areas.
If we will able to find out the main precursor behind this deadliest disease then we should start work on this and we have to design some strategies to reach the ultimate goal of no cancer occurance.
If anyone in this group can contribute some valuable comments then I will able to diversify my knowledge in this areas.
Any study evidence to prove that the skin of moringa olifera has carcinogenic (cancer causing) compounds , however the inside of roots be used to treat cancer?
May I treat cancer cells once a day during treatment period (repeated or chronic) or only once a period of treatment (single) before MTT Assay?
I’m doing cancer treatment in my project. Their treatment will continue till 7 days. During these days, the medium of treated cells become yellow and it caused to die the cells, and give me false results. So, what should I do?
Can I change the medium?
Should I change only the yellow wells or I have to change all wells same time together?
And, during these 7 days before adding MTT, can I add my drug everyday, instead of once?
Please help me suggest the appropriate solvent for the ferric oxide nanoparticles for the possibility of exploring their use in cancer treatment .. Your suggestions are very important to me.
hyperthermia is the technique that neglects the use of chemicals or harmful radiations. The elevated body temperature can damage the cancerous cells.
I cannot find the IC50 value of 5-FU against HT-144 cancer cells, as determined via cytotoxicity analysis. I shall be thankful if someone help me with relevant literature.
Can you help with the referencing materials for the mathematical modelling of behavior of 'Tumor size','Toxicity', and 'Drug resistance' during the Chemotherapy cycles. ?
Thanks so much in advance.!!!
I'm looking for a ML dataset that could be used to recommend treatment or targeted therapies for cancer patients, based on different factors such as the primary tumor location, age etc.
I am looking for a scientist who have experance in histopathology and cytology to advise me the essential equipments that using in Histopathology and cytology Laboratory. We want to establish this Laboratory in our new centre for cancer treatment.
"In conclusion, high-dose intravenous ascorbate represents a promising and inexpensive anticancer therapeutic option that should be further explored in clinical trials. Given its low toxicity and low financial cost, ascorbate could become an important weapon in our arsenal against cancer, either acting as a single agent with predictive biomarkers or used in combination as an adjuvant therapy."
Targeting cancer vulnerabilities with high-dose vitamin C
Bryan Ngo, Justin M. Van Riper, Lewis C. Cantley & Jihye Yun
Nature Reviews Cancer volume 19, pages 271–282 (April 2019)
Invitation: Start a clinical trial.
There are currently 15 clinical trials. See details of those trials here: https://www.nature.com/articles/s41568-019-0135-7/tables/1
I’m doing a study of gut microbial interactions with cancer treatment, so I need to remove their normal gut microbes. I’ve tried giving the mice antibiotics in their drinking water but they won’t touch the stuff, leading them to become dehydrated. I want to supplement their water with Ribena To sweeten the water and encourage them to drink the antibiotics. What concentration is appropriate? Is there a ‘goldilocks’ concentration I should be aware of (i.e., too much makes the mice sick, but too little is pointless)?
As we knew that, chemotherapy drugs produces many side effects so is it possible to prevent them effectively in patients with cancer treatment
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are being diagnosed with increasing frequency. IPMNs comprise a histologic group that ranges from adenoma to invasive carcinoma with different degrees of aggressiveness (borderline tumor). Actually, it is not known whether all IPMNs have this malignant potential or what is the best treatment of IPMNs. The'identify the right time of surgical treatment or follow-up is the great dilemma .
As we all knew that the advanced technology can treat cancer in a better way so which are most advanced treatment modalities in cancer treatment at present in the world.
Recent studies have clearly shown that by administrating IV magnesium PRIOR to giving cisplatin for cancer treatment, renal toxicity is reduced. Cisplatin is thought to be transported into the kidney tubules by the OCT2 transporter. Is magnesium a substrate for this transporter and thus reduce the availability of cisplatin in entering the kidney tubules and causing the acute inflammation and cellular damage?
At different time points, if it is possible to observe shift in MHC-phenotype (MHC1 to MHC2 and/or vice-versa) due to pharmaceutical intervention during cancer treatment?
I am looking for information concerning the effect of publications regarding 5-year survival of diseases, like cancer, on the feelings of the patient. As the statistics are frequently published, and available on many websites with information on serious diseases, I was wondering whether psychological research was done as to the impact these statistics have on patients, dealing with diseases. I have tried to find such research myself, but the overwhelming majority of research I have found deals solely with diagnostic importance of these analysis. I will be most thankful for any advice and references on this issue.
Some notable scientists have been claiming that amygdalin (Laetrile) is effective against cancer based on a cyanogenic compound specific for cancer cells.
Please does any one have solid article supporting this claim or any scientific research that refute this claim?
Autoimmune diseases tend to be a relative contraindication for immunotherapy in cancer treatment. Is immunotherapy safe for cancer treatment in a patient with multiple sclerosis?
I'm a trainee in a lab related to brain.
Now I'm studying about Brain tumor (pediatric or adult whatever).
I'm interested in using miRNAs for cancer treatment or biomarkers.
I searched papers about that, but it looks like studying about this topic hasn't been that long.
So I wanna know your opinions "Does this subject look promising?"
Though, CRC is constantly increasing in south east Asia due to various factors such as food habits, etc., I'm expecting answers in diagnosis and treatment.
Cancer treatment with three different concentrations has been used on cancer cell line for 24hr, and then ab139418 – Propidium Iodide Flow Cytometry Kit was used for cell cycle analysis. The attached file shows the results, where the DNA content in the second concentration (T2) is higher in G2 than S and G0.
I'm looking for relevant articles on the roles of gene therapy as cancer treatment in canine cancer. Can someone guide me in the right direction or link some peer reviewed articles? I found one, but it mostly talks about several animals and canines aren't the main focus. Thanks!
The War on Cancer refers to the effort to find a cure for cancer by increased research to improve the understanding of cancer biology and the development of more effective cancer treatments, such as targeted drug therapies.. The signing of the National Cancer Act of 1971 by United States president Richard Nixon is generally viewed as the beginning of this effort, though it was not described as a "war" in the legislation itself.
War stated as “a state of usually open and declared armed hostile conflict between states or nations” in Merriam-Webster dictionary. War indicated attack of foreign army.
On the other hand meaning of rebel is opposing or taking arms against a government or ruler. Something has to cause rebellion. There are complaints. These complaints have usually been ignored over so long a period of time that people have become impatient with the slow pace of change; they begin to feel that conditions are unbearable. These complaints are most important causes of rebellion.
I think that cancer cells are rebels (cells live in bad conditions) and they try to live .
We must change our philosophy. We must accept cancer cells as rebels not enemy and we must try to correct bad environment to calm rebels.
+Studies have shown expressive writing to be effective in enhancing self-reported, health-related outcomes for cancer patients (e.g.,
This question is of rather general nature.
Since quite some time, I have been wondering how people determine their values for their heating capacity of magnetic nano-particles in hypothermia. If you consult the literature, there is some kind of agreement on the lack of accuracy of the SAR value. Eg. the IPL got introduced to account for the physical parameters of the field. Nevertheless, concentrations for example are seldom quoted and this makes it rather difficult to confirm certain values.
Let's take a commercial Iron oxide particle system, where you can assume some consistency in the quality of the particles (size distribution, surface functioanlity etc.)... even there are multiple values for the SAR out in the literature.
I am uncertain, weather I do understand this completely wrong or miss some kind of important piece of information.
I take this formula for calculation of the SAR value:
- C is the specific heat capacity (eg. water 4185 W*s/l*K) (assuming 1l=1kg water)
- (dT/dt) is the heating rate in Kelvin per second
- m the concentration of the nanoparticles in g/l
So now I look at the rare examples out there where all the essential information is given, eg. this one
They state that they can confirm a SAR value of around 1300 W/g close to literature.
So if I take the concentration given and a rough estimation of the heating rate from the linear part of the temperature rise (plot figure), this gives me
4185Ws/lK*20K/150s*1/(25mg/ml) = ~ 22 W/g
This initially looked like an unit error to me, but I cannot seem to find it (I stated all the units above therefore). Also if I then take other core/shell nano particles out of current hyperthermia literature which state SAR values close to 3000 W/g and back calculate the heating rate, this leads to tremendous values or ug range of needed concentration which is essentially the same.
I thought about SAR values changing multiple magnitudes due to concentration effects from the mg/ml to ug/ml range as well, due to increased interparticle interactions, but then literature proves otherwise although this topic is covered as well...
Maybe I am just missing a little essential piece here... any input is appreciated.
Cancer scientists are targeting sleeper cells that lie dormant in the body after breaking off of their parent tumour. These cells seed the metastases responsible for about 90% of cancer deaths. New animal models and techniques for identifying these rogue cells are helping researchers to discover the triggers that rouse them and how to keep them at bay.
According to a 2004 report by Morgan, Ward, and Barton: "The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. ... survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA." See http://www.ncbi.nlm.nih.gov/pubmed/15630849, or https://www.burtongoldberg.com/home/burtongoldberg/contribution-of-chemotherapy-to-five-year-survival-rate-morgan.pdf
Although such conditions may vary for different types of cancer, it is commonly held that 80% of oncologists will not take chemotherapy if they suffer from cancer themselves.
Another possible approach is perhaps herbal chemotherapy, which according to another report may yield an 85% success rate. See http://breastcancerconqueror.com/85-success-rate-with-herbal-chemo/
So why is the success rate of chemotherapy very low? And is it possible to improve that?
Since there are long term treatments for some diseases or many type of cancers not knowing how to be treated, im wondering how brain activity can ever control the disease.
Although thousands of scientists and specialists around the world are working on different types of cancer to find certain treatment for them, There is no definite way to cure that and we lose our relatives and friends every day. So what is the most important and challenging property of cancer that stands in front of us?
Cancer drug hobbled by diagnostic-test confusion
A landmark cancer drug was approved last year to target tumours with specific mutations, no matter where in the body the cancer first took root. Yet physicians are struggling to identify which patients are likely to respond to the treatment, because of limitations in diagnostic tests to pick out molecular markers that indicate susceptible tumours.
The autophagic network is important for cancer initiation, progression, and response to therapy. What activates the autophagy?. Is there a relation between the daily fasting of 8-12 hours and autophagy in cancer treatment?
Nature Cell Biology | VOL 20 | MARCH 2018 | 243–251
Recently, researchers have been looking for a optimum combination of chemicals to boost up the anticancer potential of certain chemical compounds. May be to overcome the resistance to of some drugs like cisplatin, 5FU etc. I am curious to know the updates regarding this type of research outcomes. Thank you!!!
The number of people who diagnosed as cancerous patient is increasing every year. By increasing in cancerous population, the number of researchers and research group that working on cancer treatment is increased.
One of the famous method in cancer treatment is chemotherapy. But, it seems that this method didn't have considerable advancement in cancer treatment during the past decade and needs serious revolution in it.
What is your opinion about it, comparing to other cancer treatment method?
While early screening and advances in treatment have allowed breast cancer patients to overcome their disease, these treatments often have side effects that can reduce patient's survival. Also, there is a need to develop new therapeutic strategies that can either prevent resistant-development caused by cancer therapeutics Over the last several decades, the therapeutic potential of cell-based therapy has been investigated for cancer patients in pre-clinical and clinical stem cell researches. However, it is important to consider potent adverse impacts of cell-based therapy in cancer treatment.
I want to determine whether elevated amount of OH., super-oxide radical and hydrogen peroxide were produced and create oxidative stress during cancer treatment or not by molecular imaging technique.
formulation of gold nanoparticles for cancer treatment.
There are so many studies which explains the interaction of anticancer drugs with the mismatch DNA base pairs (AA, GG, CC etc). During de novo mutations, once a mutation is introduced, the corrupted DNA contains regular base pairing. Thus, interaction of anticancer drug like 6-Mercaptopurine with mismatched base pairs cannot play a significant role in cancer treatment. Hence, how this kind of studies can be implemented in cancer therapy?
I am trying to combine other therapies with the nanoparticles-induced photothermal therapy for cancer treatment, and looking for the disadvantages of the photothermal therapy or the cancer cell resistance to PTT. As the best of my knowledge and the papers I have red, only the HSP proteins could affect the efficiency of PTT, do anyone know other factors? Thank you.
Generation of Reactive Oxygen species (ROS) leads to cure of various tumors. This is the mechanism behind the working of various cancer treatments. Howeve, are there free ions generated during the formation of ROS? Could ROS generation be co-rrelated with the increase/decrease in electrical conductivity?
- Do you believe that it is a result of long-term DA treatment or its a primary variant of pituitary tumour?
- Do you observe the correlation between the invasiveness and firmation of PA?
Lately, I've been researching about the use of Chitosan Hydrogels in Cancer treatment and its use with antibodies. I noticed that the mention of this gels is not as frequent and the application for cancer treatment is not as popular as I would have thought. Does anyone know if there is a practical reason for this? I know that right now the use of nanoparticles much more popular but I'd like to know if there is a problem with therapies that use Chitosan Hydrogels.
Do you know of any reports or raw data depositories that may give me an insight into the rate of change in prescription share of cancer drugs?
While you see both these with respect to cancer screening, I wanted to know the difference between the two to compare between interventions and survival.
Consider two groups A and B.
Group A: Receives treatment with A and then is followed until death.
Group B: Receives treatment with A. After several weeks receives treatment with B. And then followed until death.
Note: This is not a prospective randomized trial.
Now, an early death prevents a patient from getting B. Patients who died
quickly had less time available to get transplants and will be counted as group A. Is this (Time A to B) causing an immortal time bias or lead time bias?
- Any help on the Type of pharmaceutical biotechnology that help in treating cancer ,I know that Monoclonal antibodies is one of them but not sure if all biologics including (Cytokine therapy,Vaccine therapy,Adoptive T-cell therapy,Oncolytic virus therapy,Gene therapy,DNA oligonucleotide therapy,RNA oligonucleotide therapy),
- Also not sure if using proteomics and genomics as biomarker fall under biotechnology application