CHO - Science topic

Electrochemical CO2 reduction to multicarbon products provides an attractive route to store intermittent renewable electricity as high value‐added chemicals. Oxide‐derived Cu (OD‐Cu) has been widely investigated for its tunable selectivity toward multicarbon (C2+) products; however, it still remains a challenge to understand and regulate the retain...

Cu‐based catalysts for electrochemical CO2 reduction reactions facilitate the transformation of CO2 into economically viable multicarbon products. There remains a pressing need to design efficient, stable, and cost‐effective catalysts to enhance the selectivity for these multicarbon products. Metal‐oxide heterogeneous interface can modify the elect...

Background The United States Food and Drug Administration (FDA) recently published a model observer‐based framework for the objective performance assessment of computed tomography (CT) metal artifact reduction (MAR) algorithms and demonstrated the framework's feasibility in the low‐contrast detectability (LCD) task‐based assessment of MAR performan...

NISTCHO is a Chinese hamster ovary (CHO) cell line expressing the same amino acid sequences as the heavy and light chains of the National Institute of Standards and Technology (NIST) monoclonal antibody [Reference Material (RM) 8671 NISTmAb]. NISTCHO was generated by MilliporeSigma to be developed by NIST as a RM to support biomanufacturing researc...

Tóm tắt: Bài viết tập trung nghiên cứu khái quát các quy định về bảo vệ dữ liệu cá nhân tại Trung Quốc trước và sau khi ban hành Bộ luật Dân sự (BLDS) Trung Quốc năm 2020, nghiên cứu sâu các quy định về bảo vệ thông tin cá nhân (TTCN) theo Luật Bảo vệ thông tin cá nhân Trung Quốc năm 2021 (PIPL). Từ đó, nghiên cứu đối sánh các quy định tương ứng tr...

Background: Ireland’s aging population represents a measure of success in improving health and extending life expectancy however, while many older people remain well, engaged and active well into later life and continue to make a major contribution to local communities and society, increasing age is associated with long-term medical conditions, fra...

Introduction: The Republic of Ireland’s national mental health policy Sharing the Vision – A Mental Health Policy for Everyone has prioritised early interventions and improved access to person-centred Mental Health services for everyone, in particular when experiencing acute crisis. The vision is ’to provide integrated Crisis Resolution Services (C...

Copper–silica‐based catalysts have drawn much attention for the remarkable product selectivity in the electrochemical CO2 reduction reaction, particularly toward CH4 and C2H4. However, systematic studies exploring the underlying reasons for the selectivity differences are lacking. Herein, Cu/SiO2 catalysts with different Cu/Si ratio are controllabl...

Older adults, identified as 65 years and over, a population for which low health literacy is prevalent, represented the majority of people attending HSE primary care services in 2019. Any limitation in a person’s health literacy, specifically their ability to access, understand and use health information, can affect healthcare related decision-maki...

Background: The REACH Collaboratory (Research and Engagement Across Community Health) was established in January 2022 as a collaboration between the Health Service Executive Community Healthcare Organisation 9 (CHO 9) and Dublin City University. The mission of the Collaboratory is to improve the health and wellbeing of the community by generating e...

Background: Ireland’s aging population represents a measure of success in improving health and extending life expectancy however, while many older people remain well, engaged and active well into later life and continue to make a major contribution to local communities and society, increasing age is associated with long-term medical conditions, fra...

Introduction - What we did The team was tasked with the following: Identify top 10 administratively time consuming processes currently in place in CHN which could be supported by robotic process automation (RPA). Deep dive into 3 processes. Provide recommendations including benefit analysis of implementing RPA. Outcomes and what was achieved: The t...

Background: Enabling older adults to engage with and participate in their care planning requires specific geriatrician input to overcome the complex challenges facing frail patients in the community setting. Planning for future events is an integral component of the evolving collaboration between the older person, those closest to them and members...

Usufruct rights as one of the important property rights in the civil laws have been recognized in Roman Law in the 3rd century, and currently recognized in the contemporary civil code of Vietnam and many countries around the world. In Vietnam, those rights have been stipulated in the Quoc Trieu Hinh Luat Code (also known as Hong Duc Code) - a mixed...

Background Coenzyme Q10 (CoQ10) is a natural antioxidant and plays a vital role in the energy production of animal cells; however, its physiological and biochemical properties in fish are unclear. Objectives The current experiment was investigated to explore the effects of dietary CoQ10 on growth performance and biochemical and physiological attri...

Background: Branched-chain amino acids (BCAAs, isoleucine, leucine, and valine) are commonly applied to promote muscle protein synthesis. However, the effects of BCAAs on exercise-induced substrate metabolism, performance and post-exercise fatigue during endurance exercise remain unclear. Methods: In a double-blind cross-over design, eleven active...

A alimentação adequada é essencial para atletas de endurance, influenciando diretamente o desempenho, a recuperação e os estoques de glicogênio muscular e hepático. O objetivo deste trabalho foi demonstrar a importância da ingestão adequada de carboidratos por atletas de alta performance em treinos e competições de endurance, abordando estratégias...

In this report, the synthesis of 5‐hydroxymethylfurfural from concentrated feeds of two low‐cost and industrially abundant chemicals: Furfural and formaldehyde is explored. By adjusting the acidity of the solvent, an alternative mechanism is discovered in which the reaction selectivity stops to the hydroxymethylation step, in contrast to previously...

Photocatalytic C2H4 synthesis from CO2 and H2O by utilizing solar energy represents a promising sustainable process, yet its efficiency remains significantly limited. Herein, we proposed a dual‐engineered strategy integrating 3D ordered macroporous (3DOM) architectures with heteronuclear dual‐metal active sites to synergistically promote the photoc...

Electroreduction of carbon dioxide (CO2) is a key strategy for achieving net‐zero carbon emissions. Copper (Cu)‐based electrocatalysts have shown promise for CO2 conversion into valuable chemicals but are hindered by limited C2+ product selectivity due to competing hydrogen evolution and ineffective dimerization of adsorbed CO intermediate (*CO). H...

Childhood obesity is rising in the city of Colombo and the composition of children’s diet, which has a direct link to it, has not been adequately investigated. Hence a cross-sectional study was conducted recruiting 634 school-children (11-13 year-old) using multistage stratified cluster sampling technique to assess dietary energy contribution from...

This study presents a detailed kinetic and deactivation analysis of a 24 wt.% Ni/Al2O3 catalyst for the hydrogenation of CO2 and CO to CH4, focusing the attention on the CO2 and CO co-methanation. More than 300 reaction conditions were tested on a fixed-bed reactor obtaining 907 observations. Among them, 852 measurements were used to derive the kin...

Enhancing athletic performance through the manipulation of nutritional intake has ancient roots, with early guidance from “philosophical giants” like Hippocrates, who describes the balance between diet and exercise. Modern sports nutrition emerged in the 20th century, with research identifying carbohydrate (CHO) intake as beneficial for endurance....

This paper studies the application of the 5E model in teaching the topic "Acid, Base, pH, Oxide, Salt" in Natural Science subject for grade 8, with the aim of developing students' Scientific Inquiry Competence. The study analyzed the relationship between the 5E model and the manifestations of Scientific Inquiry Competence, pointed out the requireme...

Bài báo đề cập đến các biện pháp cụ thể để nâng cao chất lượng đào tạo sinh viên Lào ngành sư phạm Địa lí. Các biện pháp được đưa ra bao gồm việc nâng cao năng lực giảng viên, đổi mới phương pháp giảng dạy, ứng dụng công nghệ thông tin và truyền thông cũng như cải thiện cơ sở vật chất phục vụ dạy và học. Đồng thời, bài báo cũng nhấn mạnh tầm quan t...

Trải nghiệm toán học là một trong những nội dung trọng tâm của chương trình giáo dục phổ thông. Gắn định hướng nghề nghiệp vào quá trình trải nghiệm toán học góp phần thực hiện mục tiêu tạo cho học sinh hiểu biết ngành nghề qua môn Toán. Bài báo đề xuất nội dung rèn luyện nghiệp vụ sư phạm của trường sư phạm về tổ chức hoạt động trải nghiệm toán họ...

Introduction Sorafenib (SF) is a small molecule involved in tumor proliferation and angiogenesis. SF is inhibitor of several kinases, including RAF, VEGFR, and PDGFR. However the weak targeting ability of SF for liver tumor tissues is the major problem in clinical therapy. Therefore, a SF-loaded folic acid-targeted liposome drug delivery system was...

Although an electrochemical CO2 reduction reaction (ECO2RR) can provide an ideal route to produce CH4, its selectivity is significantly hindered due to kinetically complex steps. To improve CH4 selectivity, this study focuses on microenvironmental engineering using an additive of ethylene diamine tetraacetate (EDTA) in electrolyte. EDTA interacts w...

The difficulty in treating cancer has led to several studies on the development of systems that perform targeted drug delivery, with the aim of increasing the effectiveness of treatment and reducing adverse effects. In this study, a series of chalcones were tested for cytotoxic action on gastric adenocarcinoma cells (AGS) and breast cancer cells (M...

Electroreduction of CO2 to chemical fuels offers a promising strategy for controlling the global carbon balance and addressing the need for the storage of intermittent renewable energy. In this work, it is demonstrated that tuning adjacent active sites enables the selection of different reaction pathways for generating C1 or C2 products during the...

Sleep and nutrition play a crucial role for athletes, contributing to the quality of recovery, optimization of performance, as well as the preservation of health and injury prevention. This study aimed to explore the potential relationships between sleep quality, nutritional status, and dietary habits among Moroccan male professional football playe...

Chronic kidney disease (CKD) and atherosclerotic heart disease, frequently associated with dyslipidemia and hypertension, represent significant health concerns. We investigated the interplay among these conditions, focusing on the role of oxidized low-density lipoprotein (oxLDL) and angiotensin II (Ang II) in renal injury via G protein αq subunit (...

Novel “task-specific” deep eutectic solvents (DESs) were synthesized and were used in the Beckmann rearrangement reaction to prepare ε-caprolactam, with DES [InCl3][AA]2 achieving 100% cyclohexanone oxime (CHO) conversion and 99.5% ε-caprolactam (CPL) selectivity under 80 °C for 2 h. This “task-specific” approach gives some advantages to the reacti...

Background/Objectives: Dietary manipulation with carbohydrate restriction has been extensively investigated in diabetes prevention programmes. Carbohydrate (CHO) quality, rather than quantity, is associated with various metabolic outcomes. Few studies examined the fibre/CHO ratio on lipid profiles, liver fat and insulin resistance in individuals wi...

Recombinant monoclonal antibodies (mAbs) are commonly produced using Chinese hamster ovary (CHO) cells and the cell culture medium used in bioreactors influences the yield and quality attributes of the protein drug products. The COVID 19 pandemic revealed a vulnerability in the supply chain for necessary reagents (such as culture medium and raw mat...

Delivery of DNA into nucleated eukaryotic cells is known as transfection and has been essential in establishing technologies such as recombinant protein production and gene therapy. Considerable research efforts have led to development of a variety of transfection methods for a multitude of applications and cell types. Many methods are efficient in...

Low-carbohydrate diets and intermittent energy restriction may offer metabolic advantages in fuel utilisation, that are independent of weight loss. The underlying mechanisms for these effects are unclear but may involve extensions of the catabolic phase and/or attenuation of insulin secretion. To address this gap, we aimed to investigate the indepe...

Introduction Lung nodule detection is a crucial task for diagnosis and lung cancer prevention. However, it can be extremely difficult to identify tiny nodules in medical images since pulmonary nodules vary greatly in shape, size, and location. Further, the implemented methods have certain limitations including scalability, robustness, data availabi...

Purpose: Targeting the programmed death protein 1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint blockade therapy plays a critical role in cancer therapy. However, not all patients benefit from this approach, with PD-L1 expression levels being a significant contributing factor. Positron emission tomography (PET) imaging of PD-L1 offers a...

Background Rugby union is a high-contact team sport where professional rugby players are exposed to considerable training and game loads in pre-season and in-season. Some studies have shown that rugby players’ dietary intake remains inadequate for the three macronutrients (carbohydrates [CHO], proteins and fats) required for optimal performance. Th...

The analysis of extraterrestrial organic matter in samples returned by space missions provides a unique opportunity to study prebiotic chemistry. A comprehensive understanding of the occurrence and composition of organic matter is fundamental to unraveling its origin and evolutionary history. However, the scarcity and complexity of these materials...

Context. Many complex organic molecules (COMs) observed in the interstellar medium (ISM) are probably not formed in the gas phase. A large consensus has developed that it could be related to the icy surfaces in this environment. Aims. We investigate the process of building N-substituted formamides in the ISM by successive additions of atomic hydrog...

Studies have shown positive results from faba bean forage and legume–cereal intercropping in cow performance. This study aimed to evaluate the effects of maturity stages (MS) on intercropped faba bean (Vicia faba, CDC Snowbird)–oats (Avena sativa, CDC Haymaker) silage. Oats and faba beans were seeded together in Outlook, SK, CA. The faba–oat crop w...

Highly selective photocatalytic CO2 reduction (PCR) to methane is restricted severely due to the multiple consecutive proton‐coupled electron transfer steps and the stabilization of crucial intermediates. Herein, an In2O3/CuInS2 composite with multifunction is meticulously fabricated via heterojunction engineering and achieves a remarkable selectiv...

Background Endurance athletes’ competitions have increased over the decades and marathon races are becoming increasingly popular. Proper nutrition is critical for optimal performance and long-term health in marathon athletes. This study aimed to investigate runners’ nutritional intake, especially fluids, food, and supplements, competing in the Sevi...

Background The implication of body composition and energy metabolism in the control of human energy intake (EI) has been well described in adults, remaining however unexplored in adolescents with obesity. The aim of this study was to question the role of body composition, energy expenditure (EE) and substrate metabolism in the control of EI of adol...

Context. Compared to Class 0 protostars, the higher densities and lower temperatures of the disk midplanes of Class I young stellar objects (YSOs) limit the detectability of complex organic molecules (COMs). The elevated luminosities of eruptive YSOs increase disk temperatures causing frozen molecules to sublimate, thus making them easier to detect...

Background: Various factors influence the immunologic responses to HBV vaccines in adults, including unchangeable individual characteristics. Personalized vaccination regimens accounting for host factors can enhance immune efficiency, particularly for adults at higher risk. Methods: In this two-center controlled trial, HBV vaccine-naïve participant...

Diabetic retinopathy (DR), a prevalent microvascular complication of diabetes mellitus (DM), can be prevented with early detection and timely intervention. DR is asymptomatic in its early stages, highlighting the importance of screening for accurate referral and effective management. Multiple barriers impede access to diabetic retinopathy screening...

Context . Acetone (CH 3 COCH 3 ) is a carbonyl-bearing complex organic molecule, yet interstellar observations of acetone remain limited. Studying the formation and distribution of CH 3 COCH 3 in the interstellar medium can provide valuable insights into prebiotic chemistry and the evolution of interstellar molecules. Aims . We explore the spatial...

Background: Cheilocostus speciosus (J. Koenig) C. Specht, commonly known as “Crepe-ginger”, is a traditional plant with edible flowers utilized in folk medicine. This study employs crepe-ginger flowers to evaluate their role in boosting liver immunity, hepatoprotective actions through oxidative stress management. Methods: Cheilocostus speciosus flo...

Purpose of Review The ketogenic diet (KD) has gained clinical attention for its potential benefits in weight loss and metabolic syndrome. By mimicking fasting through carbohydrate (CHO) restriction, KD shifts energy utilization to ketone bodies (KB) instead of glucose. Despite promising results, the effects on different weight loss indicators remai...

There are cases when a small change, such as capture of a simple particle, has a significant impact on the molecular properties. This indeed happens with the “proton sponges”. It is shown how the substituent effect (SE) and the presence of an intramolecular hydrogen bond modulate the properties of 1,8‐bis(dimethylamino)naphthalene (DMAN), its proto...

Acetaldehyde (CH3CHO) is of great industrial importance and serves as a key intermediate in various organic transformations. Photocatalytic production of acetaldehyde from CO2 represents a sustainable route compared to conventional oxidation processes. However, current photocatalytic systems often face challenges, including limited product selectiv...

Gamma radiation and In Vitro technique were applied in this study to evaluate some morphological and physiological parameters in callus of irradiated Cowpea (Vigna ungiculata. L) seedlings. Local variety seeds of Cowpea were exposed to (0, 25, 50 and 75) Gy of Gamma radiation (60 Co). Seeds were sterilized and germinated on Murashige and Skoog (MS)...

Introduction Primary healthcare is broadly acknowledged as the cornerstone of any strategy aimed at achieving Universal Health Coverage (UHC). This study aims to evaluate the costs, work patterns and efficiency of comprehensive primary healthcare (CPHC) in India. Methods and analysis We will use a top-down microcosting approach to estimate the econ...

Introduction Increasing evidence indicates that cellular senescence is a significant risk factor for atherosclerosis (AS). Methods In the present study, we used an apolipoprotein E knockout (ApoE−/−) mouse model to address the effect of sodium nitrate on senescence accompanied by atherosclerosis. After sodium nitrate intervention, the degree of AS...

Recombinant proteins are critical for modern therapeutics and diagnostics, with Chinese hamster ovary (CHO) cells serving as the primary production platform. However, environmental and chemical stressors in bioreactors often trigger cell death, particularly apoptosis, posing a significant challenge to recombinant protein manufacturing. Rapid, label...

Biopharmaceuticals are medical compounds derived from biological sources and are often manufactured by living cells, primarily Chinese hamster ovary (CHO) cells. CHO cells display variation among cell clones, leading to growth and productivity differences that influence the product's quantity and quality. The biological and environmental factors be...

Background: Ganoderma lucidum spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. This study aimed to systematically evaluate the efficacy and safety of GLSO extract in individuals with dyslipidemia. Methods: In a randomized, double-blind, placebo-controlled trial, 110 participants were enrolled and randomly...

Bài báo này đề xuất một chiến lược lướt qua điện áp thấp (LVRT) cho hệ thống tua bin gió dùng máy phát điện đồng bộ nam châm vĩnh cửu (PMSG) khi lưới có sụt áp lưới. Ở phía máy phát, bộ điều khiển điện áp DC-link được thiết kế dựa trên tối ưu hóa bầy đàn hạt (PSO). Trong khi đó, ở phía lưới, công suất tác dụng được điều chỉnh để dò tìm điểm phát cô...

The electrochemical CO2 reduction reaction (CO2RR) exhibits significant potential to efficiently convert CO2 into ethylene (C2H4). However, achieving high C2H4 selectivity remains a considerable challenge due to the difficulty in effective C─C coupling and stringent requirements on CO2 purity. Herein, a novel contact‐electro‐catalysis method for CO...

Controlled photocatalytic conversion of CO2 into premium fuel such as methane (CH4) offers a sustainable pathway towards a carbon energy cycle. However, the photocatalytic efficiency and selectivity are still unsatisfactory due to the limited availability of active sites on the current photocatalysts. To resolve this issue, the design of oxygen vac...

Nghiên cứu được thực hiện nhằm mục đích xác định thực trạng, xây dựng thang phân cấp dinh dưỡng và chẩn đoán các yếu tố thiếu hụt góp phần điều chỉnh chế độ sử dụng phân bón cho giống xoài Cát Chu tại tỉnh Đồng Tháp. Đã tiến hành điều tra, quan trắc, lấy mẫu trên 90 vườn, liên tục trong giai đoạn 2021-2022, áp dụng phương pháp Hệ thống Chẩn đoán và...

The proton‐coupled electron transfer process (PCET) plays a crucial role in both natural and artificial photosynthesis, including CO2 fixation chemistry. However, difficulties in capturing the transient intermediates generated during the protonation process impede the clarification of the fundamental mechanism behind photocatalytic CO2 reduction. H...

The electrocatalytic CO2 reduction is a promising path toward the carbon‐neutral goal but remains a huge challenge due to the high activation barrier for CO2 and poor selectivity. Herein, the highly dispersed triruthenium single cluster (Ru3‐SCs) is confined into the nanospace of pyrrole‐3‐carboxylic acid (PyrA)‐modified nickel‐porphyrin‐based meta...

The co‐expression of different types of G protein‐coupled receptors (GPCRs) in the same cells can have implications for receptor signaling and receptor cross‐talk, potentially altering the apparent potency or efficacy of ligands targeting each receptor. The endocannabinoid and orexinergic systems, consisting of class A GPCRs and their endogenous li...

Background Postoperative metabolic disorders and inflammatory responses are closely associated with postoperative delirium (POD). Preoperative oral carbohydrate intake can alleviate postoperative insulin resistance and the inflammatory response. This study aimed to evaluate the effects of preoperative oral carbohydrate intake on the incidence of PO...

Designing effective photocatalysts for carbon dioxide reduction reaction (CO2RR) requires a precise understanding of the dynamically photocatalytic mechanism under real conditions (e.g. solvent, light field). Herein, we coupled ab‐initio non‐adiabatic molecular dynamics (NAMD) simulation and density functional theory (DFT) calculation to theoretica...

The acetone‐sensitized [6π]‐electrocyclization of unsubstituted, mono‐, and disubstituted triarylamines (TAAs: substituents H, CH₃, CH₃O, Cl, CnF₂n+1; n=1, 3, 4, 6, 8, 10) under 310 nm light led to the formation of endo‐ and exo‐carbazoles in high yields; particularly, TAAs substituted with inductive electron‐withdrawing groups (Cl, CnF2n+1) exhibi...

In conventional Chinese hamster ovary (CHO) cell line development, static culture is used for early-stage screening, whereas suspension culture is generally used for the manufacturing process. Shaken flask (SF) fed-batch culture allows evaluation with culture mode, which is closer to the final process. However, due to its laborious and low-throughp...

Context. Young low-mass protostars often possess hot corinos, which are compact, hot, and dense regions that are bright in interstellar complex organic molecules (iCOMs). In addition to their prebiotic role, iCOMs can be used as a powerful tool to characterize the chemical and physical properties of hot corinos. Aims. Using ALMA/FAUST data, our aim...

The inadequate generation of reactive oxygen species (ROS) and metastasis of malignant tumors are critical factors that limit the efficacy of conventional sonodynamic therapy in cancer treatment. Herein, an engineered piezocatalyst: cholesterol oxidase (CHO)‐loaded Pt‐ZnO nanoparticles (Pt‐ZnO/CHO) that can explosively generate large amounts of ROS...

Monoclonal antibodies (mAbs) are considered one of the most game-changing products of the biopharmaceutical industry. The introduction of several diverse and complex formats consisting of several polypeptide chains and engineered with multiple antigen-binding domains has made the manufacturability process particularly challenging, especially in the...

Compared to other types of rice, brown rice is known to be rich in many nutrients. This product development project utilized brown rice and other natural flavorings to create ice cream. The addition of ginger extract gave the product a unique taste, while sugarcane served as the main sweetener. The final product was developed after seven trials, f...

In this study, two Category 3 carbonaceous particles (RB-CV-0008 and RB-CV-0031) among more than 700 Hayabusa-returned particles were analyzed by molecular imaging using desorption electrospray ionization–high-resolution mass spectrometry (desorption electrospray ionization (DESI)–high-mass-resolution mass spectrometry (HRMS)) with an electrically...

Equine chorionic gonadotropin (eCG) hormone, comprising highly glycosylated α- and β-subunits, elicits responses similar to follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in non-equid species. This study aimed to establish a mass production of recombinant eCG (rec-eCG) using CHO DG44 cells. Single-chain rec-eCG β/α was expressed in...

In teaching in general and teaching mathematics in particular, creating learning motivation for students is a critical task, significantly impacting the quality of students' learning. This paper studied the concepts of learning motivation, types of learning motivation, and some measures to create learning motivation for students proposed by other a...

Zirconium(IV) isopropoxide complexes supported by the ligands 2-pyridylamino-N , N-bis(2-methylene-4,6-dimethylphenolate), L1, 2-pyridylamino-N , N-bis(2-methylene-4,6-tert-amylphenolate), L2, and N , N-dimethyl-N , N-bis(2-methylene-4,6-dimethylphenolate)ethylenediamine, L3 (1–3) when combined with cocatalyst, 4-dimethylaminopyridine (DMAP) or bis...

Carbon-free fuels like ammonia (NH 3) and hydrogen (H 2) offer significant potential in combating global warming by reducing greenhouse gas emissions and moving toward zero carbon emissions. Over the past few years, our research has focused on understanding the combustion behavior of carbon-neutral and carbon-free fuels. In particular, we have expl...

Objectives The present study was done to study the knowledge change among Medical Officers (MO) and Community health officers (CHO) regarding menstrual hygiene, early marriages, and HIV/STI with emphasis on adolescents after online training. Methods This is a retrospective record-based analysis conducted in the State Adolescent Health Centre, AIIM...