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Article
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Epidermal growth factor receptor (EGFR) is the primary target for the treatment of colorectal cancer, the third most diagnosed cancer worldwide. In recent years, regulatory changes have facilitated the approval of biosimilars aimed to bring more access to biologics to patients. However, it has also expended the requirements of non-clinical characte...
Article
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With the aim of increasing protein productivity of Chinese hamster ovary (CHO) cells, we sought to generate new CHO hosts with favorable biomanufacturing phenotypes and improved functionality. Here, we present an innovative approach of enriching the CHO host cells with a high mitochondrial membrane potential (MMP). Stable transfectant pools and clo...
Article
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Background: A food and fluid intake program is essential for ultraendurance athletes to maximize performance and avoid possible gastrointestinal symptoms (GIS). However, the ability to follow such a program during a race has been under-assessed. We thus investigated the fluctuations of food and fluid intake during the 24-h run World Championship o...
Article
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N-terminal heterogeneity resulting from non-uniform signal peptide (SP) cleavage can potentially affect biologics property attributes and result in extended product development timelines. Few studies are available on engineering SPs systematically to address miscleavage issues. Herein, we developed a novel high throughput computational pipeline cap...
Article
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Background Ageing affects metabolic flexibility, although physical status could influence this relationship. This cross-sectional study aims to describe and analyse the metabolic flexibility/inflexibility in a group of active older women, together with the impact of ageing and physical status on their oxidation rates and maximal fat oxidation (MFO)...
Article
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Introduction The consumption of yerba mate (YM), a source of antioxidants, in a fasted state increases fatty acid oxidation (FAT ox ) during low–moderate-intensity exercise and improves performance in high-intensity exercise. However, the impact of a pre-exercise carbohydrate (CHO) meal on YM effects during exercise is unknown. Objective We invest...
Article
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Background Chinese hamster ovary cell line has been used routinely as a bioproduction factory of numerous biopharmaceuticals. So far, various engineering strategies have been recruited to improve the production efficiency of this cell line such as apoptosis engineering. Previously, it is reported that the caspase-7 deficiency in CHO cells reduces t...
Article
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Introduction Scientific and public interest in the potential ergogenic effects of sodium alginate added to a carbohydrate (CHO) beverage has increased in the last ~ 5 years. Despite an extensive use of this technology by elite athletes and recent research into the potential effects, there has been no meta-analysis to objectively elucidate the effec...
Article
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Four aluminum, zinc, and aluminum/zinc heterometallic complexes 1‐4 stabilized by o‐phenylenediamine bridged poly (phenolato) ligands were synthesized and characterized. It was found that the reaction sequence has significant influence on the formation of the Al‐Zn heterometallic complex AlZnL1Me (4), which was prepared through successive complexat...
Article
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Bile acids (BAs) play an important role in the digestion of dietary fats and act as signaling molecules. However, due to their solubilizing properties, high concentrations in the gut may negatively affect gut epithelium and possibly afferent fibers innervating the gastrointestinal tract (GI). To determine the effect of BAs on intracellular Ca²⁺ and...
Article
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TÓM TẮT Tại tỉnh Bà Rịa-Vũng Tàu, thời gian gần đây do việc đánh bắt tận diệt đã làm cạn kiệt nguồn hải sản gần bờ, việc triển khai đánh bắt xa bờ giúp khai thác tốt nguồn lợi thủy sản và bảo vệ an ninh, khẳng định chủ quyền biển đảo được lãnh đạo tỉnh khuyến khích. Tuy nhiên với các thiết bị định vị hiện có trên tàu cá rất khó để xác định vị trí b...
Article
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The aim of this study is to explain the effect of Linum usitatissimum on lipid profile physiology parameter in female mice twelve adult female mice were used in this study divided into groups .First group is controL (C) received (D.w.) for four weeks. The second (treated group) injected intraperitonial with of Linum usitatissimum in dose 100mg/kg B...
Article
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Background Nanosecond electric pulses showed promising results in electrochemotherapy, but the underlying mechanisms of action are still unexplored. The aim of this work was to correlate cellular cisplatin amount with cell survival of cells electroporated with nanosecond or standardly used 8 × 100 μs pulses and to investigate the effects of electri...
Preprint
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The disk midplane temperature is potentially affected by the dust traps/rings. The dust depletion beyond the water snowline will cast a shadow. In this study, we adopt a detailed gas-grain chemical reaction network, and investigate the radial gas and ice abundance distributions of dominant carbon-, oxygen-, and nitrogen-bearing molecules in disks w...
Article
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Recombinant human bone morphogenetic protein-2 (rhBMP-2), a key regulator of osteogenesis, induces the differentiation of mesenchymal cells into cartilage or bone tissues. Early orthopedic and dental studies often used mammalian cell-derived rhBMP-2, especially Chinese hamster ovary (CHO) cells. However, CHO cell-derived rhBMP-2 (C-rhBMP-2) present...
Article
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Designing cost‐effective and durable Pt‐based catalysts is vital and challenging for practicable energy storage and conversion technologies. Here, a fast phosphating strategy to establish a Pt/Pt5P2 porous nanocage with numerous heterointerfaces and defects is presented. It exhibits extraordinary activity and stability for both hydrogen evolution r...
Article
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Targeting cells specifically based on receptor expression levels remains an area of active research to date. Selective binding of receptors cannot be achieved by increasing the individual binding strength, as this does not account for differing distributions of receptor density across healthy and diseased cells. Engaging receptors above a threshold...
Article
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Aim To investigate the impact of deficiency of LIG4 gene on site-specific integration in CHO cells. Results CHO cells are considered the most valuable mammalian cells in the manufacture of biological medicines, and genetic engineering of CHO cells can improve product yield and stability. The traditional method of inserting foreign genes by random...
Article
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The protocol presents conversion of furfural (FFL) to furfural-diethyl-acetal (FDA), using ionic liquid tangled, sulphonic acid functionalized, porphyrin (ILSAFPc) as a photocatalyst under visible light at ambient conditions. The formation of FDA was achieved by reacting furfural and ethanol (1: 2.2) over ILSAFPc photocatalyst in a home-made photor...
Article
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The 70-kDa heat shock protein (HSP70) is a ubiquitous molecular chaperone which is highly inducible by cellular stress such as exercise. To investigate the role of muscle glycogen content on the HSP70 expression, muscle glycogen was manipulated by consumption of either water (H2O) or a carbohydrate-enriched diet (CHO) during recovery from 4 h of gl...
Article
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A combination of online and offline mass spectrometric techniques was used to characterize the chemical composition of secondary organic aerosol (SOA) generated from the photooxidation of α-pinene in an atmospheric simulation chamber. The filter inlet for gases and aerosols (FIGAERO) coupled with a high-resolution time-of-flight iodide chemical ion...
Article
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Pyrraline in petfood Pyrraline (Pyr) may be seen as the product of heat-induced reactions between a sugar, such as glucose, and the amino acid lysine. Pyr may be formed during thermal processing of foods, including petfoods (cf. Note 1). Data on Pyr analyses in commercial dog and cat foods were not found. Using analysed Pyr contents in proxy ingred...
Preprint
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Comets are a rich reservoir of complex organic molecules, such as alcohols, aldehydes, acids, carbon chains, diols, the N-bearing organics formamide, acetonitrile, cyanoacetylene, imines and the simple amino acid glycine. It has not yet been proven that all of the molecules identified in the coma of comets originate from the frozen ices inside the...
Article
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Refractory hypertension seriously affects the life safety of patients. To investigate the effect of carvedilol combined with conventional antihypertensive therapy on blood pressure, blood sugar, blood lipids, and cardiovascular and cerebrovascular complications in elderly patients with refractory hypertension, a total of 80 elderly patients with re...
Article
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Background The systemic immune-inflammation index (SII), system inflammation response index (SIRI), neutrophil/high-density lipoprotein (HDL) ratio (NHR), lymphocyte/HDL ratio (LHR), monocyte/HDL ratio (MHR), and platelet/HDL ratio (PHR) have been recently investigated as new markers for inflammation. The purpose of this research is to use large-sc...
Article
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Objective: Whether dietary carbohydrate (CHO) or fat is more involved in type 2 diabetes (T2DM) induction uncomplicated by dietary fiber was addressed in a spontaneous diabetic model, the diurnal Nile rat that mimics the human condition. Methods: A total of 138 male Nile rats were fed plant-based and animal-based saturated fat where 10% energy a...
Article
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Background A dysregulated balance between bone formation and bone resorption controlled by osteoblast and osteoclast will lead to osteoporosis. Cholesterol (CHO) is a crucial factor leading to osteoporosis, and autophagy appears to involve it. Therefore, we aimed to study the molecular mechanism of autophagy in CHO-induced osteoclasts differentiati...
Article
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Biofloc technology has a high impact on enhancing shrimp production. Suitable supplemented carbohydrates (CHO) could affect the type of microorganisms developed in the system, which reflects on shrimp production, food safety, and public health. Here, we aimed to compare the effects of sugarcane molasses and wheat flour as carbohydrate sources on bi...
Article
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The development of sustainable plastic materials is an essential target of chemistry in the 21st century. Key objectives toward this goal include utilizing sustainable monomers and the development of polymers that can be chemically recycled/degraded. Polycarbonates synthesized from the ring-opening copolymerization (ROCOP) of epoxides and CO2, and...
Article
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This study recorded the dietary intakes of young male ice hockey players (10–13 year (yr)) for 3 consecutive days while participating in a 5-day summer hockey camp. Players were categorized as older children (OC, n = 10; 10.7 ± 0.2 yr; 37.1 ± 1.5 kg; 147.9 ± 2.1 cm) and young adolescents (YA, n = 10; 12.9 ± 0.1 yr; 45.2 ± 1.5 kg; 157.0 ± 2.4 cm). P...
Article
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Alzheimer’s disease (AD) is complex and highly heterogeneous. Less than 10% of AD cases are early-onset (EOAD) caused by autosomal dominantly inherited mutations in amyloid precursor protein (APP), presenilin 1 (PS1), or presenilin 2 (PS2), each of which can increase Aβ generation and thus lead to earlier deposition of amyloid plaques. The remainin...
Article
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The volatility of organic aerosols plays a key role in determining their gas–particle partitioning, which subsequently alters the physicochemical properties and atmospheric fates of aerosol particles. Nevertheless, an accurate estimation of the volatility of organic aerosols (OAs) remains challenging because most standards for particulate organic c...
Article
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Based on the randomized design, a 3 × 3 factorial experiment was designed to examine the effects of dietary calcium (Ca), phosphorus (P), and vitamin D3 (VD3) supplemental levels with a fixed 1.5/1 ratio of Ca to P on the growth performance, nutrient digestibility, and serum biochemical indices blue foxes’ growth. In total, 135 male blue foxes with...
Article
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Background Carbohydrate (CHO) ingestion has an ergogenic effect on endurance training performance. Less is known about the effect of acute CHO ingestion on resistance training (RT) performance and equivocal results are reported in the literature. Objective The current systematic review and meta-analysis sought to determine if and to what degree CH...
Article
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Introduction Nutrition education attempts to maintain and enhance good eating habits to achieve optimal metabolic control in people with type 1 diabetes (T1D). Recommendations for patients with T1D are comparable to those of the general population. This Study Aimed To investigate dietary habits and adherence to nutritional recommendations of patie...
Article
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Red clover (Trifolium pratense L.) is characterized by high dry matter (DM) yield and a high nutritive value. It has a higher concentration of soluble carbohydrate than lucerne and its protein is less degradable in the rumen than lucerne protein. The aim of this study was to quantify the main crude protein (CP) and carbohydrate (CHO) fractions of a...
Article
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Dietary effect of cinnamon powder on haematology and serum biochemistry indices of cockerel chickens. Zhivotnovadni Nauki, 59(3), 26-31 (Bg). Abstract The experiment was conducted to investigate the blood indices of cockerel chickens fed varying inclusion levels of cinnamon powder. A total bird of 150 day old ISA Brown strain was used for the study...
Article
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Background: The purpose of this case study was to implement an evidence-based dietary approach to peaking for a bodybuilding competition and monitor its impact on body composition, muscle thickness (MT), intra-to-extra-cellular fluid shifts, subcutaneous thickness (ST), and hydration status. Secondarily, to document any adverse events of this peak...
Article
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The electroreduction of CO2 to CH4 has attracted extensive attention. However, it is still a challenge to achieve high current density and faradaic efficiency (FE) for producing CH4 because the reaction involves eight electrons and four protons. In this work, we designed Cu nanoparticles supported on N-doped carbon (Cu-np/NC). It was found that the...
Article
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The renewable energy-powered electrolytic reduction of carbon dioxide (CO2) to methane (CH4) using water as a reaction medium is one of the most promising paths to store intermittent renewable energy and address global energy and sustainability problems. However, the role of water in the electrolyte is often overlooked. In particular, the slow wate...
Article
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Coal spontaneous combustion (CSC) is a disaster that seriously threatens safe production in coal mines. Revealing the mechanism of CSC can provide a theoretical basis for its prevention and control. Compared with experimental research is limited by the complexity of coal molecular structure, the quantum chemical calculation method can simplify the...
Article
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Cu2O based electrocatalysts generally exhibit better selectivity for C2 products (ethylene or ethanol) in electrochemical carbon dioxide reduction. The surface characteristic of the mixed Cu+ and Cu0 chemical state is believed to play an essential role that is still unclear. In the present study, density functional theory (DFT) calculations have be...
Article
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Tigecycline is a broad-spectrum active intravenous antibiotic that is active against methicillin-resistant staphylococcus aureus. In Phase 3 and 4 clinical trials, increased all-cause mortality was observed in patients treated with tigecycline compared to patients in the control group. The reason for the increase is unclear. In this study, we found...
Article
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Recombinant therapeutic proteins (RTPs) are important parts of biopharmaceuticals. Chinese hamster ovary cells (CHO) have become the main cell hosts for the production of most RTPs approved for marketing because of their high-density suspension growth characteristics, and similar human post-translational modification patterns et al. In recent years...
Article
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Hepcidin is a liver‐derived hormone that regulates iron metabolism. Recent studies suggest that an energy‐deficient diet or low carbohydrate (CHO) availability may increase hepcidin in the absence of inflammation. The purpose of the present study was to examine the impact of either an energy‐deficient diet or an ED diet with low CHO intake during t...
Article
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Mục tiêu của nghiên cứu này là đánh giá xu thế biến động mực nước dưới đất (NDĐ) tầng Holocene (qh), Pleistocene thượng (qp 3), Pleistocene trung thượng (qp 2-3) và khả năng bổ cập NDĐ tầng qh từ nước mưa tại vùng thượng nguồn đồng bằng sông Cửu Long. Các phương pháp được sử dụng gồm: (i) kiểm định Mann-Kendall và xu thế Sen's Slope cho mực NDĐ; (i...
Article
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The application of DFT computational method (B3LYP/6-311++G(d,p)) to mono- and poly(CF3)substituted naphthalene derivatives helps to study changes in the electronic properties of these compounds under the influence of 11 substituents (-Br, -CF3, -CH3, -CHO, -Cl, -CN, -F, -NH2, -NMe2, -NO2, and -OH) to confront substituent effects in naphthalene wit...
Article
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Peaking carbon emissions and achieving carbon neutrality have become the consensus goal of the international community to solve the environmental problems threatening mankind caused by accumulative greenhouse gases like CO2. Herein we proposed vacancy engineering of two-dimensional (2D) topological W2N3 for efficient CO2 hydrogenation into high val...
Article
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This study was designed to test whether adaptation to a CHO-restricted diet affects physical capacity during prolonged exercise. It is hypothesised that chronically reducing an individual's dietary carbohydrate intake during training will increase their ultra-endurance exercise capacity compared to a chronic high carbohydrate diet. Thirteen highly...
Conference Paper
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The Maras on the Path belongs to the Second Noble Truth and we can comprehend them from the wievpoint of the enlightenment phases of the Buddha or the negative causes of karma and from the wievpoint of obstacles of meditation.
Article
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In this study, we synthesized a poly(cyclohexene carbonate) (PCHC) through alternative ring-opening copolymerization of CO2 with cyclohexene oxide (CHO) mediated by a binary LZn2OAc2 catalyst at a mild temperature. A two-dimensional Fourier transform infrared (2D FTIR) spectroscopy indicated that strong intramolecular [C–H···O=C] hydrogen bonding (...
Preprint
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Background Contemporary sports nutrition guidelines recognize that endurance athletes should periodize their daily carbohydrate (CHO) intake according to the demands of their training and competitive schedule. However, objective assessments of the dietary CHO periodization practices adopted by endurance athletes during prolonged training periods ar...
Article
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We sought to examine whether dietary intakes may affect the relationship between ApoB EcoRI and lipid profile, as well as serum inflammatory markers, in patients with type 2 diabetes (T2DM). This current study consisted of 648 diabetic patients. Dietary intake was calculated by a food frequency questionnaire. Biochemical markers (high-density lipop...
Preprint
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The astronomical detection of formamide (NH$_2$CHO) toward various star-forming regions and in cometary material implies that the simplest amide might have an early origin in dark molecular clouds at low temperatures. Laboratory studies have proven the efficient NH$_2$CHO formation in interstellar CO:NH$_3$ ice analogs upon energetic processing. Ho...
Article
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Colorectal cancer (CRC) is one of the most common malignancies and one of the leading causes of cancer-related death worldwide, urging the need for new and more efficient therapeutic approaches. Ruthenium complexes have emerged as attractive alternatives to traditional platinum-based compounds in the treatment of CRC. This work aims to evaluate ant...
Article
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Torrefaction techniques are often used to improve the properties of biomass fuels. This study developed a new detailed lumped model to investigate the reaction mechanism of rice husk (RH) and rice straw (RS) degradation during the torrefaction process. The validity of this model was confirmed by comparing it with the experimental result. The van Kr...