Brain Diseases - Science topic
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Questions related to Brain Diseases
It is well known that Doose and Lennox-Gastaut syndromes are drug resistant epileptic encephalopathies. There do exist typical AED for them. Nevertheless, although AED as
carbamazepine is not recommended -as a result of the many possible side effects it may cause- does there exist any report about any child/adult which was in good control of seizures with levetiracetam, etosuximide, topiramate, lamotrigone and clobazam and - in order to "increase seizure control" those AED are retired slowly, levetiracetam is changed by brivaracetam BUT CARBAMAZEPINE is introduced as "the new one" and is suppported by risperidone...?
I will acknowledge any comment.
The association of free radicals in the pathophysiology of chronic diseases like degenerative brain disorders (AD, PD, HD, Stroke) has been evident by a substantial research.
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a quite hot topic these days among those who are concerned with dementia, memory deficits and neurodegenerative diseases.
It has been suggested that LATE is distinguished from frontotemporal lobar degeneration (FTLD) with TDP-43 pathology based on its epidemiology.
What do you think about this newly recognized disease?
Any idea about the potential or promising diagnostic approaches?
Possible future biomarkers and mechanisms...
05 months old child .
rare brain diseases.
my reading is .
megalencephalic leukodystrophy DDX Canavans, Alaxanders.
any body with expertise in pediatric neuro radiology to help me with this patient.
Please write to me and give some info about yourself. The reviews are going to be published in Q1 journals.
The blood–brain barrier is composed of high-density cells restricting passage of substances from the bloodstream much more than do the endothelial cells in capillaries elsewhere in the body. over 95 percent of drugs do not show any useful activity in the brain due to the blood–brain barrier. therefor opening them for a short while can be very effective.
Epilepsy is a chronic brain disorder characterized by recurrent seizures. Globally, 50 million people around the world live with it, while ,annually, a rate of 2.5 million new case is diagnosed to have it.
Unfortunately, one-third of the cases had shown a resistance to the Anti-Epileptic Drugs(AEDs) being prescribed for them by the physician. In these cases, the surgical intervention becomes a must. So we need to precisely localize the region involved in this disease and asses the eligibility of the patient for such surgery.
Many functional neuroimaging techniques have been used in order to perform such kind of assesment (such as MRI, PET,SPECT, etc.) but these methods provide a low temporal resolution which is needed for transient events such as the spikes. While the EEG method can provide a high temporal resolution. Hence, Many researches have been conducted on how to use the EEG along side the signal processing techniques to provide a better understanding of the spatio-temporal activity in the brain (solving the inverse problem).
I am interested in time varying source localization. So kindly, can any one of you suggest some literature review related to this issue?
Thank you in advance.
Postop craniotomy and AVM malformation. Discussing the safety of Ketoroloc for pain control in postoperative period in this patient population
I am performing western blot analysis to detect the protein expression changes in the brain tissues from several neurodegenerative diseases (e.g Alzheimer's, Parkinson's) as compared to normal control (age-matched). In your experience, which is a better loading control - GAPDH, ßActin or α/ßTubulin?
If you are aware of any articles that addresses above question, please do share.
Thank you for your feedback!!
Need to apply life-cycle asset management approaches to enhance sports engineering. Like infrastructure, the human body has an 80-year+ life-span - which is why we go to the dentist and have regular check-ups. Preventive maintenance, proservation techniques, life-cycle value engineering can all play into the sports engineering field. Sports engineering has the $$$ incentive to produce great results in longevity of life spans. Look how the results of war have contributed to human reconstruction. Sports madicen can also benefit from sports engineering - consider the extension to robotics.
In the March 5 update of the project "Prescriptive ontology in the Hebrew Bible", the resonant interaction of a number N of two level systems (TLS) in a cavity with an electro-magnetic field at a cavity mode frequency was discussed . When the transitions from the lower to the upper level of the TLS are in phase, the interaction energy is largest and the in phase oscillating system is the polariton Bose-Einstein condensate. It can occur at ambient temperature because it is stabilized by the matter-field interaction, which occurs in the strongly coupled, robust, pumped polariton condensates but not in systems composed of matter alone, such as the fragile Fröhlich condensates . At high interaction energies, optics becomes non-linear, The TLS oscillates between the upper state and the lower state at the Rabi frequency, by emission and re-absorption of resonant photons. The Rabi frequency is equal to the light- TLS interaction energy of the Bose-Einstein condensate divided by Planck's constant.
In microtubules, at the cavity mode resonance, the interaction energy of the polariton condensate is largest, not only because of the large Rabi frequency but also because of the strong induced dipole-dipole interaction between tubulin rings. This leads to an interesting polariton-condensation-induced chemical effect: the increase of the length of the microtubule molecule by polymerization of tubulin. The maximum effect of microtubule lengthening is obtained at the electromagnetic field frequency which resonates with the cavity mode frequency. Changing the cavity dimensions will change the electromagnetic field frequency producing maximum microtubule lengthening. Electromagnetically-induced polymerization of neuron tubulin in a cavity was obtained in 2014 by Bandyopadhyay et al, without noticing that thereby they introduced polariton chemistry; see https://www.nature.com/articles/srep07303.pdf This discovery can lead to new treatments of Parkinson's disease and other brain disorders, as was noted by Stuart Hameroff in his YouTube presentations.
The question presented here is whether cavity polariton polymerization is a general mechanism in biology.
review article needed foe machine learning approaches to detect brain disoredr
Optogenetics is branch of biotechnology, which is growing and emerging in the treatment of many brain diseases including depression, Parkinson, so what are new innovations related to obesity and diabetes.
A recent landmark Nature paper (attached) following up on a cohort of congenital toxoplasmosis since 1981, has described the association between Toxoplasmosis infection and certain degenerative brain disease. Baring in mind that the studied cohort does not represent the population at large, would you consider Toxoplasmosis testing in an adult with degenrative brain disease (E.g Parkinson's, Alzeheimer's...)
Zipurshy RB, Reilly TJ, Murray RM. The myth of schizophrenia as a progressive brain disease. Schizophr Bull 2013;39:1363-72
Andreasen NC, Liu D, Ziebell S, et al. Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study. Am J Psychiatry 2013; 170:609-15
Dorph-Petersen KA, Pierri JN, Perel JM, et al. The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology 2005;30:1649-61
I am designing an automatic diagnosis system for detecting some brain diseases like Epilepsy,Alzheimer's and sleep disorders like Insomnia,Narcolepsy. But the problem is the features I have extracted are giving values in the same range for two diseases. So individually if I detect a single disease for my test EEG signal then it is showing positive for two disease. How can we solve this problem. Can we design a single system for all diseases rather than one system for each diseas.
I want to do a research about the the protecting fuction of Nuclear factor-erythroid 2-related factor 2 (Nrf2) in ischemia brain disease.
However, I do not konw what kind of Nrf2 activator and inhibitor we always use？
Can they pass through blood brain barrier and regulating the Nrf2 protein level of brain tissues？
Would you mind telling me which article is the most authoritative one？
Thanks for your great answer！
A new comer of ischemia brain disease.
I am working on a family with autosomal recessive in which affected members have CP characters so how will i differentiate between whether it is Cerebral Palsy or Heredity Spastic Paraplegia?
Let me first apologize for putting this collaboration request in question-answer section. However, I could think of any other way to reach to relevant researchers faster.
I am an MRI scientist working at the dept. of Neuroradiology, University Medical Center, Hamburg.
I have been working towards making T2-relaxometry based myelin imaging as a feasible clinical (MRI) marker. For that, I am using the gold standard CPMG sequence and exploring ways to cut down the scan time for whole brain coverage < 15-20 minutes using various regular and random under sampling (compressed sensing).
I am planning to apply for an international collaboration grant between India-EU. This grant aims to make collaboration between India and following EU countries: Belgium, Estonia, Portugal, France and Norway. More information here: http://indigoprojects.eu/funding/indigo-calls/call-2015
I am looking for collaborators (from India/ Belgium, Estonia, Portugal, France and Norway):
1) who is interested in white matter disorders: It could be any white matter disease.
2) who may have following backgrounds:
a. Sequence development
b. Compressed sensing
c. Medical background
d. Histological background
Any interested MRI/ “white matter disorder” researcher can contact me: