Borderline Personality Disorder - Science topic

This study analyzed the psychometric properties of the Meaning in Life Questionnaire (MLQ) in a sample of people diagnosed with Borderline Personality Disorder (BPD). Participants were 102 residents in Spain (74 women, 72.55%; 26 men, 25.49%; and 2 missing data, 1.96%) age-ranged from 18 years to 68 years old (M = 37.69; SD = 12.66) diagnosed with...

Background Psychodynamic psychotherapy is a type of psychotherapy for individuals with borderline personality disorder (BPD). However, competency in conducting effective psychodynamic psychotherapy for BPD is difficult to evaluate. Therefore, this study aimed to identify the psychometric properties of a comprehensive scale to assess cognitive, affe...

Background Subjective emptiness is a transdiagnostic clinical dimension related to suicide, distress, and other maladaptive outcomes. Although it is typically conceptualized as a symptom of borderline personality disorder, it has a different pattern of correlates than other symptoms of that phenotype and is present in individuals with other diagnos...

The aim of the present study was to compare risk factors for death by suicide and sudden violent death (SVD) among young people aged 10–25 years. Two target samples, 63 consecutive cases of youth suicide and 62 cases of SVD, were compared on potential risk factors differentiating the two groups from 104 controls. Data on psychiatric diagnoses, psyc...

Purpose of Review Clinicians treating patients with borderline personality disorder (BPD) experience concerns about risk for adverse events that can lead to litigation or complaints to administrative boards. This paper’s goal is to outline steps to ensure the safety of both the patient and clinician. Recent Findings Review of available data confir...

Background: Women with borderline personality disorder (BPD) show increased basal levels of testosterone. We investigated whether salivary testosterone levels in women with BPD were indicative of specific symptoms associated with BPD. Based on the assumed link between testosterone and interpersonal dominance, we hypothesized a positive association...

Background. Borderline Personality Disorder (BPD) is a prevalent psychopathological condition, affecting 0.7–2.7% of the general population. Given the known link between identity formation and the temporal, metacognitive, and narrative processes that contribute to its coherence, the aim of the present systematic review is to synthesize the current...

O Transtorno de Personalidade Borderline (TPB) é caracterizado por instabilidade emocional, impulsividade, dificuldades nos relacionamentos interpessoais e uma autoimagem instável. Embora compartilhe características com outras condições psiquiátricas, como o Transtorno Afetivo Bipolar (TAB), o TPB pode ser diferenciado por fatores como a história d...

Background Psychogenic Non-Epileptic Seizures (PNES) and Functional Neurological Disorders (FND) are progressively attracting the attention of healthcare professionals both in the medical or surgical specialties and in psychiatric ones. Methods Due to FND and PNES complex presentation, often comorbid with other neurological, medical, and psychiatr...

ABSTRACT: Aim: The purpose of this research is to determine whether young adults with features of borderline personality disorder (BPD) can benefit from Acceptance and Commitment Therapy (ACT). Method: The research used a 12-session ACT program to enhance valued living, to reduce experiential avoidance, and cognitive fusion in six females with feat...

Background Differentiation of borderline personality disorder (BPD) and bipolar I disorder (BD) has been challenging. The assessment of shared symptoms in the context of the overall personality functioning, the patient’s sense of self, and the quality of his object (interpersonal) relations is proposed to be valuable for the differential diagnosis...

Background Interpersonal impairments in patients diagnosed with borderline personality disorder (BPD) are characterized by the fear of being rejected and high levels of loneliness. Potential underlying factors are alterations in the processing of social interactions and the associated perceptions of social partners. In this regard, BPD patients ten...

Borderline personality disorder (BPD) is associated with pervasive stigma that contributes to several consequences, such as inaccessible and inadequate healthcare. Existing literature concerning the experiences of BPD stigma within healthcare settings predominantly centers on mental healthcare contexts. However, individuals with BPD also present wi...

Borderline personality disorder (BPD) is a psychological disorder that is diagnosed predominantly in females yet is equally as prevalent in males. Many empirical research studies on the treatment of BPD have been conducted with only female participants. We aimed to investigate the impact of current treatments for BPD on men compared to women. Using...

Introduction This meta-analysis aimed to quantitatively evaluate the association between homosexual and bisexual orientation and borderline personality disorder (BPD), including factors contributing to the association and clinical outcomes of homosexual and bisexual patients with BPD. Methods We systematically searched PUBMED, PsycINFO, Cochrane L...

Objective No drugs are currently approved for the treatment of borderline personality disorder (BPD). These studies (a randomised study and its open-label extension) aimed to evaluate the efficacy, safety and tolerability of brexpiprazole for the treatment of BPD. Methods The Phase 2, multicentre, randomised, double-blind, placebo-controlled, para...

A tendency to merge mental representations of self and other is thought to underpin the intense and unstable relationships that feature in Borderline Personality Disorder (BPD). However, clinical theories of BPD do not specify, in computational terms, how the perspectives of self and other might become confused. To address this question, we used a...

Background Borderline personality disorder (BPD) is a debilitating condition characterized by pervasive instability across multiple major domains of functioning. The majority of persons with BPD engage in self-injury and up to 10% die by suicide – rendering persons with this condition at exceptionally elevated risk of comorbidity and premature mort...

Background Engagement in Non-Suicidal Self-Injury (NSSI) is high among adolescents with borderline personality disorder (BPD), but the trajectory of NSSI in the transition period from adolescence to adulthood is unclear, and studies that look at predictors of persistence are highly needed. Methods This study followed 111 adolescents aged 14–17 wit...

The validity of psychiatric diagnoses has been at the heart of enduring and divisive debates in mental health discourse for over fifty years, often reaching a stalemate. Whilst some consider a diagnosis essential for validation and support, others view it as an obstacle to personal meaning-making. This chapter proposes that considering epistemic in...

Introduction: Impulsivity is one of the overlapping symptoms common to borderline personality disorder (BPD) and attention deficit hyperactivity disorder (ADHD), but the neurobiological basis of these disorders remains uncertain. This systematic review aims to identify abnormalities in the gray and white matter associated with impulsivity in BPD an...

Borderline personality disorder (BPD) is a complex psychiatric disorder characterized by an unstable sense of self and identity, emotional dysregulation, impulsivity, and disturbed interpersonal relationships. This narrative review examines the interplay between dysregulation of the autonomic nervous system, metabolic changes, and cardiovascular ri...

This research examines the intricate connection between Borderline Personality Disorder (BPD), life's meaning and the interpersonal difficulties related to the search for meaning, in the cultural context in Pakistan. As BPD is frequently accompanied by extreme interpersonal problems and problems with identity, it's valuable to learn how these eleme...

Gay and bisexual men are more likely than heterosexual men to be diagnosed with borderline personality disorder (BPD). Evidence also suggests an elevated presence of mental health issues and psychological difficulties among gay and bisexual men. This review of literature evaluated previous attempts to understand the relationship between male homose...

Mental diseases are a serious worldwide problem that requires precise and effective diagnosis techniques. This paper provides an in-depth overview and analysis of the latest developments in the application of deep learning techniques to identify mental illnesses. The key objective of this investigation is to evaluate the potential of DL algorithms...

Background Missing outcome data can pose a serious threat to the validity of randomised clinical trial results. We aimed to study the extent of missing outcome data in randomised clinical trials of psychological interventions. Methods We performed a retrospective study of randomised clinical trial reports of psychological interventions published i...

Sexual minority men are more likely to be diagnosed with borderline personality disorder compared to their heterosexual counterparts. Minority stressors have been associated with criteria for borderline personality disorder (e.g., substance use, suicidality, impulsive behaviors, and interpersonal difficulties with rejection). However, to date, ther...

Environmental and genetic risk factors contribute to the development of borderline personality disorder (BPD). We conducted the largest GWAS of BPD to date, meta-analyzing data from 12,339 cases and 1,041,717 controls of European ancestry, and identified six independent associated genomic loci. Gene-based analysis identified nine risk genes. We obs...

Background Non-suicidal self-injury(NSSI)is a widespread occurrence among adolescents, and this behavior can bring serious consequences. In recent years, the prevalence of NSSI continues to rise, which has attracted the attention of many researchers. But currently there is no research exploring the overall research distribution of NSSI in adolescen...

We assessed if generative artificial intelligence would BPD symptoms similarly in young and older adults. We also assessed gender differences across gender and age.

We examined gender bias and public stigma expressed by generative artificial intelligence apps for women and men with Borderline Personality Disorder.

For those with borderline personality disorder, trauma-informed therapies can improve symptom management by fostering emotional regulation, interpersonal skills, and distress tolerance. Integrating trauma-focused cognitive behavioral therapy (TF-CBT) into treatment for substance use disorders has shown particular effectiveness, given the strong lin...

Borderline personality disorder constitutes a significant medical challenge. Despite the fact that its occurrence among adolescents is currently attracting increasing interest from both clinicians and researchers, there is still insufficient data on this phenomenon. The etiology and maintenance of borderline personality disorder are not yet fully c...

Borderline personality disorder (BPD) is a complex mental health condition characterized by emotional instability, impulsive behavior, and challenges in interpersonal relationships. Effective management of BPD requires a holistic, interdisciplinary approach, leveraging psychotherapy as the primary treatment and fostering strong therapeutic alliance...

This article examines the complex phenomenon of self-harm, exploring its motivations, theoretical underpinnings and the intricate transference and countertransference reactions that arise in clinical settings. It aims to integrate psychiatric understanding with contemporary theories of the impact of trauma on both the body and the mind, to deepen t...

Importance A decline in nonsuicidal self-injury (NSSI) behavior is often viewed as an indication of mental health improvement when treating adolescents and young adults with borderline personality pathology. However, evidence shows that an initial decrease in NSSI behavior does not always signal recovery, and potential symptom shifting needs to be...

The identification and management of Autism Spectrum Disorder (ASD) and its associated psychiatric comorbidities pose significant clinical challenges. This comprehensive review explores the multifaceted relationship between ASD and depression, suicidality, and borderline personality disorder (BPD), highlighting the intricate interplay between these...

It is about understanding and managing borderline personality disorder.

Background Mentalization‐based treatment (MBT) has been proposed as a promising approach when treating patients suffering from borderline personality disorder (BPD) and severe self‐harm. Though study findings on MBT for patients who self‐harm are convincing, a meta‐analysis showed mixed results, calling for further research and the development of t...

Introduction Traits of borderline personality disorder are important for the determination of the prognosis of mental illnesses and in evaluating risks of negativity as well as impulsivity. But, there is a lack of information about the distribution characteristics of borderline personality disorder traits and symptoms within clinical groups. The go...

Social and family factors also contribute to BPD risk, though these factors are not unique to the disorder. Risk indicators include low socioeconomic status, family adversity, parental psychopathology or substance abuse, harsh or neglectful parenting, and childhood abuse or neglect. Additionally, certain temperamental traits, such as high sensitivi...

BPD was officially recognized as a unique diagnosis with the publication of the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) in 1980, a pivotal moment that established specific criteria for BPD diagnosis and fueled further research and understanding. Revisions in subsequent DSM editions, including the DSM-IV in 1...

Genetic studies indicate a hereditary component in BPD and other personality disorders, with BPD heritability estimated at around 40%. Studies in Sweden have shown the strongest familial association among monozygotic twins, followed by dizygotic twins, full siblings, and half-siblings. However, it’s essential to consider that twin studies may overe...

Background Borderline personality disorder (BPD) is characterized by changes in selfimage and interpersonal relationships that are characterized by sudden shifts between idealization (overly positive views of self and others) and devaluation (overly negative views of self and others). People with borderline personality disorder typically suffers fr...

This brief commentary critically examines the study “Psychotherapies for the Treatment of Borderline Personality Disorder: A Systematic Review” by Crotty et al. (2023) It highlights several methodological and reporting concerns that impact the study’s credibility and conclusions. Key issues include the retrospective registration of the study protoc...

Background. Altered temporal experience lies at the core of various psychiatric conditions, including Borderline Personality Disorder (BPD). Mainstream research in psychopathology tends to explore BPD with scrutiny while neglecting other personality disorders (PD). At the same time, the dimensional approach to PD proposes looking through the disord...

Replies to comments made by Mattos et al. (see record 2025-49982-003) on the original article (see record 2024-19816-001). Mattos et al. critiqued our assessments of the certainty of evidence as being overly permissive and not adhering to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group's guidelines. GRAD...

This paper synthesizes research on temporal experience in Borderline Personality Disorder (BPD) from a phenomenologically grounded perspective. It advocates for a closer integration of phenomenology with empirical research results, with the specific goal of bridging the gap between theoretical and evidence-based understanding of BPD temporality. Ut...

Background: The mentalization model of borderline personality disorder (BPD) utilizes a developmental psychopathology lens, emphasizing an unstable or reduced capacity to mentalize—stemming from early attachment disruptions and relational trauma—as the core feature of BPD. While the empirical evidence for the proposed intersections between mental...

Background and Objectives: Fifty percent of individuals with borderline personality disorder (BPD) experience self-harm. One of the crucial factors related to self-harm is feelings of emptiness. While inner strengths, such as the Five Precepts, meditation, and equanimity, have been identified as potential buffers against negative mental health outc...

Purpose of Review This review summarizes recent advances in research on the neurobiology of borderline personality disorder (BPD) according to structural brain imaging investigations and resting-state and task-based functional brain activation studies. Recent Findings Extending established findings on differences in regional brain volumes and cort...

Background Insecure adult attachment has been associated with psychiatric disorders characterized by emotional dysregulation, such as borderline personality disorder (BPD), bipolar disorder (BD) and attention deficit/hyperactivity disorder (ADHD). However, little is known about the differences in attachment patterns between these diagnostic groups....

Indonesia is an archipelagic country located at the confluence of four tectonic plates and there are volcanic arcs along the islands of Sumatra-Java-Nusa Tenggara-Sulawesi. This condition causes Indonesia to be in a condition prone to natural disasters, especially volcanic eruptions. Disasters have a more serious impact on vulnerable groups. Semi-s...

Purpose Child abuse and trauma are significant risk factors in the etiology of borderline personality disorder (BPD). Apart from affecting the risk of developing BPD, adverse childhood experiences seem to increase its symptoms and related disability. Self-stigma presents another common issue with equally prominent consequences for mental health. De...

This study aimed to explore how certain marginalized adult white male incels choose to present themselves to a global YouTube audience and address the misunderstandings about them perpetuated by often negative media portrayals. This qualitative case study, conducted on July 24, 2024, analyzed four purposively-sampled YouTube confessionals from adul...

Background Perinatal borderline personality disorder (BPD) is a common condition in perinatal mental health settings with few specialised treatment options, and little is known about the enduring effects of available treatment programs. This study explored the follow-up experiences of women with BPD after completing Mother-Infant Dialectical Behavi...

Background Childhood traumatization can result in physical and mental health problems in adulthood, such as post-traumatic stress disorder (PTSD), which negatively influences quality of life and social functioning. Similarly, personality disorder may be a consequence from childhood traumatization, and these conditions often co-occur. Although evide...

Background: Borderline personality disorder (BPD) is a debilitating psychiatric illness whose symptoms frequently emerge during adolescence. Initial studies in adults suggest that the interpersonal difficulties common in BPD may emerge from disrupted processing of social and emotional stimuli. Less is known about these processes in adolescents with...

Background Borderline Personality Disorder (BPD) is a prevalent and debilitating psychiatric condition often accompanied by Post-Traumatic Stress Disorder (PTSD), with a substantial prevalence of trauma history among affected individuals. The clinical, cognitive, and cerebral parallels shared with PTSD suggest a trauma-related etiology for BPD. Stu...

Childhood abuse is a significant factor in the development of borderline personality disorder (BPD) and many physical health disorders, including polycystic ovary syndrome (PCOS) and fibromyalgia. This study aimed to examine the prevalence of PCOS and fibromyalgia in women with BPD compared to the general population. Additionally, it compared the p...

Background Medications are commonly used to treat co-occurring psychopathology in persons with borderline personality disorder (BPD) Aims To systematically review and integrate the evidence of medications for treatment of co-occurring psychopathology in people with BPD, and explore the role of comorbidities. Method Building on the current Cochran...

Background: Meaning in Life (MiL) represents a key variable in mental health models of personal recovery. There is a need for straightforward and concise instruments to assess this construct quantitatively in individuals diagnosed with severe mental illness (SMI). Objective: The aim of the present study was to test the psychometric properties of th...

Background Current treatments for mental disorders, like pharmacotherapy or psychological approaches, do not lead to full remission in all individuals. Physical activity (PA) is effective at improving psycho-physical health in major depressive and anxiety disorders. However, the efficacy of PA as an adjunctive treatment for borderline personality d...

The inclusion of complex post-traumatic stress disorder (cPTSD) in the International Classification of Diseases 11th Revision in January 2022 marks a significant advancement in trauma recognition. However, while cPTSD offers a more inclusive framework, it risks perpetuating trauma hierarchies by reinforcing a division where some trauma responses ar...

This chapter focuses on navigating alliance rupture and repair with emotionally dysregulated clients with personality disorders. Most of the evidence supporting this chapter derives from research on borderline personality disorder; however, the clinical strategies presented are applicable also other personality disorders characterized by emotional...

Dialectical Behavioral Therapy (DBT) is an evidence-based, comprehensive, transdiagnostic treatment for nonsuicidal self-injurious (NSSI) and suicidal behavior. Since its original inception into the psychotherapeutic reserve, DBT moved from a singular treatment for Borderline Personality Disorder (BPD) to the general marketplace of treatments for a...

Introduction In this study, we mainly evaluated the associations of borderline personality disorder (BPD), neuroticism, and childhood trauma with the self-rated and clinician-rated overall functional impairment levels of adult euthymic patients with bipolar disorder-1 (BD-1). In addition, we compared patient and healthy control groups regarding the...

Psychotherapy as First-Line Treatment: Evidence-based therapies, including MBT, DBT, TFP, and schema therapy, have shown efficacy in reducing BPD symptoms and improving psychosocial functioning. Limited Role of Pharmacotherapy: No psychotropic medication is FDA-approved for BPD, and pharmacotherapy should be reserved for managing comorbid condition...