Blood Cells - Science topic

La demanda de organismos acuícolas para consumo humano, tales como pescados, mariscos y sus derivados, es cada vez mayor debido a su calidad nutricional; la disminución de los rendimientos de las pesquerías ha mostrado un estancamiento. Los Lutjánidos son peces objetivo de las pesquerías artesanales en los estados costeros de las zonas tropicales y...

Leukemia is a serious problem affecting both children and adults, leading to death if left untreated. Leukemia is a kind of blood cancer described by the rapid proliferation of abnormal blood cells. An early, trustworthy, and precise identification of leukemia is important to treating and saving patients’ lives. Acute and myelogenous lymphocytic, c...

Cancer remains one of the leading causes of death worldwide, with metastasis being the main contributor to its high mortality. In this study, based on the immersed boundary-lattice Boltzmann method, one blood flow model considering cell adhesion in microvasculature is established at the cellular scale to investigate the interaction mechanisms betwe...

Reservoir computing (RC) has emerged as an efficient and scalable approach for processing time-dependent data, particularly in physical reservoir computing implementations. QCi's EmuCore platform, a novel photonic-inspired time-delayed reservoir system, offers a compact and energy-efficient solution for dynamic data transformations. In this study,...

Myeloproliferative neoplasms (MPNs) are chronic, clonal blood disorders characterized by overproduction of mature blood cells. MPNs present with protean clinical manifestations, including vascular complications, with both venous and arterial thromboses, bleeding diathesis, which occur in the setting of extreme thrombocytosis and acquired von Willeb...

Background: Epigenetic clocks are widely applied biomarkers of biological age, but their biological underpinnings remain unclear. We previously showed that epigenetic clocks are affected by naive and memory T cell proportions, suggesting blood cell composition as a potential driver. Methods: Here, we quantify the contribution of cell counts to DNA...

Breast cancer remains the leading cause of female mortality worldwide, necessitating innovative and multifaceted approaches to address its various subtypes. Nanotechnology has attracted considerable attention due to its nanoscale dimensions, diverse carrier types, suitability for hydrophobic drug delivery, and capacity for controlled and targeted a...

Kolmogorov-Arnold Networks (KAN) offer universal function approximation using univariate spline compositions without nonlinear activations. In this work, we integrate Error-Correcting Output Codes (ECOC) into the KAN framework to transform multi-class classification into multiple binary tasks, improving robustness via Hamming-distance decoding. Our...

White blood cells are warrior cells that protect the human body against external factors. Each of these warrior cells performs a distinct task, making every piece of information about them highly valuable in the medical field. In this article, a classification framework for the four known types of white blood cells is proposed. It is hoped that the...

Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from technical challenges such as the sparsity and heterogeneous noise properties of these data, the crucial problem is that we know little about the pote...

Mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) has previously been shown to increase after chemo- and radiotherapy in early-stage breast cancer (BC) patients, but the persistence of the increase remains unknown. This study assessed whether changes in mitochondrial respiration and content in PBMCs from postmenopausal BC pati...

Background/Objectives: Clinical experience indicates that the determination of interleukin 6 (IL-6) in human blood can vary depending on time span between sample collection and centrifugation. Here, we evaluated confounding effects in various blood specimens. Methods: The blood of healthy individuals and critically ill patients was collected in EDT...

To construct a machine learning (ML) model to predict the progression of chronic atrophic gastritis (CAG) to gastric cancer (GC), given its precancerous significance. Using medical records from the Affiliated Hospital of Qingdao University, common laboratory indicators were extracted. LASSO regression identified 10 core risk factors, which were fur...

Medical image segmentation has numerous applications in diagnosing different diseases. Various types of diseases are found in white blood and Red blood cells. This paper represents the segmentation of WBCs from blood smear images. It is a complex and challenging task due to the frequent overlapping and variants in size and shape of WBCs with each o...

Background Early prediction of pregnancy complications is important for adequate and timely prevention, management, and reducing maternal/fetal pathogenesis. Objective To study the prognostic value of cytokines as predictors of pregnancy complications using unbiased artificial intelligence/machine learning (AI/ML) methods. Methods For this study,...

Background Chronic systemic inflammation is implicated in Alzheimer's disease (AD) pathogenesis and has measurable effects on blood cells. There is increasing interest in non-invasive diagnostic tools that use blood-based biomarkers for AD, such as DNA methylation. Notably, DNA methylation changes in blood are also linked to systemic inflammation....

La desnutrición infantil en América Latina es un problema de salud pública que afecta el desarrollo infantil y está vinculada a diversas enfermedades hematológicas. Este estudio, basado en una revisión sistemática de la literatura, analizó 76 artículos científicos publicados en los últimos cinco años en bases de datos como PubMed, Web of Science y...

Blood cell phenotypes are routinely tested in healthcare to inform clinical decisions. Genetic variants influencing mean blood cell phenotypes have been used to understand disease aetiology and improve prediction; however, additional information may be captured by genetic effects on observed variance. Here, we mapped variance quantitative trait loc...

Background and Purpose The JAK–STAT signalling pathway has been extensively spotlighted as a therapeutic target for various diseases. This study assessed the inhibitory effects of a novel small molecule, IN‐115314, on JAK–STAT pathway. Experimental Approach The IC50 values of IN‐115314 for JAK1–pSTAT3 and JAK2–pSTAT5 were determined in canine whol...

Background: Chronic systemic inflammation is implicated in Alzheimer's disease (AD) pathogenesis and has measurable effects on blood cells. There is increasing interest in non-invasive diagnostic tools that use blood-based biomarkers for AD, such as DNA methylation. Notably, DNA methylation changes in blood are also linked to systemic inflammation....

Large vision-language models (LVLMs) show impressive capabilities in image understanding across domains. However, their suitability for high-risk medical diagnostics remains unclear. We systematically evaluate four state-of-the-art LVLMs and three domain-specific models on key cytomorphological benchmarks: peripheral blood cell classification, morp...

The study was conducted in the department of animal production-college of Agriculture-Tikrit University, from 12 September to 12 December 2021 (i.e. 91 days) to study the effect of adding glycerol as an alternative energy source and feed in some productive grades that promote growth (weight gain) and some hematological and biochemical parameters (t...

Image processing and deep learning techniques have become increasingly prevalent in the analysis of microscopic biomedical images. However, illumination variability, particularly in images obtained under a microscope, represents a critical factor that directly impacts classification performance. Changes in light intensity can significantly alter ce...

Ascorbic acid (vitamin C) is widely recognized for its antioxidant properties, particularly in the context of mitigating oxidative damage induced by environmental toxins such as heavy metals. This study explores the mechanistic role of ascorbic acid in protecting human blood cells from DNA damage caused by mercuric chloride (HgCl₂) exposure, a know...

Hematopoietic stem cells (HSCs) are the primitive cells that give rise to common precursors for all blood cell lineages. Abnormalities in their number and/or function are important factors leading to the decline of immune function and the occurrence of various systemic diseases. Phase separation refers to a physicochemical mechanism in which intrac...

Background: The aim of this study was to compare blood neutrophil, lymphocyte, platelet, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), erythrocyte and systemic inflammatory index levels in children with attention deficit hyperactivity disorder (ADHD) with typically developing (TD) healthy controls and to investigate the...

Data science (DS) methods and Artificial intelligence (AI) are critical in today's healthcare services operations. This study focuses on evaluating the effectiveness of AI and DS in biomedical diagnostics, including automatic detection and counting of white blood cells (WBCs) and types, which provide valuable information for diagnosing and treating...

Abstrak: Perkembangan teknologi yang semakin berkembang pesat, maka mengharuskan sistem Pendidikan juga dapat menyesuaikan dengan perkembangan teknologi tersebut. Salah satu pemanfaatan teknologi informasi dalam bidang pendidikan adalah media pembelajaran atau aplikasi pembelajaran. Aplikasi pembelajaran adalah suatu media pembelajaran dengan metod...

Histone deacetylases (HDACs) comprise a family of 18 epigenetic modifiers. The biologically relevant functions of HDAC10 in leukemia cells are enigmatic. We demonstrate that human cultured and primary acute B cell/T cell leukemia and lymphoma cells require the catalytic activity of HDAC10 for their survival. In such cells, HDAC10 controls a MYC-dep...

Federated Learning (FL) enables model training across decentralized devices without sharing raw data, thereby preserving privacy in sensitive domains like healthcare. In this paper, we evaluate Kolmogorov-Arnold Networks (KAN) architectures against traditional MLP across six state-of-the-art FL algorithms on a blood cell classification dataset. Not...

Background Diabetic foot ulcer (DFU) is a well-known complication of diabetes. The main therapeutic options for treating DFU include surgical debridement. However, conditions such as sensory loss and insufficient blood supply can lead to lower extremity amputations. Inflammatory biomarkers, including the neutrophil‒lymphocyte ratio (NLR) and platel...

Biological tissues are composed of discrete compartments of biochemical media that often exhibit subtle differences in refractive index. Light propagating through these compartments partially diffracts in a forward direction with a pi/2 phase shift. We introduce a microscopy technique to image this scattering signal in thick tissues, called back-il...

Introducción: la cistitis enfisematosa es una infección poco común del tracto urinario inferior, con presencia de gas en la pared y la luz de la vejiga, más prevalente en mujeres de mediana edad, especialmente con diabetes mellitus, y frecuentemente asociada a Escherichia coli. En contraste, la leucemia mieloide aguda es un cáncer agresivo de los g...

Extramedullary haematopoiesis (EMH) is the production of blood cells outside the bone marrow. EMH is frequently seen in organs such as liver and spleen. Intrathoracic EMH can be diagnosed without histopathological confirmation by typical paravertebral radiological location and association with accompanying haematological disease. We report a patien...

Bone marrow (BM) plays a crucial role in the hematopoietic process, producing all of the body’s blood cells and maintaining the overall immune and health system. Red and yellow BM are the two various kinds of BM. A comprehensive identification of these cells assists in the primary and precise recognition of these disorders. The recognition and iden...

Le thiaclopride, un insecticide néonicotinoïde largement utilisé, s'accumule dans divers fruits et légumes, notamment les tomates fraîches, suscitant des inquiétudes croissantes quant à ses effets néfastes sur la santé, en particulier durant des périodes sensibles comme la gestation et la lactation. Bien que les effets toxiques des néonicotinoïdes...

Prospective birth cohorts offer the potential to interrogate the relation between early life environment and embedded biological processes such as DNA methylation (DNAme). These association studies are frequently conducted in the context of blood, a heterogeneous tissue composed of diverse cell types. Accounting for this cellular heterogeneity acro...

Under stress conditions, such as ex vivo culture, chemotherapy, irradiation and infection, haematopoietic stem cells (HSCs) actively divide to maintain blood cell production. This process leads to production of reactive oxygen species (ROS) that causes HSC exhaustion and haematopoietic failure. Here we show that ferumoxytol (FMT; Feraheme), a Food...

Background Gastrointestinal bleeding (GIB) is associated with high mortality rates among critically ill patients. The hemoglobin-to-red blood cell distribution width ratio (HRR) has recently emerged as a potential prognostic marker in various clinical settings. However, the association between HRR and prognosis in critically ill patients with GIB i...

Single-cell large language models (scLLMs) capture essential biological insights from vast single-cell atlases but struggle in out-of-context applications, where zero-shot predictions can be unreliable. To address this, we introduce a single-cell parameter-efficient fine-tuning (scPEFT) framework that integrates learnable, low-dimensional adapters...

Conventional Light emitting diode and photo‐diode integration is the best suitable combination for point‐of‐care diagnostic in the field of sensor applications. However, these approaches based on inorganic devices are not scalable to incorporate multiple bio‐marker. As a solution, this work proposes the methodology for bio‐medical application using...

In this study we investigate the blood flow in capillaries through rheological properties as small density limit of fluid. Here we know that blood viscosity is an important for flow of particle RBC, WBC and Platelets. The characteristics of blood flow exhibits shear thinning behavior of flow. It decreases exponentially with increasing shear rates....

Circulating cell-free DNA (cfDNA) has emerged as a promising non-invasive medium for studying tumor molecular profiles. Non-random fragmentation patterns in plasma cfDNA, particularly around nucleosome-depleted regions (NDRs) near transcription start sites (TSS), have been shown to reflect epigenetic regulation and gene expression. In this study, c...

Background Cardiopulmonary bypass (CPB) is associated with activation of pro-inflammatory cells, which infiltrate tissues and cause injury. Here we explored a novel disposable remover to remove inflammatory leukocytes in order to reduce risk of complications after CPB. This is a substudy within a previously registered clinical trial (NCT05400356) t...

Background/aim Peripheral blood smear (PBS) and bone marrow aspiration are gold standards of manual microscopy diagnostics for blood cell disorders. Nowadays, data-driven artificial intelligence (AI) techniques open new perspectives in digital hematology. This study proposes an AI learning technique for the classification of blood cells over PBS sa...

Objective: We aimed to evaluate associations of blood gene expression with menopausal status and hormone therapy (HT) use among women who had never been diagnosed with cancer in the Norwegian Women and Cancer (NOWAC) postgenome cohort. Methods: This cross-sectional study comprised microarray-based gene expression profiles obtained from the whole bl...

Introdução: O CellAtlas e CellQuiz são aplicativos desenvolvidos pela empresa CellaVision, que abordam conteúdos referentes à Hematologia. O CellAtlas é um extenso banco de imagens e de informações sobre células sanguíneas normais e alteradas. O CellQuiz é um jogo que tem como proposta realizar a avaliação de conhecimentos referentes aos conteúdos...

L'élevage, en particulier celui des volailles, est soumis à des pressions sociétales et environnementales considérables, notamment en ce qui concerne le bien-être des animaux et la durabilité des pratiques agricoles. En outre, des maladies chroniques et émergentes peuvent entraîner d’importantes pertes économiques. L'amélioration de la robustesse e...

Saline-alkaline water fishery has emerged as a highly promising aquaculture mode in China. To identify potential species suitable for saline-alkaline water aquaculture, this study investigated the effects of different alkalinity stresses (0, 7, 14, 21, 28 mmol/L) on the survival, growth performance, physiology, and muscle quality of largemouth bass...

Introduction The hemoglobin-to-red blood cell distribution width ratio (HRR) is acknowledged as a promising new prognostic biomarker. Nevertheless, investigations into its connection with cognitive function have yielded unclear results. Aim This study aimed to investigate the association between the hemoglobin-to-red blood cell distribution width...

The blood of a septic patient contains only a few bacteria per milliliter. Recently, various techniques have been developed for extracting these few bacteria from a blood sample. Independent of how these bacteria are separated from the blood cells, we want to learn from them how to treat the infection. Here, we describe how a phenotypic Antibiotic...

Analyzing biomedical images is vital in permitting the highest-performing imaging and numerous medical applications. Determining the analysis of the disease is an essential stage in handling the patients. Similarly, the statistical value of blood tests, the personal data of patients, and an expert estimation are necessary to diagnose a disease. Wit...

The RUNX1/AML1 transcription factor is one of the key regulators of definitive hematopoietic development in mice. However, its role in early human hematopoiesis remains poorly investigated. In this study, we integrated a tdTomato reporter cassette into the RUNX1 locus of human pluripotent stem cells (hPSCs) to monitor and block the expression of th...

Leukemia diagnosis requires highly skilled pathologists, as it is often based on the morphology of microscopic blood samples from the patient. In this context, the segmentation of microscopic blood cells plays a vital role in improving the final diagnosis of leukemia. This study applies an enhanced segmentation methodology, which includes optimizin...

Bone marrow is vital for hematopoiesis, producing blood cells essential for oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, and myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy and stem c...

Introduction: it is known that the proportions of different blood cell components are new inflammatory markers that have good predictive value in the outcome of chronic kidney disease, cardiovascular diseases, rheumatic diseases, among others, including the neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and platelet/lymphocyte ratio. Objec...

Objective Monocytes play a significant role in the pathophysiology of acute myocardial infarction (AMI). The relationship between monocytes, their derived indicators, and the severity of acute heart failure following AMI remains unclear. Therefore, this study aims to investigate the association of monocytes and their derived indicators with clinica...

Inflammatory bowel disease (IBD) is a chronic and relapsing disorder influenced by immune dysfunction and other systemic factors. However, the exact pathogenesis of IBD remains incompletely understood. In addition to the traditionally recognized immune dysregulation, recent studies have suggested that the hematopoietic system also plays an importan...

Clonal hematopoiesis (CH) is an age-associated phenomenon characterized by the proliferation of blood cells carrying somatic mutations. Recent studies suggest a potential link between CH and periodontitis, but the causal relationship remains unclear. A two-sample Mendelian randomization (MR) analysis was implemented, examining whether CH phenotypes...

Hematopoietic stem cells (HSCs) sustain lifelong haematopoiesis as their progeny differentiate into all blood cell lineages. Homeostatic HSCs are mostly quiescent and only rarely divide, however their proliferation and differentiation rates can be modulated by external factors. Acute and chronic infections from a wide range of pathogens are known t...

Peripheral complete blood cell count (CBC) and blood ratios, including neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-red blood cell ratio (NRR), and platelet-to-lymphocyte ratio (PLR), have been used in the diagnosis and prognosis of several cancers; however, their relevance in canine splenic hemangiosarcoma (HSA) remains to be investigated....

Background: Hematologic disorders occur frequently in patients with Ebola virus disease (EVD) and are characterized by one or several abnormalities in blood cells, including hemostasis, which is poorly documented. This study described the hematologic abnormalities of Ebola patients and the impact on the outcomes of patients who were admitted with E...

Objectives Identification of abnormal promyelocytes is crucial for early diagnosis of Acute promyelocytic leukaemia (APL) and for reducing the early mortality rate of APL patients, which can be achieved by microscopic blood smear observation. However, microscopic observation has shortcomings, including interobserver variability and training difficu...

Objectives and Background Chronic subdural hematoma (CSDH) is characterized by the develeopment of a membranous hematoma following mild to moderate head trauma, with its pathophysiology involving posttraumatic inflammatory processes. The aim of our study was to investigate the relationship between peripheral blood cell inflammatory markers and vari...

The tumor microenvironment (TME) is a critical determinant of tumor progression, immune evasion, and response to treatment, particularly in immunotherapy. The TME is not only composed of cancer cells but also immune cells, stromal cells, blood vessels, and extracellular matrix components, all of which interact in complex ways that influence tumor b...

Turtles are organisms with high vulnerability due to the impact on their ecosystems and the lack of biological knowledge. Hematological studies in chelonians are limited by the absence of specific techniques-procedures; for this reason, adopted methodologies are not always appropriate. The study aim was to compare variations in fixatives concentrat...

Introduction: Polycythemia vera is a rare type of blood cancer characterized by the overproduction of blood cells in the bone marrow. Left untreated, it can lead to severe complications, recurrent hospitalizations, and reduced life expectancy. Limited research exists on gender, ethnic, and racial disparities in PV occurrence, prompting our analysis...

Anemia is a decrease in hemoglobin and red blood cells and due to a decrease in hemoglobin, oxygen carrying capacity reduce. In this disease, the red blood cell the amount and volume decrease. In this research, healthy and live food powder were synthesized by a green route. This organic biomaterial was named NBS. The NBS healthy and live food powde...

Blood cells and supporting tissues are typically affected by neoplastic lesions, which mostly damage embryonic tissue in adolescents and children. The purpose of this study was to collect the scientific information that was accessible about the frequency of neoplastic lesions in children and adolescents. A systematic review was conducted using four...

Insulator-based dielectrophoresis (iDEP) technology manipulates particles by creating a non-uniform electric field using insulating microchannel structures. It offers advantages such as high operability and electrode-free fabrication. However, the fluid driving and construction of non-uniform electric fields based on iDEP currently mainly relied on...

The integration of artificial intelligence (AI) into medical diagnostics is transforming the landscape of healthcare, particularly in hematology. AI technologies, leveraging advanced machine learning algorithms and big data analytics, are revolutionizing the diagnosis of hematological disorders such as anemia, leukemia, and lymphoma. This review ex...

This work dives into the world of deep learning software, focusing specifically on Convolutional Neural Networks (CNNs) using the VGG16 architecture. The goal? To improve the detection of blood cancer through microscopic images. Traditional diagnostic methods often struggle with accuracy and speed, making advanced techniques essential for clinical...

Expression of concern for ‘A rhodamine–quinoline based chemodosimeter capable of recognising endogenous OCl⁻ in human blood cells’ by Shyamaprosad Goswami et al., RSC Adv., 2014, 4, 24881–24886, https://doi.org/10.1039/C4RA03200D.

Humans encounter ionizing radiation (IR) through various ways, such as medical applications, agricultural industry, and potential exposure from radioactive materials or acts of radiological terrorism. Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) are crucial for maintaining the balance of blood cell lineages. The hematop...

Objective The aim of this study was to explore the efficacy and safety of azacitidine (AZA) in middle-aged and elderly patients with myelodysplastic syndrome (MDS). Methods The clinical data of 59 middle-aged and elderly patients with middle- and high-risk MDS, who attended our hospital from April 2019 to January 2024, were retrospectively analyze...

Genomic imprinting is required for normal development, and abnormal methylation of differentially methylated regions (iDMRs) controlling the parent of origin-dependent expression of the imprinted genes has been found in constitutional disorders affecting growth, metabolism, neurobehavior, and in cancer. In most of these cases the cause of the impri...

To date, one of the most important problems for researchers is the study of the morphology, physiology and pathology of the immune system, which is primarily related to the demands of clinical medicine[12,21,24]. New environmental, social and other factors have also begun to have a significant impact on the human body. The thymus gland, being an en...

Resumen Objetivos La lipemia es un problema preanalítico reseñable para el proceso de recuento de células sanguíneas (CBC), ya que no existe un método estandarizado para su identificación y eliminación. El objetivo de presente estudio es verificar la medida de la hemoglobina óptica (Hb-O) en el hemoanalizador (HA) Sysmex XN-1000 como método fiable...

Plain Language Summary What is this summary about? This is a summary of the ARROYO study, originally published in the British Journal of Dermatology. Chronic spontaneous urticaria (CSU) is a skin condition that lasts for at least 6 weeks, appears suddenly with no known cause, and develops temporary, raised red itchy skin (also known as hives or whe...

The increasing use of computed tomography (CT) has led to a rise in cumulative radiation dose due to medical imaging, raising concerns about potential long-term adverse effects. Large-scale epidemiological studies indicate a higher tumor incidence associated with CT examinations, but the underlying biological mechanisms remain largely unexplained....

Cell segmentation is a critical process in biomedical image analysis. This study evaluated the performance of three state-of-the-art deep learning models—DeepLabV3+, U-Net++, and Attention U-Net—using the Blood Cell Count and Detection (BCCD) dataset, which contains annotated images of blood cells. The models were rigorously analyzed through qualit...