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Publications related to Bioscience (10,000)
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Riok PAH, Hariani N, Nugroho RA, Arif MF, Syafrizal, Aryani R, Manurung H, Rudianto. 2025. Fermented black soldier fly (Hermetia illucens) carcass meal as a substrate for its larva. Nusantara Bioscience 17: 49-56. The black soldier fly (Hermetia illucens (Linnaeus, 1758)) is an insect commonly used as an organic waste decomposer. The Black Soldier...
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Kachi JB, Binashikhbubkr K, Naim DM. 2025. Morphological differentiation of Pennahia aneus (Bloch, 1793) populations from Northern Peninsular Malaysia using geometric morphometrics. Nusantara Bioscience 17: 30-38. The investigation of geometric morphometrics offers evidence for the adaptive traits shown by fish in response to their aquatic environm...
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Agustiani A, Garvita RV, Siregar HM, Windarsih G. 2025. Morphological and flowering phenology characterization of wild Begonia (B. hooveriana and B. hijauvenia) collected at Bogor Botanic Gardens, Indonesia. Nusantara Bioscience 17: 1-10. Begonia hooveriana and B. hijauvenia are known for their varied morphology. This study aimed to describe the mo...
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Understanding the complex interplay between food safety, nutrition, bioscience, and data algorithms is crucial for effectively managing autoimmune diseases. However, the current literature often needs a comprehensive resource that integrates these disciplines, leaving researchers, clinicians, and industry professionals needing a clearer understandi...
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Mental health disorders represent a significant public health concern globally. With the increasing burden of psychiatric conditions such as depression, schizophrenia, and bipolar disorder, there is a growing interest in understanding the genetic underpinnings of these illnesses. This paper explores the role of genetics in mental health through an...
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Background: As soon as the COVID-19 epidemic outbreak in Cameroon, the Douala General Hospital (DGH) was performed to monitor the evolution of this infection with RT-PCR analysis. The aim of this study was to identify risk factors associated with viremia of samples analyzed by molecular biology at the Douala General Hospital laboratory, in the cont...
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We had previously reported a convolutional neural network (CNN) based approach, called the holistic kinetic model (HK model 1), for detecting 5-methylcytosine (5mC) by single molecule real-time sequencing (Pacific Biosciences). In this study, we constructed a hybrid model with CNN and transformer layers, named HK model 2. We improve the area under...
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The present investigations were undertaken to study antixenosis resistance in selected rice genotypes against brown planthopper (BPH) Nilaparvata lugens(Stal). Settling and egg laying behavior of BPH on selected genotypes along with susceptible and resistant checks was studied. BPH nymphs did not show variation in settling preference at 2 hours aft...
Research
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Useful bibliography, on 75 pages, Environmental science, bioscience, ecology, ecotoxicology, biosphere, aquatic science, water self-purification, Экология, экотоксикология. MSU, and other universities. Публикации. Часть 2. Источник scipeople.ru. This list is on 75 pages. Tags: Environmental science, bioscience, ecology, ecotoxicology, biosphere, aq...
Research
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Useful bibliography, on 37 pages, with favorable evaluations of independent experts. Environmental science, bioscience, ecology, ecotoxicology, biosphere, aquatic science, water self-purification, MSU (Moscow State University) research results, Экология, экотоксикология; with useful links and keywords; in English, in Russian. https://www.researchga...
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Original Research Article Background: The present study examined some relationship between anthropometric parameters; including height, weight, and body mass index (BMI) and athletic performance of male and female student-athletes. Methods: The descriptive statistics measured parameters between male and female athletes and illustrated the mean valu...
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Aims: Evaluate the anti-anemic potential of aqueous root bark extract of Morinda lucida against induced hemolytic anemia in Wistar rats in addition to its total phenol content and its acute toxicity. Study Design: Experimental Design. Place and Duration of Study: Laboratory of Biology and Health, Training and Research Unit Biosciences, Félix Houpho...
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Variable Number Tandem repeats (VNTRs) refer to repeating motifs of size greater than five bp. VNTRs are an important source of genetic variation, and have been associated with multiple Mendelian and complex phenotypes. However, the highly repetitive structures require reads to span the region for accurate genotyping. Pacific Biosciences HiFi seque...
Article
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Metasurfaces have emerged as a rapidly evolving frontier in the fields of optics and photonics, with a growing emphasis on their potential for practical applications. The considerable volume of contributions to the study on metasurfaces has expanded, creating challenges in tracking all the advancements within this dynamic field. In this review, we...
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Recent advances in long-read sequencing (LRS) and assembly algorithms have made it possible to create highly complete genome assemblies for humans, animals, plants and other eukaryotes. However, there is a need for ongoing development to improve accessibility and affordability of the required data, increase the range of usable sample types, and rel...
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Please cite this article as: Khan M.J., Chaudhary S., Ali A. & Manickavasagan A., Ultrasonic extraction of protein from whole navy bean flour: a comparative study on structure, functionality and amino acid profile, Food Bioscience, https://doi. 2 proteomics, amino acid profile, structure and functionality 3 Revised Title [R1]: Ultrasonic extraction...
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Aims: This study aimed to isolate Aspergillus species from peanut (Arachis hypogaea) and toor dhal (Cajanus cajan), extraction and characterize of aflatoxin, assessment of its degradation by Bacillus subtilis metabolites. Study Design: The study was conducted involving sample collection, fungal isolation, toxin extraction, and bacterial degradation...
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Cells possess the remarkable ability to generate tissue-specific 3D interconnected networks and respond to a wide range of stimuli. Understanding the link between the spatial arrangement of individual cells and their networks’ emergent properties is necessary for the discovery of both fundamental biology as well as applied therapeutics. However, cu...
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Objectives Rhizoctonia solani AG-3 is the casual pathogen of tobacco target spot, a serious fungal disease of tobacco that severely decreases yield and quality. To examine the pathogenic mechanisms of this fungus, it is crucial to understand its genetics. The objective of this work was to generate the first fine mapping of a R. solani AG-3 strain f...
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Deep learning (DL), a pivotal artificial intelligence (AI) innovation, has dramatically transformed biosciences, aligning with the surge in complex data volumes to foster notable progress across disciplines such as genomics, genetics, and drug discovery. DL's precision and efficiency outmatch conventional methods, propelling advancements in biomedi...
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Background: The discovery of profound differences in the brain microbiota of Alzheimer’s disease (AD) patients and age-matched controls (AMCs) raised questions of postmortem contamination and bacterial transport processes which could be informed by microspatial heterogeneities. Methods: We performed semiquantitative species-specific bacterial analy...
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Moringa oleifera (Lam.), sometimes known as the “miracle tree,” has traditionally been used in folk medicine for a variety of therapeutic uses. This study explored the antidiarrheal, analgesic, and antioxidant properties of M. oleifera flower methanolic extract using in vivo and in vitro methods. A castor oil-induced secretory diarrhea model in Swi...
Preprint
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Variation in short tandem repeats (STRs) is implicated in Mendelian disease and complex traits, but can be difficult to resolve with short-read genome sequencing. We present STRkit , a software package for genotyping STRs using long read sequencing (LRS) that uses nearby single-nucleotide variants to improve genotyping accuracy without a priori hap...
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Objectives Hygroryza aristata, an aquatic plant native to Southeast Asia, shows a high degree of adaptability to aquatic environments. H. aristata, which belongs to the Oryzeae tribe and is closely related to rice (Oryza sativa), holds potential for crop improvement, particularly in flood tolerance. This study aimed to sequence and assemble the gen...
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The coming decade might see major cuts to the United States Government funding for biomedicine and the mainstreaming of pseudoscience. But your biosciences PhD gives you the problem-solving skills to navigate this maelstrom, especially if you maintain flexibility, optimism, and enthusiasm for uncharted paths.
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Pictures, photo, images, affiliations: Info on active scientists, who made the citations. Their affiliations with the top universities and institutions of U.K., the U.S., Canada, China, Netherlands, Italy, New Zealand, Luxembourg, Austria, Hungary, Brazil, Greece, India, Indonesia, Russia, Australia, Lebanon, Ireland, Mexico, Philippines, Nigeria,...
Article
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I have been investigating and reporting on image manipulation in the bioscience literature since 2011. During this time, several new tools have emerged to streamline the processes of image analysis and reporting. When presenting and discussing examples of scientific image manipulation, a common question is “how do you find this stuff?” Herein, I ou...
Article
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In renal cell carcinoma (RCC), tissue inhibitor of metalloproteinase (TIMP) 3 expression is lost, suggesting that the TIMP3 gene may function as a tumor suppressor gene. Cadmium (Cd) and arsenic (As) exposure may affect the expression of TIMP3. Here we investigate the association of clear cell RCC with TIMP3 polymorphisms, and explore whether TIMP3...
Book
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The Omics Days Abstract Book. An event organized by Plant Health and Integrated Pest Management Branch, The Agri-Food and Biosciences Institute (AFBI) Belfast, Northern Ireland, UK (2025). The Omics fields constitute a recent paradigm in biological research. Based on comprehensive and holistic approaches and analytic tools, the Omics aim at the ex...
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Genomics is the science that investigates the entire organism’s DNA. This has made remarkable strides, influencing our understanding of genomes. This article offers a thorough overview of genomics, outlining its historical progression and branches, including structural, functional, comparative, and mutational genomics. It focuses on genomic analysi...
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Pictures of U.S. universities and institutions whose researchers made citation of environmental science papers of MSU. Multiple photos of U.S. universities and institutions. Citation of enviro. sci. papers of MSU. Researchers and experts, faculty at these institutions cited favorably the results of enviro. sci., bioscience research results obtained...
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Annotation: The present research involves the synthesis of new imidazole derivatives, known for their good biological activity, prepared by the reaction of Schiff bases with the amino acid glycine in the presence of absolute ethanol in a conventional manner. Physical and spectroscopic techniques, including FT-IR spectroscopy, proton and carbon nucl...
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The list of links to 90 Scopus-indexed (and also Web-of-Science indexed) publications of Moscow State University, MSU (Sergei A. Ostroumov and co-authors). The list was edited on 16.03.2025, updated on 17.08.2023. Tags: environmental science, biochemical ecology, biology, water self-purification, ecotoxicology, pollution control, biomembranes, memb...
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In recent years, agroforestry has been gaining increasing interest from several land-based sectors in Northern Ireland, notably agriculture. In Northern Ireland the first agroforestry research programme was established in 1989 at the now Agri-Food and Biosciences Institute (AFBI) station at Loughgall, as part of the United Kingdom (UK) National Net...
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The study of the stereochemistry of organic sulfur compounds has been ongoing for over a century, with S-chirogenic pharmacophores playing an essential role in drug discovery within bioscience and medicinal chemistry. Traditionally, the synthesis of sulfinamides featuring stereogenic sulfur(IV) centers involves a complex, multistep process that oft...
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One major cause of prenatal mortality and morbidity is congenital abnormalities. Knowing the prevalence and etiology of congenital malformations is essential for analyzing trends and improving neonatal care. Objective: the team aimed to evaluate the utility of whole-exome sequencing (WES) in Romanian prenatal care, highlighting its diagnostic effic...
Research
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Editorial on the Research Topic Metabolomics perspectives for clinical medicine, volume II s Metabolomics, including lipidomics, is a rapidly evolving field that profoundly impacts clinical medicine. It facilitates precise disease diagnosis, personalized treatment strategies, and the identification of novel biomarkers and mechanisms of pathogenesis...
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Nanopipette‐based assays have gained widespread applications in electrochemical and analytical technologies, achieving significant advancements over the past decade in DNA sequencing, biosensing, targeted delivery, and bioimaging. The ultrasmall tip size of nanopipettes bridges the gap between the macro‐ and nano worlds, which can be attributed to...
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The NeuGeneration Case Competition is an annual research case competition organized by students in the NeuGeneration Club at Queen’s University. Held during our 10th annual neuroscience conference on January 25th and 26th, 2025, at Queen’s Biosciences Complex, the competition aims to provide undergraduate students with valuable research experience...
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Background Advanced long-read sequencing technologies, such as those from Oxford Nanopore Technologies and Pacific Biosciences, are finding a wide use in de novo genome sequencing projects. However, long reads typically have higher error rates relative to short reads. If left unaddressed, subsequent genome assemblies may exhibit high base error rat...
Preprint
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PiEEG kit is a multifunctional, compact, and mobile device that allows measure EEG, EMG, EOG, and EKG signals. The PiEEG Box incorporates the Raspberry Pi-based PiEEG shield, an EEG electrode cap, a display screen, additional sensors about body parameters and the environment, and other necessary peripherals, software, and an SDK course to learn sig...
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This paper explores the evolution of biosciences in India, tracing its development from ancient to contemporary times and examining its trajectory as a significant player in the global scientific community. The historical roots are deeply embedded in traditional practices such as Ayurveda, which laid the groundwork for early understandings of healt...
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Introduction Hepatitis E virus (HEV) is a major cause of acute hepatitis in humans and recognized as a zoonotic pathogen, with swine serving as a primary reservoir. Despite substantial research, comprehensive analysis encompassing regional variations and pig growth stages within China, as well as the influence of recent biosecurity measures on HEV...
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Determining the stereochemical structures of biomolecules is very important for biomedicine, bioscience, and food safety due to the distinct biological functions of enantiomers. Chiral plasmonic sensors (CPSs) have demonstrated their ultra-sensitive detection ability to a few picogram levels due to the excited superchiral electromagnetic field near...
Preprint
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This protocol describes the single-index PCR procedure for Parse Biosciences Evercode WT and WT Mega v2 kits. Each subpool is barcoded with a single Illumina index on the 3' end of the cDNA library. This acts as the fourth "round" of cell barcoding and must be included in the final cell ID/barcode in order to ensure unique barcodes across subpools...
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CRISPR Detect enables analysis of single guide RNAs (sgRNAs) in studies using CROP-seq or similar methods. Compatible methods generate a polyadenylated transcript containing the sgRNA sequence downstream of a human U6 promoter. When CRISPR Detect is combined with Evercode WT v2, paired sgRNA detection and whole transcriptome expression can be analy...
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Modern stalked crinoids, an important group of echinoderms, represent the ancestral mode of crinoids, and studying their evolution is key to understanding the evolution of echinoderms. In this study, we selected Metacrinus rotundus, a species of modern stalked crinoids, for investigation. We generated M. rotundus transcripts using Pacific Bioscienc...
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Background Periodontitis and bone loss in the maxillofacial and dental areas pose considerable challenges for both functional and aesthetic outcomes. To date, implantable dental barrier membranes, designed to prevent epithelial migration into defects and create a favorable environment for targeted cells, have garnered significant interest from rese...
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Active student involvement and instruction through experience in everyday contexts are pedagogical approaches suitable to promote inquiry-based learning and improve learners’ cognitive skills. Nevertheless, many university and postgraduate courses offer lecture-based instructions of theoretical concepts to the students; little attention is still de...
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The Editor-in-Chief has retracted the article entitled “Lonicerin prevents inflammation and apoptosis in LPS-induced acute lung injury” [1] due to significant concerns regarding the reliability and integrity of the data presented.
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Objective: The development of mechanistic-based modeling and simulation (M&S) tools is essential for advancing our understanding of biological systems. This study presents a novel M&S software tool, Cyborgs Simulator (CybSim), which employs a novel modular modeling paradigm on top of an acausal object-oriented modeling language (OOML)-defined archi...
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Hibiscus, which belongs to the Malvaceae family, is primarily distributed in tropical and subtropical regions. Hibiscus species are known for their large, visually striking flowers, which are highly valued for ornamental purposes and are widely admired. Despite this diversity, the mitochondrial DNA of Hibiscus species remains largely unexplored. He...
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The automated detection of tumors using medical imaging data has garnered significant attention over the past decade due to the critical need for early and accurate diagnoses. This interest is fueled by advancements in computationally efficient modeling techniques and enhanced data storage capabilities. However, methodologies that account for the u...
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Antibodies are valuable biological reagents used in a wide range of discovery research, biotechnology, diagnostic and therapeutic applications. Currently, both commercial and laboratory-scale antibody production is reliant on expression from mammalian cells, which can be time-consuming and requires the use of specialist facilities and costly growth...
Article
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Advancements in sequencing technologies have dramatically transformed genomics research by enabling the analysis of genetic information with unprecedented scale and efficiency. Next-generation sequencing, renowned for its high-throughput capabilities, has significantly reduced costs and expanded the scope of sequencing applications. Among these, se...
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Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in the field of biosciences for their role in intercellular communication in various physiological and pathological processes. Their ubiquitous presence in bodily fluids and cell-specific character...
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The Editor-in-Chief has retracted the article entitled “miR-1 inhibits migration of gastric cancer cells” [1] due to significant concerns regarding the reliability and integrity of the data presented.
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Since its development, scientists have proclaimed that the novel gene editing technology CRISPR-Cas will allow them to modify organisms with unprecedented speed and accuracy. In agriculture, CRISPR-Cas is said to significantly extend the possibilities to genetically modify common livestock animals. Genetic targets in livestock include edits to opti...
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Increasing forage proportion (FP) in the diets of dairy cows would reduce competition for human edible foods and reduce feed costs, particularly in low-input systems. However, increasing FP reduces productivity and may increases methane (CH4) emission parameters. This work aimed to investigate the impact of FP and breed on feed efficiency and CH4 e...
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Parasitic infections pose a significant global health challenge, particularly in areas lacking advanced diagnostic resources. Traditional approaches for detecting and measuring parasitemia in blood films rely on manual microscopy, which is susceptible to human error and subjectivity. The rise of artificial intelligence (AI) offers a viable option f...
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Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approximately one million new cases projected in 2024, worldwide mortality of HNSCC is estimated to reach 50% of detected cases the same year. Patients with ea...
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Environmental enteric dysfunction (EED) is a subacute syndrome characterized by increased intestinal inflammation and permeability that affects children in low-income countries. It is associated with growth and neurodevelopmental deficits, and there is currently no known treatment for EED. VS001 (AmiLyfe Bioscience, LLC, Norwood, MA) is a medical f...
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Vanillin is the significant flavor ingred.ient use in the food industry. There is plenty of microorganisms use for various applications in the field of biosciences. The current study deals with the screening of indigenous bacterial strain capable to biotransform ferulic acid present in corn cob to industrially important food flavor vanillin. On the...
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The analysis of citation flow from a collection of scholarly articles might provide valuable insights into their thematic focus and the genealogy of their main concepts. In this study, we employ a topic model to delineate a subcorpus of 1,360 papers representative of bioethical discussions on enhancing human life. We subsequently conduct an analysi...
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https://www.vibesinkpress.com/store/978-81-972472-4-8-modern-researches-in-biotechnology-and-bioscience?ref=MRBB-01
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Biological accelerator mass spectrometry (AMS) provides ultrasensitive carbon-14 isotopic analysis enabling a deeper understanding of human health concerns by enabling quantification of pharmacokinetics and other molecular endpoints directly in humans. It enables environmentally and human relevant studies of metabolic pathways through the use of ve...
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Connectivity—the flows and exchanges of organisms, materials, and energy within and among watersheds—is a central paradigm in ecosystem science. Changes in those connections have consequences for ecosystem functioning and water quality downstream and upstream. Therefore, connectivity is a cornerstone for federal water protection under the United St...
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Background and Aim: The regulation of energy balance in humans is a complex and ambiguous issue. Various studies have shown the relationship between physical activity and creating a negative energy balance in the body. The aim of this study was to compare the effects of the different exercise types on appetite, calorie intake, calorie consumption a...
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Nonrapid eye movement sleep is characterized by high-amplitude and low-frequency electroencephalography signals. These signals are thought to be produced by the synchronized activity of cortical neurons, demonstrating the alternating bursting (up) and resting (down) states. Here, such an activity is referred to as up–down oscillation (UDO). Previou...
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Root-knot nematodes (RKN) of the genus Meloidogyne are obligatory plant endoparasites that cause substantial economic losses to agricultural production and impact the global food supply. These plant parasitic nematodes belong to the most widespread and devastating genus worldwide, yet few measures of control are available. The most efficient way to...
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Mycoplasmoides cavipharyngis is one of the closest relatives of the highly host-adapted and uncultivable hemotrophic mycoplasma. The complete genome of strain 117C was constructed from long-reads derived from Pacific Biosciences single-molecule, real-time sequencing technology. The genome is organized into one circular, gapless chromosome with a le...
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Copper oxide nanoparticles (CuO NPs) have significant applications in bioscience and biomedicine. Numerous physical and chemical methods exist for synthesizing CuO NPs; however, the biogenic synthesis of nanoparticles using bacterial metabolites offers a sustainable approach to obtaining metal nanoparticles with specific shapes and sizes. In this s...
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The complete genome sequence of Colletotrichum jinshuiense, a goldthread anthracnose pathogen, was sequenced using PacBio Revio and MGI DNBSEQ-T7 PE150. It contains 10 chromosomes, 5 mini chromosomes, a circular mitochondrial chromosome, and 13,129 genes predicted with RNA-Seq data in a 52.13-Mb genome with an N50 of 5.05 Mb.
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HLA‐A*02:01:01:257 differs from HLA‐A*02:01:01:01 by a single nucleotide substitution in intron 7.
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This paper briefly overviews the application of total-reflection X-ray fluorescence (TXRF) spectrometry in the biosciences, focusing on key bioanalytical applications. It seeks to review and update the current state of TXRF’s use in biomedical, biochemical, and pharmacological research. The review highlights relevant works in the field, summarising...
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This Bioscience special issue explicitly focuses on One Health in advancing effective health interventions today and in the future. Interdisciplinarity is emphasized, especially across the biomedical and social sciences. We identify here an important disciplinary perspective yet to be incorporated within this important vision: One Paleopathology wi...
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We have previously described the reformed introductory physics course, collaborative learning through active sense-making in physics (CLASP), for bioscience students at a large public research one university (Original University) and presented evidence that the course was more successful and more equitable than the course it replaced by several mea...
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Background The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood. Objective Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long‐term course of orally administered prednisolone. Animals Eight hea...
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Background Pacific Biosciences (PacBio) circular consensus sequencing (CCS), also known as high fidelity (HiFi) technology, has revolutionized modern genomics by producing long (10 + kb) and highly accurate reads. This is achieved by sequencing circularized DNA molecules multiple times and combining them into a consensus sequence. Currently, the ac...
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Metabolic syndrome (Mets) represents a constellation of metabolic disorders, including diabetes mellitus, obesity, dyslipidemia, and hypertension. Since it is associated with different risk factors of cardiovascular diseases (CVD), studying its prevalence is important. The main objective of this work was to find out the prevalence of metabolic synd...
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Introduction Chronic kidney disease (CKD) is a major public health concern, and early detection is crucial to prevent adverse outcomes. Albuminuria is an early marker and key prognostic marker in CKD, but reliable tools for its detection are limited particularly in low resource settings. We tested the utility of a novel, affordable point-of-care te...
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BioThink: National Academy of Biosciences E-Magzine, Vol. 2, Issue 1, ISSN: 3048-7943.
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Mouse models are vital tools for discerning the relative contributions of host and microbial genetics to disease, often requiring the transplantation of microbiota between different mouse strains. Transfer methods include antibiotic treatment of recipients and colonization using either co-housing with donors or the transplantation of fecal or cecal...
Conference Paper
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This article is specially addressed to the undergraduate and graduate students. Present physics is faced with three most puzzling conundrums due to the recent empirical discoverires of nonlocality in quantum mechanics, dark energy and dark matter in cosmology. The situation is no less serious than the crisis faced at the end of the 19th Century, wh...
Article
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Most live broadcast work in education operates with an expert to novice delivery mode, and in indoor settings such as surgical teaching environments. Those few examples of live broadcasts from outdoor locations have heavy resource requirements, limiting their uptake within Higher Education. Working with undergraduates in a students as partners appr...
Article
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The Southern Ground Hornbill (SGH – Bucorvus leadbeateri) is one of the largest hornbill species worldwide, known for its complex social structures and breeding behaviours. This bird has been of great interest due to its declining population and disappearance from historic ranges in southern Africa. Despite being the focus of numerous conservation...
Article
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Background One hypothesis of lack of effectiveness in most current clinical trials for the AD (Alzheimer’s disease) is the advanced stages of the disease at the time of pharmacological intervention. To aim a robust effect from disease‐modifying therapies, there is an urgent need for biomarkers that can identify patients with MCI and early stages of...
Article
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Background Emerging evidence underscores the importance of neuroinflammation in the progression of Alzheimer’s disease (AD) pathophysiology. Recent studies indicate the involvement of the inflammatory mechanisms both in amyloid‐ β (Aβ) and tau deposition in the brain. Nevertheless, due to the complexity of the immune responses and the intricate int...
Article
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Background The research on Alzheimer’s disease (AD) has substantially advanced in relation to plasma biomarkers, such as pTau217, for the detection of amyloid (Aβ) pathology which identify, with high accuracy, individuals in the AD biological continuum. However, as these biomarkers become abnormal very early in the disease, biomarkers identifying m...
Article
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Background Plasma p‐tau217 is a highly promising biomarker for detecting Alzheimer’s disease (AD) pathology. However, it is unclear how p‐tau217 assays from different sources perform compared to one another. Moreover, studies in diverse cohorts and population‐based settings are limited. We performed a direct comparison of four different p‐tau217 as...
Article
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Background Alzheimer’s disease (AD) is a multifaceted condition associated with various brain pathologies, necessitating diverse biomarkers for precise prognosis, diagnosis, clinical management, and therapeutic development/evaluation. The integration of multiple biomarkers into a single test can enhance efficiency, reduce analytical errors, and sav...
Article
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Background Lewy bodies (LB), the main hallmark of Parkinson’s disease (PD), are a frequent co‐pathology in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). The varying extents of LB pathology in these disorders can influence disease progression and severity. Consequently, understanding LB impact on the proteomic profile of these diseas...
Article
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Background Plasma p‐tau217 is probably the best‐performing blood biomarker to detect brain amyloid‐beta (Aβ) accumulation. However, previous studies were mostly performed in highly selected cohorts. Thus, it is unclear if it can be used independently of confirmatory neuroimaging tests to identify individuals with abnormal brain Ab load in the wider...
Article
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Background The APOE ε4 variant is the largest known genetic risk factor for late‐onset sporadic Alzheimer's disease (AD). Recent blood biomarker models include APOE ε4 status with plasma p‐tau217 for higher accuracy for AD pathology. Thus, protein assays that can accurately determine ε4 carriership simultaneously with plasma p‐tau217 would be advan...
Article
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Background With no effective therapy targeting the pathology of genetic frontotemporal lobar degeneration (FTLD), there is a need for easily accessible biomarkers enabling the development of therapeutic agents and for clinical diagnostics. Thus, we aimed to investigate the proteomic changes in plasma of progranulin (GRN) mutation carriers using a n...