Biopsy - Science method

Amyloidosis is a rare cause of common bile duct (CBD) stricture that often presents with nonspecific symptoms. We herein report the case of a 61-year-old woman with CBD stricture caused by amyloidosis diagnosed through cholangioscopy and confirmed by a biopsy, with subsequent findings identifying it as AA-type amyloidosis. This condition poses diag...

The article highlights the stages of formation and development of colonoscopy from simple rectal examinations to modern video endoscopy. The development of imaging technologies has improved the early diagnosis and verification of colorectal cancer and inflammatory bowel disease, screening of colon tumors. Moreover, it was made possible to carry out...

Case summaryA 4-year-old male castrated domestic shorthair cat presented with a 2 cm painful cutaneous mass on its right lateral abdominal wall. The cat inflicted self-trauma to the lesion site causing secondary ulceration and mild haemorrhage. Fine-needle aspiration or incisional biopsy was advised, along with diagnostic imaging; however, excision...

Hongkongmyces is a genus of particular interest, as its type species was isolated from a biopsy specimen of a patient with an invasive foot infection, making it the only member of Lindgomycetaceae associated with human infections. However, most Hongkongmyces species have been identified as saprobes from freshwater habitats. During our ongoing inves...

O carcinoma de células escamosas é uma neoplasia maligna mais comum na cavidade oral, ocupando o quinto lugar entre os tipos de câncer. Fatores como o tabagismo, o alcoolismo e radiação ultravioleta são importantes determinantes no desenvolvimento da lesão. Os primeiros sinais deste câncer incluem ulceração, endurecida, crostosa, que não cicatrizam...

O exame colposcópico é um procedimento médico detalhado usado para examinar o colo do útero, a vagina e a vulva com um colposcópio, um microscópio com luz e aumento. É indicado para investigar alterações detectadas em exames preventivos, como o Papanicolau, ou sintomas como sangramentos anormais. Durante o exame, o médico pode aplicar soluções de á...

Background/Aim Robot-assisted radical prostatectomy (RARP) outcomes improve with surgical experience, but preoperative prediction of disease stage is crucial to avoid unexpected T stage upgrades, such as pT3b. This study aimed to identify preoperative predictive factors for pT3b (seminal vesicle invasion) following RARP. Patients and Methods Out o...

Perforating dermatoses constitute a group of diseases characterized by transepidermal elimination of dermal ma-terial, manifested as papules with a central keratotic crater, and are mainly described in patients with advanced chronic kidney disease. Erythema annulare centrifugum is a skin pathology associated with multiple comor-bidities. We present...

Cystic lymphatic malformations (CLMs) are rare benign congenital vascular malformations characterized by slow flow and composed of abnormal cystic dilations. The most widely used classification divides them into microcystic, macrocystic, and mixed lesions. Ultrasound is the preferred initial evaluation tool for CLMs due to its non-irradiating natur...

Of the 423 men, 35 (8.3%) had at least one positive screening test. The PSA-based pathway identified 25 men (5.9%), whereas the MRI-based pathway identified 16 (3.8%) with suspicion of PC, with potential to reduce the number of biopsies required by 36%. Subsequent biopsy revealed PC in seven men (1.7%) with a positive PSA test and 14 men (3.3%) wit...

Immune checkpoint inhibitor (ICI)-induced myocarditis is rare but carries a high morbidity and mortality rate. While cardiac magnetic resonance imaging (CMR) is the first-line imaging modality to support diagnosis, the need for endomyocardial biopsy is needed in negative CMR cases.

Giriş: Derin yerleşimli intrakraniyal lezyonlarda stereotaktik biyopsi, cerrahi olarak ulaşılamayan ya da yüksek riskli bölgelerde tanı koymak için tercih edilen, minimal invaziv bir yöntemdir. Bu çalışmada, 2012–2024 yılları arasında uygulanan stereotaktik biyopsilerin tanısal doğruluğu, güvenliği ve klinik sonuçları değerlendirildi. Yöntem: Ondok...

Presentación del caso. Paciente femenina de 43 años, con historia de presentar un tumor en el dorso nasal de ocho meses de evolución, que ha incrementado de tamaño de forma progresiva, y se caracteriza por rinorrea izquierda y dolor en región nasal. Se observa asimetría y una tumoración en región nasal externa izquierda que mide 2 x 2 cm, de consis...

Background: Malignant pleural effusion is defined as the presence of malignant cells in pleural effusion (PE) or biopsy specimens and occurs in 15% of all cancer patients. The most common cause is lung cancer in men and breast cancer in women. The reason for hospital admission is usually shortness of breath. The main goal of treatment is to relieve...

Introducción: el síndrome de Gorlin-Goltz (SGG) es un trastorno genético caracterizado por carcinomas basocelulares, queratoquistes odontogénicos (QQO) y anomalías esqueléticas. Caso clínico: varón de 11 años quien presenta una tumoración indolora en la región maxilar izquierda, con antecedentes familiares de SGG. En el examen físico se evidencia u...

Psoriasis is a chronic inflammatory disease that attacks the skin and can occur at any age with various clinical variations. The diagnosis is generally made clinically, but in atypical cases a biopsy is required for confirmation. The combination of clinical and histopathological examination provides more accurate diagnosis results. This study aims...

Purpose Locally advanced thyroid cancer (LATC) presents significant surgical challenges, with a high risk of incomplete resection and poor prognosis. Patient-derived organoids (PDOs) are a powerful tool to assess drug sensitivity at an individual level and to suggest new treatment options or re-challenge. This study aimed to evaluate the method’s f...

Introducción: La cromoblastomicosis (CMB) es una enfermedad fúngica granulomatosa crónica causada por la inoculación transcutánea de hongos. Sus lesiones polimórficas pueden confundirse con diversas dermatosis, tanto infecciosas como no infecciosas. Este caso se destaca por la dificultad diagnóstica, ya que simula un tumor maligno de la piel, lo qu...

Background In patients who have undergone previous prostate biopsies, surgeons are worried that enucleation may be challenging due to potential adhesions, hematoma, and fibrosis between adenoma and prostatic capsule. Therefore, we aimed in this study to evaluate the impact of previous prostate biopsy on the technique of bipolar transurethral enucle...

Background To report active surveillance (AS) outcomes in patients with Grade Group (GG) 2 prostate cancer (PCa) according to the baseline amount of pattern 4 on image-guided biopsy. Methods Our database includes GG2 PCa patients managed with AS in ten European centers. Results In total, 104 patients were included (median pattern 4: 10%, ranges 5...

Radial mini-probe has emerged as a valuable tool in the interventionist management of peripheral lung lesions. Its major limitation is the existent time lapse between image location and sample collection, which does not occur in real-time and may interfere with the quality and representativeness of the specimen. We present six cases of patients who...

To make surgery more precise and to shorten anesthesia-times for children undergoing surgery for Hirschsprung’s disease, ultra-high frequency ultrasound (UHFUS) has been suggested to replace peroperative biopsy. The study’s aim was to determine quantitatively whether aganglionic and ganglionic bowel segments could be distinguished by UHFUS. Bowel s...

Paciente de 13 años que asiste a la consulta ambulatoria, traído por su madre, del Centro Dermatológico Zacamil, debido a una dermatosis con topografía localizada a la piel cabelluda de la región occipital, presente desde el nacimiento. Se evidencio en su morfología: una neoformación de aproximadamente 2.5x2.5 cm, ligeramente sobre elevada, bordes...

Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer (PC) is the most common of tumor affecting men globally. In Mexico, it is the leading cause of cancer-related deaths, with a high prevalence of metastatic cancer. Although, historically considered controversial, screening programs have proven efficacy in reducing cancer-specific mortality. Our ob...

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare genetic condition caused by mutations in the interleukin-12/interferon-gamma pathway, leading to vulnerability to infection by weakly virulent mycobacteria. IL-12Rβ1 deficiency, the most common cause of MSMD, has rarely been associated with cutaneous leukocytoclastic vasculitis (LCV...

Video-assisted thoracoscopic surgery (VATS) is a widely used minimally invasive approach for diagnostic biopsies of mediastinal masses. Although generally safe, thoracoscopic biopsies can occasionally be complicated by life-threatening events such as hemopericardium and cardiac tamponade. We report a case of a patient who developed a hemopericardiu...

La mastocitosis sistémica es un trastorno raro con acumulación patológica de mastocitos en los tejidos. Los síntomas iniciales más frecuentes son anafilaxia, urticaria, dolor abdominal, diarrea y depresión. Existen otras manifestaciones iniciales menos frecuentes como las lesiones óseas escleróticas. Su diagnóstico se basa en la elevación de tripta...

Osteochondroma is a common benign bone tumor, originating within the periosteum as a small cartilaginous nodule. The distal femur, the proximal tibia, and the proximal humerus are the most common locations and the majority of these lesions cause no symptoms and are discovered incidentally. We present a rare solitary large (approx. 11 cm long) osteo...

La actinomicosis es infección rara causada por Actinomyces spp. Es una enfermedad oportunista, supurativa y granulomatosa, con evolución crónica y presentación variable. Se presenta tres de 11 casos reportados en un hospital de referencia en Cartagena, Colombia, que fueron confirmados por patología. Los pacientes, una mujer y dos hombres con edades...

Background Currently, Endobronchial ultrasound (EBUS) and rapid on-site evaluation (ROSE) are extensively utilized in the clinical practice of respiratory medicine. The combined diagnostic approach has been shown to enhance the clinical diagnostic accuracy; however, certain controversies remain. Methods This study included 200 patients who underwe...

Introdução: O rabdomiossarcoma é um subtipo raro de neoplasia maligna de tecidos moles cujas células são semelhantes a mioblastos. Representa 1% das neoplasias em adultos, com mau prognóstico e alta taxa de recidiva. Neste trabalho, objetiva-se relatar um caso ultrarraro de rabdomiossarcoma alveolar que acometeu a mão de uma paciente adulta, além d...

Progestin therapy is a conservative treatment option for atypical hyperplasia/endometrioid intraepithelial neoplasia (AEH/EIN), particularly for patients seeking fertility preservation or for whom surgery is not feasible. However, approximately 30% of patients exhibit resistance to therapy, underscoring the need for early identification of responde...

O esôfago de Barrett (EB) é uma condição pré-maligna caracterizada pela metaplasia intestinal do epitélio esofágico, frequentemente associada ao refluxo gastroesofágico crônico (DRGE). Sua principal importância clínica reside no risco de progressão para adenocarcinoma esofágico (AEC), um tumor agressivo com alta mortalidade. Este estudo revisa a re...

Background The goal of this research study is to determine the efficacy of dual contrast-enhanced ultrasound (US) in evaluating ductal papillary lesions associated with pathological nipple discharge. Methods A prospective multicenter study was conducted between January 2020 and December 2022. All participants were examined using dual contrast-enha...

Purpose of the Review Radial scars (RS) and flat epithelial atypia (FEA) are benign breast lesions found on core needle biopsies (CNB). Most are still being excised, but there is a recent trend towards observation. In this review, we seek to provide updated treatment recommendations. Recent Findings Upgrade rates to malignancy for RS without atypi...

Non‐specific chest pain may suggest important implications such as pleural metastasis. Therefore, active diagnostic procedures such as thoracoscopy and surgical biopsy should be considered in patients with lung mass without obvious pleural involvement who complain of non‐specific persistent chest pain, even in the absence of specific findings on im...

Objective To understand the variable utilisation of diagnostic biopsy for small renal masses (SRM) across the urology community, we worked with expert clinicians and patients to produce a consensus statement on the role of biopsy and to identify research gaps. Methods In phase I, qualitative interviews were performed to identify potential statemen...

O linfoma epiteliotrópico apresenta lesões como eritema, nodulação e ulceração em áreas como pele hirsuta, lábios e plano nasal. O prurido pode ocorrer, e a condição é associada à perda de peso e linfoadenomegalia. O curso clínico passa por três estágios: Pré-Micótico, com alopecia e prurido; Micótico, com eritema e ulceração; e Tumoral/Nodular, ca...

We present a case of pulmonary hyalinising granuloma, a rare benign disease of unknown aetiology, diagnosed using lung nodule biopsy. Glucocorticoid treatment reduced the nodule size and was effective for 5 years. Prolonged administration of glucocorticoids is associated with adverse events as seen in our patient with persistent inflammation, indic...

Background: Breast cancer is one of the most common types of cancers among women and researchers have been trying to examine it by various methods for several years. Different imaging methods have different precisions and accuracies, so choosing an appropriate imaging method, particularly for women with dense breast tissue, is very important. Since...

Despite positron emission tomography/computed tomography being a powerful evaluation for recurrence of lung cancer, surgical biopsy may still be necessary to confirm the differential diagnosis of Langerhans Cell histiocytosis.

Endovascular inferior vena cava (IVC) mass biopsy emerges as a minimally invasive promising technique for the acquisition of tissue samples for histological analysis, crucial for determining the malignant or benign nature of the lesion and guiding subsequent treatment. This report details the first successful off label use of a low-profile 5.2Fr bi...

A 78-year-old woman underwent an 18 F-FDG PET/CT scan as part of the investigation for giant cell arteritis. This demonstrated active large vessel vasculitis along with a moderately metabolically active pulmonary nodule in the left upper lobe; the appearances of which were concerning for malignancy. Subsequent biopsy of the pulmonary nodule was con...

Extraskeletal chondrosarcoma is a rare malignant tumor arising in soft tissues rather than bones, accounting for less than 2% of all soft tissue sarcomas. This report discusses a 50-year-old female diagnosed with ESC in the left gluteal region. The case highlights clinical presentation, diagnostic workup, treatment, and follow-up. The report unders...

A BSTRACT Lipofibromatosis is a rare and benign soft-tissue tumor predominantly affecting children. It commonly presents as a slow-growing, painless mass, often misdiagnosed due to its rarity and variable presentation. We report the unusual case of an 8-month-old male with a congenital upper thoracic mass initially suspected to be a lipomyelomening...

Purpose: This study aims to evaluate whether MRI-US-guided FB leads to improved diagnostic accuracy compared to SB in detecting csPCa, further assessing whether the TP or TR biopsy approach influences outcomes. Methods: A retrospective, single-center analysis was performed on 851 (Median age 70) patients who underwent combined FB and SB when PIRADS...

Purpose To evaluate the diagnostic performance of a fully automated, commercially available AI algorithm for detecting prostate cancer and classifying lesions according to PI-RADS. Material and methods In this retrospective single-center cohort study, we included consecutive patients with suspected prostate cancer who underwent 3T MRI between May...

O Condrossarcoma é considerado o segundo tumor ósseo mais comum em cães, sendo a excisão cirúrgica a principal indicação terapêutica naqueles casos aplicáveis. O presente trabalho teve como objetivo relatar um caso de exérese de condrossarcoma em costela com consequente correção de hérnia diafragmática iatrogênica devido a remoção da neoplasia. Foi...

Objective To investigate the added value of systematic biopsies in men referred with suspected PCa undergoing visual registration targeted local anaesthetic transperineal prostate biopsies (LATPB) as their first biopsy for MRI‐P visible lesions (MRI Score≥3) in a real‐world setting. Patients and methods The outcomes of 2611 biopsy naïve men with M...

Objective Procedural sedations are a growing and routine form of sedation. Some of them may not require the presence of a nurse. The purpose of this study is to assess the impact of the Medical Radiation Technologists (MRT) model, which forgo the presence of a Registered Nurse (RN), for procedural sedations in Computed Tomography biopsies. The sett...

Evaluar la densidad de antígeno prostático y la relación con los hallazgos de resonancia multiparamétrica (RMmp) de próstata como predictor en el diagnóstico de cáncer prostático. Métodos: El estudio fue tipo descriptivo, retrospectivo, de corte transversal; la muestra se tomó de la base de datos en el sistema Picture Archiving Communication System...

Zusammenfassung Zystische Lungenerkrankungen umfassen unterschiedliche Krankheitsbilder, die oft charakteristische radiologische, klinische und pathologische Merkmale aufweisen. Radiologisch werden Zysten als scharf begrenzte, strahlentransparente Bereiche mit dünnen Wänden definiert, die oft durch Atemwegsobstruktion, Wandnekrose oder systemische...

Purpose Programmed death-ligand 1 expression is heterogeneous in non-small cell lung cancer, and small specimens may not accurately represent the entire tumor. The current study investigated the discordance in programmed death-ligand 1 expression between preoperative biopsy samples and resected specimens. Methods We retrospectively collected data...

Pulmonary Mucoepidermoid Carcinoma (PMEC) is a rare, slow‐growing, low‐grade primary intrathoracic cancer of the tracheobronchial tree that manifests as an exophytic endobronchial tumour with luminal obstruction. Radical surgery is the cornerstone of treatment for low‐grade PMEC. We report a case of a 23‐year‐old woman who presented with intermitte...

We present a case of diffuse cystic lung disease without any known underlying systemic disorder, biopsy confirmed as lymphoid interstitial pneumonia (LIP). This case highlights the benefit of histological confirmation where there is diagnostic uncertainty and the clinical situation permits, particularly in the setting of symptomatic deterioration....

Introducción: los cánceres del tubo digestivo representan una de las principales causas de mortalidad por enfermedades crónicas no transmisibles tanto en Colombia como a nivel mundial. Estos padecimientos suelen ser asintomáticos en sus etapas iniciales, lo cual compromete la supervivencia y constituye un desafío relevante para la salud pública. Es...

Central Nervous System (CNS) tumors constitute a heterogeneous group of neoplasms characterized by considerable morbidity and mortality. Objective: This study aimed to utilize the new classification systems based on Molecular Biology, which, in turn, allow for improved diagnostic approaches and better therapeutic planning. Materials and Methods: Th...

Osseous choristoma constitutes the rarest category of choristoma affecting pediatric ocular regions. It predominantly composed of ectopically ossified tissue, which can involve anywhere in the eye and typically manifest as isolated anomalies. This study presents the case of an 8-year-old male patient diagnosed with epibulbar osseous choristoma. The...

neuro molecular biopsis

Background : Yokenella regensburgei is Gram-negative, oxidase-negative, non-sporing, motile rod with peritrichous flagella . It is rarely isolated from human samples. Case presentation: This a case report of a 52 year old male patient who presented to our centre with a non healing ulcer. A culture from the biopsy sample (from the ulcer) isolated Yo...

Pulmonary lymphoepithelial carcinoma (PLELC) is distinct subtype of primary lung cancer, closely associated with Epstein-Barr virus (EBV) infection. Histopathological features sometimes mimic granulomatous inflammation. We present the case of a woman who was doubted with pulmonary and lymph node tuberculosis based on a pathological demonstration of...

Lymph node management in patients with oral squamous cell carcinoma (OSCC) has been subject to surgical de-escalation. Sentinel lymph node biopsy (SLNB), as established for other entities, has emerged as the standard of care for small OSCC. Moreover, remote access surgery in head and neck oncology, using both a retroauricular approach to the neck a...

Background/Objectives: As endoscopy is increasingly being used to diagnose superficial nonampullary duodenal epithelial tumors (SNADETs), there is a growing need for their early detection and minimally invasive treatment. This study investigated the diagnostic accuracy of biopsy specimens for SNADETs. Methods: We conducted a retrospective analysis...

The appearance of whole slide biopsy images is greatly affected by various factors such as laboratory procedures or the choice of digital slide scanners. The resulting variations in image styles within and across batches of histological images represent one of the major obstacles to the development of generalizable machine learning algorithms. To o...

El lupus eritematoso sistèmico puede iniciar de diversas formas, siendo un desafío diagnóstico. Nosotros reportamos un inusual caso de una paciente pediátrica que debuta con una miositis focal. Caso clínico: Paciente de 11 años presenta cuadro que inicia con lesiones eritematosas en antebrazo derecho de un año de evolución. Se agrega aumento de vol...

Mesenteric schistosomiasis is a rare but significant cause of intestinal obstruction, particularly in endemic regions. We report a case of a 12-year-old boy from Masese Landing Site, Uganda, who presented with progressive abdominal distension, vomiting, and constipation—symptoms indicative of bowel obstruction. Surgical exploration revealed extensi...

Background Precision and operator expertise are critical for bone tumour biopsies. In this study, we investigated the impact of combining a soft guiding template with a laser device on the success rate of computed tomography (CT)-guided bone biopsies and the associated radiation dose. Methods A cohort of 114 patients with bone tumours requiring CT...

Introdução: A fibromatose mamária é uma neoplasia benigna rara. Entretanto, são tumores localmente agressivos, com infiltração e alta taxa de recidiva. Nos exames radiológicos sugerem malignidade. Para definir a natureza do tumor está indicado a biópsia. O tratamento de escolha é a excisão cirúrgica completa com margens livres.Objetivo: Relatar mai...

Plexiform schwannoma (PS) is a rare type of schwannoma, accounting for only 5% of all schwannomas, with most cases occurring in the skin and subcutaneous tissue and showing a predilection for the head and neck region, similar to ordinary schwannomas. The diagnosis is confirmed by the histopathological examination. The therapy of choice is surgical...

Background and objective Although diagnostic efficacy of multiparametric magnetic resonance imaging (MRI) in identifying index lesions (ILs) in prostate cancer (PCa) patients is well established, challenges arise when multiple lesions (MLs) are present. Determination of an optimal biopsy strategy for these patients is crucial. This study aims to as...

Oral Proliferative Verrucous Leukoplakia (PVL) is among the most high-risk premalignancies in humans, with 40-100% developing into carcinoma. It is a persistent, continuously proliferating, often multifocal form of non-homogeneous leukoplakia without traditional risk factors. When multiple cancers arise, the great majority develop at different time...

Purpose MRI-guided prostate biopsies offering improved accuracy in detecting clinically significant cancer. Image fusion (IF) techniques have shown promise, but their adoption requires overcoming a learning curve. This study evaluates the impact of operator experience on prostate biopsy outcomes using the HITACHI ultrasound system. Methods This st...

Introducción. El cáncer de mama continúa siendo un problema de salud públicaa nivel global. Se estima que su incidencia incrementará en los próximos años. Esimportante evaluar a través de indicadores los estudios de escrutinio de las clínicasde mastología con el fin de obtener una adecuada correlación clínica, imagenológicae histopatológica. Objeti...

Background/Objectives: The management of non-lifting colorectal lesions (NLCLs), often resulting from previous unsuccessful treatments or biopsies, remains challenging due to submucosal fibrosis that prevents adequate lifting. Endoscopic submucosal dissection (ESD) is a viable option for achieving complete resection in such cases. However, when sta...

The Sister Mary Joseph nodule is a rare sign of advanced malignancy, including uterine carcinosarcoma. A 55-year-old woman presented with a necrotic, bleeding 4 cm umbilical mass. Biopsy confirmed uterine carcinosarcoma (FIGO stage IVB), and she was scheduled for chemotherapy and radiotherapy. This case underscores the need to recognize umbilical n...

This case demonstrates that Nocardia beijingensis, though rare, must remain a differential consideration in complex systemic presentations. What initially appeared as a straightforward case of musculoskeletal pain and weight loss quickly unraveled into a complex, life-threatening infection. Early biopsy and microbiological identification were pivot...

A 61-year-old female presented to our breast clinic for her annual screening mammogram, which revealed an irregular, spiculated mass in the upper outer quadrant of the right breast suspicious for malignancy. Ultrasound imaging identified the mass within the upper outer quadrant of the right breast, as well as another mass within the right major pec...