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Publications related to Biomolecules (10,000)
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Extensive research over the past decades has shown that sugar ester (SE)-type biomolecules bring long-chain fatty acids with sugar moieties into the plant cells and play various important roles in food, surfactants, innovative green materials, and biological properties. Thus, in this study, dimolar isopentanoylation of methyl α-D-glucopyranoside (c...
Poster
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This Special Issue focuses on the topics of broad agricultural applications using nanosized materials or nanocarriers/particles. Studies that explore the design and synthesizing of functionalized or multifunctional nanoparticles, utilizing nanocarriers for biomolecule delivery or gene manipulation, the control of plant disease or pests via nanosize...
Article
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Cells receive, and adjust to, various stimuli, which function as part of complex microenvironments forming their “context”. The possibility that a given context impacts the response to a given stimulus defines “context-dependency” and it explains large parts of the functional variability of physiopathological and pharmacological stimuli. Currently,...
Article
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The physicochemical nature of DNA allows the assembly of highly predictable structures via several fabrication strategies, which have been applied to make breakthroughs in various fields. Moreover, DNA nanostructures are regarded as materials with excellent editability and biocompatibility for biomedical applications. The ongoing maintenance and re...
Article
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Synthetic DNA is a growing alternative to electronic-based technologies in fields such as data storage, product tagging, or signal processing. Its value lies in its characteristic attributes, namely Watson-Crick base pairing, array synthesis, sequencing, toehold displacement and polymerase chain reaction (PCR) capabilities. In this review, we provi...
Article
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Nanoscale imaging of biological samples can provide rich morphological and mechanistic information about biological functions and dysfunctions at the subcellular and molecular level. Expansion microscopy (ExM) is a recently developed nanoscale fluorescence imaging method that takes advantage of physical enlargement of biological samples. In ExM, pr...
Article
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The past decade has witnessed a rapid growth of graphene plasmonics and their applications in different fields. Compared with conventional plasmonic materials, graphene enables highly confined plasmons with much longer lifetimes. Moreover, graphene plasmons work in an extended wavelength range, i.e., mid-infrared and terahertz regime, overlapping w...
Article
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Brain diseases, including tumors and neurodegenerative disorders, are among the most serious health problems. Non-invasively high-resolution imaging methods are required to gain anatomical structures and information of the brain. In addition, efficient diagnosis technology is also needed to treat brain disease. Rare-earth based materials possess un...
Article
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Extracellular vesicle (EV) secretion is a highly conserved evolutionary trait in all organisms in the three domains of life. The packaging and release of EVs appears to be a bulk-flow process which takes place mainly under extreme conditions. EVs participate in horizontal gene transfer, which supports the survival of prokaryotic and eukaryotic micr...
Article
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Adequate serotonin levels are pivotal to human well-being; thus, serotonin can be used as a biomarker because it regulates a wide range of physical and psychological functions. As an imbalance of serotonin is highly likely to initiate the pathogenesis of various disorders, monitoring serotonin levels in real time is in high demand for the early det...
Article
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Liquid-liquid phase separation (LLPS) has received significant attention in recent biological studies. It refers to a phenomenon that biomolecule exceeds the solubility, condensates and separates itself from solution in liquid like droplets formation. Our understanding of it has also changed from memebraneless organelles to compartmentalization, mu...
Article
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Raman microscopy has been used to deduce information about the distributions of endogenous biomolecules without exogenous labeling. Several functional groups, such as alkynes (CC), nitriles (CN), and carbon-deuterium (C–D) bonds, have been employed in recent years as Raman tags to detect target molecules in cells. In this article, we review some re...
Article
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Luminescence chemosensors are one of the most useful tools for the determination and imaging of small biomolecules and ions in situ in real time. Based on the unique photo-physical/-chemical properties of ruthenium(II) (Ru(II)) complexes, the development of Ru(II) complex-based chemosensors has attracted increasing attention in recent years, and th...
Article
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This study explores the entropy generation analysis on unsteady nonlinear radiative ethylene glycol‐based Casson nanofluid flow near stagnation point towards a stretching sheet through a porous medium. Analysis has been accomplished in the presence of an inclined magnetic field, heat generation, homogeneous–heterogeneous reactions, and viscous diss...
Article
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Among the different techniques for mass analysis, ultra‐high‐resolution Fourier transform ion cyclotron resonance (FTICR) is the method of choice for highly complex samples, as it offers unrivaled mass accuracy and resolving power, combined with a high degree of flexibility in hybrid instruments as well as for ion activation techniques. FTICR instr...
Article
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Purpose of Review Graphene is introduced in dentistry as a material to be used in the fabrication or coating of dental implants due to its biocompatibility, ability to physically interact with biomolecules and very high surface area. This review highlights the current knowledge on the general properties of graphene, potential benefits especially wh...
Article
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The leaf extract of Senna alata (SA) was employed as a bio-reducing agent to prepare the bioactive Ag-NPs. The FTIR spectrum of Ag-NPs revealed the existence of biomolecules in SA leaf extract. The formation of Ag-NPs was confirmed by analyzing their XRD profile. The SPR band at 434 nm in the UV spectrum also supported the formation of Ag-NPs. The...
Article
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Pump–probe experiments at X-ray free-electron laser (XFEL) facilities are a powerful tool for studying dynamics at ultrafast and longer timescales. Observing the dynamics in diverse scientific cases requires optical laser systems with a wide range of wavelength, flexible pulse sequences and different pulse durations, especially in the pump source....
Article
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Hairy root cultures serve as a useful tool in the experiments aiming to understand plant biology (e.g. functional analysis of gene function) which affects their use in biotechnology. Due to their numerous valuable features hairy root cultures provide an economic yet secure platform to produce active biomolecules. Hence, these cultures are mainly ex...
Conference Paper
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A carbohydrate is a biomolecule consisting of carbon, hydrogen and oxygen atoms, usually with a hydrogen-oxygen atom ratio of 2:1 (as in water) and thus with the empirical formula C m (H 2 O) n. In the article, the linear and cyclic chains of the carbohydrates were drawn on a sheet horizontally and vertically. The two-dimensional tetragonal and hex...
Article
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Research on innovative surface functionalization strategies to develop materials with high added value is particularly challenging since this process is a crucial step in a wide range of fields (i.e., biomedical, biosensing, and food packaging). Up to now, the main applied derivatization methods require hazardous and poorly biocompatible reagents,...
Preprint
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Detection of enantiomers is a challenging problem in drug development as well as environmental and food quality monitoring where traditional optical detection methods suffer from low signals and sensitivity. Application of surface enhanced Raman scattering (SERS) for enantiomeric discrimination is a powerful approach for the analysis of optically a...
Article
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Background A fused method using a combination of multi-omics data enables a comprehensive study of complex biological processes and highlights the interrelationship of relevant biomolecules and their functions. Driven by high-throughput sequencing technologies, several promising deep learning methods have been proposed for fusing multi-omics data g...
Article
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Due to its chemical properties, glyphosate [N-(phosphonomethyl)glycine] is one of the most commonly used agricultural herbicides globally. Due to risks associated with human exposure to glyphosate and its potential harmfulness, the need to develop specific, accurate, online, and sensitive methods is imperative. In accordance with this, the present...
Article
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Nanoparticles exhibit diverse self-assembly attributes and are expected to be applicable under unique settings. For instance, biomolecules can be sandwiched between dimer nanoparticles and detected by surface-enhanced Raman scattering. Controlling the gap between extremely close dimers and stably capturing the target molecule in the gap are crucial...
Article
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Arsonolipids represent a class of arsenic-containing compounds with interesting biological properties either as monomers or as nanostructure forming components, such as arsonoliposomes that possess selective anticancer activity as proven by in vitro and in vivo studies. In this work, we describe, for the first time, the synthesis of novel arsono-co...
Article
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Herbal medicines have played a critical role in the treatment and prevention of some diseases. Among a diversity of natural medicinal sources, Citrus hystrix DC. is an outstanding plant broadly distributed in tropical regions. Citrus hystrix DC. has many biological activities, and it has been used in traditional medicine for treating various illnes...
Article
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Current medications used to treat alcoholic liver injury (ALD) can cause secondary damage to the liver. Therefore, it is important to improve alcoholic liver injury from the perspective of dietary and nutritional supplementation. Nucleic acids, as functional biomolecules, are present in almost all foods, especially in aquatic products, but their ed...
Article
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From the top-down view, an organism is constituted by an assembly of cells where a network of molecules interacts to create a regulated complex system. Cells are a universe of molecular interactions maintained under non-equilibrium regimes. The complex network of interactions drives life where DNA and epigenetic signals are considered as the memory...
Article
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Zileuton (ZLT) is an active oral inhibitor of enzyme 5-lipoxygenase, and long-term intake and overdose of ZLT cause adverse effects, leading to critical conditions in patients. This is a well-recognized issue that necessitates a better approach for ZLT sensing. Given the increasing interest in ZLT sensing and the limitations of previous techniques,...
Article
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In symbioses established through horizontal transmission, evolution has selected for mechanisms that promote the recruitment of symbionts from the environment. Using the binary association between the Hawaiian bobtail squid, Euprymna scolopes, and its symbiont, Vibrio fischeri, we explored the first step of symbiont enrichment around sites where V....
Article
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In recent decades, artificial nerve scaffolds have become a promising substitute for peripheral nerve repair. Considerable efforts have been devoted to improving the therapeutic effectiveness of artificial scaffolds. Among numerous biomaterials for tissue engineering scaffolds fabrication, natural polymers are considered as tremendous candidates be...
Preprint
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The MArtini Database (MAD - www.mad.ibcp.fr) is a web server designed for the sharing structures and topologies of molecules parameterized with the Martini coarsegrained (CG) force field. MAD can also convert atomistic structures into CG structures and prepare complex systems (including proteins, lipids etc.) for molecular dynamics (MD) simulations...
Article
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Since ancient times, reduction and internal fixation has been applied to restore skeletal integrity. Despite advances in the understanding of fracture healing, the risk of complication such as implant loosening or implant-related infection still depicts a challenging complication. Nowadays, a great deal of research is devoted to unreveal the impact...
Preprint
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X-ray free-electron lasers (XFELs) produce X-ray pulses with high brilliance and short pulse duration. These properties enable structural investigations of biomolecular nanocrystals, and they allow resolving the dynamics of biomolecules down to the femtosecond timescale. Liquid jets are widely used to deliver samples into the XFEL beam. The impact...
Article
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Fluorescence polarization (FP) has been applied in detecting chemicals and biomolecules for early-stage diagnosis, food safety analyses, and environmental monitoring. Compared to organic dyes, inorganic nanomaterials such as quantum dots have special fluorescence properties that can enhance the photostability of FP-based biosensing. In addition, na...
Article
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In September 2015, the ONU approved the Global Agenda for Sustainable Development, by which all countries of the world are mobilized to adopt a set of goals to be achieved by 2030. Within these goals, the aim of having a responsible production and consumption, as well as taking climate action, made is necessary to design new eco-friendly materials....
Article
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In recent years, cannabis (Cannabis sativa L.) has been legalized by many countries for production, processing, and use considering its tremendous medical and industrial applications. Cannabis contains more than a hundred biomolecules (cannabinoids) which have the potentiality to cure different chronic diseases. After harvesting, cannabis undergoes...
Article
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A highly sensitive silicon nanowire (SiNW)-based sensor device was developed using electron beam lithography integrated with complementary metal oxide semiconductor (CMOS) technology. The top-down fabrication approach enables the rapid fabrication of device miniaturization with uniform and strictly controlled geometric and surface properties. This...
Article
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Background Wound healing has become a worldwide healthcare issue. Attempts in the area focus on developing patches with the capabilities of avoiding wound infection, promoting tissue remolding, and reporting treatment status that are of great value for wound treatment. Results In this paper, we present a novel inverse opal film (IOF) patch based o...
Article
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In this study, paired blood plasma (BP) and blister fluid (BF) samples from 5 paediatric burn patients were analysed using mass spectrometry to compare their protein and metabolite composition. The relative quantification of proteins was achieved through a label‐free data independent acquisition mode. The relative quantification of metabolites was...
Article
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This review focused on sol-gel silica materials for surface modification of scaffolds for bone reconstruction. These silica materials can be tuned to adsorb and release specific biomolecules involved in bone reconstruction. This tuning can be possible by changing the synthesis parameters as the pH, the solvent or the presence of surfactant or by mo...
Article
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Annually the number of people with diabetes is increasing. Therefore diagnosing this disease in the early stages to save human lives is a great challenge. Different strategies have been reported for the monitoring and treatment of diabetes such as:lable-free detection of abnormal biomolecules,sensors for exhaled breath anlysis, biosensor based phot...
Article
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A low-cost and reliable detection of hydrogen peroxide is essential in the pharmaceutical, medical, and food industries, since H2O2 can cause irreversible cellular damage through the oxidation of biomolecules. This paper describes a sensitive luminescent sensor for H2O2 based on a dual fluorescence-colorimetric assay for determining the hydrogen pe...
Article
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Abstract Saccharomyces cerevisiae (S. cerevisiae) has been studied as a model microorganism to understand the mechanism of glutathione (GSH) production. Furthermore, magnetic field (MF) application is a novel approach to stimulate microorganism metabolism to increase growth and produce more biomolecules. This study aimed to evaluate whether GSH pro...
Article
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The present study focuses on synthesis of novel high-performance acrylic acid (AA) grafted polyethersulfone (PES) ultrafiltration (UF) membranes for purification of small therapeutic biomolecules such as urea, insulin, and cobalamin. The membranes were indigenously synthesized by adding polyethylene glycol (PEG) of 6 kDa M.Wt. as a pore former and...
Article
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Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown. Many biomolecules in the cytoplasm transition from the liquid phase to the agglutinated phase are known as liquid-liquid phase separation (L...
Article
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Phosphoinositide 3-kinase δ (PI3Kδ), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of this protein causes cellular dysfunctions in many human disorders , for example, inflammatory and autoimmune diseases, includi...
Article
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The compartmentation is critical for cells in carrying multifunctions. Besides the inner membrane system, which segregates space in cells for assembling reaction centers, phase separation could also concentrate biomolecules. Phase separation is a kind of biomacromolecular condensation driven by intrinsically disordered regions and weak multivalent...
Article
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The exceptional adhesive properties of polydopamine (PDA) and its ability to perfectly fix various biomolecules and metal ions are conducive for the development of appropriate modifications of implant surfaces. Over the recent years, several combinations of different substrates and surface modification molecules and/or ions have been tested effecti...
Article
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The National Aeronautics and Space Administration (NASA) and the European Space Agency (ESA) are studying how to improve the safety of future planetary science sample return missions that would bring back materials to Earth. Backward planetary protection requirements have been identified as a critical technology development focus in order to reduce...
Article
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In this paper, a photonic crystal fiber sensor is proposed with four open-ring channels that enhances sensor performance with increased coupling features. By detecting the optical spectrum of leakage from the fiber core to the channels, the sensitivity of the sensor can be assessed. Gold is used as the plasmonic material coated on titanium oxide fi...
Article
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Developing environmentally acceptable and reliable nanoparticle production technologies is a crucial step in nanotechnology. Because of their unique chemical, physical and biological properties, AgNPs have the potential to be used in various ways. As potential agents, biomolecules got from a variety of plant components were used to make it. Despite...
Article
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In the present study, the biosynthesis of silver nanoparticles (AgNPs) and their antibacterial activity against gram-positive and gram-negative bacteria were investigated. Glycyrrhizin (GL) was used as a reducing agent and stabilizer to rapidly prepare the AgNPs. The distinctive absorption peak at 419 nm confirmed the formation of GL-reduced AgNPs....
Article
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Background Major histocompatibility complexes (MHCs) play a crucial role in the cell-mediated adaptive immune response as they present antigenic peptides (p) which are recognized by host T cells through a complex formation of the T cell receptor (TCR) with pMHC. In the present study, we report on changes in conformational flexibility within a pMHC...
Article
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Aging is one of the causative agents associated with heart failure. Cell-based therapies show potential in the treatment of cardiac aging due to the characteristics of stem cells, including differentiation and the paracrine effect. This study aimed to investigate in detail the mechanism related to biomolecules released from mesenchymal stem cells i...
Article
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This paper focuses on the development of DNA-based stable porous aerogel membrane (PAM) via a one-pot crosslinking reaction with genipin. Meanwhile, seaweed polymer agar was added during the fabrication of the porous aerogel membrane with the desired stability and porosity for sustainable water separations. PAMs were analysed using advanced analyti...