Questions related to Biomedical Instrumentation
I am working on a project on biomedical instrumentation. So, in the data samples we have only taken five different values of pressure and corresponding to that we have measured around 80 values of voltage each. The issue that we are facing now is we are not able to find a suitable relation between pressure and voltage, for example for any particular value of input voltage, our instrument should give pressure as output( not necessarily from the same five values of pressure). Can anyone suggest which regression model should we imply?
I'm looking for a blood pressure device/module/kit which outputs raw data (serial or wireless, digital or analog). Usually, the information from these devices is on-screen only or, if Bluetooth, connected to an app that does not permit you to access the raw data.
I need to develop an instrument that measures the pressure data from the sphygmomanometer and processes it in a microcontroller to send it elsewhere.
I couldn't find this kind of solution anywhere. I'm already thinking of buying an analogical sphygmomanometer and hacking a pressure sensor in it. What do you think?
I am currently using the Seahorse Bioscience XFp to characterize my cells and assess their baseline energetic activity. However, I am having some difficulty in measuring the DNA content, as the wells of the plates are 40% smaller than a regular well of a 96-well plate. I am also using Hoechst dye 33258. However, increasing the dye concentration affects the linearity of my standard curve and my samples often do not fall on my curve. I currently normalize with protein but prefer DNA. Any assistance provided will be greatly appreciated.
I am a master candidate, i need to do a thesis related to the topic.
I would like to know your ideas about updated research topic on the field of controls and biomedical instrumentation.
I have been trying to data and wave capture from Philips IntelliVue Monitor using Matlab for our research studies in real time. Does anyone have some code they are willing to share? The community's help in this important matter?
We are working on dry electrodes and are wondering how to understand chemically what happens.
- How exactly are gel based silver electrodes measuring electrical activity? (how are electrons produced, what is happening at the interface with the skin, how is it related to the electrical activity of the body?
Thanks a lot :)
Photo-acoustic biomedical instrumentation will be a trend in the future. It uses very high sound frequency (in 100's of GHz) way above ultrasound range (1MHz to 18MHz). If there is anyone who is familiar with the technology, who is working with such a project, please let me know and give some of your ideas here.
I have been having problems with lifting off my devices. I thermal evaporate Cr (5 nm) and Au (60 nm). Apparently, the Au doesn't want to come off completely. I have severe cross talks between channels because the Au are still connected between the interdigited fingers.
I cannot ultrasonic my sample because my sensing material, graphene will rupture right away. I can only agitate the stripping solution lightly. Please advise!
SPR 220-4.5 data sheet: http://www.microchem.com/PDFs_Dow/SPR%20220%20DATA%20SHEET%20R%26H.pdf
My procedures are as following:
(1) SPR 220
Spin SPR 220 at 500 rpm for 5sec (acceleration 250 rpm/sec)
and 4000 rpm for 40 sec (acceleration 1000rpm/sec)
Recipe: Supposedly 4 um according to data sheet
Softbake: hotplate 30 sec ramp to 115°C then hold for 90 sec
(2) Photolithography of Mask
Equipment: Karl Suss Mask Aligner
Hard contact mode
Expose: 38.3 sec [ Photospeed around 345 and Intensity: 9 ]
Development: MF-26A (80 s)
Rinse with DI water and dry with nitrogen gun
(3) Cr and Au deposition
Equipment: Kurt J. Lesker Thermal Evaporator (Nano 36)
Recipe: low deposition rate
Thickness: Cr 5 nm then Au 60 nm
Time: 1 hour
(4) Metal Liftoff
Equipment: Wet Bench
Recipe: Soak the substrate in Acetone bath at room temperature
Time: 1 hour
(4 Alternative) Metal Liftoff
Equipment: Wet Bench
Recipe: Soak the Stripper 1165 at room temperature or 80 degree celcius
Thanks in advance!
I am an electrical engineer and a doing my post graduation in instrumentation and control. I want to work in the field of biomedical engineering like bio medical instrumentation and bio medical signal processing. suggest me some areas which will be suitable for me to work.
Which is more accurate among all commercially available personal glucometers to measure glucose concentration in water-glucose samples? Is there any rating available for personal glucometers based on the performance?
I am working on psychoacoustic active noise control. I want to design an psychoacoustic model for sound quality measurement. I went through the book of Zwicker's loudness: Psychoacoustic Facts and Models.
I am not able to understand how to write the program in matlab to calculate the loudness.
I have obtained impedance spectrum for single cell in experiment.
How to extract parameter in equivalent circuit based on this impedance spectrum?
Previoius studies showed that it is possible to evaluate fetal heart rate by heart sound signal. I wish to examine the previous methods. I am grateful if someone can share fetal heart sound records with me.
I am not professional about compressed sensing (CS). I know CS can reconstruct the texture of the original image from highly undersampled data if some conditions are met. However, I have no clue how CS algorithms do to the noise. Is it possible that compressed sensing reconstructed image in MRI maintains or improves SNR comparing to fully sampled original image?
I am developing an instrument - A. I have calibrated it against a reference instrument B which is believed to be very accurate. Now, I again tested 13 fresh samples in both the instruments and found out the percentage errors. Does it make sense to report a Bland Altman plot analysis to measure the agreement between the two instruments ? Technically one instrument - A is calibrated based on the reference and accurate instrument - B.
I am in need of detecting Inspiration phase of respiration cycle continuously in real time suggest me the best sensor type (Flow /Pressure /Thermal)?
I am hoping to find answers for an issue that I am facing when using LumiCycle from Actimetrics. I have been using U2OS cells with Per2-Luciferase in it, which has given me stable rhythmic outputs consistently. Over the last few months, I have encountered a strange problem when the signal dies off at the end of Day 3 after plating while previously it used to continue till day 7. This problem is erratic as it comes and goes. I have changed the batch of my cells, used fresh lumicycle media, luciferin, cell densities while plating etc. When the signal is lost, the cells still look healthy and there is definitely no contamination in the media, nor is there any loss in the volume of the media since they were set up. The problem is at times seen on all the channels or in some channels while the other channels are just fine.
I was wondering if anyone experienced in working with this instrument has encountered any similar problem and would appreciate any assistance or direction to resolve this issue.
I'm not very tech-savy when it comes to cameras, so I'm not sure how "cheap" I can go with a camera and still get good motion tracking results. What are the important specs in commercial cameras / webcams? Or, alternatively, is there a dedicated source of motion-tracking specialized cameras that I don't know about (and that aren't incredibly expensive)?
My lab will continuously processing a low volume of tissue samples. We want something relatively small, easy to clean up and maintain and preferably something that can sit on a bench top. Any recommendations?
how do you convert an ADC digitized numeric value (0...255 for 8 bit) to a voltage, i.e. how do you figure out what voltage does this number represents ?
I am looking for a wideband powerful monolayer LED in order to substitute the filament lamp in a microscope, any suggestions? Thank you.
I want to know the instrumentation facilities for cardiac pressure and haemodynamic analysis for rats in chennai or any part of Tamilnadu.
Which force is needed to make an implant move/grow through soft tissue? There seems to be a threshold to be overcome by stents (or other implants) to make them grow through tissue. Too low means no growing through. Too high would create lesions. The only reported force I know is from bracelets on the teeth (nearly constant 1-2 N for extraction).
Is there anything known for soft tissue? Ideally for stents in atrial walls? Which biological processes enable this kind of "growing through"? How could i foster it?
I'd be thrilled to hear about your input!
In previous there are many way to measuring biological information with and without driver knowledge but in my research i am used mixed signal processor and motion level detector and biological information sensors,and driver activity monitoring sensors are used to detect and find vehicle and driver activity for reference.So i want know how to interface these are the components without driver awareness biological information measurements?
I am working with cut and coagulation signals produced using electrosurgical units applied in organic tissue.
I am looking for database for these kind of signals produced by commercial units (electrosurgical devices). Could someone, please,
suggest an internet database? Thanks in advance.
as we know the bypass sugery cost much... one of the reason of that is everytime sugrery is done we have to change the oxygenator... so if can sterlize that oxygenator that can reduce the cost of surgery
We are treating A549 cells with pulsed electric fields. The media becomes more redish after prolonged treatments (11 hours). When the cells are returned to the incubator overnight, the PH changes back to its 'normal' look (less red). Is it possible the electric fields are changing the PH of the media during our experiments? Or perhaps just having them out of the incubator would cause the media to turn more redish? The media has phenol red in it.
Does anybody still use old-school electrooculography (EOG) outside the sleep lab and has experience with the type of electrodes to use? We are starting a project with mobile EOG and used ECG electrodes (which are too large and induce considerable drift over time). Since we are interested in the short-term change of the signal (aka scanpath behavior), it is quite important that the drift is minimal...
So again: Which electrodes are best?
I need clear each and everything about instrumentation setup from basic alignment to final calibration of pump-prob spectrometer. I need all laser systems functional procedure and what are the safety measures to be taken and consider while in this experimental arrangements? Give some basics to advance ideas to setup this facility. Each and every aspects of ideas will be appreciated and make an excellent setup to be utilized many researchers for their research works.
Hello Every one,
I am working on pretreatment of lignocellulosic biomass, I am facing a problem while preparing a smear for SEM analysis of pretreated sawdust. please let me know the smear preparation in-detail and suggest me one of the best methods.
Thanking you All.
I want to build this device, but I wonder if anyone has a schematic or PCB design of this system.
Preferably without using piezoelectric sensors.
Though many research groups are active in making this device from so many years, why nobody has come up yet with a great accuracy? I know calibration is one of the toughest parts.
Like many labs we are trying to stretch our budget. We've been growing primary neurons in a shared incubator, but now need to purchase our own.
From a microbiological point of view is this a bad idea?
I am interested in studying the natural mechanisms that change the appearance of the prostate under conditions of high pressure including herniation through the bladder neck and anteroposterior axis elongation.
Shall I try to tighten the screws around the hydraulic system or call the technician?
I want to construct new lab in neurodegeneration using transgenic animals and cell lines and I need to know the most important for the studies such as fluorescence and other main used devices.
I am trying to find a way to mathematically calculate the cardiac output (CO) and stroke volume (SV) from vital sign parameters such as arterial blood pressure (ABP), end tidal CO2 (etCO2), ECG, heart rate (HR), pulse oximetry (SpO2), and non-invasive blood pressure (NIBP).
Are there any mathematical formulas that can provide CO and SV from vital signs monitoring parameters? I'm trying to compare the results from a commercial-based hemodynamic device and mathematically calculated results using vital sign parameters from a patient monitoring device in the OR.
Does anyone know of an IV Infusion Pump that is FDA approved and has the ability to access the communication port to perform Closed Loop control system for clinical research purposes?
I would like to develop an electrical bio-impedance based cancer diagnosis system, but I have a doubt that which excitation approach is better. Does anyone has any idea on this? Thanks in advance.
At the moment I am trying to start a protocol involving cannulas implantation in specific regions of rat and mouse brains, and for that I will need to buy a stereotaxic instrument. I found a lot of alternative companies to buy from but I am particularly focused on two of them. If anyone can give me feedback about the instruments from Stoelting and World Precision that would be really good.
Suggestions needed regarding some previous works done in the field of measuring mechanical properties of human brain cortex tissue.
Also the response to stress, strain, compression force that any electrode implanted in the cortex in the top 5-6 mm range will experience.
I'm trying to monitor oocyte and embryo vitrification process using a tiny micro-camera which requires at least x400 augments. Have you any recommendation?
I am currently studying gait and posture analysis. What are the factors that you need to consider while dealing with pressure sensors? (Example: type of sensors used in force platforms)
I have two Ag/AgCl electrodes and a circuit to obtain SCL signal. While doing experiments I observed that when I left electrodes open and used two fingers and touched on two electrodes, it took a period of time for SCL signal to rise a stable value (let's call it rising time). The curve is similar to the capacitor voltage vs. time in RC circuit. When I used the inner side of a palm to touch on these two electrodes it took much longer time to rise to a stable level. During the experiments, there was no stimulus hence, the rising time was not the 1-3s rise time of SCL signal after the appearance of a stimulus. I think it's because of the capacitance of the skin. However, I am not sure which part of the finger or palm (skin or inner tissues) causes that. Is the simplified equivalent circuit of the electrodermal system explained in http://www.bem.fi/book/27/27.htm sufficient enough?
Could anyone help me to answer this question?
What is the typical threshold for tetanic contraction and how much variability might there be in humans? Is there a relationship between fatigue and frequency? When would higher frequencies be needed (e.g. to overcome some degree of axonal degeneration as a result of a nerve electrode implantation)?