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Questions related to Biology
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To save life in desminopathy, can the body purposefully reduce muscle mass, for example, due to decreased heart function or for another reason?
It is known that when hypothermia, the body sacrifices limbs for survival. Is it possible with desminopathy a similar phenomenon?
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Dear Ioana-Dana Ganta, Asif Bilal, Fakhira Afzal, thank you very much for your answers!
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Human activities have greatly changed the natural environment since the Industrial Revolution. Have migratory birds changed their migration routes? Why can migratory birds do this?
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Hi Shu, Yes, James is right, in Google Scholar you can fin many citations.
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Does the DNA remain stable or degrade at this temperature? Would there be any difference in thermal stability between supercoiled and linear forms of say, 3 kb plasmid.
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The question of the structure of DNA is not a question of the origin of the Universe. It must and can be solved experimentally. But for this you need to have a desire to know the truth. The problem is lack of desire.
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Hello everyone,
I did the assembly of chloroplast genomes for some Boraginaceae species, in a few species, I got an orientation problem where the rbcl gene position is within the circular shape in a clockwise direction, and the atpB and atpE genes position is are outside the circular shape in the anti-clockwise direction (please see the picture), and this is a different result from most assemblies of chloroplast genomes that have been published !!!. (usually, the rbcl gene is outside the circular shape and in the anti-clockwise direction while the atpB and atpE genes are within the circular shape and in a clockwise direction)
I am using Chlorobox to draw the gene map after Novoplast finishes the assembly, this issue happened with only two of 7 samples, the two samples are from the same family !!!, I change the seed and reference many times and still got the same result.
Any idea what I need to fix this?
Thanks!
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I think that maybe you have used blunt end digestion endonucleases, this makes inserts to be ligable in both directions (as your experimental results suggest). If that's the case, maybe this information is useful:
Both the Costa and Weiner or Delphi genetics Staby methods could fix this orientation problem.
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Hi,
I wonder if anyone knows how to use sample release reagent from Sansure Biotech ?
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Hi,
The supplier claims that their "sample release reagent" (nucleic acid release technology), can lyse pathogens at room temperature very fast, with no need to heating, centrifuging or replacing tubes, the sample DNA/RNA can be extracted quickly through simple operations. The reagent is applied for the pretreatment of nucleic acid molecules, to release them from specimens, then the released nucleic acids can be used for clinical in vitro diagnosis or for the detection through appropriate apparatus.
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The 2023 ranking is available through the following link:
QS ranking is relatively familiar in scientific circles. It ranks universities based on the following criteria:
1- Academic Reputation
2- Employer Reputation
3- Citations per Faculty
4- Faculty Student Ratio
5- International Students Ratio
6- International Faculty Ratio
7- International Research Network
8- Employment Outcomes
- Are these parameters enough to measure the superiority of a university?
- What other factors should also be taken into account?
Please share your personal experience with these criteria.
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Cenk Tan; There are, of course, several websites that rank the universities worldwide. However, QS is the most famous of which.
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I was able to study biology but not enough to understand the difference between B-phycoerythrin and R-phycoerythrin. Quite "simply" could someone answer to this question? Can we switch from one form to another? :)
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B-Phycoerythrin (B-PE), a fluorescent protein from phycobiliprotein family, is isolated from cyanobacteria and eukaryotic algae. Its primary absorption peak is at 545nm with a secondary peak at 563nm. B-PE consists of α, β and γ subunits and is present as (αβ)6γ. B-PE and the closely related R-PE are the most intensely fluorescent phycobiliproteins having orange fluorescence. They are significantly brighter and more photostable than conventional organic fluorophores. B-PE labeled streptavidin, primary and secondary antibodies have been widely used in applications such as flow cytometry and multi-color immunofluorescent staining.
While
R-phycoerythrin (R-PE) is an intensely bright phycobiliprotein isolated from red algae that exhibits extremely bright red-orange fluorescence with high quantum yields. It is excited by laser lines from 488 to 561 nm, with absorbance maxima at 496, 546, and 565 nm and a fluorescence emission peak at 578 nm. R-PE is a large molecule used for fluorescence-based detection, primarily in flow cytometry, microarray assays, ELISAs, and other applications that require high sensitivity but not photostability.
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Hello everyone:
Like Darwin reading Malthus "for amusement", I've been reading the 2nd chapter, "Systematics and Evolution", of the 3rd edition of "Vertebrate Biology", by Donald W. Linzey (2020).
When reading the section on "Species and Speciation" in this chapter, and more specifically when reading about the founder effect and its relationship with the origin of new species, I found the following sentence: "(...) speciation can proceed rapidly since only a portion of the original gene pool is normally present in the small, newly relocated population, and NATURAL SELECTION CAN WORK MORE QUICKLY ON SMALLER GENE POOLS" (capital letters are mine).
To the best of my knowledge, mathematical models of natural selection include parameters like relative fitness and/or selection coefficients, whereas population size is included in models for the evolutionary effects of random genetic drift.
So, do you have any idea on the reasons why natural selection could go faster in small populations (i.e., small gene pools)?
Any help will be welcome. Best regards, and thanks in advance:
Jose.
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Hello; Small samples taken from a large pool will not reflect the gene distribution of the larger pool. Founders' effects, genetic bottlenecks, etc. are what are under discussion and the basis for many examples of speciation. The extreme example might be parthenogenetic species arising from hybridization. Fun stuff! Cheers, Jim Des Lauriers
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Hi! I am a 3rd year biology student, and currently working on my undergraduate thesis, which has an objective to determine the presence of metallothioneins on several candidates from different microalgae genera. But, I don't have a background on various bioinformatics tool, may I ask if you know any software that could possible help me achieve my study's motive? Thank you
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You might want to look at this recent paper:
Bioinformatic prediction of putative metallothioneins in non-ciliate protists
Sergio Balzano and Angela Sardo
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I am a student of biotechnology and an independent SARS CoV-2 researcher from India. For finding the academia research status and analysis of the integration of innovation with research, I have created a set of Multiple choice type questions about your experience as a researcher. The google form requires nothing but your honesty and openness for research. Feel free to ask questions and DM. The questions will assist in gauging the level of innovation and writing in academia.
If possible, please do forward this little form to your fellow researchers and other amazing scientists. I would be highly grateful.
Thank you
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I would be happy to help; please let me know how, Joel
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If I wanted to introduce a foreign protein into the human stomach without it getting cleaved up by proteases such as trypsin, how would I do so?
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Hello Chris Lee
You may introduce protective groups that will help prevent enzymatic degradation of the foreign protein.
Cyclization of foreign protein can increase its half-life by protecting it from the digestion of exo- and endopeptidases. Cyclization of peptides and proteins generate more rigid conformations, and it exhibits decreased susceptibility to enzymatic degradation.
You can also protect the foreign protein from proteases by covalently attaching it to a biocompatible polymer, leading to reduced immunogenicity, enhanced bioavailability, and enriched pharmacokinetic profile.
For more information, you may refer to the attached paper.
Best.
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Complex systems are becoming one of very useful tools in the description of observed natural phenomena across all scientific disciplines. You are welcomed to share with us hot topics from your own area of research.
Nowadays, no one can encompass all scientific disciplines. Hence, it would be useful to all of us to know hot topics from various scientific fields.
Discussion about various methods and approaches applied to describe emergent behavior, self-organization, self-repair, multiscale phenomena, and other phenomena observed in complex systems are highly encouraged.
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Jiří Kroc: Greetings Prof. Kroc. In neurology the cutting-edge research is on 1) neurodegeneration, 2) neuroprotection, 3) the unification/entanglement between the nervous system and the immune system and 4) disorders of consciousness. thanks, Mustafa.
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In my previous question I suggested using the Research Gate platform to launch large-scale spatio temporal comparative researches.
The following is the description of one of the problems of pressing importance for humanitarian and educational sectors.
For the last several decades there has been a gradual loss in quality of education on all its levels . We can observe that our universities are progressively turning into entertaining institutions, where students parties, musical and sport activities are valued higher than studying in a library or working on painstaking calculations.
In 1998 Vladimir Arnold (1937 – 2010), one of the greatest mathematicians of our times, in his article “Mathematical Innumeracy Scarier Than Inquisition Fires” (newspaper “Izvestia”, Moscow) stated that the power players didn’t need all the people to be able to think and analyze, only “cogs in machines,” serving their interests and business processes. He also wrote that American students didn’t know how to sum up simple fractions. Most of them sum up numerator and denominators of one simple fraction with the ones of the other, i.e. as they did it, 1/2+ 1/3 according to their understand is equal to 2/5 . Vladimir Arnold pointed out that with this kind of education, students can’t think, prove and reason – they are easy to turn into a crowd, to be easily manipulated by cunning politicians because they don’t usually understand causes and effects of political acts. I would add, for myself, that this process is quite understandable and expected because computers, internet and consumer society lifestyle (with its continuous rush for more and newer commodities we are induced to regard as a healthy behavior) have wiped off young people’s skills in elementary logic and eagerness to study hard. And this is exactly what the consumer economics and its bosses, the owners of international businesses and local magnates, need.
I recall a funny incident that happened in Kharkov (Ukraine). One Biology student was asked what “two squared” was. He answered that it was the number 2 inscribed into a square.
The level and the scale of education and intellectual decline described can be easily measured with the help of the Research Gate platform. It could be appropriate to test students’ logic abilities, instead of guess-the-answer tests which have taken over all the universities within the framework of Bologna Process which victorious march on the territories of former Soviet states. Many people can remember the fact that Soviet education system was one of the best in the world. I have therefore suggested the following tests:
1. In a Nikolai Bogdanov-Belsky (1868-1945) painting “Oral accounting at Rachinsky's People's school”(1895) one could see boys in a village school at a mental arithmetic lesson. Their teacher, Sergei Rachinsky (1833-1902), the school headmaster and also a professor at the Moscow University in the 1860s, offered the children the following exercise to do a mental calculation (http://commons.wikimedia.org/wiki/File:BogdanovBelsky_UstnySchet.jpg?uselang=ru):
(10 х 10 + 11 х 11 + 12 х 12 + 13 х 13 + 14 х 14) / 365 = ?
(there is no provision here on Research Gate to write square of the numbers,thats why I have writen through multiplication of the numbers )
19th century peasant children with basted shoes (“lapti”) were able to solve such task mentally. This year, in September, this very exercise was given to the senior high school pupils and the first year students of a university with major in Physics and Technology in Kyiv (the capital of Ukraine) and no one could solve it.
2. Exercise of a famous mathematician Johann Carl Friedrich Gauss (1777–1855): to calculate mentally the sum of the first one hundred positive integers:
1+2+3+4+…+100 = ?
3. Albrecht Dürer’s (1471-1528) magic square (http://en.wikipedia.org/wiki/Magic_square)
The German Renaissance painter was amazed by the mathematical properties of the magic square, which were described in Europe firstly in Spanish (the 1280s) and Italian (14th century) manuscripts. He used the image of the square as a detail for in his Melancholia I painting , which was drawn in 1514, and included the numbers 15 and 14 in his magic square:
16 3 2 13
5 10 11 8
9 6 7 12
4 15 14 1
Ask your students to find regularities in this magic square. In case this exercise seems hard, you can offer them Lo Shu (2200 BC) square, a simpler variant of magic square of the third order (minimal non-trivial case):
4 9 2
3 5 7
8 1 6
4. Summing up of simple fractions.
According to Vladimir Arnold’s popular articles, in the era of computers and Internet, this test becomes an absolute obstacle for more and more students all over the world. Any exercises of the following type will be appropriate at this part:
3/7 + 7/3 = ? and 5/6 + 7/15=?
I think these four tests will be enough. All of them are for logical skills, unlike the tests created under Bologna Process.
Dear colleagues, professors and teachers,
You can offer these tasks to the students at your colleges and universities and share the results here, at the Research Gate platform, so that we all can see the landscape of the wretchedness and misery resulted from neoliberal economics and globalization.
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Every time i working with hyaluronic acid I got some bubbles inside gel. It desn't matter in lab and do not affect on the acid. Few days ago I saw syringe (with a needle) with clear hyaluronic acid without any bubbles. Friend send me a photo of bottle with the product without bubbles too. How do they made it??? I was trying vacuum suction but did not get proper effect.
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Problem solved. Thanks to all!
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Hello everyone, any system can be thought of as a collection of its fundamental building blocks. There are well defined fundamental parts in certain systems (attached image) like the basis vectors for a vector space or the 5 fundamental tastes. Then there are systems where the fundamental parts aren't as well defined but we can still think of the best candidate parts for such systems. For example,
  1. Colours: RGB
  2. Nations: Government, Bureaucracy, Civilians, Judiciary.
Which principal or fundamental parts can be thought of as the building blocks of fruits and vegetables? I can think of a few:
  1. Sugar content
  2. Vitamin content
  3. Citric acid content
  4. Skin
Can we come up with a master list of all possible principal components which are the bare minimum to construct any fruit or vegetable?
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A rephrasing of the question to make it a bit clearer:
Imagine you have the power to create any fruit/vegetable out of thin air (F&Vman). What minimum amount of data would you need to make a specific fruit/vegetable with your power? (let's use apple as an example for the discussion)
You want to earn a living by doing this so you wish to standardize the process. For that, you need an exact list of basic/fundamental characteristics of F&V (both, regarding their physicality and their chemical make-up) from your customers that can be used to make almost any, if not all, F&V.
That list is what I'm looking for.
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Also, kindly check the following link that may be useful:
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Compiled allometric data might help to detect scaling patterns.
Or similarities in the scaling relationships might suggest connections otherwise too subtle to find.
Does such a list exist?
Does such a list exist for biological phenomena?
If such lists do not exist should they?
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No such compilation that I know of (only some reviews, for the scaling of a specific trait in a specific group). So regarding your last question "should it exist", I think creating such a list would be an admirable but difficult task - depends on what you're thinking of exactly as "all known instances". Using all the raw data available would basically be a "database of everything", virtually impossible. It would still take a ton of work to even make a list of every allometric equation ever explicitly stated for every trait in every organism, and you'd also need to be able to update it, and to subset it by trait, taxa (down to intraspecific resolution, don't forget), external factors such as region/temperature/season/age/sex, etc.
(btw if somebody does go and make such a database it should definitely be named ALLometric right?)
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Hello everyone,
I need help understanding whether my two groups are paired or not.
I am collecting data from one group of cells. We have developed two different workflows (let's call them A, and B) for data analysis. We want to test whether these two workflows give the 'same' results for the same set of cells.
At the end, I obtain:
  1. Group 1 (contains the variable obtained with workflow A)
  2. Group 2 (contains the variable obtained with workflow B).
I have been considering the two groups as independent because the two workflows do not interfere with each other. However, the fact that both workflows operate on the same cells is throwing me off and I am wondering if these groups are actually paired.
Could you advise me on this and on what test is best to use?
The hypothesis for the test would be:
  • the distributions of the variable is the same with both workflow A and B; and/or
  • the median of the distribution from workflow A equals the one from workflow B
Thank you.
GN
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If you have two samples, from two measurement methods (workflows), but from the same subject (single group of cells), then you can use a paired samples test.
The benefit of this is that it has more statistical power than an unpaired test.
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Over the last few months, I have come across several posts on social media where scientists/researchers even Universities are flaunting their ranking as per AD Scientific Index https://www.adscientificindex.com/.
When I clicked on the website, I was surprised to discover that they are charging a fee (~24-30 USD) to add the information of an individual researcher.
So I started wondering if it's another scam of ‘predatory’ rankings.
What's your opinion in this regard?
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Dear friends, I am a master's student in biology. Now I need to added drug to the medium after being diluted into PBS. How much PBS can be added to the medium without affecting the cell growth. The medium I use is DMEM and 10% serums
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Hello Chaoqun Huang,
Its seems that the drug of your interest is water soluble. If it is so, then I would suggest to make the stock solution fist in sterile distilled water and then final working concentrations in Dulbecco′s Modified Eagle′s Medium (DMEM) culture medium. Make sure that the solvent (here water or PBS) final amount should not literally exceed more than 1% in culture medium in order to avoid disturbance in physical, chemical proprieties, and concentrations of other component of the culture medium.
DMEM is a modification of Basal Medium Eagle (BME) that contains four-fold concentrations of the amino acids and vitamins. The original formulation contained 1000 mg/L of glucose and was used to culture embryonic mouse cells. Since then, it has been modified in several ways to support primary cultures of mouse and chicken cells, as well as a variety of normal and transformed cells. It is a widely used basal medium for supporting the growth of many different mammalian cells including primary fibroblasts, neurons, glial cells, smooth muscle cells, as well as cell lines such as HeLa, 293, Cos-7, and PC-12 etc.
Hence, addition of large amount of solvent (here water or PBS) may alter/dilute the constituents of DMEM specifically made for specific type of cell culture or purpose. In any condition, try to ensure that the solvent present in final working concentration is not more that 1% (v/v) in DMEM culture medium in order to retain the osmolarity and other ingredients concentration in culture medium.
Good luck
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Example:
1. You use Material 1 in Biology and after using it, you recycle it in Chemistry to come up with Material 2.
2. You use Material 1 in Biology and then its product is used in Chemistry, Physics, Earth Science.
3. Or any related activities that make use of similar or related ideas.
If you can share also your related studies, I highly appreciate it. Thanks!
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I used 1 material in biology lab and recycle it that's used it in Field work
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Like I want to prepare a senior secondary Biology Subject curriculum block for instruction.
I need the block format, the contents examples etc
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I'm a maths teacher by profession - but here's a few bullet points:
* allow time to pre-assess find out what learners know already
* allow time to cycle through the curriculum twice,
* once at the level the pre assess indicates and to set the ground work of the big picture,
* cycle through the curriculum a 2nd time to either review what wasn't learned or teach to greater depth what was learned
* use retrieval practice questions to follow on from teaching (in maths about 30% of learners forget what they learned in less than a week, but if reviewed by questions within e.g. 5 days and depending on response 2 further weeks or fewer, the retention for learners will be much higher).
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As far as I know it has been dismissed as a closed cased of the history of science having no defenders left. However, that's not the feeling I get when the issue comes up in private discussions. I'm wondering if I have missed something, and if and how vitalism (or some refined modern form of it) is still considered to be a viable option by some biologists?
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Vital force(s) are beyond materialistic description as is very carefully explained by @Reza Sayed . Yet, the recent discoveries on the effects of cell membrane potential on cancerous growth, morphological development, regrowth of organs and limbs that is led by Professor @Michael Levin [1,2] are telling us that it is possible to shift materialistic description of forces shaping living entities a bit further into that was up to a recent time assumed to be undescribable using materialistic science. Electricity plays indispensable role in morphogenesis.
The way, the biological systems think is closely related to self-organizational and their emergent properties when observed from the materialistic point of view. There are observed some very interesting effects within experimental and computational studies, many of them are shared in my projects and are part of my research on emergents in biology [4-6].
Emergents are one of the crucial parts of every single living system in existence. As already said in one of the first answers, emergents are not equal to living systems because we do observe them in non-living systems too.
As a mathematician working in complex system applied to living entities, it is well-known fact to me that emergent behavior is one of the crucial parts of living creatures. Emergence is not sufficient to explain life, but it is its inseparable constituting and organizational feature.
My research brings me in this area and hence, I decided to find out robust emergent structures in simple (very primitive) massive-parallel computational environment called a cellular automaton, which serves as an oversimplified proxy of living system [3].
Surprisingly, it was found that we can construct a simple cellular automaton called r-GoL (robust Game of Life), which is resistant against random injection of one percent of errors into the computation. In other words, emergents do not collapse when subjected to a certain fraction of faulty operations [3].
From the point of view of living systems, it means that we do have means of construction of deterministic rules, which produces emergent structures, that are resilient against errors. This means nothing less than that we are capable to construct reliable computations above unreliable hardware/wetware.
Life itself is very probably exploiting unreliable computational media that is giving rise to very robust emergent and reliable emergent structures. 
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[1] Brook Chernet, Dany S Adams, Maria Lobikin, and Michael Levin: "Use of genetically encoded, light-gated ion translocators to control tumorigenesis", Oncotarget 7(15):19575-19588 (March 2016) DOI: 10.18632/oncotarget.8036
[2] Chris Fields and Michael Levin: "Does evolution have a target morphology?", Organisms: Journal of Biological Sciences 4: 1, 57-76. (August 2020) DOI: 10.13133/2532-5876/16814
[3] Jiri Kroc: "Why Do Biology and Medicine Need to Study Robust Massive Parallel Information Processing Environments: Explained on the Game of Life and Its Generalization?", ResearchGate (Feb 2022) https://www.researchgate.net/publication/358446061_Why_Do_Biology_and_Medicine_Need_to_Study_Robust_Massive_Parallel_Information_Processing_Environments_Explained_on_the_Game_of_Life_and_Its_Generalization
[4] Project: "Complexity in Medicine: Practical Problems, Their Definitions, Models, and Solutions", ResearchGate, March 7, 2020,
[5] Project: "Complex Systems in Physics, Biology, and Medicine: Backgrounds, Understanding, Modeling, and Software", ResearchGate, April 3, 2017, https://www.researchgate.net/project/Complex-Systems-in-Physics-Biology-and-Medicine-Backgrounds-Understanding-Modeling-and-Software
[6] Project: "Complexity Digest -- Toolkit Containing Root Research Results, Articles, Books, and Software -- Covers Emergence, Self-Organization, and Beyond", ResearchGate, February 11, 2020, https://www.researchgate.net/project/Complexity-Digest--Toolkit-Containing-Root-Research-Results-Articles-Books-and-Software--Covers-Emergence-Self-Organization-and-Beyond
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Most biologists and philosophers understand vitalism as the doctrine of the entelechy, originally proposed by the German biologist Hans Driesch in the early twentieth century. According to Driesch, entelechies were nonmaterial, bio-specific agents responsible for governing a few peculiar biological phenomena. Current attitudes towards vitalism and the doctrine of the entelechy are almost universally negative. Numerous biologists and philosophers today endorse this metaphysical refutation of vitalism. For them, since all events and processes in the world, from the metaphysical point of view, must be identical or reducible to some material (or physical) events and processes, there is no room for nonmaterial agents such as entelechies. The addition of the information instead of the concept of entelechy will change the perspective on vitalism.,
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You might dispense with entelechy or élan vital in favor of information (à la Shannon & Weaver), but wouldn't the resulting theory be a replacement of vitalism with an information-theoretic biology rather than an updated vitalism?
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Hello,
my name is Carolin Fischer, a sociology student from the Friedrich-Schiller-University Jena. I am currently writing my Bachelor's Thesis in the field of Cultural and Environmental Sociology. As this will be a qualitative study on environmental topics I am looking for interview partners, who work (or used to work) in the field of environmental and climate change research. The interviews will be held via video chat either in German or English.
If you're interested in being interviewed and in helping me with my thesis please feel free to contact me via Research Gate or mail: fischer.carolin@uni-jena.de
Thank you and kind regards,
Carolin
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Hi there Carolin,
sounds like a great topic for a BA thesis :-) I'm interested in your project - potentially also in participating as an interviewee. What precisely are you investigating in your research?
Feel free to contact me at Julius.Riese@web.de
With best wishes from Berlin,
Julius
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Can you please suggest what could be the possible reasons for the confirmation of only 4 out of 13 genes (by qPCR), not all 13? Have anyone observed the same ChIP-qPCR validation issues? Any PubMed suggestion would be great. Thank you for your help in advance.
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Hi Amit
getting results from one experiment and failing to reproduce in an other experiment can allow you the differences and biases from both techniques. maybe you could look at the specificities of all your primers and see what's different in the 9 remaining genes. for instance you can check for specificity by testing your primers in silico at the UCSC website (http://genome.ucsc.edu/cgi-bin/hgPcr).
all the best
fred
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For thinking - in regard to overtaking "believes, dogmas"
Blind adoption of believes, dogmas by people in populations (Psychology of the Crowd, by Gustave Le Bon) seems to be psychologically coupled and physically from a social scientific point of view explainable:
here, too, synchronization within masses occurs
- and it seems also in accordance to the Kuramoto model.
For this, only a corresponding marketing strategy, seems to be necessary (applied maths / physics).
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Basis:  Yoshiki Kuramoto assumed in 1975 that there is a weak relationship (better coupling) of oscillating systems (oscillators) and that these are almost identical. Kuramoto found that mathematically between each pair of coupled oscillators, their interaction is sinusoidally dependent on the respective phase difference, resulting into the so-called *Kuramoto Model* This even can be illustrated using initially non-synchronous metronomes, which in the course (under certain conditions: moveable surface) synchronize themselves.
This even seems a basic model in nature, biology, chemistry, physics and/or social sciences: – synchronizing of coupled systems:
– collective flasing of fireflies [Buck 1988]
– collective oscillation of pancreatic beta cells [Sherman 1991]
– the heartbeat synchronized with ventilation [Schäfer 1998]
– pedestrian induced oscillations on bridges [Strogatz 2005]
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References
-Kuramoto, Yoshiki (1975) Self-entrainment of a population of coupled non-linear oscillators. In: Araki H (eds.) International Symposium on Mathematical Problems in Theoretical Physics, Lecture Notes in Physics, Volume 39, Springer-Verlag Berlin, Heidelberg. DOI: 10.1007/BFb0013365.
-Buck J (1988) Synchronous rhythmic flashing of fireflies, IIi. Q Rev Biol (63)3), 265–289. DOI: 10.1086/415929.
-Sherman A, Rinzel J (1991) Model for synchronization of pancreatic betacells by gap junction coupling. Biophysical journal 59(3), 547–559. DOI: 10.1016/S0006-3495(91)82271-8.
-Schäfer C, Rosenblum MG, Kurths J, Abel HH (1998) Heartbeat synchronized with ventilation, Nature 392(6673), 239–240. DOI: 10.1038/32567.
-Strogatz SH, Abrams DM, McRobie A, Eckhardt B, Ott E (2005) Theoretical mechanics: Crowd synchrony on the millennium bridge, Nature 438(7064), 43–44. DOI: 10.1038/43843a.
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Credit 'spontaneous synchronization of metronomes' video
#psychology #synchronization #nature #physics #chemistry #biology
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Yes, Björn, these phenomena of spontaneous synchronization of motions include the so-called nano-resonance or Egorov resonance, which explains, for example, the nature of the well-known narrow and intense optical J-band, where, under certain (resonant) conditions, the electronic motion and the motion of the nuclear reorganization of the environment are synchronized. There are good reasons to believe that nano-resonance plays an important role in the life of living organisms.
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Kindly discuss your ideas and viewpoints on the origin of life and the RNA world hypothesis.
What are the contradictory views on why researchers are still unsure about the origin of life through RNA or such analogous molecular intermediate pre-cursors preceding its existence?
"The general notion of an “RNA World” is that, in the early development of life on the Earth, genetic continuity was assured by the replication of RNA and genetically encoded proteins were not involved as catalysts. There is now strong evidence indicating that an RNA World did indeed exist before DNA- and protein-based life. However, arguments regarding whether life on Earth began with RNA are more tenuous. It might be imagined that all of the components of RNA were available in some prebiotic pool and that these components assembled into replicating, evolving polynucleotides without the prior existence of any evolved macromolecules. A thorough consideration of this “RNA-first” view of the origin of life must reconcile concerns regarding the intractable mixtures that are obtained in experiments designed to simulate the chemistry of the primitive Earth. Perhaps these concerns will eventually be resolved, and recent experimental findings provide some reason for optimism. However, the problem of the origin of the RNA World is far from being solved, and it is fruitful to consider the alternative possibility that RNA was preceded by some other replicating, evolving molecule, just as DNA and proteins were preceded by RNA." - Robertson and Joyce
[This is as per the explanation by Michael P Robertson and Gerald F Joyce in the article: "The origins of the RNA world." published in the Cold Spring Harb. Perspect. Biol. 4, a003608 (2012).]
The scientific community must resolve this contradicting conjecture through rational discussion and debate backed by strong experimental evidence on what must be the pre-cursor molecule to the Origin of Life if it is not RNA!
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Dear Mrutyunjaya,
I am not really in a position to assess the likelihood of an RNA World scenario for the origin of life on Earth. However, I would like to point out that from an astrobiological standpoint, I think that we should keep an open mind on the huge variety and broad range of potential (evolutionary) pathways leading to life. Moreover, a lot also depends on the precise definition of "life" and from which stage or time onwards we classify certain phenomena as "life". If life exists outside of Earth, it may look very different to what we have become accustomed to on our "pale blue dot". Once we have confirmed at least a second, independent instance of a living system in the universe, we may also see clearer on how probable a RNA World scenario may have been for the case of Earth (even if we may never be able to reconstruct and verify the exact pathway...).
Thanks & all the best,
Julius
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Yesterday I have read a news stating that The embryo fossil, nicknamed “Baby Yingliang,” was discovered in Ganzhou, Jiangxi Province in southern China, and is believed to be at least 66 million years old. Researcher Dr. Fion Waisum Ma told the AFP news agency that the discovery is “the best dinosaur embryo ever found in history” (globalnews, 2021).
Although there were several discoveries of Dinosaur components such as:
Eggs
DNAs from thier remains
are frequently being discovered, Since the biotechnology development is in its Zenith at 2022, Why nobody has attempted to create a dinosaur?
What type of scientific constraints would be encountered in such a laboratory experiment?
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The science fiction book Jurassic Park and the movies based on it are about recreating dinosaurs by extracting their DNA from the guts of dinosaur-biting insects trapped in amber.
DNA is not sufficiently stable to survive for the necessary 65 million years or longer since dinosaurs roamed the Earth, so dinosaur DNA is not available. What you would do with it, if you could get it, in order to recreate dinosaurs is another issue.
The oldest DNA ever recovered was recently reported from 1.2 million year old mammoth teeth in Siberia.
It has been seriously proposed to recreate mammoths, which went extinct several thousand years ago. Mammoth DNA is available from animals preserved in permafrost.
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I consider doing research relating biomechanics to the quality of food people eat, but the methodology to access what people eat seems a strong limitation. Questionnaires/surveys seem to be the way, but the accuracy of the information may be questionable, and the reported habits may not necessarily explain the current biology of the cohort. How do you all approach investigating the quality/quantity of food intake?
I'm curious to know your thoughts!
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Another way is to utilise Computer vision /ML approaches to extract the food content, and from that, a picture of the dietary habit can be built. As an example
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Dear colleagues, our lab is having a new project in synovial fluid processing. We need filtered from all the cells SF.
Does anyone have experience in filtering the SF sample through 0.22 um filters? If it is possible to isolate the cells and keep them (maybe in case of filtering via a vacuum system, not via just syringe and filter).
One more question: what is your typical protocol to get synovial fluid cells spun?
Best regards,
Mariia, PhD in Biology, Ukraine
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Please check the following references :-
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Hi Academics,
Kindly could you clarify the meaning of the term " Researcher"?
Best.
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In my opinion, a true researcher is someone who try to find solutions for the well-being and prosperity of humanity and not to serve individual / personal interest.
That's why a good researcher should be modest, generous and have perseverance since this capacites or should I say personality traits make (in my own vision) a huge difference to qualify a person as a reserahcer since intelligence / competence alone are not enough.
Best wishes,
Sabri
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Hi everyone,
I seed MCF-7 cells (15000 cell/well) into 96-well plates using DMEM with 10% FBS. They seem equally distributed after seeding. However, after 24h incubation they kind of clump into each other and does not show their usual morphology. They just look very weird, I don't know how to describe it so please see the attached photo.They grow perfectly fine in flask with same growth medium (second photo, 24h incubation after splitting).
I do this procedure for 3 years and never had a problem like this. It would be highly appreciated if you could comment what can cause this.
Thank you
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Based on my experience, I would suggest you these points, that you may consider-
First, MCF7, growing in clumps is not an issue, but a common phenomenon. It shall depend on the density of cells. Simultaneously, I thing 15000 cells for a 96 well plate is on a higher side. You should try 7000 cells and repeat the same experiment. Let the cells settle and adhere for the 1st day, then you may start your treatment or further experiment. I have used this concentration for most of my experiments, that are published. Alternatively, you may try standardising the cell count from 5k to 15k, and use the cell density of your choice.
Secondly, I am presuming that there is no contamination and all your media constituents, pH, Incubator temperature, CO2 level, etc all are ok. You may consider analysing what exactly have changed in supplies. If any thing remarkable, like Brand of 96-well plate, new Medium, etc., consider reverting it back to that you were using initially.
And Finally and most important point is that the cells might have undergone many passages and entered Senescence Phase. Its then time to replace and discard cells and use a new stored vial or procure new lot of cells.
Try these and let me know, if it helps!!
Regards
Dr. Satyam Kumar Agrawal
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I'm looking for journals in the field of biology/ecology or on the topic of plastic pollution that publish short article types: a short communication or a natural history note for example. I have a few of these spin-off stories from my main research, which are interesting enough to publish but don't come close to a full research article. All suggestions would be welcome!
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You can check if "Microbiology resource announcement" will be good
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Is it possible to use Artificial Intelligence (AI) in Biological and Medical Sciences to search databases for potential candidate drugs/genes to solve global problems without first performing animal studies?
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We hypothesize that future generations of Artificial Intelligence (AI) technologies specifically adapted for biological sciences will help enable the reintegration of biology.
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Taxonomy (a branch of biology), for example, is a basic science discipline that primarily deals with the identification, classification, and nomenclature of plants. It also contributes to biodiversity and conservation. However, it has been largely overlooked in recent times due to the fact that it has been unable to grow broader impacts or, maybe, due to other emerging applied fields. This question is being posed to discuss the broader impacts of basic sciences in general, and taxonomy in particular.
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Basic science are the backbone of all advance research and technology..it will give you a proper insight for the innovative technology.for example if take aquaculture unless and until you are not able to identify the species your future research will be vain.so all basic science should be studied and then future research and enterpinersh I can be developed.
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How are "levels" of thought or processing validly seen as hierarchical? This turns out to be a very basic and important question, BECAUSE most often behavior Researcher(s) decide what is at one "level" and what is involved with another "level" and a [supposed] relationship is seen that is thought to be hierarchical (one level using the previous ones (which is fine and good), <- BUT all these "levels" are also seen subjectively). This is a damned poor way of classifying, if [supposedly] for science purposes: it is quite arbitrary and subjective (and task dependent). WHAT'S THE ANSWER?
For those who understand Piaget, the better Answer for what are hierarchical "levels" is: there is a hierarchy developing/unfolding/emerging where qualitative (big differences) in processing occur AND .... This also clearly indicates the Subject 'sees' differently .... The only strictly empirical way to account for all this is that a new "level" involves seeing more or different things or significantly seeing certain things ANEW (in a different way); all those possibilities, in Ethogram Theory, are explained by perceptual shifts (at the beginnings or inceptions of a new level). AND: This also more than strongly indicates that at each new level MORE types of objects/actions are involved.
THUS, for there to be a true empirical hierarchy, SOMETHING (_OR_ type of thing) NOT PRESENT BEFORE IS ADDED (in an objectively verifiable way).
Those who "define" hierarchies without this requirement have lost touch with empirical grounding and have lost touch with science itself. (In Psychology science (like with other real sciences): The SUBJECT, specifically BEHAVIOR PATTERNS, define ALL !; the Researcher(s) merely using his/their own imaginative thought/"analysis" DEFINES NOTHING. Try to remember that the organism, in all aspects of its behaving (including behavior (behavior patterns themselves, per se)) IS ORGANISMIC; if this does not "show", then you are off track and almost certainly in a way that will NOT SELF-CORRECT (as good science does).)
All the above is very much related to questions of concepts being concrete or "abstract" (INTEGRAL to the issue , in fact); AND, not understanding true ontogeny (cognitive development in childhood) leaves "levels of abstraction" in confusion (a pseudo-mystery, seen generously as simply [supposedly] a mystery .)
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Dear Professor, please look at this related reference.
Thank you
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Hello!
I isolated some T-cells with some very interesting TCRs from primary cultures. I sent them to Genewiz to get chromium single cell TCR sequencing done, however the sample viability was super low. I sent them 8 more vials so that they could do a dead cell removal and then isolate the live population and perform single cell sequencing on the remaining cells. The sequencing results show that whatever is left over after DCR is most likely another contaminant cell type, not a TCR. I now only have one vial left, so whatever I choose to do next is very critical and essentially has to work the first try.
At this point I dont care about chain pairing, I can piece that back together afterwards by trial and error, I just want to get some data from these cells. I was wondering if anyone knows if I can thaw my cells directly into RNA later and then do either normal NGS or another single cell sequencing method to get any info on the TCR sequences? Should I just amplify the TCR regions on thawing with some kind of primer pool and then send that for NGS? In general, what's the most robust process for getting out TCR information from low viability samples?
Some other notes:
1. I didnt personally do the T cell isolation but my thinking is they were pretty much exhausted at the time of freezing which is why we have viability issues on thawing
2. They were frozen in 10% glycerol + 10% FBS in a Mr Frosty at -80C and then maintained in LN2 and shipped on dry ice.
3. Observed viability is ~30% on thawing however this could just be the contaminant cell population....
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Definitely a fair assessment, Ive made other samples that have similar properties as this, but none of the other samples Ive generated have responded with as much vigor as this sample.
Definitely will invest in generating another panel of T-cells but from what I can tell so far, this sample had a particularly rare phenotype that i may or may not see again in a relatively limited panel size. every once in a while I remember I have this last vial and wonder if I can do anything with it, in the end its always for the birds...
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I propose the following idea.
1. attach ions to a virus
2. localize it with ion trap
3. burn a hole in the middle thus destroying DNA
4. put in water
I would like to hear both physicists and biologists? Is this possible?
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Scientists exploring the physics of the virus which facilitate to study mode of infection and vaccine prepatation while both physics and chemistry will never tell us how to design an effective vaccination programm or solve the problem of the crossing pedestrain .Recently the science events to watch for in 2022 Nature Omicron,Moon missions and particle physics are among the theme set to .....make their vavvines more affordable for lower_income countries.mor detailed in the attached ref.
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I know that several genes come one after the other under a single promoter in an operon, but what is exactly between those genes? Does the start codon of the second ORF come right after the ORF of the first gene? If there is a specific example with the dna sequence, that would be great.
Also, does an operon always require an operator?
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ORFs of eukaryotes are typically different from those of prokaryotes. In eukaryotes, mostly, genes do not come as long ORFs; they are "mixed up" with introns. Thus, providing substantially large spaces for non-coding genes (which has been demonstrated to be as high as 62% in the human genome). In bacteria, there is relatively very low non-coding DNA in the genome (approx 11%) which therefore gives in a continuous ORFs. What may be located between ORF's of two different genes, or the intergenic regions may comprise of the list succinctly put by Dr Frank Burns. It is also however, important to remember that some overlaps do occur that complicates the assessment in a single shot.
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If I have an experience but no certificate in Machine Learning, and have both experience and certifcate in Medicine (Urology) ... and want to publish a peper that include an interaction between these 2 feilds, in either Urology or CS journals. Should i add a coauthor who is certified in Data science or CS? ... if not, Would it be necessary to prove my competency in ML by any means?
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Publishing on a particular area does not require one to necessarily have a certificate in that area. However, if you find yourself to be inadequately equipped with the requisite knowledge to do a good job in that specific field, you may overcome that by collaborating with someone with that knowledge so that together you can bring out a very good and scientific work.
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The Fig2A of the paper shows that a tiling library of a gene was prepared containing 50bp fragments. The fragments span over the entire gene sequence incrementing about 7bp from each other. Later this sample was used to study the sequence dependence on DNA bendability over genome scale. This is a very interesting study but I am unable to figure out how the tiling library was prepared. Is it done by preparing a sequences for primer pool for every fragment and ordering them? Can we prepare a tiling library with any amount of spacing between them? Please let me know if you have any idea.
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Red biotechnology: This area includes medical procedures such as utilizing organisms for the production of novel drugs or employing stem cells to replace/regenerate injured tissues and possibly regenerate whole organs. It could simply be called medical biotechnology.
nuha hamid taher
Senior lecturer
Faculty of Basic Education
Mustansiriya University
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In a patient with hereditary desminopathy (mutation Thr341Pro DES in the heterozygous state) over the past three years, an increase in the blood uric acid level up to 440-480 µmol / l was established by 1.5 times (the norm is 428.4 µmol / l). With the progression of the disease, the level has risen and is above normal. It is known that uric acid is an antioxidant. Is it necessary to reduce the level of uric acid? The patient has no problems with the joints.
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The change in the level of uric acid and biochemical parameters in a patient with an identified case of desminopathy is presented in the article https://www.researchgate.net/publication/357311034_CHANGE_IN_REDOX_STATUS_AND_BIOCHEMICAL_PARAMETERS_IN_PATIENT_WITH_DESMINOPATHY_T341P_SEVERAL_YEARS_AFTER_DISEASE_SYMPTOMS_ONSET
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In my personal experience I have find the higher rate of sprouting when fresh cow dung is applied on the top side of cutting what might be its reason.
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Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally regulate each other, are among the well-known cancer hallmarks. Studies have reported use of Onco-metabolites to metabolically reprogram the epigenetic of cancer. I was wondering what might be major limitations of such techniques?
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Hello. This topic is not exactly my field, so I cannot give you a satisfactory answer. I will be happy to follow all the news and discussions in this field.
Regards, Zlata Felc.
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Hello.
I would like to check cell changes by culturing T cells isolated from PBMC in amino acid-rich or deficient medium. How long should I culture in rich and deficient mediums to check cell changes?
It is also a concern whether it should be cultured in rich/deficient medium from the beginning, or whether it should be cultured in normal medium at first and then moved to culture them.
I'm sorry that my English is not good! Please give me a lot of answers! :)
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Global warming affects many processes in biological ecosystems.
Different species of flora and fauna change their habitats and geographical areas according to climate change and specific geographical environments.
Areas of occurrence of specific species, for example insects in terrestrial areas and fish and arthropods in the seas and oceans, change.
For example bird habitats change, so migrations of some bird species may also be subject to modification. In the situation when forest areas dry out and turn into steppes and deserts, changes in natural habitats and areas of occurrence of species change and concern simultaneously many species of flora and fauna.
Do you agree with me on the above matter?
In the context of the above issues, I am asking you the following question:
What changes in natural ecosystems are caused by the ongoing global warming process?
Please reply
I invite you to the discussion
Thank you very much
Best wishes
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Dariusz Prokopowicz still learning from your questions...thanks
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I want to count these fragments for image analysis of autolysis. Please suggest good software, it is so critical in my work.
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Having a background in health science I am aware that the term "interphase" is a biological one which describes a stage of cell division. Specifically it is defined as the resting phase between successive mitotic divisions of a cell, or between the first and second divisions of meiosis.
This may be compared to a materials science definition for "interface" as the region formed when two phases (systems) are in contact through which the intensive properties of one phase transfer to the other.
When I would read "SEI" defined as solid electrolyte interphase in papers within my current field, I would always have a quiet giggle to myself and wonder how it gets past the editors, even in high impact publications. But I recently found myself forced to reassess my position, after digging around in foundational work on the SEI thing by Peled et al (1979). This paper has "interphase" in its title, and I believe there are peers who consider this to be the original work defining SEI. An excerpt from the paper:
It acts as an interphase between the metal and the solution and has the properties of solid electrolyte, through which electrons are not allowed to pass. Therefore, it is called "Solid Electrolyte Interphase (SEI)."
So the discussion is this, if these authors coined the term SEI, shouldn't it be acceptable for us as materials scientists to misappropriate "interphase" for our own purposes, and to hold our ground on it? On the other hand, what is science without clarity in our terminology? And how is "interphase" in a materials context saying anything more or less than the previously defined term "interface"?
The one thing I feel confident about is that we shouldn't be reading interchangeable definitions for the same thing, just depending on the source. Let alone seeing it arbitrarily interchanged within a single source - yes I have read individual papers where SEI is both "interphase" and "interface"...
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Hello. I received a compound with molecular weight 453.292 and the only mass information for it is 1 micromol. This is very confusing because usually chemicals have a mass in grams or milligrams. I do not know how to calculate from this. I need to make up either 10mM or 1mM of the compound. Please can someone show me your calculation for either obtaining a final concentration of 10mM or 1mM (please show calculations for both, as i havent decided which one to make yet), how much DMSO I will need to use. Thank you
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I agree with dr.John Machell,it’s far a away from my speciality.
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I am carrying out a research on science self efficacy and meta variables as correlates of biology achievement among secondary school students
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This thread is for those who want to know how to calculate Research Interest (RI) and participate in this validation study. *** Welcome to the validation study of my formula for Research Interest (RI) on the RG site! Details are in the first reply in this discussion.
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We know that the brain sends and directs meaningful messages to control the patient's cells.
as we know, The brain is affected by factors such as diseases And we know that the brain also controls other organs of the body.nevertheless,Damage to the CELLS is visible on eeg?
Is Cancer Effective In EEG?
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Stomach cancer is cancer that may affect any part of the stomach and extend to the esophagus or small intestine, and it causes the death of nearly one million people annually. It is more prevalent in Korea, Japan, England and South America. It is more prevalent among men than women. It is associated with eating too much salt, smoking, and also low intake of fruits and vegetables. Therefore, it is believed that its spread in countries such as Korea and Japan is due to the consumption of salted fish mainly by Koreans and Japanese, as well as the use of canned food and food preservatives. Mucosal colonization of H. pylori is believed to be the main risk factor in about 80% of stomach cancers
Stomach cancer is diagnosed through an endoscopic examination that allows a biopsy to be extracted from the affected tissue, and then analyzed to confirm the presence of a tumor. Dr. Riccardo Rosati, a specialist in gastroenterology at San Raffaele Hospital in Milan, says, "Before undergoing treatment, the patient needs to do a series of other ultrasound and other examinations to check the areas, glands and organs covered by the disease, in order to determine the degree of its progression.
As a researcher, I believe that stomach cancer cells do not send messages to the brain due to the lack of associated neurons
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I'm doing a research project where we are testing different methods of fluorescent live/dead stains and we need to kill some strawberry and potato roots so we can stain them. The only method we know will work well is boiling them in 70-80 degree water, have any other ideas?
thanks!
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Starting to boil in a waterbath or autoclaving are two options for heat treatment. This is the section of the operation that requires the most improvement. Only 15 minutes of autoclaving (without preceding KOH immersion) is required for greenhouse-grown plant roots that are ~4 weeks old. Adventitious roots that are 1 centimeter in size and ~3 months old must be soaked overnight and autoclaved for 60 minutes. Multiple soakings and more than one hour in the autoclave may be required for some tissues. The time it takes to boil something is usually longer than the time it takes to autoclave it.
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Context: Biology, Anticancer, Cell Signaling, Medicinal Chemistry, Apoptosis
Your answers are highly appreciated! Thank you!
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You can try to check Bioorganic Chemistry and Journal of Medicinal Chemistry. wishing you all the best
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How should the systems of nature protection and biodiversity of natural ecosystems be dispersed in order to increase the effectiveness of these systems and reduce the scale of degradation of the natural environment?
What do you think should be improved in nature conservation systems and biodiversity of natural ecosystems in addition to just increasing financial outlays on nature conservation policies conducted by government agencies and ministries of the environment?
A significant part of financial expenditures of nature conservation and biodiversity policy is devoted to the promotion of nature protection and natural environment protection issues. However, the effectiveness of this type of promotional campaigns is low, because without applying legal restrictions, enterprises do not change their technologies to be more ecological if they do not see in this business realized in a short time. Even the occasional UN climate summits in which government representatives from the majority of countries take part do not cause significant real changes in the policy of nature protection and biodiversity? Usually, the largest industrial economies in the world do not sign the obligations of rapid reduction of greenhouse gases and the issue of increasing spending on environmental innovation in the energy sector. Why, despite the growing scale of public awareness, there is no significant improvement in the implementation of nature conservation and biodiversity policy, there are no real measures that would result in a significant reduction of greenhouse gas emissions and the slowing of the global warming process?
Please reply
I invite you to the discussion
Thank you very much
Best wishes
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Dear Roman Bohdan Hołyński,
Thank you for your response. Yes, of course population growth has been going fast for hundreds of years. This issue has been pointed out since the beginning of the first industrial revolution in the 17th and 18th centuries. We now have the fourth technological revolution, the problem is many times larger and still the same questions. Until now, technological progress, including in the field of new technologies increasing the efficiency of agricultural production, has solved the problem of feeding the rapidly growing population. On the other hand, however, in the least developed countries, the scale of poverty and food shortage is becoming a rapidly growing problem. In addition, climate change causing droughts, forest fires, soil barrenness, pest infestations etc. exacerbate these problems. Until recently, technological progress seemed to solve the key problems of the development of civilization. However, in recent years there has been more and more evidence to challenge this thesis. If the process of global warming accelerates in the next decades, the above problems will quickly worsen and the technological progress will become insufficient to solve them. Therefore, our view on this issue is very similar.
Thank you very much,
Best regards, Greetings,
Dariusz Prokopowicz
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Introduce a database that predicts lncRNA and gene(mRNA) interactions. Thanks
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Hello Mehrdad Rostami,
you may try this tool, looks fine, but works only for human and mouse:
Further tools available (not limited to specific organisms) are below:
Hope this help,
Martin
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Teaching biology.
Practices and strategies in teaching biology. 
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Danilo Rogayan Jr. There is a online paper available on this topic and Structure Matters yes and the papers says all about the same
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Usually in our university we recommend the book of Schoonhoven et al., 2005 "Insect-Plant Biology", and of Karban, 2015 "plant sensing and communication", however, this year we are looking for any other recent good books published on these topics.
Please could you know some?
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Thank you for your suggestions. Chemical Ecology of Insects by Jun Tabata appears to be a relevant book.
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A performance task? A standardized test? Or some other means? Why?
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A question that needs more thought
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During my first year of M. Sc. of Biology this year (2021), I did an exercise to learn how to write a grant proposal.
I wanted to do it on a topic which seem "taboo" : HUMAN OVERPOPULATION.
Could you share some references about this topic please ?
Like Climate Change, I think this topic is very urgent to discuss, to treat.
I share my modest, naive and fictive work on it.
Thanks for your collaboration.
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Please have look on our(Eminent Biosciences (EMBS)) collaborations.. and let me know if interested to associate with us
Our recent publications In collaborations with industries and academia in India and world wide.
EMBS publication In association with Universidad Tecnológica Metropolitana, Santiago, Chile. Publication Link: https://pubmed.ncbi.nlm.nih.gov/33397265/
EMBS publication In association with Moscow State University , Russia. Publication Link: https://pubmed.ncbi.nlm.nih.gov/32967475/
EMBS publication In association with Icahn Institute of Genomics and Multiscale Biology,, Mount Sinai Health System, Manhattan, NY, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918
EMBS publication In association with University of Missouri, St. Louis, MO, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30457050
EMBS publication In association with Virginia Commonwealth University, Richmond, Virginia, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211
EMBS publication In association with ICMR- NIN(National Institute of Nutrition), Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611
EMBS publication In association with University of Minnesota Duluth, Duluth MN 55811 USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211
EMBS publication In association with University of Yaounde I, PO Box 812, Yaoundé, Cameroon. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30950335
EMBS publication In association with Federal University of Paraíba, João Pessoa, PB, Brazil. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30693065
Eminent Biosciences(EMBS) and University of Yaoundé I, Yaoundé, Cameroon. Publication Link: https://pubmed.ncbi.nlm.nih.gov/31210847/
Eminent Biosciences(EMBS) and University of the Basque Country UPV/EHU, 48080, Leioa, Spain. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852204
Eminent Biosciences(EMBS) and King Saud University, Riyadh, Saudi Arabia. Publication Link: http://www.eurekaselect.com/135585
Eminent Biosciences(EMBS) and NIPER , Hyderabad, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29053759
Eminent Biosciences(EMBS) and Alagappa University, Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30950335
Eminent Biosciences(EMBS) and Jawaharlal Nehru Technological University, Hyderabad , India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/28472910
Eminent Biosciences(EMBS) and C.S.I.R – CRISAT, Karaikudi, Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237676
Eminent Biosciences(EMBS) and Karpagam academy of higher education, Eachinary, Coimbatore , Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237672
Eminent Biosciences(EMBS) and Ballets Olaeta Kalea, 4, 48014 Bilbao, Bizkaia, Spain. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918
Eminent Biosciences(EMBS) and Hospital for Genetic Diseases, Osmania University, Hyderabad - 500 016, Telangana, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/28472910
Eminent Biosciences(EMBS) and School of Ocean Science and Technology, Kerala University of Fisheries and Ocean Studies, Panangad-682 506, Cochin, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27964704
Eminent Biosciences(EMBS) and CODEWEL Nireekshana-ACET, Hyderabad, Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/26770024
Eminent Biosciences(EMBS) and Bharathiyar University, Coimbatore-641046, Tamilnadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27919211
Eminent Biosciences(EMBS) and LPU University, Phagwara, Punjab, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/31030499
Eminent Biosciences(EMBS) and Department of Bioinformatics, Kerala University, Kerala. Publication Link: http://www.eurekaselect.com/135585
Eminent Biosciences(EMBS) and Gandhi Medical College and Osmania Medical College, Hyderabad 500 038, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27450915
Eminent Biosciences(EMBS) and National College (Affiliated to Bharathidasan University), Tiruchirapalli, 620 001 Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27266485
Eminent Biosciences(EMBS) and University of Calicut - 673635, Kerala, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611
Eminent Biosciences(EMBS) and NIPER, Hyderabad, India. ) Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29053759
Eminent Biosciences(EMBS) and King George's Medical University, (Erstwhile C.S.M. Medical University), Lucknow-226 003, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25579575
Eminent Biosciences(EMBS) and School of Chemical & Biotechnology, SASTRA University, Thanjavur, India Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25579569
Eminent Biosciences(EMBS) and Safi center for scientific research, Malappuram, Kerala, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237672
Eminent Biosciences(EMBS) and Dept of Genetics, Osmania University, Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25248957
EMBS publication In association with Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/26229292
Sincerely,
Dr. Anuraj Nayarisseri
Principal Scientist & Director,
Eminent Biosciences.
Mob :+91 97522 95342
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there are various bioinformatics tools that show the patients' mortality rate related to gene expression such as prognoscan! if you know other bioinformatics platforms or approaches please let me know!!!
regards
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Dear Dr Mohammed,
I also suggest you to read these recent articles:
Best regards,
Pr Hambaba
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I'd love to see a rough sketch of how the task would go.
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  1. Give students raw data and ask them to write an argument or analysis based on the data.
  2. Have students explore and write about unfamiliar points of view or “what if” situations.
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During promotion application, there seems to have increasing emphasis not only on the impact factor of the journal you publish, but also its RANK in a particular field. Does it affect your choice of which journal you submit your work (as an example, a journal with a JIF of 9 can be regarded as top 5 percentile in the category of "Biology" but only top 20 percentile in "Cell Biology")?
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Dear Dr Kwok-On Lai ,
You have underlined a very important point, and personally I think that the impact factor / citation index of a specific journal does not always refer to its quality. For example, you may encounter many journals with an impact factor >10, but the quality isn't always present.
Best wishes,
Sabri
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The current technological revolution, known as Industry 4.0, is determined by the development of the following technologies of advanced information processing: Big Data database technologies, cloud computing, machine learning, Internet of Things, artificial intelligence, Business Intelligence and other advanced data mining technologies.
In view of the above, what kind of information technologies from the Industry 4.0 range and how will they help to protect the natural environment and biodiversity?
Please reply
Best wishes
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In my opinion, in recent years, the possibilities and needs of using new information technologies, ICT, Internet, Industry 4.0 in the field of improving nature protection systems have been growing. For example, these technologies can be combined with satellite analytics of changes in the state of biodiversity of natural ecosystems, changes in the level of pollution of the natural environment and other types of impact of civilization development on nature.
I invite you to the discussion,
Greetings,
Dariusz Prokopowicz
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how do you understand life as it is really big suspense, why we are here, our consciousness is big unconsciousness and our unconsciousness big consciousness.
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My philosophy in life is to treat people as you would like them to treat you, help others as much as possible, worship God as much as possible, and everything you do will pay off for you.
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I think this is the most difficult and interesting question in the biology. I don't think that this great secret will be ever solved scientifically ! Since unsolvable until now by any means therefore this question can also be considered as the main question of biologic philosophy !
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The question is perfect, but as we know the theories of evolution and finally the formation of a primitive type of cell from the nonliving materials first in the dark liquid area. Once the first cell formed after that only the concept of Omnis cellula e cellular is applicable...
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Hello, I am currently an undergraduate student at Purdue. I am currently looking at potential research topics to get into during graduate school. Right now I work in a botany lab studying ABA levels in deciduous trees. However, in my own free time, I have been obsessed with the interaction between tree species through different mycorrhizal networks. I have a decent list of researchers working on this topic (I will put their names below), but I was wondering if there are any schools or individuals I should strongly consider and reach out to before applying.
1. Rolf Geisen (Max Rubner-Institut, Germany)
2. Marc Stadler (Helmholtz Centre for Infection Research, Germany)
3. John Pitt (Australia)
4. Jens Frisvad (Technical University of Denmark)
5. Vit Hubka (Charles University Prague, Czech)
6. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences http://english.im.cas.cn/rh/rd/Mycology1/
8. Dr. Catherine Aime (Purdue University)
9. Songlin Fei (Purdue University)
10. Peter Kennedy (University of Minnesota)
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Ectomycorrhizae have many differences from Endomycorrhizae. Each one has it's own mode of action with the plant root which related with.
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Dear everyone,
We know that in human and animals, diet cupric ions (Cu2+) are reduced to the cuprous form (Cu+) by the metalloreductase six-transmembrane epithelial antigen of prostate member 1 (STEAP1) and then absorbed by enterocytes via a specific transporter (CTR1). But I really don't know why metal ion could not directly get in the enterocytes? In addition, I would like to know whether lithium will be absorbed by any cells in human body?
My knowledge of biology is very scarce. I implore any biology or medical experts to answer this questions. Thank you!
Best wish to everyone who sees this question
Junhang Dong
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Dear Junhang Dong thank you for posting this very interesting technical question which is really several questions in one. For the question why metal ion could not directly get in the enterocytes I would like to suggest to you the potentially useful reference cited below. It is outlined there that on the one hand micronutrients such as zinc, copper, and iron are essential for our life because they serve as cofactors for a large number of different proteins. However, the other hand, these transition metal ions can be toxic to cell growth when they are taken up in excess. This is the reason why all organisms developed mechanisms to strictly regulate the heavy metal ion levels. Please have a look at this paper:
Cellular sensing and transport of metal ions: implications in micronutrient homeostasis
Unfortunately this article has not yet been posted by the author as public full text on RG. However, the author has an RG profile (https://www.researchgate.net/profile/Amanda-Bird-2). Thus there is a good chance that you can request the full text directly from her.
I hope this answers part of your question. Good luck wth your research and best wishes, Frank Edelmann
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