Science topics: Biology
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Am new in Master of Biology and in my Practicum Lab I was asked to reverse the sequance that give to me in the scripts, why should I do that ? how can one tell if he is using forward or backword sence ?
Why and how is this kind of long-term potentiation (LTP) possible?
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
Long-term potentiation (LTP which is necessary for synaptic plasticity and long-term memory formation) needs repeats and reinforcement of the engrams to be triggered.
However, apparently everybody automatically "absorbs" a lot of information immediately and also permanently, even without needing any extra effort (at least any conscious effort), which seems to be needed for LTP to happen. Everyone seems to have this ability, although it is even stronger in those with better memories.
People simply "learn" many things once; and many of those learned items remain there for a pretty long duration, and in many cases even for the rest of their lives. This seems to happen without any repeats, at least without any apparent or conscious efforts to remember or re-remember those memories. This is the case for a lot of semantic information (especially the information of interest or importance to the person) as well as a large portion of the contents of episodic memory.
Why and how is this kind of LTP possible?
Perhaps attention plays a major role here, e.g., being interesting and important automatically triggers LTP without a further need for repeats.
But such effortless long-term memorization happens also in the case of a lot of semantic information or autobiographical events that are not inherently interesting or significant to the person.
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
I'm in the last year of undergraduation and I want to do research and publish paper on HIF Signalling in Fin or limb regeneration. I don't know how to take a start and I'm unable to find the methods and protocol to use. Can anyone guide me?
What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
I have had the honor of witnessing very rare people who have some strange forms of mega memory: They effortlessly, automatically, and immediately memorize many difficult things such as phone numbers or their difficult and comprehensive books, etc. And they retain those easily captured memories for a very very long time (a couple of decades at least), without any smallest effort or reinforcement. Not to mention that they record or remember almost everything else (semantic or episodic) quite easily, and also with a lot of details. Furthermore, they are very very accurate in recalling those items. For example, they can serve as pretty reliable living phone books; or for example, they are extremely awesome at medicine, etc.
But when I am talking about "strange", I don't mean their super-human ability to easily capture such vast amounts of information for such long durations and recall them accurately.
Their super-human ability is of course strange. But the even stranger part of their memory is that once it is captured, it cannot be updated or revised easily. For example, if they misunderstand something the first time, it will take perhaps 10 or 20 attempts over days or weeks for their colleagues to remind them of the mistake and ask them to correct their misunderstanding.
It is like that once their memory is formed the very first time, it is set in stone. It is absorbed very efficiently and strongly, and at the same time, not much prone to future updates.
What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
As is well known, Continuous models are richer , more powerful and above all, more intuitive , easy to understand and extendable. So let us say, we are trying to find a biomarker for a disease \ trait. Instead of just looking at absence / presence or frequencies, could one try to establish continuous trackers / markers that positively or negatively correlate with the propensity to contract the disease , such as concentration levels of a chosen set of biomolecules ?? Possibly, this may involve some kind of preliminary pathway analysis. Could one also look at morphological parameters (fractal / scaling dimension of tumors etc ??) ??
Does the DNA remain stable or degrade at this temperature? Would there be any difference in thermal stability between supercoiled and linear forms of say, 3 kb plasmid.
Hello I am a nuclear master student, so my main focus is physics. I want to pursue a career in research, my main domain will be dosimetry and radioprotection. I want to study the irradiation of cells but this also implies a lot of biology.
How a physicist can approach this interdisciplinary subject for a PhD?
Bio-sensor development demands a variety of fields in cooperation. However, this breakthrough would not result in the case of doing research with a single attitude. I am calling researchers from biology or biochemistry, genetics, or related science to come into the discussion. Let me know if somebody has any knowledge in this field.
#Bio-sensors #Biochemistry #Genetics
Hi All, I am working with A549 cell line and trying to culture spheroids using low attachment 96 well plates. So far I have attempted some different seeding densities from 2000 to 10,000 cells and can either form very large spheroids (700-900um), which are more compact and have a spherical defined shape, or alternatively smaller spheroids (still fairly big though around 500um) are less compact and not completely spherical. However for my experiment where I wish to add drug compounds (2D IC50 approx 1uM) I am not observing significant size/morphology change on the larger spheroids despite at least a 10uM concentration for 1 week. I am thinking possibly I can try to treat smaller spheroids for a more obvious visual change. Does anyone know how i might successfully make small compact spheroids (less than 500um) which are reproducible with this cell line? Thanks in advance for any help someone may be able to provide.
Please spread the word: Folding at Home (https://foldingathome.org/) is an extremely powerful supercomputer composed of thousands of home computers around the world. It tries to simulate protein folding to Fight diseases. We can increase its power even further by simply running its small program on our computers and donating the spare (already unused and wasted) capacity of our computers to their supercomputation.
After all, a great part of our work (which is surfing the web, writing texts and stuff, communicating, etc.) never needs more than a tiny percent of the huge capacity of our modern CPUs and GPUs. So it would be very helpful if we could donate the rest of their capacity [that is currently going to waste] to such "distributed supercomputer" projects and help find cures for diseases.
The program runs at a very low priority in the background and uses some of the capacity of our computers. By default, it is set to use the least amount of EXCESS (already wasted) computational power. It is very easy to use. But if someone is interested in tweaking it, it can be configured too via both simple and advanced modes. For example, the program can be set to run only when the computer is idle (as the default mode) or even while working. It can be configured to work intensively or very mildly (as the default mode). The CPU or GPU can each be disabled or set to work only when the operating system is idle, independent of the other.
Please spread the word; for example, start by sharing this very post with your contacts.
Also give them feedback and suggestions to improve their software. Or directly contribute to their project.
Folding at Home: https://foldingathome.org/
Folding at Home's Forum: https://foldingforum.org/index.php
Folding at Home's GitHub: https://github.com/FoldingAtHome
Additionally, see other distributed supercomputers used for fighting disease:
Rosetta at Home: https://boinc.bakerlab.org/
I am on the hunt for the following paper that I cannot seem to access online:
Jensen and Jensen 1969. On the Breeding Biology of African Cuckoos. Ostrich 40: 163-181.
Would anyone that has access to this paper be willing to send me a digital copy?
We have a Flask that contains broth, and we want to inoculate it with Bacteria inoculum, Can we simply take a touch by the loop or by micropipette?
In most contexts, the terms alternative medicine, complementary medicine, integrative medicine, holistic medicine, natural medicine, and unconventional medicine are almost synonymous.
is there a specific ratio to follow during the addition?
How many grams of K2Cr2O7 to dissolve it in 1 liter Distilled water to obtain 50 ppm of Chromium? to become aqueous solution, Is there a specific equation to apply? Thanks
When I tried to remotely accessed the scopus database by login into my institution id, it kept bring me back to the scopus preview. I tried cleaning the cache, reinstall the browser, using other internet and etc. But, none of it is working. As you can see in the image. It kept appeared in scopus preview.
I am running a qPCR assay. I chose gradient temperature option for each of my primer to get the best conditions the amplification happens (without heterodimers- NA in negative controls). However, I have seen that my housekeeping gene and one of my target gene have different annealing temperature. Can I run another qPCR set-up just for this gene by choosing gradient temperature option ? For instance; my gene in question in a row with 54C and housekeeping gene in a row with 60C. I think as far as the machine reads the signals at the same time, it won't pose a problem but I just want to make sure.
I was offered, like I believe many others, to publish in this relatively new open journal
It that not seem to be a predator journal, but I cannot decide if its a good place to publish
Irrational numbers are uncomputable with probability one. In that sense, numerical, they do not belong to nature. Animals cannot calculate it, nor humans, nor machines.
But algebra can deal with irrational numbers. Algebra deals with unknowns and indeterminates, exactly.
This would mean that a simple bee or fish can do algebra? No, this means, given the simple expression of their brains, that a higher entity is able to command them to do algebra. The same for humans and machines. We must be able also to do quantum computing, and beyond, also that way.
Thus, no one (animals, humans, extraterrestrials in the NASA search, and machines) is limited by their expressions, and all obey a higher entity, commanding through a network from the top down -- which entity we call God, and Jesus called Father.
This means that God holds all the dice. That also means that we can learn by mimicking nature. Even a wasp can teach us the medicinal properties of a passion fruit flower to lower aggression. Animals, no surprise, can self-medicate, knowing no biology or chemistry.
There is, then, no “personal” sense of algebra. It just is a combination of arithmetic operations.There is no “algebra in my sense” -- there is only one sense, the one mathematical sense that has made sense physically, for ages. I do not feel free to change it, and did not.
But we can reveal new facets of it. In that, we have already revealed several exact algebraic expressions for irrational numbers. Of course, the task is not even enumerable, but it is worth compiling, for the weary traveler. Any suggestions are welcome.
Hello All... I am trying to install Gromacs on windows using conda i have attempted to run "conda install -c bioconda gromacs_py" but it's not working. Any recommendations shall be highly appreciated.
I am a field biologist and especially work with birds and need a good GPS for my field work. If you could recommend one economical one and one intermediately priced one, that would be great. Thanks in advance!
It is extremely hard to get on board of international science (by that I mean enter an abroad university, and visit international conferences) when you are from a developing country and at the start of a research career. You need an impressive CV to get funding, so I wonder if someone can share information about contests for undergraduates or/and Master students of Life Science.
From my side, there is International Student Tournament (https://www.facebook.com/intscitour/), iGEM (https://igem.org/) ... and that`s basically it.
Hi, I am a 1st-semester biology student. i would like to know the opinion of you, that your field of study is biology and how do you think ethics relates to the decisions you make day-to-day.
Sorry for the inconvenience, I'm Johana, a biology student at the Francisco Jose de Caldas-Colombia district university, I have a job for which I need to contact a researcher and I found your articles very interesting. For this reason, I was motivated to write to you to request A help in front of work, our subject is bioethics and I would like to ask you some questions that you can answer briefly.
How does ethics influence biology?
What happens in situations where ethics is worth more than
Thank you for your attention and if possible please answer the questions, thank you very much
Biosocial studies encompass a set of approaches constituted by the space of knowledge generated by the interaction between biology and sociology. This space takes us back to the beginnings of social studies where biology and social sciences walked side by side. At present, these studies are being revitalised. For this reason, we want to contribute at Societies to strengthening this discipline and its research. When we conceive of biosocial research, we automatically think of medicine. However, the relationship between genetics and society, epigenetics, social evolution, the environment and the social, etc. can also be present in this field of study. In short, biosocial study is a diverse and plural set of approaches of great interest and relevance for today's world. In this Topic, we want to bring together the best international biosocial research. For this reason, we hope to feature the work of social scientists interested and concerned with the environment, health, diseases, biology, disability, old age, climate and energies in their relation to society. All these approaches also need a broad methodological perspective, so the issue is open to theoretical and empirical (quantitative and qualitative) work. We believe that studies of a conceptual nature with future hypotheses would also be of great interest. This issue aims to advance biosocial studies from a broad and diversified approach. Biosocial study helps us to better understand the surrounding reality. This is apparnt is we consider, for a moment, the numerous studies on SARS-CoV-2, or the possibilities that the social sciences offer to biomedicine or the science of care. On the other hand, we would like this issue to help biologists understand that the social sciences can help and complement their research. All in all, this is an exciting and thought-provoking Topic.
Which software is best for making high-quality graphs? Origin or Excel? Thank you
Suppose we conveniently extended the standard concept of cellular automaton to include
graphs and state-spaces Q of any cardinality and that the transition function F belonged to a certain adequate notion of "(hyper)computable function". We call this a hyper-cellular automaton HCA.
Consider the postulate: the universe can be described by a HCA with transition function F.
We cannot escape the problem of the initial condition Q_0. In the Wolfram Classification random initial conditions are considered. Hence the expediency for some topology or measure on Q.
Q will include for instance the usual sheaves (principle bundles and connections) considered in the standard model. It will also include other aspects to account for quantum gravity, consciousness, emergent biological complexity, etc.
It is an empirical fact that this HCA must be WC4 "complex patterns of localised structures" in the Wolfram Classification.
A major problem is the goal of reverse engineering F is that we do not have evolutions for other initial conditions at our disposal neither for the universe nor for subsystems of the universe. For physics at least a lot of locality and invariance hypotheses come in to play to justify the universality of experimental conclusions. The chemistry we observe on earth must also be that of the most distant star.
For biology the situation is drastically different. My question is: how can biology go beyond being a merely descriptive science as contrasted with fundamental physics ?
Biology seems to be mainly a "reverse engineering" affair. But it is also important
to have detailed, mathematically precise models - perhaps using HCAs - that can be used to test hypotheses and perform simulations.
Molecular biology suggests a new paradigm for software-hardware, a fluid mobile computer with essentially interconnected parts. A key characteristic is that information operations are tied to material and energetic constraints.
Also we must focus on ecosystems (the analogue of the cell ? ) rather than individual species. What about the idea of a "natural internet" (via horizontal gene transfer, etc.) ?
Can someone can please explain how Triton causes permeabilisation of the cell membrane without causing cell contents to leak out?
Is it because my cells are fixed with pfa and that plays a role in preventing leakage of contents?
Also, how exactly does Triton work anyway, with regards to its structure affecting membrane? It is a detergent but what im understanding is it partially permeabilises membrane (not fully) otherwise whole cell would fall apart
If we take a description of the solar system in terms of Newton's equations then the solutions are time-reversible.
But many phenomena in nature are observed to be non-reversible, "dissipative", hence not having time-reversible solutions. For instance, a glass falling off the table and breaking.
The big question is: can the second law of thermodynamics be deduced from the fundamental differential equations of physics ?
Or more generally are there differential equations whose solutions are mostly entropy-increasing ?
On the other hand can we find (a system of) differential equations whose solutions are generally entropy-decreasing ? Or in which entropy-decreasing phenomena occur in relatively frequent bursts ? Differential equations which would have solutions in which the pieces spontaneously assemble into the glass on the table ?
Contemporary physics is essentially incomplete (cf. the need for dark matter, dark energy, extra dimensions, etc.). Perhaps in the complete picture entropy is actually strictly conserved. The entropy-increasing forces/fields are counterbalanced by (at present unknown) entropy-decreasing ones, in which entropy-decreasing phenomena occur in relatively frequent bursts.
Then it is this entropy-decreasing aspect of nature that is the main cause of life, the cause of the relatively frequent bursts of increased self-organisation and complexity (which would then be further modulated (or "selected") by the constraints of the environment and the ecosystem).
Perhaps the "collapse of the wave-function" could be approached thermodynamically as well ?
I am an undergraduate at the University of Cross River State, Nigeria currently pursuing a microbiology program. For familiarity and enhanced understanding of the course, I wish to seek recommendations on the virtual/simulation laboratory software that would be very helpful to me and my colleagues. With my interest in research too, I will be pleased if a research simulator is recommended to help widen my understanding of Microbiological research.
Your recommendations would go a long way to significantly contribute to my academic career as well as my colleagues.
In our diagnostic lab, we extract pure viral RNA (Qiagen viral RNA extraction kit).
Therefore, no 28S and 18S rRNA can be traced in agarose gel for total RNA integrity assesment. However, very small bands appear on gel (as seen in picture), are those 5S rRNA or other small RNA moleculea? If so, may they be correlated to total RNA integrity?
Is there any other way to asses the pure viral RNA integrity (besides Bioanalyzer)?
which animals on the planet are net-zero on negative entropies?
Is it a necesssity for survival to socialize negative entropies? Does it need some sort of animal group code to overcome animal behavior?
Cherish your feedback.
I found a species of Coniopterygidae preying on eggs and nymphs of Aleurothrixus floccosus in a lemon tree. I have followed its biology and have pictures of eggs, larvae, pupae and adults. With my thanks in advance, any help is welcome.
Which potential insect extinctions cause irreversible tipping points?
Cherish your insights.
I have noticed while reading different publications that some have used collagen to coat slide/chamber surface in fluid-flow cell experiments, while others used fibronectin. Does coating rely on the type of cells that I am going to use? Example: collagen coating for bone cells, fibronectin coating for endothelial cells?
Hi everyone, I was wondering about the possibilities of performing numerical taxonomy with SPSS software. I would be very thankful to recieve advice!! For now I have been reading about hierarchical clustering, principal component and discriminant function analysis... Help!!
I am writing a review article in biotechnology and as you know graphic images are so important in these papers. I would appreciate it if you suggest the best options. Thank you
It requires about 5.3 kcal/mol (or 8 kBT) of energy to break one phoshodiester bond of DNA. How do these enzymes cut the DNA only by using thermal energy and not ATP? I am only considering the ATP-independent restriction enzymes (Type II). How do these enzymes manage to generate the necessary energy? I couldn't find the exact mechanism with energetics of restriction enzymes cleaving DNA. Please provide me any relevant references.
The link given below is the journal list for no APC.
(Link built by Jeysson Sánchez-Suárez)
Can anyone include more Scopus journals in Genomics, Biochemistry, Biotechnology, Microbiology, and Biology as a whole with no APC?
Thanks in advance.
Human activities have greatly changed the natural environment since the Industrial Revolution. Have migratory birds changed their migration routes? Why can migratory birds do this?
I'm an undergrad biology student from Denmark, and i work on a project with D. melanogaster. We're having a problem we can't figure out, and therefore i've created this account, hoping some of you have had the same experience with the CAFE and knows the reason.
We're feeding D. melanogaster with the Capillary Feeder Assay (CAFE) with 5 μL capillary tubes. Our problem is that after we've been feeding the flies for 24 hours or so, an air pocket starts to form in the bottom of the capillary tubes (green arrow, see attached picture), therefore making the liquid food inaccessible to the flies. The liquid food should "fall down" after the flies drinks from the capillary tubes, but instead this air pocket forms. This happens to at least 9/10 capillary tubes. The red ring (see attached picture) is how the capillary tubes should look like with liquid food and no air pocket in the bottom.
We're feeding them with 5 % sucrose and tap water in both 20 and 23 degrees Celsius.
Capillary tubes are 23 mm long and made of glass. Unknown inner or outer diameter. The capillary tubes we use: https://www.sigmaaldrich.com/DK/en/product/sigma/p1799
I hope the problem is clear and that i've provided all the necessary information
Hi, everyone i hope you are doing well.
I need some insight, as i am going to start my PhD in 2023.
I am little lost about the research as i have been not in touch with the latest growing reseach.
I did my MS research on "Endophytic Pseudomonas mediated activity against phytopathogenic fungi".
I was thinking about doing the PhD research on the similar topic but as i read literature, there have been alot of research on this topic already.
I want to ask,
1. Can i change my research field in Phd, even i have experience in different field in MS.
2. What biology field is more in scope now a days?
What is the level of biodiversity loss of the planet's natural ecosystems as a result of the progressive process of climate change?
During the SARS-CoV-2 (Covid-19) coronavirus pandemic in 2020, there was a recession of the economy, the level of consumption, the scale of international transport of products, international tourism, car use, fuel and energy consumption, etc. declined.
There was then an opportunity to accelerate the processes of pro-environmental transformation of the economy, including the pro-environmental transformation of the transport sector, energy, construction, etc.
Unfortunately, this opportunity was not seized. As a consequence of these omissions, the subsequent economic and energy crises will be deeper than if the necessary transformation of the energy sector, which is being implemented through the development of renewable and emission-free energy sources, had been carried out in the past.
As a result, the global warming process continues to accelerate and progress faster than even the earlier IPCC reports published a few years ago and earlier.
One of the negative consequences of the continuing process of global warming is the loss of biodiversity of natural ecosystems.
I would therefore like to ask the following question:
Is there research on the extent of the loss of biodiversity of natural ecosystems on a global scale as a result of the progressive process of global warming?
Is there data on the state of biodiversity loss in natural ecosystems as a result of the progressive process of global warming, as a result of civilisation's emissions of CO2 and other greenhouse gases since the beginning of the first industrial revolution?
What is the scale of the loss of biodiversity of natural ecosystems, fauna and flora as a result of the progressive process of global warming?
What is the past and projected scale of loss of biodiversity of the biosphere as a result of the progressive process of global warming?
What is the level of biodiversity loss of the planet's natural ecosystems as a result of the progressive process of climate change?
What do you think?
What is your opinion on the subject?
What do you think about this issue?
I invite you all to discuss,
Thank you very much,
The phrase in the Title line imitates Karl Popper’s All Life is Problem Solving.
Since thermodynamics plays a role in life processes, it was surprising that searching “All life is thermodynamics” on Google on August 16, 2022 gave no results.
Don’t organisms seek to optimize and preserve the entropy of their internal energy distribution? And to optimize their use of energy and outcomes based on energy inputs? Aren’t survival and procreation ways of preserving previous products of energy use?
Is there justification for the statement, All life is thermodynamics? Or is the statement too simple to convey any insight?
Schrodinger in What is Life referred to thermodynamics, statistical mechanics; chapter 6 is Order, Disorder and Entropy. And more recently there is: J. Chem. Phys. 139, 121923 (2013); doi: 10.1063/1.4818538 Statistical physics of self-replication by Jeremy England.
I'm searching for a good collaborator or a research group that might want to tackle an interesting problem involving the relationship between quantum dots generating nanoparticle clusters and their DNA/proteins corral. This relationship is encapsulated by geometric proximity, that is I'm looking for someone who might know how quantum mechanics impacts something like these nanoparticles, such as how close a nanoparticle is to another nanoparticle or a protein and whether sized clusters form. Ping me if you're in the bio sciences, computational biology, chemistry, biology or physical sciences and think you might be able to shed some light on the above.
Currently, in Japan, physics, chemistry, biology, and geology are taught independently in science education context. So I would like to know, has any country developed a curriculum that emphasizes the relationship or overlaps between these four fields? I know that similar movement is occurring under the name of "STEM integration." But how about the case of physics, chemistry, biology, and geology? (Or I should say "PCBG integration") I would appreciate it if you could let me know anything.
Olen R.Brown & David A.Hullender published a paper in Progress in Biophysics and Molecular Biology journal in August 2022 with the name ( Neo-Darwinism must Mutate to survive ) : https://www.sciencedirect.com/science/article/abs/pii/S0079610722000347
the writers doubt macroevolution or the ability of known mechanisms of evolution to explain macroevolution as they say :
The central focus of this perspective is to provide evidence to document that selection based on survival of the fittest is insufficient for other than microevolution. Realistic probability calculations based on probabilities associated with microevolution are presented. However, macroevolution (required for all speciation events and the complexifications appearing in the Cambrian explosion) are shown to be probabilistically highly implausible (on the order of 10−50) when based on selection by survival of the fittest. We conclude that macroevolution via survival of the fittest is not salvageable by arguments for random genetic drift and other proposed mechanisms.
Forests are the biodiversity wealth of natural ecosystems and a key factor in the wealth of the planet's biosphere. However, this natural wealth is rapidly being eroded by human civilisational activities. The scale of forest fires has been increasing in recent years. The increasing scale of forest fires is a result of the ongoing process of global warming. In some regions of the world, forests are also being burned in order to acquire more land for the cultivation of agricultural crops, which is usually carried out under predatory and unsustainable farming practices. It is well known that forests are one of the key factors in reducing the rate of increasing CO2 in the atmosphere, an important factor in slowing down the greenhouse effect and consequently also in slowing down global warming. It is therefore essential to increase the scale of forest fire protection.
The following questions are therefore becoming increasingly topical:
How to protect forests from fires?
What is your opinion on this subject?
What do you think about this topic?
I invite you all to discuss,
Thank you very much,
I do recognise that there’s a well-known problem (hard though it is) of establishing how consciousness emerges or can be accounted for in physical processes. But I can’t at all agree that there’s a naturalistic, absolute hard problem of consciousness, because it’s an incoherent concept.
Nobody (at least nobody with a clue) supposes that neurophysiology can explain a qualitative difference in the way you and I experience the content of my music mix playing quietly in the background, or see the light reflect off a rainbow, or any of the other ways in which our qualitative experience discriminates from that of other live organisms. To suppose that just because you don’t know the mechanisms of the experience in your own head you will deny them the existence of them in somebody else’s is bizarre and reductionist.
Construct an imaginary metaphor of a magical, wizardry, thing-maker consciousness and you haven’t explained the qualitative data there either. It’s still the question of how consciousness comes into the work whether any magical things happen or whether there’s anybody there at all. To suppose a separate, inexplicable, mysterious, magic ingredient does neither any explanatory good, solve the hard problem, nor explain the evidence. All such arguments for a separate consciousness occurrent substance do, again, be it a magic nonsense or magic substance involved, reduce the hard problem of explaining thisness-of-consciousness (to pick a crazy approach) to the very same hard problem of explaining how consciousness arises in the first place.
If you identify the hard problem entirely with the mechanism through which the feeling-of-redness arises, or "the feeling of the future in an invariant past", or anything else you allude to, then you plainly have just traded in one way of asking a very simple question of the wrong approach. The question is, how do the millions of biological chunks and sub-systems interact with one another and integrate information over time and space? The sense of sight, sound, touch and soil all raise a “hard problem” of projection-understanding and categories-beyond-the-reliable-input-enumeration because by a vast over-engineering of the metaphor arms race (as even you must agree) the response-device signals of a single kind of appropriate examination will allow all in-the-know people to interpret an external reality quite differently. But the “hard problem” isn’t WHY is it that we can punch those signals at all, or make sense of the signals that come out the other end. That’s just the default condition of our very real neurological symposium. Whereas the “humanness” of that experience is also an entirely benignly apparent phenomenon, just as water’s polar nature is an entirely benignly apparentity.
For me the cardinal point is to reckon with how we perceive our own subjective value via multi-sensory data input both direct and indirect in both our two and three dimensional waking experience. And because at the very least you have to be wrong or qualified immensely if you think it’s not merely the interaction between general anatomy, organisation, information processing and output of your brain and all subjective processes such that personal conclusions then magically appear as relevant claims about reality.
P.S. I don't think evolution throws up any magical consciousness, either on its petri-dish experiments, or those novelty subjectiveness media that it comes up with sometimes. So I'd like to challenge that viewpoint, particularly in terms of our understanding of the nuances.
Globally, deforestation processes continue to outpace aforestation processes.It is well known that forests are one of the key influences on the climate, on the stability and sustainability of the climate, the maintenance of a humid microclimate, local water management, the state of biodiversity in regions.
Forests are also one of the key factors in reducing the amount of CO2 entering the atmosphere. At the UN climate summit COP26, it was agreed that by the end of this decade, i.e. by the end of 2030, national and global forest deforestation processes should be completed and forest afforestation processes should be accelerated. The restoration of forest ecosystems should be carried out in accordance with the principles of ecology of specific environmental formations of forest ecosystems consisting of replacing monocultures of tree crops with biodiverse restored, tree-rich forest ecosystem formations adequate to the specific local environment, geological and climatic setting.
But why do we have to wait so many more years for this? Why have such decisions not been taken earlier?
Why do the processes of afforestation not already prevail over deforestation?
Why are forests still being cut down when we know how important they are for slowing down the progressive process of global warming?
What needs to be done so that aforestation processes already prevail over deforestation?
How can afforestation processes be implemented quickly and effectively?
How can afforestation processes in civilisationally degraded areas be carried out quickly and efficiently?
How can afforestation be carried out with a high level of biodiversity in restored natural forest ecosystems?
What do you think about it?
What is your opinion on this topic?
I invite everyone to the discussion,
Thank you very much,
A patient with desminopathy survived Covid-19 six months ago without pneumonia, but with a temporary loss of smell and taste. After Covid-19, we note an accelerated progression of desminopathy, penetration accelerates, new muscles are quickly involved in the pathological process, muscle mass decreases, and heart function worsens. Perhaps the infection or its consequences are somehow connected with the mechanism of progression of desminopathy?
To save life in desminopathy, can the body purposefully reduce muscle mass, for example, due to decreased heart function or for another reason?
It is known that when hypothermia, the body sacrifices limbs for survival. Is it possible with desminopathy a similar phenomenon?
A patient with desminopathy (mutation Thr341Pro DES in a heterozygous state) with the progression of the disease has a decrease in taste and smell, immunosuppression, and an increase in IgA in the blood.
Oddly enough, but all this is characteristic of infections, including viral ones. For example, it is known that if the hepatitis C virus is not treated, then death will occur in 20 years.
In the identified case of late onset desminopathy, muscle weakness manifests itself at the age of 30, and death occurs 20 years after the onset of the disease.
Could the desmin mutation in myofibrillar myopathy be caused by an infection?
Perhaps the infection contributes to the progression of desminopathy?
I was wondering if anyone could point me to any references that show that with increasing oligo length, there is a significant reduction in ssDNA generation efficiency. Im specifically curious at what point heating to separate dsDNA becomes ineffective and some sort of legitimate physical experiment to quantify this reduction with increasing DNA length.
Some authors use either correlation matrices or VIF to identify collinearity between variables, while others apply both to improve model performance and interpretability. Therefore, I would be happy to get statistical explanations from anyone about the tools used separately and simultaneously or I want to know if other robust mechanisms to check collinearity are extant.
Thank you in advance!
I just received this email from Peer Review Department from "Insights in Biology and Medicine" Journal.
I think that this journal is not indexed.
Here is the email:
Dear Dr. Hany Mansour,
In the view of your eminence in the field, we kindly request you to review a manuscript from the Insights in Biology and Medicine.
This is to bring to your kind notice that we have received a manuscript entitled "Dead Sea Salt Solution: composition, lack of cytotoxicity and in vitro efficacy against oral leukotoxins, endotoxins, and glucansucrase"
We believe that your expertise and experience in the subject matter will certainly help in enhancing the quality of the manuscript.
We request you to accept this manuscript for review purpose and send the comments in the stipulated date.
Please find the attachments of the manuscript and Evaluation form.
Your support will be highly appreciated in publishing the research and development works in Open Access.
i have a general question about tissue culture.
I have found the following recipe for Epipremnum Aureum "Marble Queen":
Leaf Explant: MS Medium + 4.54 µM TDZ + 1.07 µM NAA (Thidiazuron in Micropropagation of Aroid Plants by Chen and Wei (2018), p. 105, DOI: 10.1007/978-981-10-8004-3_4)
Specifically, I have the following questions.
1) Do i only need to autoclave the agar with distilled water (I use a pressure cooker for this) and when the agar has cooled down a bit just add the MS, TDZ and NAA and mix it or do i need to autoclave the MS as well?
2) Will the TDZ dissolve in the agar water at all and how hot can the agar water be to add the MS, TDZ and NAA?
3) Is it even necessary to autoclave the water incl. agar (in the pressure cooker) if I clean all the jars with NaClO (sodium hypochlorite)?
Thank you in advance!
I'm using Sporosarcina pasteurii to remove heavy metals from wastewater by producing metal carbonates. The issue I encounter is that high metal concentrations (i.e. Co 2g/L) strongly inhibit bacterial growth and activity.
One of the existing solutions is to isolate another already metal-tolerant strain (such as Lysinibacillus sphaericus). (source :
I have read that it is possible to adapt a bacterial culture to a high concentration of metals by serial acclimatisation, where the bacteria are successively grown in a medium of increasing metal concentration. (source : 10.1016/j.wasman.2018.07.010)
Can this method be adapted to ureolytic bacteria? Are there any examples?
If not, what other methods would you suggest?
Thank you !!
Kindly discuss your ideas and viewpoints on the origin of life and the RNA world hypothesis.
What are the contradictory views on why researchers are still unsure about the origin of life through RNA or such analogous molecular intermediate pre-cursors preceding its existence?
"The general notion of an “RNA World” is that, in the early development of life on the Earth, genetic continuity was assured by the replication of RNA and genetically encoded proteins were not involved as catalysts. There is now strong evidence indicating that an RNA World did indeed exist before DNA- and protein-based life. However, arguments regarding whether life on Earth began with RNA are more tenuous. It might be imagined that all of the components of RNA were available in some prebiotic pool and that these components assembled into replicating, evolving polynucleotides without the prior existence of any evolved macromolecules. A thorough consideration of this “RNA-first” view of the origin of life must reconcile concerns regarding the intractable mixtures that are obtained in experiments designed to simulate the chemistry of the primitive Earth. Perhaps these concerns will eventually be resolved, and recent experimental findings provide some reason for optimism. However, the problem of the origin of the RNA World is far from being solved, and it is fruitful to consider the alternative possibility that RNA was preceded by some other replicating, evolving molecule, just as DNA and proteins were preceded by RNA." - Robertson and Joyce
[This is as per the explanation by Michael P Robertson and Gerald F Joyce in the article: "The origins of the RNA world." published in the Cold Spring Harb. Perspect. Biol. 4, a003608 (2012).]
The scientific community must resolve this contradicting conjecture through rational discussion and debate backed by strong experimental evidence on what must be the pre-cursor molecule to the Origin of Life if it is not RNA!
I am a student of biotechnology and an independent SARS CoV-2 researcher from India. For finding the academia research status and analysis of the integration of innovation with research, I have created a set of Multiple choice type questions about your experience as a researcher. The google form requires nothing but your honesty and openness for research. Feel free to ask questions and DM. The questions will assist in gauging the level of innovation and writing in academia.
If possible, please do forward this little form to your fellow researchers and other amazing scientists. I would be highly grateful.
I wonder if anyone knows how to use sample release reagent from Sansure Biotech ?
The 2023 ranking is available through the following link:
QS ranking is relatively familiar in scientific circles. It ranks universities based on the following criteria:
1- Academic Reputation
2- Employer Reputation
3- Citations per Faculty
4- Faculty Student Ratio
5- International Students Ratio
6- International Faculty Ratio
7- International Research Network
8- Employment Outcomes
- Are these parameters enough to measure the superiority of a university?
- What other factors should also be taken into account?
Please share your personal experience with these criteria.
I was able to study biology but not enough to understand the difference between B-phycoerythrin and R-phycoerythrin. Quite "simply" could someone answer to this question? Can we switch from one form to another? :)
Like Darwin reading Malthus "for amusement", I've been reading the 2nd chapter, "Systematics and Evolution", of the 3rd edition of "Vertebrate Biology", by Donald W. Linzey (2020).
When reading the section on "Species and Speciation" in this chapter, and more specifically when reading about the founder effect and its relationship with the origin of new species, I found the following sentence: "(...) speciation can proceed rapidly since only a portion of the original gene pool is normally present in the small, newly relocated population, and NATURAL SELECTION CAN WORK MORE QUICKLY ON SMALLER GENE POOLS" (capital letters are mine).
To the best of my knowledge, mathematical models of natural selection include parameters like relative fitness and/or selection coefficients, whereas population size is included in models for the evolutionary effects of random genetic drift.
So, do you have any idea on the reasons why natural selection could go faster in small populations (i.e., small gene pools)?
Any help will be welcome. Best regards, and thanks in advance:
Hi! I am a 3rd year biology student, and currently working on my undergraduate thesis, which has an objective to determine the presence of metallothioneins on several candidates from different microalgae genera. But, I don't have a background on various bioinformatics tool, may I ask if you know any software that could possible help me achieve my study's motive? Thank you
If I wanted to introduce a foreign protein into the human stomach without it getting cleaved up by proteases such as trypsin, how would I do so?