Questions related to Biological Science
I have discovered a unique protein expressed in various tissues, yet its function remains unknown. To gain insight into its role, I seek your expertise in the latest techniques and verified methodologies in biological sciences. Please contribute your knowledge and perspectives to this thread on how to find a function of a gene.
I know some of them like biorender. But biorender is not free and I am not good at illustrator. Can anyone suggest what should I do?
Among hundreds of Linux distributions, what are the most suitable ones which can be used by a biological science researchers whose workflow is largely based on genomic data science and its analytics (Bioinformatics), scientific manuscript preparation, illustration etc.
No doubt 'Charles Darwin's Evolution Theory' had tremendous impact on modern biological sciences. To become more science-based rather than religious belief, is it really important to think and rely on evolution theory?
Currently, I am looking for free-to-publish journals with an impact factor of more than 4 or 5 in food science and nutrition. It would be very helpful if anyone could suggest some good journals with free or low-cost publication processes. Thanks, anyone in advance if you provide any information or guidance.
I am a very curious person. During Covid-19 in 2020, I through coded data and taking only the last name, noticed in my country that people with certain surnames were more likely to die than others (and this pattern has remained unchanged over time). Through mathematical ratio and proportion, inconsistencies were found by performing a "conversion" so that all surnames had the same weighting. The rest, simple exercise of probability and statistics revealed this controversial fact.
Of course, what I did was a shallow study, just a data mining exercise, but it has been something that caught my attention, even more so when talking to an Indian researcher who found similar patterns within his country about another disease.
In the context of pandemics (for the end of these and others that may come)
I think it would be interesting to have a line of research involving different professionals such as data scientists; statisticians/mathematicians; sociology and demographics; human sciences; biological sciences to compose a more refined study on this premise.
Some questions still remain:
What if we could have such answers? How should Research Ethics be handled? Could we warn people about care? How would people with certain last names considered at risk react? And the other way around? From a sociological point of view, could such a recommendation divide society into "superior" or "inferior" genes?
What do you think about it?
Note: Due to important personal matters I have taken a break and returned with my activities today, February 13, 2023. I am too happy to come across many interesting feedbacks.
I want to learn graphic design related to biological science. Please recommend me a course or software.
Component: Pure water, Bsm buffer, Bsm polymerase, primer, MgCl2, dNTP, DNA Salmonella
Heat 60 Celcius 1h and 80 Celcius inactivation 10min
Sometimes the results from gel electrophoresis appeared DNA bands but sometimes less band intensity. What happen? Not suitable primer or expired chemical?
When run a LAMP reaction, sometimes false positive appeared in agarose gel electrophoresis. What are factors to create contaminations to false positives? What contaminations do in LAMP?
Do you have any experience or opinion about the accuracy of scientific information? The paper describes the accuracy of Wikipedia. I am experiencing resistance from wiki-bot/automatic response that prevents me from correcting the wrong knowledge. Thank you.
Dear scientific community,
What is your view on adopting the Blockchain and Non-Fungible Token (NFT) technologies in Biological Sciences? and how it can transform the genome storage or genome bank (governments of many countries are planning)?
Also, how this technique can be adapted to the local level or, say at the hospital level, to store any particular portion of human DNA in the worst-case scenarios like accidents or any disasters.
Also is it possible to donate blood can be stored in the hospitals and it can be connected through the NFT and once the owner wants to sell it can (Anyhow the blood business is unethical but if it can be tokenised people might move more towards donating it, also the hospitals are making money out of taking blood freely)
Also, you can suggest on your behalf, what are the latest area (with respect to biological sciences) where these techniques can be applied.
#MachineLearning Hello researchers, I was wondering that what are the most remarkable applications of machine learning algorithms in Biological sciences? My naive thoughts are: DeepMind by Google: Protein Structure predictions #Epitope predictions by DTU - Technical University of Denmark in Immunology Predicting tumor entities by DKFZ German Cancer Research Center for Central Nervous System. Please add to this list, looking forward for an interactive discussion. #structuralbiology #bioinformatics #research #immunology #cancerresearch
In the last three decades, the number of biological data has diversified and grown. This growing increase has resulted in the development of computer applications to ensure better handling of biological data. In the midst of this situation, for some, it is essential to develop programming skills and use professional software in undergraduate teaching in Biological Sciences careers. However, another group thinks that training in biostatistics specialists is the key to guaranteeing the proper use and handling of biological data. Faced with this problem, the following questions arise that I would like to invite you to debate:
1. Would success lie in including programming courses in the curricula of life sciences majors?
2. What will be the best programming language to teach, R or Python?
Should biological data management skills training be developed in graduate education?
I read this report that 3% (v/v) Ethanol increases recombinant protein expression in Escherichia coli. The SDS PAGE gels seem pretty convincing (1).
However, assuming I get great expression of recombinant protein with 3% (v/v) Ethanol, how am I supposed to decontaminate the biohazardous cell waste from the experiment?
Bleach decontamination isn't a good idea because bleach would react with the ethanol.
Autoclave decontamination isn't a good idea because ethanol is flammable.
Is safety just not a priority?
1) Chhetri G, Kalita P, Tripathi T. An efficient protocol to enhance recombinant protein expression using ethanol in Escherichia coli. MethodsX. 2015;2:385-391. Published 2015 Oct 8. doi:10.1016/j.mex.2015.09.005
bioRxiv is an open access preprint repository for biological science papers starting in November 2013 and hosted by the Cold Spring Harbor Laboratory. How important, useful and informative are these preprints, which are not peer-reviewed, but are screened and checked against plagiarism?
bioRxiv seems to fill an important need based upon the number of submitted papers. Do you submit preprints to this server? Do you think it help or harms research communications?
If so, how much are your bioRXiv papers read and cited verses the typical journals you would send to for a given paper? How much do you read and cite bioRXiv papers compared to other journals?
I'm sorry if we are supposed to ask only about specific research topics, but lately, I've been wanting to learn a new language that could also help me on my research field.
I'm not sure which one should I pick because I'm interested in Reproductive Toxicology (hopefully I can apply that knowledge on wildlife and conservation), but I haven't been able to find any trustworthy link that could guide me to the job and research offer on this fields worldwide.
Even though there are some sites that talk about it, they are either old publications or emphasize more on the "diplomatic and corporate" side of language learning.
If someone could please guide me at least a little bit to have a better understanding on the Biological Sciences opportunities attached to different languages, I would really appreciate it.
Thanks in advance!
There has been many occasions where people do not expect to be answered in terms of engineering, especially in biological sciences. However, it is more common to find the answer in terms of an engineering only in biological sciences. We have reached a point where it is impossible to separate, the engineering from the biological discipline.
The most common one is genetic engineering. How many more engineerings are there and can anyone explain the differences and what they are?
I would like to add the engineerings I can think of, but I am afraid I am not an expert on these areas, as I still need to give a definition to all of them. I will appreciate if anyone could complete the definitions, and make a list of them.
Is there anything else on these engineerings?
Any contribution is welcome.
Please can anyone suggest fast publishing Scopus indexed journals, which can publish research articles in biological science?
Biodiversity is diverse in virtually unlimited degree, which results from the essence of processes of evolution of species, filet lines and entire ecosystems. It is thanks to the millions of years of evolutionary processes on Earth that there are so many different natural and highly diverse ecosystems in which different species of flora, fauna, fungi and microorganisms adapt to life in different and very diverse geographical and climatic environments.
The largest biodiversity of ecosystems and species functions in natural environmental environments in which ecosystems have evolved without human impact through millions of years of climatic and geographical conditions enabling the development of various life forms. These types of high biodiversity sites can be found in unpolluted rainforest ecosystems in tropical forests, in temperate climates and in coral reefs.
Unfortunately, human civilization activity contributes to the successive and accelerating process of biodiversity reduction by dying out species of living organisms. The areas of natural natural ecosystems are decreasing, including those in which the greatest biodiversity is diagnosed, such as the rainforests of the Amazon. The protection of naturalistic ecosystems and thus the protection of the planet's biodiversity is the most important challenge for mankind in the 21st century.
Do you agree with my opinion on this matter?
In view of the above, I am asking you the following question:
What do you think is the importance of biodiversity in natural ecosystems?
I invite you to the discussion
Thank you very much
Today we can speak of the existence of a global crisis of specialists taxonomy. However, a little-addressed topic is undergraduate training in this important branch of the biological sciences. How is taxonomy research motivated in Biological Sciences majors? Is the teaching of taxonomy adequately and intentionally approached? Final Degree Projects are done today on topics related to taxonomy?
I am not sure if any one study on this topic. It has been observed in certain cases that success-full researchers have poor academic record. These are exceptions, I am interested to know any study on this topic. Please also cite examples that shows negative or positive examples. Ideally there should be high positive correlation, if it is not than why?
I mean if person got good grade/marks or rank at school/university level will be a grate scientist. For example if topper of JEE (top exam in India for getting admission in engineering college) join research, he/she will be best scientist in the world.
I read in many articles a statement that best proximity point theory has applications in the field of Economics, game theory, biological science. But I want to see some physical problem that was mathematically modeled and then solved by using best proximity point theory or fixed point theory.
I would like to draw a figure for nucleic acids strands in pipe-like appearance with some curvatures and colors. I want the figure to be attractive, not just a collection of dull thick lines.
I found this research article where they did tested the antimicrobial activity of some plant oils using Agar Well Diffusion ( Esmael, A., Hassan, M. G., Amer, M. M., Abdelrahman, S., Hamed, A. M., Abd-raboh Hagar A., & Foda, M. F. (2019). Antimicrobial activity of certain natural-based plant oils against the antibiotic-resistant Acne bacteria. Saudi Journal of Biological Sciences. doi:10.1016/j.sjbs.2019.11.006).
I presume they use parafilm to seal the Petri dish; but how would you prevent the oils from evaporating from the well and settling onto the agar surface?
Seeking answers from the experts.
If you had a choice of equipment for your lab, what items do you think would be essential for advanced biological science research? We have a pretty well stocked lab, but I add one piece of equipment every year. We would be looking for something that would last for a minimum of 10 years, be scalable and versatile but still fit in a relatively small lab. Getting access to core facilities is very difficult so we have to plan...
Also, can anyone recommend a couple of good options for a
1. bench top flow cytometer
2. bench top sequencer (is it worth getting a next get sequencer)
3. Any thing else?
I'm looking for areas in which high impact journals published results that were the opposite results to other publications by high impact journals.
Thank you in advance
What are the application of thermodynamics (Physical Chemistry) in Biotechnology ?
Would appreciate any feedback on the following scenario - especially how to think about it in biological and science related to consciousness studies:
I am an addiction psychiatrist and I have ample time to explore the subjective aspects of addiction - specifically how it starts and is maintained. Many people tell me that the addictive compound they are using no longer has the desired effect, does not treat the target symptom, and may in fact make them slightly ill but they keep taking it any way.
Example: Patient A is taking very high doses of benzodiazepines for anxiety. He does not notice any anti-anxiety effect but wants to continue taking them anyway. He is seen to taper and discontinue the benzodiazepines and a standard approach is to take gabapentin for this process. He notices a marked antianxiety effect from the gabapentin but not the benzodiazepines. It is not a tolerance effect because he never got any relief from the benzodiazepines and described that to me as "always having a high tolerance".
I have seen the identical phenomenon with opioids and stimulants.
Any ideas about how to conceptualize this in terms of neurobiological substrates?
We have reared this insect from the leaf galls of Alstonia scholaris. The rearing of insects has been done in the Biological Sciences Laboratory, Department of Biological Sciences, Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalaya, Chitrakoot., District Satna (MP)India.The image of eggs and adults are attached
What kind of scientific research ( hypothesis ) can I do and complete it in the absence of availability or absence possibilities to do this research. Knowing the research I want to do is related to biological sciences in the specialty (immunology)and medical science. Is it possible to do this and what are the ways or methods to do such researches ?
Current technologies restrict the speed biological research can be conducted. The majority of research requires invasive procedures (time consuming and prone to health risk). The adoption rate of technologies is impeded by the requirement of wearing technology or undergo surgery. Implants or the wearing of devices reduces convenience, is physically limiting, and is viewed as being visually unattractive.
I believe that with the removal of these limitations, the speed of which research is conducted will 'explode' - people will be able to perform their daily functions, with full range of motion, without having to wear any devices or be hooked up to equipment.
DARPA has recognized this, and is pushing magnetic field sensing to a new era with through the “Atomic Magnetometer for Biological Imaging In Earth’s Native Terrain (AMBIIENT) program”. They want to be able to read the magnetic field generated by the body without needing the subject to be shielded from the Earth’s magnetic field.
I am expecting the Darpa initiative to be successful. I am looking to discuss how it might be possible to remotely read biological signals, leveraging our environment.
If you could name the most important publications relating to any of the biological sciences over the last 100 years what would those be? Beginning with Francis & Crick's paper on DNA...
For many fellowships, postdocs may be given smaller ($10-30,000/year) amounts of independent research funds.
Do you have any tips for how best this money can be spent? What is the most bang-for-your-buck for a young independent researcher? Are there things that can be purchased that might benefit the researcher beyond their postdoc experience?
There are many definitions of model-based sciences, which have a different philosophical meaning. This is due to the fact that the signification of the term ‘model’ is ambiguous: some of these theories may be based only on one kind of models and are unable to integrate in their field the other ones. I will give here two examples of model-based theories, but you can find many other ones.
The semantic theory of models, more recently called a ‘model-based’ view of science attacked the empirical explanatory models, which dominated the philosophy of science before the 1960’s, and promoted formal explanatory models during the following decade. Even if various versions of this approach differ (Patrick Suppes, Frederick Suppe, Bas van Fraassen, etc.), it continues to be developed nowadays. In this approach models, as abstract representations of some portion of the world which are different from empirical laws, are the central element of scientific knowledge. For 21st century researcher, computer modelling will permit the statement, manipulation, and evaluation of more and more complex theoretical models, as Thomas Burch (2017) said. But how in this case identify the relations between the theoretical model and the empirical observations, and test the fit of a simulation model? There is a real danger to construct theoretical models without any relationship with observed data and no way to verify this relationship.
The mechanistic view, which had been mainly developed for biological sciences during the 1990’s, is also considered as a model-based science. Again various versions of this approach differ (William Bechtel, Carl Carver, Stuart Glennan, etc.), but its development nowadays is increasing not only for biological sciences but for social sciences. A more recent version of this view is given by Robert Franck (2002) as the functional-mechanistic approach. As the semantic view the mechanistic theory of models rejects the empirical explanatory approach, and may appear as similar. But, while for the semantic approach a theory is a formal system empty of any empirical content, the mechanistic one infers, from the sustained observation of some property of nature, its functional structure –in classical terms the axiom, form, principle or law- which rules the process generating this property, and without which this property could not come about as it does. By focusing on the mechanism, generating a social property, the functional structure is treated independently of the causal structure, and may be generalized. We used this approach, with other researchers, in a recent paper on model-based demography (2017).
Under this question, I would like to discuss here the different model-based theories, their main aims, and the use of the term model.
Burch T. (2017). Model-based demography. Springer.
Courgeau D., Bijak J., Franck T., Silverman E. (2017). Model-based demography: towards a research agenda. In Agent-based modelling in Population Studies, Grow A., van Bavel J. eds., Springer.
Franck R. ed. (2001). The explanatory power of models. Kluwer Academic Publishers.
Mäki U. (2001). Models: philosophical aspects. In International Encyclopedia of the Social & Behavioral Sciences, Smelser N.J., Baltes P.B. eds., Elsevier Ltd.
with my immense pleasure, the college where I teach asked me to deliver a course of statistics for animal science/marine science/bioscience students (2nd and 3rd year of Bachelor's degree).
Can you suggest a good book I can use for the course, ideally tailored for animal/biological sciences?
I have read a lot of papers from neuroscience ... psychology ... Biological sciences... they talk about the roles of astrocytes in synaptic plasticity? Is there any evidence to consider astrocytes as the main player of plasticity not the neurons?..is it possible that the plasticity definition based on changing of astrocytic strength by synapses, as well as altering synaptic strength by asrtrocytes?
Just wondering if anyone has used this extractor and what you think of it? Any tip's or tricks or pitfalls related to it that I should be aware of?
Do the extraction kits give a good quality yield in your opinion?
I'm taking a survey to identify potential uses of cloud computing in the biological and biomedical sciences. How would or do you use it? For what tasks/methods/questions? What would you like to be able to use cloud computing for?
In cytotoxicity experiment like MTT assay etc. for toxicity reason amount of DMF or DMSO used should be within 0.1 % range. Is there any proper reference that is showing this permissible amount of DMF?
In recent years we have witnessed some breakthroughs in biology with significant progress being made, similar to the progress of physics made in the 19th century. Furthermore, it seems that with the help of new technology, biology can continue its progress towards further glory. What are your views on this? And do you think biology is better equipped to reach an adequate intellectual intensity as physics once was and still is?
Models are abstracts of reality. They also represent prototypes. The need to include modelling and simulation in the Computer Science and Biological Science curriculum of some Universities in different continents, especially in some developing countries, has been an object of debate. They keep asking about the significance of modelling to Computer Science and Biological Sciences.
What are the important things other than qualifications, experience and research funding to apply for the academic level position in university. How to prepare for the interview. Suggestions welcome