Biocompatibility - Science topic
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Questions related to Biocompatibility
I need to use it in the medical application.
What is the measurement of osteoinductivity, bioactivity and biocompatibility of materials for bone tissue engineering?
Hi, Anyone please help me to give a protocol or link to get magnetic iron oxide nanoparticle, Now i am making it by fecl3. anhydrous and iron sulphate in 2:1 ratio with base (nh4oh) at ph 10. it was not stable. stability increased by adding ph regulated curcumin to it. Sometimes i get good magnetite. but sometuimes the particle doesnt show any magnetic property. I dont know how to optimize. anyone please help.
Which works contain information about the mechanical as well as biological properties of the cerabone AW biomaterial, namely biodegradation. bioactivity, biocompatibility, osteoconduction, osteoinduction? Thank you!
Are there standards for porosity, osteoinductivity, biocompatibility, biodegradation for porous hydroxyapatite, bioglass 45c5 and Cerabone A/W? Thank you!
It is necessary to select biomaterials (hydroxyapatite, 45c5 bioglass and A/W bioglass) using a hierarchical method, but I cannot find indicators of biocompatibility, biodegradation, osteoconductivity of these materials. What studies or standards have information about these indicators of these materials? Thank you!
It is necessary to select the optimal one from three materials based on hydroxyapatite, which are used to replace bone, by analyzing hierarchies. Could you please tell me scientific papers in which for all three materials there is the same information on mechanical parameters and biological (bioactivity, biodegradation, biocompatibility, osteoconductivity, osteoinductivity) parameters. One of the materials is pure hydroxyapatite.
Want to coat biocompatible positively charged polymer on a glass slide to perform the biological tests? Kindly suggest some excellent papers?
Which buffer can be used for adsorption and desorption of DNA to chitosan-coated magnetic nanoparticles?
I am planning a fluid dynamic experiment and wonder what tubing material is biocompatible for cell culturing experiment. Also wonder if there is a tubing material that can be sterilize.
I want biocompatible PEEK material for my research purpose.
We need to attach metal beads to contact lenses for a project, and I could not find any adhesive that works with contact lenses (preferably biocompatible) . I know that they are made of hydrogels , any suggestions on what to search/look for would be helpful.
Why nature-based products are considered biocompatible for drug delivery although many natural products can be toxic or dangerous
I am currently working on quaternary titanium alloys like Ti-Nb-Ta-Zr with single and duplex phases. May anyone suggest a better method for study the corrosion behavior of biocompatible titanium alloys like Ti-Nb-Ta-Zr alloys?
I would like to make some tests, implanting a small datalogger under the skin of an animal.
Problem: for this tests, the datalogger needs a hard, biocompatible coating.
Could you recommend a easily available resin that is resistant, and biocompatible, so it could be used under the skin?
the reagent should be biocompatible other than ethanol and the method should be except plasma treatment. your response would be highly appreciated.
I have a critical question about the correctness of the following expression which is the title of a published research paper (the attached picture). The authors used the word "biocompatiblity" as an adjective for "characteristics". However, the word "biocompatible" itself is an adjective but the word "biocompatibility" is a derived term of "biocompatible". Why the authors used "biocompatibility" instead of "biocompatible"? Do you think this is Ok? If so, please explain more.
"Biocompatibility characteristics of the metal organic framework ZIF-8 for therapeutical applications"
Thank you in advance
I am looking for different assays to study the biocompatibility of different manufactured membranes. I have read loads of papers but I keep finding similar assays, so I would like to hear from experienced researchers about other assays that would provide me with string data for my research. I have used MTT assays to analyse cell growth in the scaffold, but I would also like to study cell viability as well. Would you recommend me any assays for cell viability, phenotypical change, migration, cellular structural growth? And would you recommend I look at any other characteristics?
Thank you for your help.
Could someone help me understand this: since pla is a biocompatible, can you use a, let's say, hobbyist 3d printer print a medical implant with pla and then thoroughly sterilize it (using gamma irradiation/gas plasma), then can you put it into human body ?
I am wondering is there some chemicals that manufactures used during manufacturing PLA filaments that make it not biocompatible any more ? (can u use a PLA print as a cup to drink water ? )
I just wanted to ask the appropriate dose for Biocompatibility studies? Should it be the one administered to Human or mouse model or it should be calculated with respect to number of cells. In case of microbubbles normal dose for 70kg Adult is 5*10^6 bubbles with respect to 5L of blood. So for biocompatibility assay, should the starting dose be 5*10^6 or less?
Do you know an article about preparing the most biocompatible injectable dermal fillers(should include quantity of materials used)?
Phalloidin stained filaments and dapi stained nucleus
I am looking for a non-toxic and ineffective hydrogel that can be converted into fibers by electrospinning. I also need to know its solvent. Since I am going to use these fibers for medical purposes, it is very important that these fibers be made of biocompatible super absorbent.
Preferably, the flexural strength of the fibers should be low to minimize the amount of lint.
for theraputic application we need to nanoparicle by high magnetic propertis ,Fe is a good section, but for Biocompatibility we need to coat...
can you help me ?
Most biocompatible, conductive polymers on the market are filled with silver particles as conductive filler.
What are the reasons graphene isnt used so often? It has higher electrically conductivity and it is biocompatible.
What are the advantages and disadvantages of graphene and/or silver?
I want to design a biocompatible functionally graded cylinder that ranges approximately from 200 to 5 in terms of elastic modulus.
since the elastic modulus of cobalt-chrome-molybdenum and hydroxyapatite coating are 200 and 5 respectively, is it possible to fabricate this FGM of cobalt-chrome-molybdenum and hydroxyapatite?
I need to reduce the viscosity of PCL.
One way would be increasing the temperature, but I need to keep the temperature stable.
As a second choice, is there any biocompatible solvent to dissolve PCL?
Thanks in advance.
It thus needs to be biocompatible and should not interfere with free radical production (redox insensitive). Many thanks!
I mean density and biocompatibility of ceramic,
When we implant PLA TiO2 bionanocompoiste combination into a biological system what are the things to be considered? Other than Biocompatibility, Antimicrobial and load-bearing capabilities (mechanical properties)
I have my research in green synthesis of nanoparticles, and I wants to know that why nanoparticles synthesized through green synthesis method are biocompatible need reference papers.
Hello. I want to crosslink using natural or synthetic polymers. I need an elastic and highly biocompatible polymer.
Hello, dear colleagues. I am trying to make an SBF and have some problems with it. First problem is how do you measure temperature in process? And what color should be ultimately succeed?
Biocompatible porous ceramic is first choice if these could be made resorbable
I tried to dissolve UHMWPE for cytotoxicity examination but unsuccess to dissolve.
Is there any other technique to find biocompatibility of specimen having dimensions 10 mm X 10 mm?
Hi, I am creating a 3D model for in-vitro drug screening. In one step, I want to create a hydrophobic surface on the coverslip, which is needed to have resistance to acetone and also need to biocompatible for culturing a different kind of cells. Can anyone suggest me a product to create such coating?
I need to know if substrate material of a printed circuit board ( PCB ) is bio-compatible? Really, I want to fabricate a biosensor on a PCB substrate and I need to ensure biocompatibility of the substrate material.
Cellulose is a abundant biocompatible polymer can be functionalized in different ways. However, how the antibacterial functionality can be introduced in the cellulose moiety in microcysts or in nanocrystalline form?
I am doing my research on electrospun scaffolds for tissue regeneration and my team will have it them tested for biocompatibility and cell proliferation soon. I'm not yet sure which cell line will be used but I came across several papers that use cancer cells for such tests. I don't have a background on cell testing but I do know that cancer cells can proliferate indefinitely in a culture without the need for additional growth factors unlike normal cells which makes things easier. But how can it provide evidence of compatibility when my application is solely for normal cells (i.e. scaffolds for skin cell regen.)? I mean will the results be the same for normal version of the cell?
Please enlighten me about this. Thank you
A new excipient has been developed that enhances the stability of insulin. However, we wish to evaluate the in-vitro toxicity profile before evaluating the toxicity in-vivo. I would like to know on how to shortlist various assays.
Developed an oxide coating on SAE 420A stainless steel. Need to evaluate the corrosion behavior in body fluids.For that which is the best ASTM standards.
How can I conduct the biocompatibility tests for some composites by electrochemical tests?
I work on my thesis by electrospinning method. I use materials collagen type 1, hyaluronic acid, and polyethilene oxide (PEO). Acetate acid as the solvent doesn't evaporate at room temperature which effect the result (nanofibrous). So that, i need solvent which can dilute both collagen and polyethylene oxide (PEO) and has characterictis volatile in room temperature and nontoxic (biocompatible). Thanks !
I want to know about the impact of porosity on the implant surfaces and what kind of variation we will get on its biocompatibility and strength.
I am looking for some positively charged polymeric nanoparticles that are biocompatible. The basic use of these nanoparticles will be in drug delivery in vivo
I will be testing the biocompatibility of my staphylocoagulase extract from Staphylococcus aureus on human keratinocytes and fibroblasts. Should I use MTT assay or Trypan Blue Exclusion assay? Or both?
What are their pros and cons?
- To better understand the immune response to nanoparticles.
3-D printers are one of the almost new technologies.
Can these printers be used in biomedical engineering?
(For example, to build artificial veins and arteries, joints, and so on.)
I have a limited background in chemistry and need to synthesize particles that have functional EDA groups populated on the outer shell.
Reading about spermatogenesis, I thought that would can be change the process to make empty acrosomes without DNA to drugs carriers and target to specific tissues with the help of flagellums. Making a biocompatible nanocarrier.
Hi, which tagged nanoparticle 1-2nm in diameter is best for an in vivo delivery towards Macrophage and CD4+ T cell-protein-membrane attachments? Meaning which nanoparticle is most biocompatible, potent, affective, stable etc. for this task?
After some preliminary research I have narrowed this down to gold or iron-oxide with gold seeming better for this application since iron-oxide seems to be more applicable to imaging, opinions appreciated?
The question concerns the possibility of external influence to degradation alginate gels.
As much as i am aware of Bone, it consists of phosphate and calcium as major contents. If possibly someone can help me in what biocompatible milling tools with grades can be used for cutting bone of skull of human that would be great.
I want to evaluate a new material biocompatability and I want to find the appropriate animals sample size ?
could you help me to find the rational of using rats in like this experiment ?
Nowadays as we know , there is different ways for surface modification of dental implants ( sputter deposition,Electrophoretic deposition, laser treatment, coating and etc.)
I was wondering if anyone could answer my question:
what is the priority of sputter deposition in comparision with other techniques such as coating ?
Am aware, 400 series of steel possess high strength, high wear and acceptable corrosion resistance. Also, it has been extensively used as Cutting tools for Medical surgeries but why not as an Implant (orthopaedic or stents).
I looked for papers which relates the Bio-response of the cell or platelet adhesion over Martensitic steel ( ex. 420 or 440 ) but i couldn't see any published work explaining the same.
It would be great if someone could help me to understand better or to suggest some more research articles ?
Thank you in advance.
Could it possible to silver metal implant in cranial bone? have any biocompatibility with bone or tissue or fluid.
Why is biocompatibility(MTT) Assay done on cancer cell lines like MG -63 though it is a sarcoma cell line.I have read in many papers where it is said the test material is biocompatible to osteoblast cell line though it is a osteosarcoma cell line.
I need to check the cytotoxicity and biocompatibility of the silicone breast implants. Kindly suggest the cell line to proceed with?
Especially for organic materials such as hydroxyapatite, TCP, Collagen etc.
I am considering to synthesize Manganese oxide nano-particles for biological purposes but I am not sure of their biocompatibility.
hydroxyapatite coating duplex stainless steel for surgical implant
We want to obtain a drug delivery system
I want to enhance the dermal as well as systemic delivery of my compounds for the acceleration of wound healing by nanotechnology. But, I am not sure about the right approach. So, please tell me that formation of nanoparticles of my compounds is better or their Nanoencapsulation is better than the parent drug.
I am doing some research into new coatings used for recent ceramic-based biomedical implants and devices. And specifically, I need some articles and resources about the latest version of ceramic biomaterials.
PhD interested in the development of any of these products: bioinks, scaffolds for bone regeneration, resorbable dressing for wound healing, resorbable microcapsules for drug delivery, please, contact me at email@example.com,
More details in the attached file.
Various researchers are using different mg/ml like 1 or 5 but which one is the most appropriate
I would like to test the biocompatibility of my hydrogel with cardiac progenitors and mesenchymal stem cells. I am using UPy hydrogel at pH 8.4, this is a pH switchable gel and has fairly solid consistency at this pH. Other groups have used lactate dehydrogenase assays to test cell damage. Are there any other protocols that would work with this set-up?
In my study, I'll use a lot of Transwell membrane for cell culture but transwell are a little bit expensive. Does any know where to buy the transwell membrane? Or, does anyone know the difference between the membrane (wha70604704, polyester) and transwell membrane(Corning, 3470) in term of porosity, thickness or biocompatibility etc of membrane? Thanks
Invitro hemolysis of human/sheep blood is tested in order to detremine biocompatibility. my question is that why only erythrocytes?? why cant any other cell be tested for checking biocompatibility?? if there is a relation between antimicrobial biocompatibility and hemolysis or if there is any special significance of hemolysis in such aspects, please let me know
I'm trying to adhere some wetted electrospun nanofibers to the glass slide. Is there any biocompatible glue can be used?
we have used to prepare alginate ionotropic gelation technique and Na-alginate is homogenization. After that we producing from na-alginate to ca-alginate. we are using calsium for biocompatible alginate. calsium is connecting a cross-link to na-alginate but formed this bond, is weak. because of the fact that calsium-alginate is less mechanical strenght.
what can ı do to improve the mechanical strength?
na-alginate solution is 5%, cacl2 solution is 5%. changing percentages in solution does not have impact role in mechanical strenght. i have tested.
ı have one more question. Is there a duty of chlorine in the solution CaCl2?
Dear colleagues, could you, please, suggest a reliable and affordable protocol, which can be used without changes in parallel to MDA-MB-231 and MCF7 breast cancer cells? We expect that MDA-MB-231 may require something to increase cell-cell interaction, while the MCF7 do not need that.
Basically, we intend to measure the effect of a substance on invasiveness of these cells placed in 3D environment. So, we expect to incubate the spheroids in liquid medium, containing a range of the substance concentrations for 24-72 h and then we intend to graft the spheroids into 3D gel to measure the invasion as maximal invasion distance and invasion area. The gel will be, probably, collagenous, but other options are also interesting for us (the preference now is to use some non-expensive biocompatible and transparent 3d gel, even synthetic as well). Thank you very much.
Due to their morphological properties, GQDs (Graphene Quantum Dots) can enter the cell.. Are there any reports on their effect on the generation of Reactive Oxygen Species (ROS) by causing infiltration into the mitochondrial double membrane structure? If that is the case, then I think, it is too immature to call GQDs as bio-compatible.
I am looking for a service/company that does 3D printing of biocompatible silicone (LIM or comparable) for device prototypes. Is this possible and does anyone have suggestions?