Questions related to Ayurvedic
We are willing to create a pool of researchers interested to work in the area of Gut Microbiom Studies in RA receiving whole system Ayurveda ( Traditional Indian Medicine ) interventions .
We have theoretical reasoning for hypothesizing that following the Ayurvedic interventions , gut microbiota in RA population changes. This change reflects through improved gut symptoms and improved RA symptoms. We however do not have experimental proves for this change. Therefore we are initially planning to do some ground work through a set of pilot studies .
We will be very happy to get joined by the scientists of common interest to check on the current outcome parameters , diagnostic criteria and intervention plan .
I can be reached at firstname.lastname@example.org and also at 0091- 9415022955
Prof Sanjeev Rastogi
PG Department of Kayachikitsa
State Ayurvedic College and Hospital, Lucknow University
Actually I want to prepare polyherbal ointment for wound healing study, but how can I decide the concentration percentage of plant extract for formulation preparation. I have read a lot of papers and ayurvedic pharmacopoeia but I have not found any strong criteria to prepare the ointment.
Journal in which I was ask to pay publication charge for my manuscript already accepted and find attached, the snapshots of the payment as requested.
Your professional response will be highly appreciated. Thanks.
It is observed that significant % of population has followed a wide range of ayurvedic formulations to boost immunity and to prevent COVID. Many have found significant benefit at clinical level. How to analyze the role of any of such Ayurvedic formulations/Rasoushadhies in COVID prevention at Preclinical level?
I am currently working with TNBS model of ulcerative colitis in rats to evaluate the effect of an Ayurvedic drug which is used in grahini roga. It will be very helpful if anyone will help me by discussing the pathogenesis of grahini roga.
It is said that kabasura kudineer a product of Indian traditional medicine siddha/ayurveda has some beneficial effects against covid 19 infection. I would like to know more about this.
Many clinical studies in periodontics compare a new antimicrobial (mouthwash/chip/gel/subgingival irrigation/etc) which could be allopathic/ayurvedic/herbal. These new agents have a positive group, mostly chlorhexidine and one negative control group (either placebo or only SRP without any adjunctive agent. Is it justifiable to use a negative control when previous studies have proven that adjunctive use of Chlorhexidine is better than only SRP or placebo. When we know that adjunctive use of a gold standard is available that will give additional benefit to the patient, is it ethical to include only SRP or placebo group?
Cant we compare only two groups: test agent against gold standard?
Simple search in Google Scholar shows that since 1960-70 many articles in peer-reviewed journals have supported various desirable effects of Transcendental Meditation (TM) but some people here and there claim that the research has always bee. Funded by certain organizations and people who benefit from advertising TM and the published evidences are not so reliable. Is that really true?
Ayurvedic herbo-mineral formulations are very complex in nature. Even their methodof preparations is also very complex. So in such cases the modern advanced analytical tests are employed to understnad their structure. But is it possible to know the complex structures of the formulations with adopting tests like X ray diffraction, Spectroscopy, FTIR, Scanning electron microscopy etc.
Ayurvedic drugs are largely criticized for their unproven safety. Number of case reports are available in the literature showing Ayurveda drug related adversities. These adversities are by and large found to be associated with heavy metals found in Ayurveda drugs. We however have also seen the contrary and found that Ayurveda drugs , despite their heavy metal content, proved to be beneficial in many clinical conditions without causing any adversity.
In this context , this seems highly relevant to establish safety of heavy metal containing Ayurveda drugs in human population which are routinely prescribed and consumed. What should have been the common parameters to evaluate and establish safety of such drugs prescribed in a set of clinical condition? Suggestions are welcome
I am a undergraduate following a research on identifying Ayurvedic medical plants in Sri Lanka. For sure I know there are many apps ("PlantNet" , "PlantSnap") in finding a unknown plant in your garden, but still the above problem appears to be in the society when finding the medical plants if you are on a prescription with Ayurvedic treatment. So let me know your ideas as solutions for this problem.
How can this practice of on paper or fake teachers can be prevented as many ayurvedic colleges are encouraging this trend for their financial benefits. Even this practice is also there in post graduate colleges which seriously affect the quality and standard of education of ayurveda.
Had Pharmacovigilance proved to be relevant for Ayurvedic drugs yet ?
Has these cases been reported and resolved upto a significant level ??
Specifically in India ??
Microbial contamination, infestation and heavy metal content is of grave concern these days in herbal medicines. I wish to know various practical ways to protect the product against contamination. Still, in case, the count is found above permissible limits in the end product... what are the ways to sterilize the same?
I need to do the study on a HER2 positive cell line Either SKBR3 or MDAMB-453 (HER-2 positive cell line) for 2-3 extracts..and this is a bit urgent. I checked at ACTREC, Mumbai but that option is not open, and there are very few option but they take a lot of time for processing.
Infac, there are few terminally breast/ovarian cancr patients who are being treated on this treatment by an Ayurvedic practitioner (as they are declared incurable by doctors)..so we wanted to knw atleast if this works or not.... on an invitro level, so that the treatment regime becomes a bit clear....
I hope you understand the gravity of the situation and help me or suggest me to facililate the issue. I am ready to bear the charges or cost of chemicals that may be required in the process, only time is a bit issue as the necessity stands for a real time clinical scenario....
Lots of Herbs are described in Ayurveda for Gastritis but it not provide quick results in Acid reflux or Hyperacidity like fennel, liquorice etc..
In present times two school of thoughts are working on herbs :
1st is conventional Ayurvedic herbs and another one is ORGANIC herbs approved by different organisation (USDA) etc.
As for Shrubs or some other herbs these can be grown under few climatic conditions but what about Tree like Arjuna(Terminalia arjuna) ,Ashoka( Saraca asoca ) etc and so on.
I am researching, if an ayurvedic procedure is helpful in managing lower back pain. This is called Kati Basti or Kati Vasti or Grdhrasi Basti. I will create a study to treat patients with this kind of treatment. But there is nothing mentioned in the old texts. So this type of thing must be a creation out of something different... I don´t know, if somebody is there who have ever heard of it. But let´s see what will come around :)
How important is powder size in its effect in case of Ayurvedic dry powder formulations? I want to know if there are any published references.
I am planning to work on the integration of ayurvedic drug and allopathic system using an animal model. So kindly suggest good ayurvedic or herbal medicine for the treatment of diabetes but which are not scientifically validated.
The research is focused in folklore and traditional use of plants for hair care (dandruff, oily hair, hair growth, hair lost prevention, etc...).
Thank you in advance.
if we are working in traditional plants or foods or ayurvedic medicine is there is need to file IND application for clinical trials
Dear Experts, gau piyush is commonly available in the name of Cow Colostrum. it selling under Ayurvedic product. did any Ayurveda class texts described this? any other name?
I am planning to make a research on the history of instruments, utensils and materials of ayurvedic therapies, e.g. swedana, shirodhara, udvartana, abhyanga, etc. This project has the following goals:
1.- Compare the instruments and utensils used in ayurvedic therapies from ancient times in India to those one used nowadays. For example, when ayurvedic therapies were described in old ayurvedic texts there were no plastic objects, electricity, ... Perhaps today the use of artificial materials is damaging the results of these therapies.
2. - Analyse the possible consequences of those changes mentioned in point 1.
3.- Study the exact recommendations about the use of certain materials and instruments given in the most relevant ayurvedic texts, i.e. Charaka Samhita, Sushruta Samhita and Ashtanga Hrdaya. Contrast this information with the ayurvedic practice from ancient times to the present.
4.- Determine the materials the different ayurvedic utensils and instruments are made of and analyse how their quality depends, for example, on the social position of the patient, etc.
I want to carry out a research on the material history of Ayurveda. In this sense we would like to study the instruments, utensils and materials used for ayurvedic therapies, including surgery, as well as those involved in the preparation of ayurvedic medicines (Rasashastra). Due to the vast information covered by these aspects, we can distinguish three sections in this research:
1. Material history of ayurvedic therapies (e.g. swedana, abhyanga, udvartana, kizhis, pizhicil, etc.)
2. Material history of ayurvedic surgery.
3. Material history of the preparation of ayurvedic medicines (Rasashastra).
Ayurveda has concept of Rasa, Vipaka, & Virya which may be correlated with Pharmacokinetics and pharmacodynamics. And here I want to know how can we correlate the AVASTHHA -PAK, NISTHAA-PAK (A stages of Ayurvedic pharmacokinetics) with phases of metabolism.
Phase -I & II are the stages of metabolism in which body try to make the xenobiotic more polar so that it can get eliminated as soon as possible. Since the product of these phases of metabolism may also acts a active pharmaceutical moiety (e.g. in case of prodrug).
Since ayurveda explains the concept of "Aasthapak and Nishtapak" about oral transformation of drug, so the question arises for Ayurvedic views about pharmacokinetics for non oral routes.
I'm planning to conduct a systematic review with meta analysis of Effect of Ayurvedic medicine in Hypertension. There is already a shortage of RCTs in Ayurveda. I'd highly appreciate if anyone can suggest me some RCTs done in the field of Ayurvedic medicine.Thanks!
- Please give your opinions after considering the following points. [look at the PDF file bellow]
- In most of ayurvedic literatures which have been translated in modern times (after 1600 AD) “Tiniśa” has been recognized with Ougeinia oojeinensis (Roxb.) or O. dalbergioides (Benth.), belonging to family Leguminoseae by various reputed authors. In Ayurvedic fraternity Tiniśa even does not come under controversial drugs due to its strong authorized identity as mentioned before.
- But a thin yarn of controversy was emerged when an author, Balakrishna Gowda recognized Melastoma malabathricum L. as “Thimisah” in his book ‘Vanaspati Kosha’  and again this controversy gained some blaze of wind when NMPB (National Medicinal Plant Board) of India in its website  mentioned “Tinisah” as the Sanskrit name of Melastoma malabathricum L. under the section of Folklore plants. The irony is that NMPB has also mentiond Ougeinia oojeinensis as the biological source of Tiniśa under the section of Ayurvedic plants.
- Logical discussion:
- CSIR in ‘The Wealth of India’  had recognized Ougeinia oojeinensis (Roxb.) as synonym of O. dalbergioides (Benth.) and considered it as a biological source of ‘Tinsa’ along with its trade name ‘Sandan’ which are the vernacular name of Tiniśa.
- Shri Bapālāl Vaidya in ‘Nighantu Ādarsa’  recognized Ougeinia oojeinensis as synonym of O. dalbergioides (Benth.) and considered as the biological source of ‘Tinisa’. He even clarified & discussed about the various synonyms of the same plant as follows.
- Tinisa: Because of its long life it can pass many nights (Nishi) or it is blackish.
- Rathdru: Its wood is useful in making of chariot.
- Chitrakut: Even though this tree is not very large in size but because of its steady and long living nature it amazes all.
- All these Sanskrit synonyms fit perfectly to O. dalbergioides (Benth.). But M. malabathricum L. does not fit into the scaffold of these Sanskrit synonyms.
- First of all, habit of Melastoma malabathricum L. is shrub or under shrub (4-5 ft. in height) and its stem does not develop a rigid form of wood. So there is no question of its use in making of chariot.
- It’s true that being a shrub size of M. malabathricum L. plant is small. But it is neither very firm (strong) on its stem (or on soil) nor it enjoys the life for a prolong period of times.
- Fresh plants (stem/ leaf) of M. malabathricum L. do not seemed to be blackish in its natural habitat. But stem of O. dalbergioides (Benth.) evidently appears to be blackish in its natural habitat.
- Ougeinia oojeinensis (Roxb.) or O. dalbergioides (Benth.) had also been considered as authentic source of Tiniśa in number of other ayurvedic literatures such as
- Bhāvprakāsh Nighantu of Sri Bhāvmisra  by Prof. KC Chunekar;
- Kaiyadeva Nighantu  by Prof. Priyavrata Sharma & Guruprasād Sharma;
- Rāja Nighantu of Pandit Narahari  by Dr. Indradev Tripathi;
- Dravyaguna Vijńāna  by Prof. PV Sharma;
- Indian Materia Medica  by Dr. KM Nadkarni;
- Dravyaguna Vijńāna  by Gyanendra Pandey;
- Gowda Balakrishna. Vanaspathi Kosha. 1st ed. Kalpatharu Research Academy; Sringeri: 2004. p. 121.
- www.nmpb.nic.in ª Indian Medicinal Plants ª Search in Folk.
- Anonymous. The Wealth of India. Vol. 7. Council of Scientific & Industrial Research; New Delhi: 2001, p. 195-196.
- Bapālāl Vaidya. Nighantu Ādarsa. Vol. 1. Choukhambha Bharati Academy; Varanasi: 2007, p. 389.
- Chunekar KC. Bhāvprakāsh Nighantu of Sri Bhāvmisra. Chaukhambha Bharati Academy; Varanasi: 2013. p. 536.
- Sharma Priyavrata, Sharma Guruprasad. Kaiyadeva Nighantu. 1st ed. Chaukhambha Orientalia; Varanasi: 1979. p. 152.
- Tripathi Indradev. Rāja Nighantu of Pandit Narahari. Chowkhamba Krishnadas Academy; Varanasi: 2003.
- Sharma PV. Dravyaguna Vijńāna. Vol. 4. Chaukhambha Bharati Academy; Varanasi: 2003. p. 191.
- Nadkarni KM. Indian Materia Medica. Vol. 1. Popular Prakashan Private Limited; Mumbai: 2009. p. 561.
- Pandey Gyanendra. Dravyaguna Vijńāna. Vol. 3. Chowkhamba Krishnadas Academy; Varanasi: 2004. p. 646.
- Botanical name : Ougeinia oojeinensis (Roxb.) Hochn.
- Family : Leguminoseae-Fabaceae
- Classical name : Tiniśa
- Sanskrit names: Syandana, Nemi, Cakrasamvarana, Asmagarbhaka, Tiniśa, Rathadru, Vanjula, Rathavrksa.
- Regional names: Sandan, Chhanan (Hindi); Tinish (Beng.); Tinas(Mar.); Syandan (Maha.); Tanachh (Guj.); Tella motuku(Tel.); Narivengai(Tam.); Malavinna (Mal.); Kurimutal(Kann.) ; Anjan (Uriya).
- Description: Medium-sized deciduous trees; bark thin, grey or pale brown, blaze streaked with red. Leaves pinnately 3-foliolate, stipulate petioles 5-15 cm. long; leaflets broadly elliptic-obovate, acute 6-5 Î 3-9 cm; glaucous above, finely pubescent below, entire or obscurely crenate. Flowers in axillary racemes, fascicled at the nodes of old wood; bracts scale-like. Calyx 3-4 mm., tube campanulate; teeth small, 2 upper teeth connate, lower ones longer than laterals. Corolla white or pink, exerted 8-13 mm. long, standard orbicular wings spurred and slightly connate to the obtuse keal. Stamens 9-1, diadelphous. Pods linear-oblong, flat 5-10 cm. long, 2-5 jointed; seeds reniform.
- Flowering and fruiting time: Plant flowers in February- April and fruits in April- June. Generally flowering is during spring season and fruiting season is summers.
- Distribution: Plant occurs in mixed forests in various provinces; Uttar Pradesh, Central India (Madhya pradesh).
- Chemical composition: The bark contains tannin 7%. A kino-like exudation from the incised bark is obtained. The heartwood contains a dimethoxy-7-methoxy-6-methyl isoflavanone. Heartwood contains homeferreirin and oujenin.
- Rasa : Kasaya
- Guna : Laghu, rurksa
- Virya : Sita
- Vipāka : Katu
- Dosakarma: Kaphapittasamaka.
- Properties and action:
- Karma : Mutrasangrahaniya
Sothahara, kusthaghna, medohara
- Roga : Prameha
- Therapeutic uses:
- The drug Tinisa is mutrasangrahaniya (antidiuretic) and useful (bark and heart-wood) in prameha (group of urinary anomalies).
- It is useful in diarrhoea, dysentery, blood diseases, intrinsic haemorrhage, kustha, debility, inflammation, ulcers, fever, burning sensation and ailments caused by aggravation of kapha and pitta dosa. It also belongs to rasayana drugs.
- Externally the drug is applied as paste over ulcers, inflammation, leucoderma and kustha.
- The drug is used in anaemia (pandu), worms (krimi) and obesity (meda). The bark is used as a febrifuge and also as fish poison. The kino-like exudation from the incised bark is used in diarrhoea and dysentery.
- Tinisa (sandan) wood leaves and bark are also economically useful (including timber, cordage and cattle fodder, implements etc.).
- Parts used: Heartwood, bark.
- Dose: Decoction 50-100 ml.
- Group(gana): Sālasārādigana (Suśruta Samhita).
- Susruta Samhita: uttar, 40/119 [ raktātisar]
- Carak Samhita: cikitsā, 7/95; 7/98 [ kustha]
- Carak Samhita: cikitsa, 1-2/12
- Nighantu Sesh: Vrikskanda.
- Bhāvaprakāsh Nighantu: Vatadi varga, 76.
- Kaiyādeva Nighantu: Ousadhi varga, 815-817.
- Rāja Nighantu: Prabhadrādi varga, 114- 115
It is found that Ayurvedic bhasmas if not prepared in a standardized manner may contain heavy metal contamination.To reduce this contamination Green Synthesis could be of great importance,however in depth studies will conclude the same.
I would like to know is there any Siddha or Ayurvedic formulations available for the treatment of external parasites like ticks, lice, fleas, etc. The formulations available for human use is fine for me to give a try in animals for its efficacy. If anyone is aware of such formulations please let me know.
I am working on a thesis using a polyherbal formulation of several herbs and looking for merits and demerits of large vs. small particle size, 80 sieve, 120 sieve, fine, coarse, very fine.... Can someone point me to some reading, esp if it is in Bhaisajya Kalpana and Ayurvedic pharmaceutic? I think pharmacies that make powders must have examined this issue, but can't find anything...
Being a Physician Scientist, I have always observed a significant improvement in the patients with relation to their overall metabolism, signs and symptoms and disease severity if done in a scientific way. The sad thing about this is no strong comprehensive trial is observed to my knowledge. What do you people from varied expertise think about all these procedures from your personal and scientific experience. Can you suggest a probable study which would justify and validate their use?