Science topic

Autism - Science topic

A topic to foster discussion of autism research among investigators. This topic is not intended for those seeking clinical advice. Autistic spectrum disorders (ASD) are marked by significant social, communication, and behavioral problems. It is estimated that 1 in 110 children (correction: now 1 in 88) in the US have an ASD. Although several genes have been implicated in ASDs, a systems biology approach will be required to adequately understand the molecular underpinnings of these conditions.
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Unilateral ICV administration of 1M Propanoic acid is generally done in rats to induce autism like symptoms.
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Hi,
I think the mechanism is more important than the sit and route of administration. Here are a few references on the topic which you have raised:
Paudel R, Raj K, Gupta YK, Singh S. Oxiracetam and Zinc Ameliorates Autism-Like Symptoms in Propionic Acid Model of Rats. Neurotox Res. 2020;37(4):815-826. doi:10.1007/s12640-020-00169-1
Erten F. Lycopene ameliorates propionic acid-induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats. J Food Biochem. 2021;45(10):e13922. doi:10.1111/jfbc.13922
Witters P, Debbold E, Crivelly K, et al. Autism in patients with propionic acidemia. Mol Genet Metab. 2016;119(4):317-321. doi:10.1016/j.ymgme.2016.10.009
Mehta R, Bhandari R, Kuhad A. Exploring nordihydroguaretic acid (NDGA) as a plausible neurotherapeutic in the experimental paradigm of autism spectrum disorders targeting nitric oxide pathway. Metab Brain Dis. 2021;36(7):1833-1857. doi:10.1007/s11011-021-00811-7
Meeking MM, MacFabe DF, Mepham JR, et al. Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats. Prog Neuropsychopharmacol Biol Psychiatry. 2020;97:109794. doi:10.1016/j.pnpbp.2019.109794
Alfawaz H, Al-Onazi M, Bukhari SI, et al. The Independent and Combined Effects of Omega-3 and Vitamin B12 in Ameliorating Propionic Acid Induced Biochemical Features in Juvenile Rats as Rodent Model of Autism. J Mol Neurosci. 2018;66(3):403-413. doi:10.1007/s12031-018-1186-z
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This autistic child may prevent self-stimulation through these repetitive movements
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Biopsychological correlates that have been involved in the origin of RRBs include: (a) A decrease in GABA associated with an increase in serotonin and glutamate, (b) alterations in the volume of the brain, (c) improper levels of growth factors, and (d) hypo- or hyperconnectivity among different brain regions.
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I'm building a catalog of characters representing autism in popular media for research I'm doing.
I can't physically watch all the TV and movies ever made or read all the books ever written to make this as complete as possible, so I've created a survey to gather more information.
You can participate here: https://forms.gle/6Y7iQC6UZogUmE6RA
Thanks in advance for your help adding to this database!
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I was planning to end this in May, but I'm getting such interesting responses I'll keep it going. Please do share the link if you are so inclined!
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Project Title: Exploring the properties of the Accessible AQ in children.
Dear all,
I am currently recruiting participants to take part in my final year dissertation research project. I am investigating the properties of an accessible version of an autism screening tool (the Autism Quotient) when used with children.
The study has received ethical approval from Northumbria University (Ref:44763) and all data will be kept secure and anonymous.
We are looking for participants that:
  • • are aged 18 years or over;
  • • are able to give informed consent;
  • • have a child aged between 6 and 17;
  • Your child does not have to have a diagnosis of autism to take part.
The study will involve:
  • • Completing a few questions asking for demographic information about you and your child, such as age and gender.
  • • Completion of two questionnaires about your child. The first is a screening tool (the AQ) that measures autistic like traits, such as preferring set routines. These traits can be found among the general population to different degrees. The second is a screening tool for learning disability. These will take approximately 10 minutes to complete.
  • • Your child will be asked to complete two short questionnaires that are ‘easy read’ versions of the AQ.
If you have any further questions regarding the study, please contact sally.e.lamb@northumbria.ac.uk
To find out more information about the study and to take part, please go to: https://nupsych.qualtrics.com/jfe/form/SV_8zYLleeCRtFvKWG
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Sally Lamb Thanks. I posted the request to some contacts.
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Project Title: Exploring the properties of the Accessible AQ in children.
Dear all,
I am currently recruiting participants to take part in my final year dissertation research project. I am investigating the properties of an accessible version of an autism screening tool (the Autism Quotient) when used with children.
The study has received ethical approval from Northumbria University (Ref:44763) and all data will be kept secure and anonymous.
We are looking for participants that:
  • • are aged 18 years or over;
  • • are able to give informed consent;
  • • have a child aged between 6 and 17;
  • Your child does not have to have a diagnosis of autism to take part.
The study will involve:
  • • Completing a few questions asking for demographic information about you and your child, such as age and gender.
  • • Completion of two questionnaires about your child. The first is a screening tool (the AQ) that measures autistic like traits, such as preferring set routines. These traits can be found among the general population to different degrees. The second is a screening tool for learning disability. These will take approximately 10 minutes to complete.
  • • Your child will be asked to complete two short questionnaires that are ‘easy read’ versions of the AQ.
If you have any further questions regarding the study, please contact sally.e.lamb@northumbria.ac.uk
To find out more information about the study and to take part, please go to: https://nupsych.qualtrics.com/jfe/form/SV_8zYLleeCRtFvKWG
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Dear Sally, the offered link is not available. Regardless, I wish you all the best during your research!
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I'm a PsyD student doing my dissertation on differences in identity development between adolescent females diagnosed with autism before, during, and after adolescence. For my literature review, I need research on autism in females as well as how autism/disability influences identity development. I'm particularly interested in the neurodiversity paradigm and any empirical research supporting this approach. Any articles or books would be appreciated!
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Angelina Inesia Forde
that would be fantastic, I anticipated that may be challenging! Thank you!
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In my current thinking/writing I have been exploring ideas behind quantum social theory, for example the potential of an entropic society. Here, such a society exhibits a default (temporal) tendency toward disorder. Entropy increases unless society works to reduce it. Why? Because, from a quantum super-positional perspective on a society of individuals, there is an infinite potential for interference through quantum interdependency: there is an indeterminate potentiality to disorder, with only a limited number of determinable, observable events that may signify order.
Statistically, unless we invest in reducing the range of interdependencies and thus work to reduce the indeterminacy of state changes and/or interferences, by implementing (social) negentropic constraints, we will experience emergent disorder. Such constraints, including our social institutions, laws, ethics and morals, are designed to increase the probability that a given/anticipated/expected/desired state change within society may be observable. This is society’s desire for normativity.
Yet, as I think on these lines, I begin to see the potential of the autistic mind and its consciousness as a radical free agent unbound to the idea of negentropic normativity. This, to my mind is a positive prospect: autism’s value to society. Society needs its free radicals to prevent excessive negentropy. By attention to the radical free agents of society, we can be reminded that social normativity cannot rule out indeterminacy entirely: society must respect its entropic potential. And, while all about us seek to normalise our activities, we can look to autism to remind us of our full, unrealised potential.
Thoughts? All opinions, normative and non-normative are welcome.
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What type of design was used and how was statistical computation and graphing achieved? Was a software package used?
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Yes to all your questions. The tutorial is currently under review.
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Hi Please can someone explain what interventions are best to implement to improve communication with children aged 6-12years old? And what evidence would you use to justify using them?
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There are psychosocial factor that come up during pubery for all Adolescent, especially with autism.
What's difference between their behavior in this area. And how we can help them to over come on it?
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I have some ideas about this issue.
And really appreciate if we can have a discussion about it.
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I would love to collaborate! Let's share the energy!
My primary interest is the broad scope of the working lives of people with ADHD or other neurodiverse conditions. I would like to look at positive approaches to employment situations and relationships.
Many people with ADHD and low-moderate impact Autism are very successful in the workplace. Additionally, late diagnosis of these conditions is growing so people who have been working for decades are getting diagnosed. Looking at their success can define effective inclusive processes for managers going forward.
Other topic areas I would be happy to work with include:
  • Management Theory testing
  • Human Resource issues relating to DEI
  • Case Studies
  • Teaching online, hybrid, and experiential
My direct email is jhosmer@csumb.edu
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Hi Joseph, every article will list a corresponding author. You can start there - if you find a recent article in your area of interest, you could contact the corresponding author and see if they may need any assistance in their current research. Someone in their lab (or a current graduate student/ post-doc) may also be working on a certain aspect of a larger research project and may be seeking a writing/ research partner. Best of luck in your research endeavors!
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I would like to know how helpful information technology could be for the development of children with ASD.
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Hi Pavlo,
Here are some references related to the topic:
Szymona B, Maciejewski M, Karpiński R, et al. Robot-Assisted Autism Therapy (RAAT). Criteria and Types of Experiments Using Anthropomorphic and Zoomorphic Robots. Review of the Research. Sensors (Basel). 2021;21(11):3720. Published 2021 May 27. doi:10.3390/s21113720
Choi H, Song J, Park G, Kim J. Modeling of Autism Using Organoid Technology. Mol Neurobiol. 2017 Dec;54(10):7789-7795. doi: 10.1007/s12035-016-0274-8
Pennisi P, Tonacci A, Tartarisco G, Billeci L, Ruta L, Gangemi S, Pioggia G. Autism and social robotics: A systematic review. Autism Res. 2016 Feb;9(2):165-83. doi: 10.1002/aur.1527
Bölte S, Bartl-Pokorny KD, Jonsson U, Berggren S, Zhang D, Kostrzewa E, Falck-Ytter T, Einspieler C, Pokorny FB, Jones EJ, Roeyers H, Charman T, Marschik PB. How can clinicians detect and treat autism early? Methodological trends of technology use in research. Acta Paediatr. 2016 Feb;105(2):137-44. doi: 10.1111/apa.13243
Scassellati B, Admoni H, Matarić M. Robots for use in autism research. Annu Rev Biomed Eng. 2012;14:275-94. doi: 10.1146/annurev-bioeng-071811-150036
Shic F, Goodwin M. Introduction to Technologies in the Daily Lives of Individuals with Autism. J Autism Dev Disord. 2015 Dec;45(12):3773-6. doi: 10.1007/s10803-015-2640-1
Scherf KS, Griffin JW, Judy B, Whyte EM, Geier CF, Elbich D, Smyth JM. Improving sensitivity to eye gaze cues in autism using serious game technology: study protocol for a phase I randomised controlled trial. BMJ Open. 2018 Oct 4;8(9):e023682. doi: 10.1136/bmjopen-2018-023682
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Asperger syndrome, Rett syndrome, PDD, and Childhood disintegrative disorder were removed from the category of autism spectrum disorder in DSM5. Given this, what is your opinion about the inclusion of studies related to this older category of autism (on Asperger, Rett, PDD population) in the systematic review studies of autism?
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أنا لدي دراسة حول التوحد وسأعتمد التصييف الرابع
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We have published today a paper at Springer Nature journal of Scientific Reports entitled "Optimal time lags from causal prediction model help stratify and forecast nervous system pathology" by Theodoros Bermperidis and co-authors from my lab at Rutgers, colleagues at Stevens Institute of Technology and Columbia University. The paper describes how to standardize signals from wearables and make causal predictions forecasting disorders of genetic origins and unknown etiology. These included Fragile X and SHANK3 deletion syndromes, both linked to Autism, and Parkinson's disease and Vestibular Dizziness Handicap. I wonder if we could use gait more often in the clinical settings now that we have off-the-shelf wearables at our disposal. Research shows that it would improve classification and help stratify heterogeneous disorders like Autism and Parkinson's disease. Read more here https://www.nature.com/articles/s41598-021-00156-2
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Excellent, Elizabeth. Congratulations on this groundbreaking contribution.
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Social cognition deficits have been classically studied in psychotic conditions (Schizophrenia, Bipolar disorders) or in Neurodevelopmental disorders (Autism spectrum disorders). But is there a sound rationale in studying this area in individuals with sub-threshold/sub-clinical depression (who usually don't seek any mental health service, and even if they do, they're most likely to visit a psychologist's clinic than a psychiatric set-up)? I'd like to know the research community's views on this.
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Hi,
Zhang Z, Wei F, Shen XN, Ma YH, Chen KL, Dong Q, Tan L, Yu JT; Alzheimer's Disease Neuroimaging Initiative. Associations of Subsyndromal Symptomatic Depression with Cognitive Decline and Brain Atrophy in Elderly Individuals without Dementia: A Longitudinal Study. J Affect Disord. 2020 Sep 1;274:262-268. doi: 10.1016/j.jad.2020.05.097
Geng R, Li Z, Yu S, Yuan C, Hong W, Wang Z, Wang Q, Yi Z, Fang Y. Weighted gene co-expression network analysis identifies specific modules and hub genes related to subsyndromal symptomatic depression. World J Biol Psychiatry. 2020 Feb;21(2):102-110. doi: 10.1080/15622975.2018.1548782
Yi Z, Fang Y. Are subsyndromal symptomatic depression and major depressive disorder distinct disorders? Shanghai Arch Psychiatry. 2012 Oct;24(5):286-7. doi: 10.3969/j.issn.1002-0829.2012.05.006
Yang C, Hu G, Li Z, Wang Q, Wang X, Yuan C, Wang Z, Hong W, Lu W, Cao L, Chen J, Wang Y, Yu S, Zhou Y, Yi Z, Fang Y. Differential gene expression in patients with subsyndromal symptomatic depression and major depressive disorder. PLoS One. 2017 Mar 23;12(3):e0172692. doi: 10.1371/journal.pone.0172692
Hu G, Yu S, Yuan C, Hong W, Wang Z, Zhang R, Wang D, Li Z, Yi Z, Fang Y. Gene expression signatures differentiating major depressive disorder from subsyndromal symptomatic depression. Aging (Albany NY). 2021 May 8;13(9):13124-13137. doi: 10.18632/aging.202995
Xu F, Yang J, Chen J, Wu Q, Gong W, Zhang J, Shao W, Mu J, Yang D, Yang Y, Li Z, Xie P. Differential co-expression and regulation analyses reveal different mechanisms underlying major depressive disorder and subsyndromal symptomatic depression. BMC Bioinformatics. 2015 Apr 3;16:112. doi: 10.1186/s12859-015-0543-y
Rodríguez MR, Nuevo R, Chatterji S, Ayuso-Mateos JL. Definitions and factors associated with subthreshold depressive conditions: a systematic review. BMC Psychiatry. 2012 Oct 30;12:181. doi: 10.1186/1471-244X-12-181
Petersen JZ, Porter RJ, Miskowiak KW. Clinical characteristics associated with the discrepancy between subjective and objective cognitive impairment in depression. J Affect Disord. 2019 Mar 1;246:763-774. doi: 10.1016/j.jad.2018.12.105
Shevlin M, Hyland P, Nolan E, Owczarek M, Ben-Ezra M, Karatzias T. ICD-11 'mixed depressive and anxiety disorder' is clinical rather than sub-clinical and more common than anxiety and depression in the general population. Br J Clin Psychol. 2021 Jul 17. doi: 10.1111/bjc.12321
The concept SSD is not included in DSM 5 or in ICD 11. Hence justification while doing a study may be a problem. Refer also to CANMAT guidelines latest if they have included. Only Judd's paper in yr 2000 seems to talk about it. Examining references above . Some recent papers talk about it while trying to distinguish based on genetic studies. There are hardly any studies in social cognition deficiets in SSD which I could lay on. I would recall my previous message here as to whether social cognition deficiets are relevant in depression?
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As alluded to in Kissine's (2021) Language paper and others, autistic individuals are egocentric language learners and users, because of “the difficulties in mind-reading that are inherent in the autism diagnosis” (cf. Andrés et al. 2017; Geurts et al. 2020). To compensate, autistic people seem to resort to self-sufficient mechanisms to acquire their grammatical competence and IPC (i.e., abstractly executing pure thought and processing communicative tasks. Cf. Mao 2020; 2021). In this case, what is a proper perspective to view the divergences between constructionists and nativists in terms of language acquisition and its use?
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To Hasan:What is the basic view of Greta Mazzaggioa et al.2010?
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ADHD about Autistique children
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The CARS-2 has some questions about activity level. the ASRS also has some scales on hyperactivity.
If your looking to diagnose comorbid ADHD, you will likely need something specialized for that purpose.
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We interrogated a random draw of 18,965 genes from 25 diseases including neurological and neuropsychiatric disorders that today often receive the Autism label. We also included non-neurological diseases in the set, and asked if using the genes' expression on 54 tissues defined by the GETex project, we could stratify Autism as we know it today, made up of all these neuropsychiatric and neurological disorders. We found a self-emerging stratification that informs us of new ways to recommend treatments in Autism by leveraging existing therapies that are not defined by "inappropriate behaviors" but rather address physiological issues.
The question is whether we are going to continue following this archaic Autism diagnosis-to-treatment pipeline and circularly informing science by criteria that feeds the Autism Industrial Complex and makes each one of these families into a commodity, or move away from all of it and rely on medical and physiological issues. The preprint is in the bioRxvi and I welcome comments on the results of this interrogation and the proposal for Precision Autism https://www.biorxiv.org/content/10.1101/2021.07.28.454081v1.full
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I fully agree that words like epidemic are inappropriate to refer to a human condition like autism. However, the medical and physiological issues of this highly heterogeneous condition (or systemic disorder with varying degrees), cannot be ignored. When they are ignored, scientists and engineers will not be aware of the issues and their knowledge will not be properly leveraged to build accommodations and support for those who badly needed. Owing to the high heterogeneity of autism and the deficits in the diagnosis and current treatments, science has fallen far behind to help support the affected families. Yet we can repurpose technology from other fields and help build a new transformative way of thinking about the autistic individual and his/her capabilities and predispositions. Autism is not a 'disease' to cure. It is a broad range of conditions that can be physiologically explained and scientifically studied, tracked and treated, much as any other human condition is.
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Autism spectrum disorder (ASD), also known as autism, is a common, highly heritable and heterogeneous neurodevelopmental disorder that has underlying cognitive features and commonly co-occurs with other conditions. The behaviours, strengths and challenges
of people with autism have attracted the attention of scientists and clinicians for at least 500 years...
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Indeed, the concept of "Autism", which was a true "mixed bag", required that it be redefined and, therefore, the DSM-5 of the APA discontinued and redefined it under the common framework of Autism Spectrum Disorders ( ASD), eliminating from the previous classification, for example, Rett Syndrome, which has nothing to do with it. As ASD is a general concept, similar to what happens with Cancer, also as an example, it brings together pictures of different etiology, clinical symptoms, symptoms, etc. but they all have a common denominator:
They are a developmental disability that can cause significant social, communication, and behavioral problems. Often, there are no clues to the appearance of people with ASD that differentiate them from other people, but it is possible for those with an ASD to communicate, interact, behave, and learn differently from other people. The learning, thinking, and problem-solving skills of people with ASD can vary; there are from people with very high levels of ability (gifted in English) and people who have many difficulties. Some need a lot of help in daily life, while others need less.
Currently, the diagnosis of ASD includes many conditions that used to be diagnosed separately and include autistic disorder, pervasive developmental disorder not otherwise specified (PDD-NOS), and Asperger syndrome.
People with an ASD often have problems with social, emotional, and communication skills. They may repeat certain behaviors or may not want changes in their daily activities. Many people with ASD also have different ways of learning, paying attention, or reacting to things. Some of the signs begin during early childhood and usually last a lifetime.
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Follow up questions
- What is the difference between therapies and interventions as a treatment option to improve the social communication skills of children with autism.
- Has there been a particular treatment option that has proved to be highly effective in the development of the social communication skills of children with autism.
- What are some aspects of certain therapies and interventions that contributed to its effectiveness as a treatment option for the improvement of social communication skills in children with autism.
- What factors are needed to be considered before deciding upon the best treatment option to develop the social communication skill of a child with autism.
*Any additional information and resources regarding this topic will be helpful
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-I-
In general, the Social Skills Training Model -SST- is followed, but adapting them to the circumstances of EACH CHILD WITH ASD; Thus, below we present a Guide offered by the COGNITIVE DEVELOPMENT Center (RED CENIT) of Valencia, Spain:
Social Skills (HHSS) are considered a set of capacities or skills that allow us to develop a repertoire of actions and behaviors that make people develop in the social sphere. But these are very complex because they are formed by a wide range of ideas, thoughts, beliefs and values ​​that are the result of learning and experiences. This will cause a great influence on the behaviors and attitudes that the person has in their relationship and interaction with others, since they are capacities that we all have to understand in the context that we unwind and adapt to that moment in which we are situated.
And, what about social skills in children with ASD?
They often fail in social competence; It is difficult for them to be able to use the different visual cues, being these fundamental in the social contexts in which they operate, especially in school: The common characteristic in people with ASD is their difficulty in understanding social relationships and situations, and therefore Therefore, the failure to develop social skills. Social skills in children with ASD are difficult to develop because they have difficulties understanding appropriate social behavior and understanding the implicit rules of social behavior, since their social learning is often rigid and not fully understood.
But, this does not mean that they do not want to have friends, socialize, play or bond with their peers, but that biological barriers do not allow it. Sometimes they do not understand social patterns or do not know how to respond to displays of both affection and anger, given their difficulty in understanding the actions of other people. And that is where we must intervene to be able to help them, from a young age, to achieve all their objectives in different areas, to promote their communication with society and that they can get to interact with their environment.
"One of the main features of the human being is to be an" object with a mind ", who is able to understand the mind and attribute it to others" (Rivière 1991). For this reason, it is necessary to handle what we call theory of mind, that is, to give the other one's own thoughts and feelings, different from one's own. People within the TEA have difficulties in this area, so it is necessary to work on this aspect first so that they are more competent in the area of ​​social skills; But it is also important for the development of these skills to make good use of executive functions (to be able to attend to the signs of the environment and of the people with whom one interacts, to plan actions, to be able to solve possible problems that may arise and to be flexible to find more than one solution evaluating the consequences of each one).
What are the essential components of social skills?
They are essentially acquired through learning (through observation, imitation, rehearsal). They contain verbal and non-verbal behaviors. They involve effective and appropriate initiatives and responses.
They increase social reinforcement, they are reciprocal by nature and involve an effective and appropriate correspondence and their practice is influenced by the characteristics of the environment
What can we do to help people with ASD understand their social environment and be successful in the social world we live in ?:
It will be necessary to direct his social and emotional learning by teaching him the essential skills to develop social and emotional competence. This includes social skills training in the areas of problem solving, conversation skills, identifying and managing feelings and emotions, and stress management.
Thus, we offer, in "-II-" 10 ideas or tips for improving social skills in children with ASD
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If someone been through stem cell therapy for Autism, kindly share experience, benefits or disadvantages
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This a very disturbing thread. Are people suggesting that autistic people need to be 'cured' or 'reversed'? Autistic people, although a minority, are highly valued humans, reflecting the biological diversity of life. The barriers they face are the result of an environment that fails to be inclusive. Suggesting a therapeutic or medical reversal sounds equivalent to offensive and harmful practices such as conversion therapy?
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Any scale or test to measure toe walking in autism
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Hi,
Some articles of interest to you:
Valagussa G, Trentin L, Signori A, Grossi E. Toe Walking Assessment in Autism Spectrum Disorder Subjects: A Systematic Review. Autism Res. 2018 Oct;11(10):1404-1415. doi: 10.1002/aur.2009
Pomarino D, Ramírez Llamas J, Pomarino A. Idiopathic Toe Walking: Family Predisposition and Gender Distribution. Foot Ankle Spec. 2016 Oct;9(5):417-22. doi: 10.1177/1938640016656780
Schlough K, Andre K, Owen M, Adelstein L, Hartford MC, Javier B, Kern R. Differentiating Between Idiopathic Toe Walking and Cerebral Palsy: A Systematic Review. Pediatr Phys Ther. 2020 Jan;32(1):2-10. doi: 10.1097/PEP.0000000000000659
Vette AH, Watt JM, Lewicke J, Watkins B, Burkholder LM, Andersen J, Jhangri GS, Dulai S. The utility of normative foot floor angle data in assessing toe-walking. Foot (Edinb). 2018 Dec;37:65-70. doi: 10.1016/j.foot.2018.07.003
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Hello,
I'm carrying out a research in visual perception in children with autism and I need to acquire eeg signal during an oddball paradigm in combination with an eye tracker. I'm using a biosemi 64 electrodes cap and the eye tribe eye tracker. At the moment I don't know how to synchronise the data with a reliable accuracy, since I work with ERPs and perfect timing is fundamental. Thanks!
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Hi Yael Afiki I see that you are from Shamir Opt. can you please write me directly at tue.hvass@imotions.com and we can take it from there. Thx.
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Living in poor regions in addition to economic difficulties, causes certain mental disorders not only related to poverty but the residents of these regions cause psychological damage in people with a tendency to depression or mild autism.
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But, even in the other pathologies that are not socioeconomically conditioned, status and economic power even influence psycholinguistically to establish differences: Thus, the poor suffer from madness, go to asylums and, at most, take psychotropic drugs; while the rich who have "nervous disorders", "mental exhaustion", "sourmenages" and other euphemisms, go to Rest Centers or Specialized Clinics for "Over stress" and, in addition to psychotropic drugs -consumed in To a lesser extent, as demonstrated, they receive Psychotherapy and Combined Therapies ... It is only an example.
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Any standardized tool for identification of ASD
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Hi,
Internationally, M-CHAT revised is a screening questionnaire. Later detailed assessment can be done by Mental Health Professionals. This is also true in India.
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researching in the area of emotion recognition
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يجب توفر هذه البيانات للتشخيص
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Very clinically relevant to reduce stress and related obesity
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Some studies show changes in the normal circadian patterns of cortisol in children with autism. Children with autism are thought to exhibit poorly regulated negative feedback from the HPA axis. Some children with autism have an abnormal daily rhythm and / or lack of cortisol suppression in response to dexamethasone, which is usually expected to elicit a severe negative feedback response. In children with autism, the negative feedback mechanism that regulates the HPA axis may be less effective, resulting in a prolonged increase in cortisol due to activation by a stress response.
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Seeking information on attention problems in the cases of high functioning autism
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Generally yes...depending on dosage.
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I want to run a variant caller on ASD sequences but I can't find any database that allows open access to it. Have we got something like SRA to download such data?
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Autism Genome Project (AGP) Consortium - Whole Genome Association Study of over 1,500 Parent-Offspring Trios - Stage I and II
dbGaP Study Accession: phs000267.v5.p2
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I am looking for research in the field of use of Machine Learning and AI in Autism Detection. Is there any proper dataset available ?
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Autism detection and gene databases are different. As previously suggested you can request authors of meta-analysis on autism. Also Cochrane database can help you and some of it is open source.
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I am looking for peer reviewed articles on self injurious behavior in children with autism for research project required in one of my class in Master's program.
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1) Waters P, Healy O. Investigating the Relationship between Self-Injurious Behavior, Social Deficits, and Cooccurring Behaviors in Children and Adolescents with Autism Spectrum Disorder. Autism Res Treat. 2012;2012:156481. doi: 10.1155/2012/156481. Epub 2012 Nov 7. PMID: 23193469; PMCID: PMC3502765.
2) Handen BL, Mazefsky CA, Gabriels RL, Pedersen KA, Wallace M, Siegel M; Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC). Risk Factors for Self-injurious Behavior in an Inpatient Psychiatric Sample of Children with Autism Spectrum Disorder: A Naturalistic Observation Study. J Autism Dev Disord. 2018 Nov;48(11):3678-3688. doi: 10.1007/s10803-017-3460-2. PMID: 29368233; PMCID: PMC6057836.
3) Gulsrud A, Lin CE, Park MN, Hellemann G, McCracken J. Self-injurious behaviours in children and adults with autism spectrum disorder (ASD). J Intellect Disabil Res. 2018 Dec;62(12):1030-1042. doi: 10.1111/jir.12490. Epub 2018 Apr 25. PMID: 29696700.
4) Steenfeldt-Kristensen C, Jones CA, Richards C. The Prevalence of Self-injurious Behaviour in Autism: A Meta-analytic Study. J Autism Dev Disord. 2020 Nov;50(11):3857-3873. doi: 10.1007/s10803-020-04443-1. PMID: 32297123; PMCID: PMC7557528.
They're much more on pubmed and some are open access
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An interactive strategy for teaching children with autism to focus on specific nonverbal social cues to promote their social skills
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Functional behavior training
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Does anyone have experience with collecting ECG data on children with autism? How was your experience? I'm interested in the tolerance levels for kids to have wires attached to their chests. What was the drop rate?
Thank you kindly.
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Just impossible, unless sedated. Under sedation nothing much can be extracted out from EEG.I think over the leadsone can attach a fancy cap if they allow and recrd video eeg through telemetry.
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Autismo y Ansiedad
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I and my colleagues have just published this paper which may be of interest:
Samadi, A., McConkey, R. and Rodgers, J. (2020) Assessing anxiety in Iranian children with Autism Spectrum Disorder. Research in Autism Spectrum Disorders. https://doi.org/10.1016/j.rasd.2020.101673
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I would like to know about different scales to measure the attention span of the autism kid and by giving intervention and check out the improvement.
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I need to calculate R-IRD for my data. I am struggling to understand {a} elimination of minimum overlap points and then {b} how to balance the quadrants to calculate R-IRD. 
I have referred the article by Parker, Vannest 2009,  as well as slides from PPT]Overlap Methods derived from Visual Analysis in Single Case ...
Is there a video tutorial that can explain the steps involved in calculation of R-IRD?
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Can anyone explain me how can i calculate the ird in single case research when the most of the data points in the baseline are over than the data points in the treatment phase?
and generally can i convert the pnd to ird ?
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I have run a study on auditory perception with a sample of children with ASD. Given the high rates of comorbid diagnoses in individuals with ASD, I have some participants with multiple diagnoses (e.g., ADHD, anxiety, speech-language impairment). Is there a way I can control for these comorbid diagnoses so I do not have to exclude these participants? Is there a way to use secondary diagnosis as a covariate? Could I run the analysis with and without the participants who have additional diagnoses? Thank you in advance for any feedback.
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You can not exclude the patients with anxiety and speech delay, since these are autistic feautures according to the DSM-V. It's hard to select patients with pure autism, because it always comorbid with other disorder such as ID, Epilepsy, regression, without neglecting the "syndromic autism". So you may just exclude the ADHD patients since it's a disorder that could influence your results and statistics.
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Thank you so much for yours answers!
Have a nice day,
Valérie
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There are several evidence based strategies available. I would start with one of those and then the key is implementing the strategy with well trained staff and with fidelity. And, collect data on progress continuously. If the child is not making progress, the treatment team needs to revise their protocols. A effective strategy is one where progress (though rate of skill acquisition may vary) is consistently seen.
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Information on impact of persons with Intellectual disability during COVD19
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I Agree this Pandemic is rather severe on Autistic People, I can speak from experience in saying that the routine from Monday-Friday has now moved to a different phase of mostly family running the Applied Behavioural therapy programme seven days a week. This is so challenging for parents.
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I have received a hear-say information, that people with autistic traits are significantly represented among policemen. Supposedly, Tony Attwood detected 15% of them in Australian police force, which is the greatest prevalence, next to IT occupation. Can you help me find that citation ? Also, I am generally interested in articles about what work positions autistic people usually take, are successful at, or at least can keep them for some time. Articles using some quantitative measures / statistics are prefered. I am volunteering to write an article about autistic people in non-stereotypical job position.
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In Germany we don't no something about policeman with ASD. But I've done a lot of research in employment of people with ASD. If you take a look at my homepage/ literature, perhaps you will find some helpful information:
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Someone's daughter is having Autism and they are interested in Stem Cell treatment , we are collecting answers for them to satisfy about this treatment.
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NO IS NOT THE BEST WITH ALL CHELDREN AUTISM me be is good with flag
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I am applying for a PhD research program which aims to investigate if the current autism diagnostic tools consider the social factors and influences in the BAME community. To enable me to do a well informed and in-depth analysis, I would like to be able to use and make an assessment using these two tools.
The proposal topic is :
Do the current autism diagnostic tools Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) consider the contextual and social drives when diagnosing Black, Asian and Minority Ethnic (BAME) children for autism?
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Dear Tendai, I would suggest you read about the validity of such tools(they have been validated and used in many countries, there are some officially translated too) and if you believe you need to experience using them, you certainly need to be trained. https://www.pearsonclinical.co.uk/Psychology/ChildMentalHealth/ChildMentalHealth/ADOS-2/ForThisProduct/clinical-workshops.aspx
I would also suggest you approach professional services using these tools (ADOS-2 and ADI-R are the gold standards so any reputable autism assessment service should use it). However, the information the scores give you is not enough for diagnosis or no diagnosis. This means that the best information these tools give you is a mix of quantitative and qualitative information, this is the clinician's opportunity to consider cultural differences and diversity. Yes, someone can score above the cutoff, but this is not always indicative of autism (it could be another neurodevelopmental condition, mental health condition, characteristics due to physical health conditions, cultural diversity, childhood adverse experiences, etc.).
ADI-R comes with DVDs to train (as part of the whole pack) but I would recommend you to approach an autism assessment service and do some shadowing with experienced professionals. Once you have established a point where your scores agree with a panel of experts (or some experienced professionals in an autism assessment service) then you can be more confident that you are using the tools assertively. Mind you, it is always good to have another pair of eyes to bring objectivity and see other contributing factors and context.
Although the tools have been used in many countries, if you use them, you may see that for example, the ADI-R may have some language that even if translated, is not context-suitable for all cultural backgrounds. Additionally, the ADOS does not explore in depth some aspects. Nevertheless, this is why there are also clinical interviews to explore things further, and this is the clinician's opportunity too, to check cultural and language differences and factors that need to be considered further.
Perhaps you will find these authors helpful as a start: Baron-Cohen, Lord, Rutter, Le Couteur, Wolstencroft, Uljarevic, Goldman, Happé, Goode, Heemsbergen, Mawhood, amongst many others.
Also, in the UK the Department of Health and Social Care have their reports with all the information about useful tools to diagnose, EBPs and guidelines (Autism Strategy-Think Autism) https://www.gov.uk/government/publications/think-autism-strategy-governance-refresh-2018
I hope this helps to give some context and direction.
Best wishes
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I am proposing a cross cultural project for people on the Autistic Spectrum that looks at :
-how the experience of Autism may be different depending on religious or political community affiliation and associated values
-provides opportunity for people on the Autistic Spectrum to explore community identity and participate in cross-cultural experiences
Are there any studies that may support an assumption that limited social network, social anxiety and other factors such as lack of tailored initiatives, may mean that a person on the Autistic Spectrum may have less opportunity to challenge received opinion associated with the religious/ political affiliations of their immediate community?
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Greetings! We are looking for research collaboration in ASD in Dubai. We are presenting a platform for integrative research in ASD.
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Hi there,
I am looking for self report moral vignette questionnaires for adults. I am looking at differences in moral behaviour outcomes between narcissists and individuals with autism. Any help or ideas would be greatly appreciated.
Laura
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Hi Laura,
I'm guessing you are talking about vignettes of moral transgressions, which participants can then rank on various dimensions?
Here's a good source with lots of short examples:
The vignettes are framed to be specifically relevant for Moral Foundations Theory, but could be used in a variety of other contexts.
Hope this helps!
Jonathan
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like controversies of autism due to some vaccines?
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Yet not reported any serious side effects.
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Using psychological evidence, critically evaluate the usefulness of Baron Cohen’s theory of mind explanation for autism.
This is the question, can you help me find good resources (only journal articles or researches from Google scholar or Science Direct) but most importantly how should I structure this essay and how to be critical and evaluate Baron Cohen’s theory of mind explanation for autism
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The latest data on autism problems prove disorders of the peripheral nervous system. For this reason, they do not send adequate signals to the brain and this leads to the impossibility of full integration of information.
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I am a physician and visiting research scientist at yale and together with my coauthors have published several studies in the field of psychology through Network Modeling and related analyses using r packages like bootnet, qgraph, NetworkComparisonTest, etc. I thought it might be a good idea to discuss different subjects related to this field, in a group. I am also interested in collaboration with other teams working in the field. Let's share our ideas, questions and suggestions in this group.
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Makes sense. Thanks for letting me know.
I hope followers of this discussion forum check your study and package,
which address an interesting topic in network analysis. Let's keep in touch!
Best Wishes,
Farhad
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Up to my understand and research work, I believe that estrogen might be protective against glutamate excitotoxicity. So please I need your opinion in this regard
Thanks
Afaf El-Ansary
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Autism as a Neurodevelopmental disorder is known to greatly affect males than females. It is very interesting to understand different mechanisms that might be related to male susceptibility or female protection such as sex hormones. Understanding the differences in vulnerability of both sexes’ to develop impaired gut microbiota, oxidative stress, glutamate excitotoxicity, and neuro inflammation as etiological mechanisms of autism.
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How do 3-7 year olds understand common illustrations in primary school literature? How often do theory of mind deficits lead to a false understanding of illustrations? Should early readers, where illustration comprehension is of utmost importance take theory of mind barriers into consideration? Are autistic children who are in school due to inclusion at a disadvantage when it comes to understanding illustrations?
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Unfortunately, the illustrations to some of the texts in children's books are not always in accordance with the age characteristics of the children - with their intellectual and emotional development. This depends on the competencies of the authors of the books, as they set the criteria for the nature of the drawings. Unfortunately, in recent years I find many illustrations that are incomprehensible to an adult reader - the images are not real and look abstract. I compared with illustrations in older books where everything is natural and attracts the child's interest.
Like any other information, illustrations should be adapted to the development of the child's brain. This is especially true of the theory of mind, which is directly related to the development of executive functions and emotional reflection. Child neuropsychology is the one that can shed much light on this issue.
Best regards,
Neli Vasileva
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Teachers’ belief has been widely researched. There is however little research that describes teachers beliefs teaching children with autism to read? How May existing research about teacher beliefs be integrated in the context of teaching children with autism to read?
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We know that teachers ’beliefs have an unclear impact on students’ achievement, depending on whether they are positive or negative.
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I'm interested in your research & I would be gratefull if you could provide the full-text. I am working with clinical thermography since 2008 and we have an autism treatment in Brazil. There are many challenges in registering themal images with autism pacients. What camera are you using for your research?
We could make a good use of this solution if monitor those data with different emotional crisis comparing the before and after between each session.
Best regards
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The improvement may or may not lead to negative results
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I am doing market research for Autism and IT-market in India. Now I am interested to combine the data of Autism and IT-Market. Which strategic or marketing model would you like to recommend?
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Following.
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Any journal or conference papers relating to the effectiveness of software used in classrooms for speech, language and communication and also for educational use. 
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Nice Dear Michael Ben-Avie
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I am a Ph.D. graduate student at Alliant International University. I am in the process of gathering data for my research study. I am attempting to understand the obstacles parents face when seeking services for their children diagnosed with autism. I am attempting to figure out which barriers parents currently face by Mexican-American and Caucasian families. The most prominent barriers are geographic location, immigration status, which has been linked to language, limited knowledge/awareness of ASD, anti-immigration laws and cultural beliefs. Ideally, I would like to publish my results to encourage agencies to modify the services offered to families, specifically, ethnic minorities.
I am reaching out to you to help advertise my study to encourage parents to participate. The Alliant International University Institutional Review Board has approved my study. I am looking for Mexican American and Caucasian parents who have a child diagnosed within the Autism Spectrum between the ages of 3 and 17, who live in California. Parents, who are would like to participate, they will complete a 15-minute questionnaire online and enter for a chance to win one of three prizes, $50 Fandango card, $50 Amazon card or $50 Visa card. By participating in my research study, they will help us understand parent’s experience-seeking resources for their children. I have flyers and a brief explanation, in Spanish and English, of the study. I ask you to distribute them and courage parents to participate in my study. Here is the link ofr the English questionnaire https://alliant.qualtrics.com/jfe/form/SV_0rHNKaZGhNhCXAx. Spanish questionnaire , https://alliant.qualtrics.com/jfe/form/SV_etD6QQMW1CvGPVr.
If you have any questions, please feel free to reach out to me at 619-356-1438.
Thank you,
Elizabeth Sanchez Arvizu
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I would love to help you. ^_^ Just drop me an email martinemussies [at] Gmail when you still need participants. Best of luck with your research!
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This is a research question for my English class that I will be doing. The question is based on how we can use a Therapeutic plan to treat mental disorders like Anxiety, Depression, Bipolar, ADD/ADHD, Autism, Obsessive, and PTSD disorders by using Nutrition, Exercise, Group and Individual therapy in a non medicated form verses a medicated form of therapy.
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Randy, yes it does help. With the Autism, I should have put it in a different category than mental disorders. I was Autism, Anxiety, Behavioral, Depression, PTSD as a way that we can possibly treat in a more non medical therapeutic plan as Meko mentioned with using yoga, meditation and breathing exercises and also adding nutritional values of foods to add in the patients diet to alleviate symptoms of these disorders and changing the patients lifestyle to improve overall health. If medication is needed in the process, then add to their therapeutic plan. This is the research I am attempting for my paper.
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Hello,
I'm currently doing a study on inclusive practice, and I am planning on doing an intervention with a young child in my class (age 3), who shows signs of autism but is undiagnosed as of yet. I am going to concentrate on improving his focus and attention span through an intervention over the next 6 weeks.
Does anyone have any reading or suggestions?
Thank you
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Many autistic children will manifest a variety of tics. When they are in this state they are the most open to learning. I would suggest the book Eikona Bridge by Jason H.J. Lu,
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Which kind of food the Aoutism patient shold avoid, and whis is advaced to take?
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Yes, of course. They need special diets.
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If you have information about animal models of autism and use of probiotics to treat them, please share your valuable information with us.
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Please also go through the following PDF attachments.
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I am looking to do a content analysis on how left and right wing UK newspapers presented the link between MMR and autism. However, the number of articles I get back when searching the terms 'autism' and 'MMR' on Nexus for each newspaper is huge. The number also differs for each newspaper.
How can I decrease these articles into a manageable size? Stratified sampling?
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There are a number of online programs that allow you to determine sample size for estimating the value of a parameter such as a percentage. Another alternative is to examine what is known as the power of your test such as a t-Test, using the software G*Power.
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It's difficult to get some participants.
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That would be one possibility, Dr. Ramos-Vera. But the questioner may also have other concerns. If she is looking for a norm sample in her country, she needs around 500 participants per subgroup. But if creativity is the dependent variable in an experiment, for example, then 30 participants may be already sufficient. We would need to know the exact aim of her study in order to give her a qualified answer.
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In field of autism or neuroscince
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JMIR Research protocols
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Anyone, please guide me about creating an effective VR environment for autistic kids? Commercially available applications can be used to record continuous EEG signal, but I want to link an event ( Target/Distractor) to train autistic kids. Your feedback will be highly appreciated. Thanking you in anticipation.
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Hello Muhammad, have you read this paper -
on my experience building VR environments and children in the spectrum, the VR environment should be light on contrast and objects. I would start with something calming, with low visual noise (not many objects around), open and not much movement, then slowly increasing the noise.
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One should never make self-propaganda – unless as a rational means to save all. I do therefore humbly apologize for my presenting the following list of highlights to you:
  • Lawful chemical biogenesis [found when I was 20]
  • Smile theory [enables a causal therapy for the physiological autism of mirror-competent bonding animals]
  • Liquid automata
  • Brain equation
  • Spiral chaos - Hyperchaos - Generic Fractals
  • Jumping identities between classical particles at invisible boundaries in position space [found when I was 40]
  • Endophysics
  • Global c, retrieved [the early Einstein, rehabilitated]
  • Zwicky’s 1929 infinite eternal cosmos à la Saint Augustine, confirmed
  • Cryodynamics, sister of deterministic Thermodynamics [found when I was 70]
  • CERN camouflages its inability to renew its planetary safety report LSAG from early 2008, but continued and plans to continue further in the biggest crime of history
January 5, 2020
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P.S.: Imagine:
NOT BEING ABLE TO RENEW A PLANETARY SAFETY REPORT!
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Hello research community.
I have been trying to find a research that points out the brain and neural differences between high functional and low functional autism to use for my university dssay which is about neurodiversity. I didn't come with any results and i was wondering why? It could be the case that i dont put on the right keywords so i would appreciate if someone could help. If there are no studies like this i am interested to know why.
Also, do you agree with the Asperger's syndrome to be combined in the autism spectrum? Since i started reading for neurodiversity it surprised me that the DSM-5 despite the politics of the movement went onwith emerging these two as the same disorder.
Thank you
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This autopsy study may be relevant to your question as most such studies have samples from more severely affected cases:
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In the Autistic spectrum quotient test (AQ) described in , some questions are worded to expect a positive answer from individual with autistic traits and some are not. The first question is "I prefer to do things with others rather than on my own", which is defenitely possible to be true for an autistic individual, but doesn't sound like an autistic trait. Still, the test does count it as one (“Definitely agree” or “slightly agree” responses scored 1 point, on the following items: 1, 2, 4, 5, 6, 7, 9, 12, 13, 16, 18, 19, 20, 21, 22, 23, 26, 33, 35, 39, 41, 42, 43, 45, 46), which is confirmed by .
Is there any reason for why this is?
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I think there is an error in the original papers description. The latter article you refer to (Table 3) actually contradicts the scoring described in Baron-Cohen et al.
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I have a Bioethics class that I don't participate a lot due to my limited knowledge, Can someone help me creating a discussion question related to autism please?
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Dear Joao,
I corroborate Ira's say.
However, what I understand from your question is that you want to discuss on autism in Bioethics class. Don't you?
That means ethical issues about Autism or ASD in the class of biology.
Is it correct?
If it is, then you would find almost every thing under the sun may swirl around ethical aspect of ASD, e.g. marriage, procreation/child-birth, education, career, treatment, society's views about ASD and people suffering from it, co-morbid diseases accompanying ASD, etc.
Secondly, your statement also declares that you have limited knowledge to start a discussion. I wonder dear, limited knowledge itself is the basis or need to start any discussion. Anyone who has adequate knowledge of the subject he/she would not start discussion but would start teaching that subject! Am I correct? What do you say?
So question crops up eventually that 'Is it limited knowledge that bothers you or shyness or low confidence or lack of skill or ability to communicate' hold you from active participation in class.
Hope, I have done justice to your question.
Please let the people in this group know about your progress in class.
All the best.
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I would like to study the quality of life of individuals with ASD who present low cognitive functioning and are non-verbal. I have found that many of the scales are applicable to only higher functioning individuals with ASD. If anyone knows if there is a quality of life scale that is geared more towards the lower functioning individuals, that would be great!
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you may check Child Health Questionnaire-Parent Form 50 (CHQ-PF50) for quality of general mental and physical health.
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The US military has extensive experience in operating bases around the world, including in Europe. As military personnel have been exposed to environmental toxins, a body of knowledge on various diseases has been accumulated. https://www.hillandponton.com/ultrafine-particle-exposure-and-your-va-disability-claim/ and other diseases found at Ultra-fine particles are found in jet fuels and in auto exhaust as well as in volcanic particulate as found in Catania, Sicily. All of these cause NCD harm to the body. The allowable levels of glyphosate in food or the use of GMO laden soybeans for animal feed also allow for toxins to enter the food chain. Looking at epidemiology studies from other countries will give insight for example on the rate of brain pathologies in children (autism rates) with a 0.98 correlation to tons of glyhphosate applied in the US. Glyphosate residue on US grains is found at 2000 parts per billion in US ready-to-eat cereals and rolled oats. Glyphosate damages gut bacteria, kidney, liver, and cardiovascular system and compromises the immune system allowing for NCDs.
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Wii start looking at
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Dear all,
We are in contact with a family whose son suffers from a Syngap1 mutation: Missense Mutation (c.968T>G bzw. p.Leu323Arg).
They are looking very much and intense to initiate research, but also to understand which kind of research could help to understand the disease better and go into the therapeutic strategy development direction.
It is presumbly a real rare disease, but which might be significant relevance for autism and other diseases.
It would be great, if we could start the discussion how to tackle this rare disease, also already with very detailed research approaches.
Thanks a lot for your contributions,
Winfried
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No deafness, hearing disorder or ear infections is related to the Syngap1 syndrome as far as I know, it is a neurodevelopmental disorder.
best wishes,
Winfried
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I am currently carrying out research into Adult Baby Syndrome for my Doctorate in Counselling and Psychotherapy, looking at counsellors and psychotherapists that may have worked with clients with autism that have pursued or wished to pursue Adult Baby Syndrome.
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I have never come across an autistic person with Adult Baby Syndrome/ Paraphilic infantilism. Many autistic people have child like obsessions special interests. Some autistic people with Pathological Demand Avoidance (PDA) may "chose" a passive dependent role, the role of a baby to stop what they see as demands from others and get others to do things for them as a form of being "in control" but the role play doesn't seem to lead in the engagement of drinking from a bottle, dressing like a baby or wishing to wear a nappy etc.
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There are many different descriptions of IQ and what they entail. To be honest, I have always considered the idea that intellect cannot be defined simply because there are so many skills and abilities as well as areas of intellect that can be defined as relative to IQ. Although recently I have come across the thought that IQ should be designated as the ability for an individual to be able to learn new subject matter or understand subject matter cognitively. This would make sense-- considering that mental retardation inhibits the individual from understanding simple and new subject matter. Autism also is a learning disability, however it is wise to notice that individuals on the autism spectrum tend to have a higher propensity toward individual areas of intellect that most cannot do. (For example, being able to read without be able to speak, I have seen this before in a case.) In summation, it would make sense not to base IQ off of what is currently known, but what an individual has the ability to learn. What are your thoughts?
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Dear all,
The intellect could be defined as ability to interact effectively with Universe as creator/builder.
The only reliable measure is evaluation of results of activity.
We think in so many different ways that it's impossible to compare them by any tests. How would be compared ability of Mozart to write beautiful music in one night to ability to write beautiful book for many years?
Best regards,
Konstantin
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What I am looking for are studies related to parents' ACES leading to autism in their children via changes in DNA; i.e. DNA methylation.
We have the link from ACES to DNA methylation 
and
We have the link from DNA methylation in the parent to autism in their child https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856164/
However, I have not seen any study going from parent's ACES to children's autism.  It might be there.  I just have not seen it. Thanks.
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Thanks for sharing this!
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Looking for a dissertation topic but I am finding it hard to narrow it down. I am interested in autism and special education practically inclusive education. I would quite like to focus on mainstream and special education and whether it is suited to all. But I am also interested in how autism presents differently in girls than boys.
Any suggestions on where to start looking or more specific topic areas would be greatly appreciated.
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social masking in girls with autism is very interesting and how they mimic their peers (other girls) or mirror one particular girl without fully understanding their actions/social behaviours. How autistic teens can "hold it together" in school then get home and have a "meltdown". You could look into school exclusions https://www.autism.org.uk/about/in-education/exclusion.aspx
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In autism science, subjective criteria largely informs basic scientific research and steers the scientific narrative at all levels.
We have found profound statistical flaws in the data generated by the ADOS instrument, leading criteria today for basic autism science. The assumptions made for its validity / reliability are not met by the data this instrument generates; consequently casting doubt on our overall knowledge of what constitute core symptoms of autism and how to steer our scientific quest.
Should we open a conversation about the idea of complementing such types of subjective criteria with objective criteria, to drive autism science? There seems to be a lack of proper collaborative platform to that end, whereby people with diverse skills sets supervise each other's work. We have uploaded ours to the bioxrvi to get people's opinion on our already peer-reviewed work and further help disseminate this concept of a truly OPEN interdisciplinary approach to science.
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It's a bunch of things - primarily changes in DSM criteria - broadening them considerably partially explaining the IQ effects as well as access to early intervention ABA services which also increase IQ; greater demand for ABA at all ages; greater awareness of ASD; parental involvement leading to increased funding of research and more specialized behavioral intervention programs (especially in NJ); the de-institutionalization movement in the 70s; increased survival rates of NICU infants and greater rates of multiple births; and pre-natal environmental exposure to toxins, etc. When I started, ASD was considered a psychosis and quite rare - no longer. (see my "What's New...") paper.
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Are observation logs completed by parent/support worker/care giver/partner useful information for clinical trials involving participants with autism? say for example testing a drug treatment or complementary therapy. Would this be useful additional information to a questionnaire? Log to monitor events of repetitive behavior, motor stereotypies, episodes of severe anxiety, aggression, "meltdowns" etc over a time period starting some time before the trial and some time after the trial has ended. I understand that participant with autism may not like the idea of a parent/SW/caregiver/parent writing information about them. Many trials involving autistic people and their families use follow up questionnaires and ask for feedback, generally with families reporting that X is doing well.
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Indeed it maybe emotive but as a person with autism myself HFA. and the point that have worked with behavioural scientists myself. I feel that to get the whole picture not just diagnostically you need observational and behavioural analysis logs for clinical trials to give the fuller picture as well as familial history etc.
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In the Autism and emotion literature, there is a strong consensus that people with Autism struggle with detecting emotions from other's facial expressions. To my knowledge, there are no studies that have attempted to control for this when assessing other forms of emotion processing in Autism (such as, via affective empathy). However, in a study that I am working on, I am trying to do just that: control for differences in participants' ability to detect emotions from other's facial expressions. Does anyone have any ideas of how I could do that? (Perhaps through some kind of control task).
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Thank you for your input Dr. Singer
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Which research topic will be more appropriate when conducting a phenomenological study among caregivers of children with Autism? I have two options here;
A. Experiences of caregivers of children with Autism.
B. Caregivers' experience in caring for children with Autism.
Which of these two topics is more appropriate? Should the phenomenon of interest be mentioned as in option B (caring for children with Autism) or it shouldn't be mentioned because it is self-implied as in option A?
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Dear Eric,
My pleasure. Moses
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