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Asymmetric Synthesis - Science topic
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A reaction of A and B, gives C. the NMR of reaction mixture contain all peaks of A,B,C. I need to calculate yield or percentage conversion of B to C. A has no role . Yield of C need to calculate with respect to B. all have distinguish peaks. On integration, specific peak of C has 1.00 while B has 0.35. both contain 2 hydrogens each. Can I say yield of C is 1/1.35 *100= 74% ? Or is there any other methods to calculate the yield ?
Folks involved in the synthesis of organic compounds or anyone with organic lab setup expertise:
Would you recommend buying a chiller over a submersible water pump (a cheaper option-can buy a few for the same price for rotovap and distillation setup)
- If we purchase a chiller, can we connect multiple units (again rotovap and distillation units) at the same time?
Thank you.
I would like to make some modifications of my flavonoids for the sake to enhance the pharmaological activity.
Is it possible and practical ? And what kind of reagents will be more convenient?
Any suggestions or articles will be more valuable.
Thank you,
Hi every body
would you please help me how is mechanism of Oxidation Alcohol to Carboxylic acid using CuCl and t-BuooH?
I found this reaction in this paper:
What will be the effect on specific rotation, if we measure the values in two different solvents?
CAS:187037-23-6, have checked with Santa Cruz, SIgma and Fisher.
I need the experimental method for the synthesis of 3-phenylpropynenitrile.
If such a protein has in fact been synthesized, has it been shown to be crystallizable and amenable to x-ray crystallographic 3D structure determination?
actually m working on asymmetric synthesis, nitro olefine as substrate and diphenylphosphonate as a nucleophile, after getting final product isnt resolving in hplc.
Provide me some stabilizer if some body knows, with some relative reference
which will be greatful
If somebody has reported first asymmetric synthesis then can some another person report first enantioselective synthesis?
Enzymatic or chemoselective resolution of corey lactone benzoate. Any literature references are most welcome.
I tried to synthesis the aforementioned compound by reacting 2,4-dihydroxybenzaldehyde and ethyl acetoacetate in the present of piperidine as catalyst. According to the method that I'm using, after being left overnight, yellow solid should be forming. However I did not obtained any solid the next day. Can somebody share another method to synthesis this compound?
Thank you in advance.
Please give details with below points......
1) Does the nucleus spin faster?
2) Does the precessional frequency of the nucleus increase or decrease?
3) Does the angle of precession " flip " so that the magnetic moment of the nucleus opposes the applied field or with the the applied?
4) Any other?
I also have an amino functional group in the molecule of interest.
We are facing 1,5-hexadiene as a major impurity.
I have tried with BF3 Etherate (Freshly Distilled) and MOMCl protection method but of no use yield was so less
I am trying to synthesize N-Protected Beta-Amino Ketones via mannich reaction. I tried to synthesize it using many reagents such as Sulfamic acid, Molecular Iodine, l-Prolin, PTSA etc., but I could not succeed. The products with CBZ protected Beta-Amino Ketone have been reported with some of the catalysts I mentioned above. The only thing I am changing is tert-Butyl carbamate instead of Benzyl carbamate.
The reaction condition I use are:
1 mmol benzaldehyde, 1 mmol acetophenone, 1 mmol tert-Butyl carbamate and 10 mol% catalyst and stirring them at RT. I tried these reactions for 48 hours but I could not get the desired products. What should I do to complete the reaction? Am I going wrong with the reaction?
Please help, the scheme is attached here.
Whereas in crystallography, as for example in the case of symmetry classification of atomic crystal groups there are only 234 possible classes of symmetry space-groups (that are precisely defined mathematically in terms of symmetry operations such as reflections and rotations, etc.), in material science, nanoscience (e.g. molecular crystals and quasi-crystals) things may appear not be as neatly and completely defined even when the local symmetries are precise and are well-defined because mathematical groups become then insufficient to classify the latter structures that possess broken symmetry, or only local symmetries thereof. A certain type of asymmetry or noncommutativity is fundamental in non-Abelian mathematics, such as Non-Abelian Algebraic Topology, Anabelian Geometry and Noncommutative Geometry.
I have tried to synthesize samarium diiodide with samarium metal and iodine in THF, but I don´t get the dark blue solution, and my reduction reaction does not work. Does anyone have experience with this reagent?