Anti Aging Medicine - Science topic

Epigenetic information polish then recessive privilege distribution. WARNING: Genetic engineering is DANGEROUS. Hopefully regularly polishing the epigenome will cure aging and other diseases, plus prevent side effects of genetic engineering. Also, hopefully and theoretically after the potential genetic engineering to provide recessive traits and recessive genes, if the surgery is simple enough, subjects will keep their genetic signatures.

See my profile or Substack:

Apparently the lack of tyrosinase:

"Inhibition of tyrosinase can reduce the production of melanin and achieve skin whitening, effectively solving pigmentation (Lall and Kishore, 2014). Therefore, the development of antioxidants, tyrosinase inhibitors, and elastase inhibitors play important roles in solving skin aging and pigmentation" ( https://www.google.com/url?q=https://www.sciencedirect.com/science/article/abs/pii/S0926669020309766&sa=U&ved=2ahUKEwjE4pTd0KyHAxUzHEQIHTzCCpIQFnoECAEQAw&usg=AOvVaw0gD_VQbHW1t1Go0zkPQyIW ).

Ming-Xiang Li, Jing Xie, Xue Bai, Zhi-Zhi Du,

Anti-aging potential, anti-tyrosinase and antibacterial activities of extracts and compounds isolated from Rosa chinensis cv. ‘JinBian’,

Industrial Crops and Products,

Volume 159,

2021,

113059,

ISSN 0926-6690,

https://doi.org/10.1016/j.indcrop.2020.113059.

(https://www.sciencedirect.com/science/article/pii/S0926669020309766)

Abstract: Rosa chinensis cv. ‘JinBian’, a cultivar of Rosa chinensis Jacq., is one of major raw material of rose tea and possesses sufficient plant resources in China. However, the studies on the chemical constituents and cosmetic activities of R. chinensis cv. ‘JinBian’ are almost blank. The main purpose of this study was to evaluate the anti-aging, skin-whitening, and antibacterial potentials of extracts and chemical constituents of the flower by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, elastase inhibition, anti-tyrosinase, and antibacterial assays. Bioassay results suggested both 95 % and 65 % ethanol extracts possessed significant antioxidant, elastase inhibition, and anti-tyrosinase activities. The combined active extract was studied with bioassay-guided fractionation to give a new compound, kaempferol 3-O-α-l-rhamnopyranosyl (1→6)-(2”,3”-O-digalloyl)-β-d-glucopyranoside (1) and fourteen known compounds (2–15). All compounds were firstly isolated from this species and subjected to the above mentioned bioassays. Ten compounds exhibited antioxidant activities with DPPH radical scavenging rate from 63.40 %–94.04 % under the concentration of 100 μg/mL. The antioxidant activities of 1, 2-phenylethyl 1-O-β-d-(6'-O-galloyl)-glucopyranoside (12), vomifoliol (14), and 4, 4'-dimethoxy-3'-hydroxy-7, 9': 7', 9-diepoxylignan-3-O-β-d-glucopyranoside (15) were firstly found with DPPH radical scavenging rate of 83.24 %, 91.10 %, 63.40 %, and 77.75 %, respectively. The moderate elastase inhibitory activities of 12, ethyl gallate (13), and 15 were firstly found with the inhibitory rate of 43.69 %, 43.25 %, and 35.34 % at the concentration of 100 μg/mL. Multiflorin B (3), 12, and 13 showed strong tyrosinase inhibitory activities with the inhibition rate at 43.83 %–55.80 %, comparing with the positive control, α-arbutin (22.15 %). In addition, 1 showed significant antibacterial activity against Staphylococcus aureus with the MIC50 of 8.51 ± 0.26 μg/mL. Compounds 2–4 and 12–14 showed moderate antibacterial activities against S. aureus. Compounds 6 and 13 also exhibited moderate inhibitory effects against Klebsiella pneumoniae. Above results manifested that R. chinensis cv. ‘JinBian’ possessed potential application values in the development of natural anti-aging, skin-whitening and antibacterial products.

Keywords: Rosa chinensis cv. ‘JinBian’; Antioxidant; Elastase inhibitory activity; Tyrosinase inhibitory activity; Antibacterial activity; Cosmetic potential

"Scientists have developed a vaccine specific to a protein found in senescent (old) cells, for targeted elimination. Age or metabolic stress promotes accumulation of senescent cells in tissues that causes pathological aging 'phenotypes'.

15 ene 2024." ( https://en.juntendo.ac.jp/highlights/news/nid69 ).

Kindly suggest the name of some antioxidants you know, which are effective to reduce free radicals in living body.

Hi Joseph, I am a Neuroscientist and have been using deprenyl as you prescribed for 20 years now and at 78 have no diabetes or heart problems and weigh 170 lbs. I still ride my dual purpose motorcycle. I have lost erectile function and wear hearing aids. What progress have you made in the last 20 years that could benefit me? Thank you for your very important work and contributions!  http://www2.hawaii.edu/~bemorton

Hi,

has anyone any idea what happened to Alagebrium (ALT-711)? It seemed to be very promissing drug candidate to retard some features of aging, but it dissapeared suddenly from experimenal works, the internet etc. etc. few years ago. It still wonders me...  

Found a quote in a paper by Judith Campisi "RAS and similar GTPases generate reactive oxygen species as signal molecules". Can anyone explain this further?

Mice, fish or any other

How reliable is the research that has gone into health, wellness and beauty products? To what extent can we trust the research? Do we have convincing evidence that research with such products was carried out and that the results showed the efficacy of these products?

Please share your specific views. Thanks.

The question of research and influence on physiological processes in the human body of cerium and barium. What is the role of these elements?