Science topics: GeriatricsAnti-Aging
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Anti-Aging - Science topic
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Questions related to Anti-Aging
Is the most significant breakthrough so far "Published in Nature Aging, the new research reveals that the trick to anti-ageing lies within the white blood cells known as T cells. The researchers behind the study discovered that they can reprogram these cells to turn them into ageing-cell-killing machines known as CAR (chimeric antigen receptor) T cells.
24 ene 2024 " ( https://www.sciencefocus.com/news/slow-ageing-t-cells ).
"SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. Medicines in the SGLT2 inhibitor class include canagliflozin, dapagliflozin, and empagliflozin.
"Cutting-edge treatments have introduced new players to the anti-ageing arena, including poly-L lactic acid (PLLA), polydeoxyribonucleotides (PDRN), and exosomes. These substances, administered through injections or micro-needling, stimulate collagen production, promote tissue regeneration, and enhance skin vitality.
Apparently the lack of tyrosinase:
"Inhibition of tyrosinase can reduce the production of melanin and achieve skin whitening, effectively solving pigmentation (Lall and Kishore, 2014). Therefore, the development of antioxidants, tyrosinase inhibitors, and elastase inhibitors play important roles in solving skin aging and pigmentation" ( https://www.google.com/url?q=https://www.sciencedirect.com/science/article/abs/pii/S0926669020309766&sa=U&ved=2ahUKEwjE4pTd0KyHAxUzHEQIHTzCCpIQFnoECAEQAw&usg=AOvVaw0gD_VQbHW1t1Go0zkPQyIW ).
Ming-Xiang Li, Jing Xie, Xue Bai, Zhi-Zhi Du,
Anti-aging potential, anti-tyrosinase and antibacterial activities of extracts and compounds isolated from Rosa chinensis cv. ‘JinBian’,
Industrial Crops and Products,
Volume 159,
2021,
113059,
ISSN 0926-6690,
Abstract: Rosa chinensis cv. ‘JinBian’, a cultivar of Rosa chinensis Jacq., is one of major raw material of rose tea and possesses sufficient plant resources in China. However, the studies on the chemical constituents and cosmetic activities of R. chinensis cv. ‘JinBian’ are almost blank. The main purpose of this study was to evaluate the anti-aging, skin-whitening, and antibacterial potentials of extracts and chemical constituents of the flower by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, elastase inhibition, anti-tyrosinase, and antibacterial assays. Bioassay results suggested both 95 % and 65 % ethanol extracts possessed significant antioxidant, elastase inhibition, and anti-tyrosinase activities. The combined active extract was studied with bioassay-guided fractionation to give a new compound, kaempferol 3-O-α-l-rhamnopyranosyl (1→6)-(2”,3”-O-digalloyl)-β-d-glucopyranoside (1) and fourteen known compounds (2–15). All compounds were firstly isolated from this species and subjected to the above mentioned bioassays. Ten compounds exhibited antioxidant activities with DPPH radical scavenging rate from 63.40 %–94.04 % under the concentration of 100 μg/mL. The antioxidant activities of 1, 2-phenylethyl 1-O-β-d-(6'-O-galloyl)-glucopyranoside (12), vomifoliol (14), and 4, 4'-dimethoxy-3'-hydroxy-7, 9': 7', 9-diepoxylignan-3-O-β-d-glucopyranoside (15) were firstly found with DPPH radical scavenging rate of 83.24 %, 91.10 %, 63.40 %, and 77.75 %, respectively. The moderate elastase inhibitory activities of 12, ethyl gallate (13), and 15 were firstly found with the inhibitory rate of 43.69 %, 43.25 %, and 35.34 % at the concentration of 100 μg/mL. Multiflorin B (3), 12, and 13 showed strong tyrosinase inhibitory activities with the inhibition rate at 43.83 %–55.80 %, comparing with the positive control, α-arbutin (22.15 %). In addition, 1 showed significant antibacterial activity against Staphylococcus aureus with the MIC50 of 8.51 ± 0.26 μg/mL. Compounds 2–4 and 12–14 showed moderate antibacterial activities against S. aureus. Compounds 6 and 13 also exhibited moderate inhibitory effects against Klebsiella pneumoniae. Above results manifested that R. chinensis cv. ‘JinBian’ possessed potential application values in the development of natural anti-aging, skin-whitening and antibacterial products.
Keywords: Rosa chinensis cv. ‘JinBian’; Antioxidant; Elastase inhibitory activity; Tyrosinase inhibitory activity; Antibacterial activity; Cosmetic potential
A vaccine is a shot of a disease into someone's body, to summon antibodies to fight the illness. If the exact and specific cause of aging could be identified then t cells may mass produce themselves for anti aging. First, aging, as a disease, must have an identified parsimonious cause.
Since most anti-aging experimenting is humanely on mice, how about a machine to automatically draw equivalence between the human and mouse body?
"Scientists have developed a vaccine specific to a protein found in senescent (old) cells, for targeted elimination. Age or metabolic stress promotes accumulation of senescent cells in tissues that causes pathological aging 'phenotypes'.
15 ene 2024." ( https://en.juntendo.ac.jp/highlights/news/nid69 ).
Correcting cellular growth errors. https://www.researchgate.net/publication/382049802_Correcting_Cell_Errors
Cellular damage, NOT mutation, causes aging. Cellular error is difficult to define.
My most thought provoking posts so far:
6)
Hello Folks,
I am working on SHSY5Y cells for D-galactose induced aging model. I want to know whether I should use differentiated or undifferentiated SHSY cells to study anti-aging effects of any test material.
Is it medically possible to have a single treatment for all diseases? One way to proceed about it is anti-aging. Aging is a process of accumulation of impairments of aging throughout life and ongoing damage of aging. If we can nullify it, our body intrinsic ability to heal would tale over, and provide a healthier system.
Kindly answer to this question with best of your knowledge. For the ongoing covid pandemic and upcoming chronic disease epidemic, we can provide a better treatment if this method works.
The incidence of COVID-19-related pneumonia is associated to overall body resistance, which in turn depends on age. Drugs such as IL-7 (which restores the aged thymus) and some others can increase resistance and reduce the likelihood of infection. Therefore, the severity of the pandemic can be reduced.
Here is an article about possible causes of thymus involution
The role of anti-aging genes such as Sirtuin 1is involved in epigenetics and is critical to the treatment of various diseases such as NAFLD, obesity, diabetes and neurodegenerative diseases. Sirtuin 1 is critical to the immune system and its repression is connected to the various chronic diseases. The role of RNA editing and genetic engineering is now important to treating various chronic diseases in the presence of Sirtuin 1 repression to prevent and reverse various chronic diseases that are linked to mitochondrial apoptosis and programmed cell death. RELEVANT REFERENCES:
A. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26
B. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017;Vol. 3 No. 3:24.
C. Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries. Top 10 Contribution on Genetics. Chapter 1, EBook. 2018. www.avid.science.com
We are reviewing whether antioxidant and anti-inflammatory polyphenols really be developed as supplements or drugs for anti-aging and aging health-related illness? Any possible or not suggestions?
RELEVANT REFERENCES:
1. Martins IJ. Advances in Aging and Health Research. Scientific Research Publishing, Inc. ISBN: 978-1-61896-569-1
2. Martins IJ. Scientific Nutritional Health and Global Chronic Disease. Scientific Media. New Distribution Report. 2018;443:1-3
3. Martins IJ. Chapter 01. Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries. Top 10 Contribution on Genetics. Book Chapter. 2018. www.avid.science.com
4. Martins IJ. Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals. International Journal of Aging Research. 2018,1(6): 1-4.
5. Martins IJ. Antimicrobial activity inactivation and toxic immune reactions induce Epilepsy in human. J Med Discov (2017);2(4):jmd17040.
6. Martins IJ. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017;3:24.
Butyric acid regulates gene expression by inhibiting histone deacetylases (HDACs). Butyrate induces growth arrest in a variety of normal cell types and senescence-like cancer cells by inhibiting DNA synthesis and cell growth and inducing stem cell differentiation and apoptosis by DNA fragmentation. Butyric acid regulates gene expression by inhibiting histone deacetylases (HDACs). Butyric acid has been assessed in NAFLD and Alzheimer’s disease as a therapeutic agent. The anti-aging gene Sirtuin 1 is a histone deacetylase and HDAC inhibition may completely interfere with its role in anti-aging and DNA repair and regulation of programmed cell death pathways.
RELEVANT REFERENCES
1. Ho L, Ono K, Tsuji M, Mazzola P, Singh R, Pasinetti GM. Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms. Expert Rev Neurother. 2018 Jan;18(1):83-90.
2. Kosta Steliou, Michael S. Boosalis, Susan P. Perrine, José Sangerman, and Douglas V. Faller. Butyrate Histone Deacetylase Inhibitors. Biores Open Access. 2012 Aug; 1(4): 192–198. 3. Bourassa MW, Alim I, Bultman SJ, Ratan RR. Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? Neurosci Lett. 2016 Jun 20;625:56-63.
4. Eva Juárez-Hernández, Norberto C. Chávez-Tapia, Misael Uribe, and Varenka J. Barbero-Becerra. Role of bioactive fatty acids in nonalcoholic fatty liver disease. Nutr J. 2016; 15: 72.
5. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26
6. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017; Vol. 3 No. 3:24.
7. Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals. International Journal of Aging Research. 2018,1(6): 1-4.
What is the scientific proof of Houttuynia Cordata's benefits for anti-ageing and skin brightening function?
Recently scientists found vitamine 3 is unique in mitochondria remedy for anti-aging,and FDA approve use of this material ,how this assist anti aging?,mwhat is mechanism of healing?
Kindly suggest the name of some antioxidants you know, which are effective to reduce free radicals in living body.
Interests in Biomarker Research has escalated with relevance to mitochondrial survival and global organ disease in diabetes and Alzheimer’s disease. Biomarker Research is expected to cost approx 118 billion dollars in the next 10 years. Bacterial lipopolysaccharides (LPS) should be measured in the blood plasma of developing world individuals with relevance to mitochondrial apoptosis and global chronic disease. The anti-aging protein such as Sirtuin 1 may also now be relevant to mitochondrial apoptosis versus mitochondrial biogenesis and may supersede the various biomarkers for mitochondrial survival relevant to diabetes, Alzheimer’s disease and neurodegenerative disease research.
RELEVANT REFERENCES:
1. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3.
2. Early diagnosis of neuron mitochondrial dysfunction may reverse global metabolic and neurodegenerative disease. Global Journal of Medical Research.. 2016;2: 1-8.
3. Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 2016. 4(2) 1-19.
4. The Future of Biomarkers Tests and Genomic Medicine in Global Organ Disease. Microbiology and Infectious Diseases. 2017; 1(1): 1-6.
5. Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities. Journal of Molecular and Genetic Medicine: 03/2015; 9(1).
6. Diabetes and Organ Dysfunction in the Developing and Developed. Global Journal of Medical Research: F Diseases Volume 15 Issue 1 Version 1.0 Year 2015.
7. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol . 2017. 2(1): 00013.
8. Dietary Interventions Reverse Insulin and Synaptic Plasticity Defects Linking to Diabetes and Neurodegenerative Diseases. SL Nutrition and Metabolism. 2017; 1:111:1-5.
9. Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer’s Disease. J Microb Biochem Technol. 2016; 8: 322-324. 10. LPS Regulates Apolipoprotein E and Aβ Interactions with Effects on Acute Phase Proteins and Amyloidosis. Advances in Aging Research 03/2015; 4(2):69-77.
11. Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci. 2015; 16(12): 29554–29573.
12. Bacterial LPS Overrides Adenosine Treatment of Epileptic Seizures. EC Microbiology 7.3 (2017): 83-86.
13. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.
14. The global biomarkers market size is expected to reach over USD 118 billion by 2026 https://www.prnewswire.com/news-releases/the-global-biomarkers-market-size-is-expected-to-reach-over-usd-118-billion-by-2026-300836830.htm
There are published reports that oral collagen supplements in the form of collagen hydrolysate, collagen tripeptide or collagen dipeptide improves the quality of skin and gives anti-aging property. How does it work? How is it metabolized in the body? When supplement is given is there any down regulation of collagen synthesis by fibroblasts?
What are the ways to isolate/extract retinol in its pure form from a mixture of retinol, polysorbate 20, BHT(butyl hydroxy toluene), and BHA(butylated hydroxyanisole)?
Retinol 50C(BASF product) is made up of :
- Retinol (49.5%)
- Polysorbate 20 (48%)
- BHT (3.5%)
- BHA (1%)
I've tried just about every search engine available, however, I am still having trouble finding the relevant information. Your help/guidance would be greatly appreciated!
Wrinkling of skin happened due to multiple factors including ageing, genetic bases, sunlight exposure, eating behavior etc. we can control these factors by applying anti age creams available in the market which slow down the wrinkling and promote collagen and elastin protein, while collaginase breaks it, now what are anti aging creams which are really beneficial and having what ingredients in it, some suggestions needed,
I have publications on using synergistic nutrient combinations on different days of the week to avoid inter nutrient interactions, reduce antagonism, improve efficiency, achieve optimum utilization. The therapy is yielding consistent results in hair loss management. It has helped improve iron levels, correct associated thyroid, PCOS, improve skin as well. Cyclical therapy utilizes antioxidants, minerals, vitamins, amino acids in an optimum dose cycles on different days. A similar approach can create an effective day to day care program for anti aging.
the ageing population is one of the greatest challenges facing society. more people are surviving to old age than even before, but we currently lack the mean to keep them healthy and independent. mean while i heard anti ageing drugs are coming what will be importance to protect cells and tissue.
REFERENCES:
1. Antibiotic Use and Nuclear Receptor Inactivation Linked to Mitophagy in Diabetes and Chronic Diseases. Journal of Diabetes and Clinical Studies. 2018,2 (1);1-3.
2. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions. EC Pharmacology and Toxicology 6.4 (2018): 209-215.
3. Antibiotic Resistance Involves Antimicrobial Inactivation in Global Communities. SAJ Pharma Pharmacol 2017;2: 102.
4. Antimicrobial Drugs and Bacterial Amyloid Peptide Induce Toxic Manifestations in Chronic Diseases. EC Pharmacology and Toxicology 6.1 (2018): 01-04.
5. Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer’s Disease. J Microb Biochem Technol. 2016; 8: 322-324.
6. Inactivation of Anti-Aging Genes is Related to Defective Drug Metabolism in Diabetes. Int J Drug Disc. 2017; 1:003.
Biological Ageing is natural decline and deleterious effects in health and diminishing life span with more diseases like degenerative like Alzhemier, Parkinson in old age, diabetes, cardiovacular diseaes and cancer. Before, 1950s there was no mention of ageing but now its emerging field in research and thinking for better cure of diseases and reverse or delay aging, metformin, rapamycin some antioxidants, herbs and aspirin are screened for anti-aging agents, some trials are needing to finalize the ageing treatments, Hope, in future, there will be less diseases and less early deaths as happening now,
Dear all,
Have you ever studied a paper about probable interaction between some of anti-aging genes, such as Klotho, TERT (Telomerase) and Sirtuins genes?
Could you please send me the document or links?
Thanks in advance
Warm regards
Azadeh
Study on anti aging effect using plant extract
Plant extract potential as anti aging.
Thinking about the importance of avoiding free radicals ... will there be a way to drink something that encapsulates them? Is it a very crazy idea?
CERTIFICATE FOR EXCEPTIONAL EFFORT
Please see Presentation below entitled
" Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic Diseases"
at the 8th World Gene Convention-2017.
Hi Joseph, I am a Neuroscientist and have been using deprenyl as you prescribed for 20 years now and at 78 have no diabetes or heart problems and weigh 170 lbs. I still ride my dual purpose motorcycle. I have lost erectile function and wear hearing aids. What progress have you made in the last 20 years that could benefit me? Thank you for your very important work and contributions! http://www2.hawaii.edu/~bemorton
I am trying to measure the anti-aging properties of specific compounds. What are the most used methods to do so?
Food restriction in diabetes is essential to activate the anti-aging genes to increase cholesterol and glucose metabolism. The brain with increased food consumption may lose synchrony (Type 3 diabetes) and careful food restriction is required to activate the hypothalamus that contains the suprachiasmatic nucleus. Food restriction for diabetes treatment may depend on the amount of bacterial LPS, mycotoxins, xenobiotics and other compounds that may enter the brain and interfere with the SCN circadian rhythm.
Does anybody know works where two or more circadian genes were overexpressed multiplexly and lifespan of a model was observed? Probably somebody knows groups solving the problem of combined overexpression for life extension, I would be grateful to recieve any information.
In the whole chain of oxidative phosphorylation, does the reduction of oxygen step limit the speed at which NADH can be processed?
Suppose you had 2 OXPHOS systems side by side - one in which O2 was always, 100% completely reduced (producing no free radicals) and one in which O2 was only reduced halfway (producing lots of free radicals). Which system would run faster, and by how much?
According to WHO, Active ageing is the process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age. It applies to both individuals and population groups.
With the population ageing world wide, Its necessary to carry out different activites to make active ageing to our senior citizens. From this active ageing it will indirectly save the health expenses and other social support related expenses of the family, society, community and of Nations. While sharing the Policy and Action program carried out in your country or region or community people from developed country or other region can also replicate the program which will be useful for the well being of aging society.
I look forward to get lots of theoretical or empirical study results as well as policy related materis will be shared in this forum related with active ageing. Thank you every one for your kind contribution.
I have done microneedling for 19 years and I always apply vitamin A, C and E to the skin immediately after the treatment. I have never seen a reaction ever and my experience covers about 2000 personal cases and in excess 10,000 when including my associates using the same regime. The product we use is Environ vitamin ACE Oil which has no added preservatives, colourants or perfumes. This is the same oil as used by Zeitter et al in their research at Hannover Medical School to test needling skin at weekly intervals. In their research the vitamin A,C E oil vastly increased the magnitude of the result.
Found a quote in a paper by Judith Campisi "RAS and similar GTPases generate reactive oxygen species as signal molecules". Can anyone explain this further?
If not, why not? Similarly, if oxytocin rejuvenates certain cells, is this observed in cases where oxytocin is used for treatment of human diseases?
I need to do western blot of RBC globin but i can't find how to extract globin from the cells. I will use anti-AGE antibody. Did somebody do something like that? Thank everybody for answers!
Since continual mitochondrial function is required for maintenance in response to stress, mitochondrial function is impaired with aging.
In response to this mitochondrial dysregulation, is MRS activated as a compensatory or quality control mechanism?
How reliable is the research that has gone into health, wellness and beauty products? To what extent can we trust the research? Do we have convincing evidence that research with such products was carried out and that the results showed the efficacy of these products?
Please share your specific views. Thanks.
Following the very interesting question: "https://www.researchgate.net/post/Is_there_is_decrease_in_number_of_neurons_with_aging/1" asked by https://www.researchgate.net/profile/Aftab_Ahmad11, I wonder if it's true that this decease of neurons with age is very decelerated by the reading in very different disciplines. especially when this read is daily and is done by concentration on the senses.
Is there a difference between intellectuals and others ...
Also, is a special diet has an influence ? the memory exercises ? etc...
TLR2 belongs to a family of pattern recognition receptors that regulate responses to extraneous pathogens as well as endogenous misfolded proteins released after cellular stress.
It is well known that this amazing linear tripeptide of L-glutamine, L-cysteine, and glycine is often referred to as the body's master antioxidant. Once generation of free radicals exceeds the body's capacity to neutralize and eliminate them, oxidative stress occurs, and primary function of glutathione is to alleviate this oxidative stress. Low Glutathione levels are associated with health diseases such as Cancer, Multiple Sclerosis, AIDS, Alzheimer’s, Parkinson’s, Atherosclerosis, Pregnancy Complications, Cataracts, Asthma, Autism, Bronchitis, Fibromyalgia, Insomnia, Male infertility, Migraines, Osteoporosis, Pain, Poor Eyesight, PMS, Psoriasis, Wrinkles, Low Sex Drive, Chronic Fatigue, Balding and Cirrhosis. So can inhibition of GSH breakdown in the stomach or a induction of GSH synthesis be a step towards the fountain of youth?

There is this f06.7 find in icd 10 and there are no real treatments for it. Using dementia as an etalon for the medication didn't gave any good answer dealing with it but more of nausea for researchers that still don't find it's place in cognitive function problems and many think of it as an predementia but the criteria for it is the absence of dementia.
Can anyone on RG give a better more up to date explanation over this diagnostic and its clinical features?
I am trying to transfect the gene of interest into HeLa cells using Lipofetamine 2000 to see if this gene would cause any changes in senescence ratio (using Senescence Associated beta-gal staining) and cell cycle profiles.
In order to maximize transfection efficiency, I have determined the plasmid to lipofectamine ratio should be 0.6:3 OR 1.2:3.6, according to the western-blot result. However, the cell toxicity induced by lipofectamine is a big issue in senescence measurement.
Is there any suggestions that you can offer to help reduce the cell toxicity while maintaining the gene transfection efficiency? How about transfecting the gene twice, at half amount of requested amount each time?
I isolated a compound from a plant source which shows nearly 80% antioxidant activity. What kind of analysis can I carry out with that compound?