Analytical Chemistry - Science method

Background Ritonavir was recently combined with nirmatrelvir in a new approved co-packaged medication form for the treatment of COVID-19. Quantitative analysis based on fluorescence spectroscopy measurement was extensively used for sensitive determination of compounds exhibited unique fluorescence features. Objective The main objective of this wor...

Ferreira, Rafael de Queiroz. F368q Química analítica experimental [recurso eletrônico] : Uma visão qualitativa e quantitativa / Rafael de Queiroz Ferreira, Josimar Ribeiro. - Dados eletrônicos. – Vitória, ES : EDUFES, 2023. 196 p. : il. ; 21 cm. - (Coleção Pesquisa Ufes ; 54) Inclui bibliografia. ISBN: 978-85-7772-533-5 Modo de acesso: http://repos...

Ribeiro, Josimar R484q Química analítica teórica [recurso eletrônico] : Uma visão qualitativa e quantitativa / Josimar Ribeiro, Rafael de Queiroz Ferreira. - Dados eletrônicos. - Vitória, ES : EDUFES, 2023. 220 p. : il. ; 21 cm. - (Coleção Pesquisa Ufes ; 55) http://repositorio.ufes.br/handle/10/774

Spectroelectrochemical (SEC) measurements play a crucial role in analytical chemistry, utilizing transparent or semitransparent electrodes for optical analysis of electrochemical (EC) processes. The EC readout provides information about the electrode's state, while changes in the transmitted optical spectrum help identify the products of EC reactio...

Controle de Qualidade Externo (QCExt): A amostra contendo a cepa código CCMR0280 cultivada em paralelo a todos os lotes servirá como referência para estudos comparativos estudo de comparação entre as cepas do CCMR (Culture Collection of Microorganisms at the Federal University of Rio de Janeiro). Após secagem da biomassa, a nova amostra da cepa cód...

Modern microcontroller Arduino platform is often used to create electronic devices with the ability to receive signals from various digital and analog sensors, further primary processing of information with transfer to a computer, as well as to control various devices. This versatility makes it possible to create low-cost equipment for analytical a...

In recent years, the Internet of Things (IoT) has revolutionized the landscape of analytical chemistry, enabling researchers and industries to obtain real-time data and perform accurate and continuous monitoring and sensing. This chapter explores the various applications of IoT technologies in analytical chemistry, focusing on how IoT-based systems...

The present investigation evaluated the pre-Hispanic food called "nicuatole" based on corn, from the Central Valleys region of the state of Oaxaca, Mexico. The objective of the present work was to present preliminary results of the physicochemical and proximate properties of the pre-Hispanic food locally known as "nicuatole". The sample was prepare...

Entrectinib is an oral selective inhibitor of the neurotrophic T receptor kinase (NTRK). It is used in the treatment of solid tumors in NTRK gene fusion lung cancer. The study aimed to develop and validate an analytical method for quantifying entrectinib plasma by UPLC-MS/MS using quizartinib as an internal standard. The method involves liquid–liqu...

Los trabajos prácticos de laboratorio integran y complementan el aprendizaje teórico, pero cuando estos espacios no están disponibles, los simuladores constituyen una alternativa viable para dar continuidad a las actividades académicas. Esta experiencia, realizada en el marco del Trabajo Final de la Especialización en Producción de Contenidos y Amb...

Circular dichroism (CD) effects have broad applications in fields including biophysical analysis, analytical chemistry, nanoscale imaging, and nanosensor design. Herein, a novel design of a tilted F-type chiral metal nanostructure composed of circular nanoholes with varying radii has been proposed to achieve remarkable CD effects, and the results d...

This book on soil analysis is framed based on the syllabus for Agricultural Science and accordingly it will serve as a text book for students of Agricultural, Horticultural Science, Home Science and Environmental Science besides the basic sciences. The main frame work of this book consists of 4 chapters and 40 sub topics and five annexure. The cont...

Nano-sized ion exchangers (NIEs) combine the properties of common bulk ion-exchange polymers with the unique advantages of downsizing into nanoparticulate matter. In particular, being by nature milti-charged ions exchangers, NIEs possess high reactivity and stability in suspensions. This brief review provides an introduction to the emerging landsca...

Oscillatory systems regulate many biological processes, including key cellular functions such as metabolism and cell division, as well as larger-scale processes such as circadian rhythm and heartbeat1–4. Abiotic chemical oscillations, discovered originally in inorganic systems5,6, inspired the development of various synthetic oscillators for applic...

The COVID-19 pandemic forced instructors of chemistry lab classes to develop a variety of alternative materials for remote delivery of traditionally hands-on content. One solution to this challenge was virtual choose-your-own-adventure (CYOA) laboratories that allowed students to practice realistic decision-making and collect authentic data. With t...

Introducción. La eficiencia de una metodología para analizar una sustancia farmacológica puede verse afectada por las condiciones reales del laboratorio de cada país, incluyendo el clima. Por esta razón, se requiere validar el método con las pautas recomendadas para ello y optimizar el proceso, para asegurar el éxito y la confianza en los resultado...

Cyrene was evaluated for the first time as a potential sustainable mobile phase solvent in re-versed-phase chromatography. As a benign biodegradable solvent, Cyrene is an attractive re-placement to classical non-green organic chromatographic solvents such as acetonitrile and a modifier, co-eluent to known green solvents such as ethanol. Compared to...

This research project explores the potential of hybrid nanoparticles as a versatile platform for mass spectrometry (MS) and electrochemical analysis. By combining the unique properties of different nanoparticle materials, such as gold, silver, or magnetic nanoparticles, with the sensitivity and selectivity of MS and electrochemical techniques, this...

There is a pressing need for the development of greener liquid chromatographic bioanalytical methods for antidiabetic drugs for plasma monitoring and revisiting patients' dosage regimens. Besides, analytical methods are also needed for the quality assurance of finished drug products and regulatory approval. Therefore, the present review focuses on...

This systematic review analysis study aimed to examine the scientific attitudes in chemistry learning. The method used a Systematic Literature Review which consists of 5 stages adopted from Denyer and Tranfield. The main criteria for the selection of articles are scientific attitude in the field of chemistry learning with a period of 2012 until 202...

Over the last 50 years, advances in the production of stable isotopes and mass spectrometry instrumentation have fueled elucidation of endogenous biochemical pathways and underpinned quantitative methodology in analytical chemistry, to name but two areas impacted. The topic covering the use of stable isotopes in pharmacological research is very bro...

Secondary metabolites—organic compounds that are often bioactive—produced by endophytes, among others, provide a selective advantage by increasing the organism’s survivability. Secondary metabolites mediate the symbiotic relationship between endophytes and their host, potentially providing the host with tolerance to, and protection against biotic a...

Lipids are a diverse class of molecules involved in all biological functions including cell signaling or cell membrane assembly. Owing to this relevance, LC-MS/MS based lipidomics emerged as a major field in modern analytical chemistry. Here, we thoroughly characterized the influence of MS and LC settings – of a Q Exactive HF operated in Full MS/da...

Assessing the timing of skeletal trauma significantly impacts the reconstruction of events surrounding death and deposition in forensic cases. However, there are no absolute time frames in which the characteristics of wet bone (peri-mortem) fractures transition to dry (post-mortem) fractures. The aim of this study was to attempt to identify a point...

This Front cover in Analytical Chemistry journal is about our article entitled "Paper-Based Analytical Devices for Accurate Assessment of Transferrin Saturation in Diagnosed Clinical Samples from Ischemic Stroke Patients" DOI 10.1021/acs.analchem.3c01982

Analytical chemistry relies on the qualitative and quantitative analysis of multivariate data obtained from various measurement techniques. However, artifacts such as missing data, noise, multiplicative and additive effects, and peak shifts can adversely affect the accuracy of chemical measurements. To ensure the validity and accuracy of results, i...

Traditionally, analytical chemistry and diagnosis relied on wet laboratories and skilled professionals utilizing sophisticated instruments for sample handling and analysis. However, with the development of novel materials and sensing techniques, there has been a significant shift towards the use of standalone sensors, allowing tests to be conducted...

Understanding the origin(s) of life (OoL) is a fundamental challenge for science in the 21st century. Research on OoL spans many disciplines, including chemistry, physics, biology, planetary sciences, computer science, mathematics and philosophy. The sheer number of different scientific perspectives relevant to the problem has resulted in the coexi...

Mathematical filtration is an efficient tool to resolve the overlapping spectra of binary mixtures in zero or first order form. Herein, a comparative study was conducted between six economic, accurate and precise spectrophotometric methods for determination of Triclabendazole (TCB) and Levamisole HCl (LVM). Each component was resolved with minimum...

Metabolomics is an analytical approach that involves profiling and comparing the metabolites present in biological samples. This scoping review article offers an overview of current metabolomics approaches and their utilization in evaluating metabolic changes in biological fluids that occur in response to viral infections. Here, we provide an overv...

Recently, magnetic solid-phase extraction (MSPE) is an important technology due to its use in analytical chemistry, biotechnology, and medicinal fields. MSPE shows rapid isolation of target analyte from large volume samples, the huge surface area of magnetic nanoparticles (MNPs), and simplicity in application due to using an external magnetic field...

The application of machine learning models in chemistry has made remarkable strides in recent years. Even though there is considerable interest in automating common proce- dure in analytical chemistry using machine learning, very few models have been adopted into everyday use. Among the analytical instruments available to chemists, Nuclear Mag- net...

RESUME Objectif : La présente étude a pour objectif d'évaluer le degré d'assimilation du cours de chimie analytique par des travaux pratiques au laboratoire. Méthodes : Il s'agit d'une étude qualitative établie sur la distribution des notes obtenues (excellente ; forte ; moyenne et faible) et quantitative car, basée sur le taux d'assimilation de la...

This paper introduces a captivating topic for upper-level analytical chemistry capstone projects, focusing on aquarium water analysis. This provides a more comprehensive understanding of the role of analytical chemistry towards sustainability and its environmental, economic, societal and education dimensions. Regarding the crucial role of maintaini...

Metals and metalloids in consumer products can be ingested by humans and cause health problems. The unified Bioaccessibility Research Group of Europe (BARGE) method (UBM, i.e., ISO 17924), with complex digestive ingredients, and the 0.07 M HCl single extraction method, as a simplified means, have been widely used to assess oral bioaccessibility in...

This study evaluated the digestibility of processed duckweed based diets and its effect on proximate composition of Oreochromis niloticus. Blanching and sun-drying were employed as the processing methods to reduce antinutrients in the duckweed meal. The experiment was conducted in two outdoor concrete ponds with an area of 5m x 3.5m (l × b) and...

Call for Chapters Book dvanced Systems for Environmental Monitoring, IoT and the application of Artificial Intelligence Book Series: Studies in Big Data Electronic ISSN 2197-6511 Print ISSN 2197-6503 Abstracted and Indexed in: Google Scholar; Scopus; British Library; Chemistry Citation Index (CCI); Cambridge Scientific Abstracts (CSA)/ ProQuest ;…...

Acriflavine is a multipurpose drug that shows antibacterial, antiviral, antimalarial, and antifungal activities. The remarkable native fluorescence of acriflavine is exploited in analytical chemistry field as an efficient probe for analysis of pharmaceutical and biological compounds. The fluorescent probe action of acriflavine is based on the remar...

Naturally derived pH indicators are always been the prime focus in analytical chemistry. Anthocyanins are among them, and their use in acid–base indicator chemistry is generating a lot of interest. The key objective of this study was to assess the feasibility of aqueous electrolyte-based extraction of plant pigment from Syzygium samarangenese and F...

One of the current research lines in analytical chemistry is the design and utilization of novel materials with higher selectivity and improved analytical performance in various steps of chemical analysis. In this sense, Metal–Organic Frameworks (MOFs) have attracted attention as a potential alternative to current commercially available materia...

Cyclin D dependent kinase 4 and 6 (CDK 4/6) inhibitors are novel anticancer drugs used in therapeutic combinations with endocrine therapy for breast cancer treatment. Their determination in patient plasma is of high interest as a prerequisite for possible therapeutic drug monitoring. Dispersive liquid-liquid microextraction (DLLME) shows great pote...

Contamination has become a major issue in all high-tech industries, with increasingly stringent cleanliness requirements. It is the case for sensitive parts of space flight hardware, such as optics or other embedded equipment for which surface cleanliness is a critical topic, since even a thin layer of contaminant can adversely affect performance....

Las demandas de sociedades de consumo han llevado a escenarios preocupantes respecto a contaminantes emergentes en el ambiente como los disruptores endócrinos, entre ellos los bisfenoles, compuestos orgánicos utilizados en la síntesis de policarbonato, resinas epóxicas, papel térmico, etc. La liberación al ambiente de bisfenoles se ha incrementado...

The Special Issue aimed to provide a forum for scientists and engineers to share and discuss their pioneering/original findings or insightful reviews on the “Characterization and Processing of Complex Materials”. Reports on the achievement of coupling the complexity of industrial materials/wastes/natural ores with non-destructive characterization m...

Resumen Resolver equilibrios complejos es uno de los temas más difíciles en Química Analítica para los estudiantes. Ejemplos de estos problemas son la obtención de las concentraciones de OH-y H3O + en soluciones de bases muy débiles o la solubilidad de sales básicas. Los estudiantes pueden tardar más de dos horas en encontrar la solubilidad de una...

Pharmacuticalcal compounds can be separated, identified, and quantified using high-pressure liquid chromatography (HPLC) in analytical chemistry. A monolithic column of glycidyl methacrylate-ethylene dimethcrylate-co-acryl amide was prepared by in-situ co-polymerization inside; a borosilicate tube as a mould (60mm in length) with 1.5mm and 3.0 mm (...

Small data sets make developing calibration models using deep neural networks difficult because it is easy to overfit the system. We developed two deep neural network architectures by revising two existing network architectures: the U-Net and the attention mechanism. The major changes were to use 1D convolutional layers to replace the fully connect...

Analytical chemistry applied to medical and diagnostic analysis, recently focused on the development of cost-effective biosensors able to monitor the health status or to assess the level of specific biomarkers that can be indicative for several diseases. The improvement of technologies relating to the possibility of non-invasive sampling of biologi...

An in-line smartphone connected to a screen-printed selective electrode hand-held device was used to determine the concentration of distigmine bromide (DB) in its pure and dosage forms as well as its degradation kinetics by continuously measuring the change in the produced emf over time. The main objective, supported by the data presented, is to pr...

In this work, chitosan / graphene nanocomposite granules with weight percentages of 0.5%, 1%, 2% and 5% were prepared using a solution method. At first, graphene was oxidized with sulphuric and nitric acid then triethylenetetramine was grafted on graphene surface. Functionalized graphene was characterized by Fourier-transform infrared spectroscopy...

Biosensors are analytical devices that utilize biological interactions to detect and quantify clinical biomarkers, contaminants, allergens, and microorganisms. They combine different disciplines including analytical chemistry, molecular biology, and electrical engineering. Biosensors operate by coupling a bioreceptor, such as nucleic acid or protei...

Proanthocyanidins (PAs), flavonoid polymers involved in plant defense, are also beneficial to human health and ruminant nutrition. To date, there is little evidence for accumulation of PAs in maize (Zea mays), although maize makes anthocyanins and possesses the key enzyme of the PA pathway, anthocyanidin reductase (ANR). Here, we explore whether th...

In general, concepts such as chemical equilibria and classical analytical chemistry, as well as instrumental methods such as potentiometry and flow injection analysis (FIA), are taught separately in the curricula of chemistry-related degree programs. However, FIA provides an opportunity to connect all of these important topics. This article shows h...

Alizarin is one of the popularly used and wide separated compounds with a chemical name (1,2- dihydroxy-9,10-anthraquinone) which belong to the anthraquinones family that contains three aromatic conjugated rings and in the central rings it contains two ketonic groups.Huge attention and high interests are focused on theoretically and experimentally...

The article recalls important anniversaries associated with chemistry and Charles University. Personal anniversaries of individuals associated with chemistry and our oldest university include commemorations of the life milestones of Jan Jakub Václav Dobřenský of Černý Most (400 years since his birth), Johann Jakob Geelhausen (285 years since his de...

The toxicity of oil sands process-affected water (OSPW) has been associated to its dissolved organics, a complex mixture of naphthenic acid fraction components (NAFCs). Here, we evaluated solar treatment with buoyant photocatalysts (BPCs) as a candidate passive advanced oxidation process (P-AOP) for OSPW remediation, according to both analytical ch...

The teaching of Natural Sciences becomes increasingly demanding in the sense that students can assimilate scientific knowledge. The experimental activity of Physical Chemistry, in the school environment, constitutes a space that enhances the cognitive and educational aspects of the students. In this sense, the formative itineraries must guarantee t...

In ecotoxicology, evaluation of toxicities and no observed effect concentrations (NOEC) of test compounds in experimental fish is commonly based on molecular-, biochemical- and analytical chemistry analyses of organ/tissue samples and the assessment of (histo-) pathological lesions. Standardization of organ/tissue sampling locations, sample numbers...

Carbonyl compounds are ubiquitous in outdoor and indoor air. Due to the high electronegativity of the oxygen atom, they are polar in nature and the C=O group opens possibilities for...

Due to the inherent merits of the anodic photoelectrochemical (PEC) sensor, it was widely utilized in the field of analytical chemistry. However, it must be noted that the anodic PEC sensor was susceptible to interference in practical applications. The situation with the cathodic PEC sensor was exactly the opposite. Therefore, this work fabricated...

Denoising, detrending, deconvolution: usual restoration tasks, traditionally decoupled. Coupled formulations entail complex ill-posed inverse problems. We propose PENDANTSS for joint trend removal and blind deconvolution of sparse peak-like signals. It blends a parsimonious prior with the hypothesis that smooth trend and noise can somewhat be separ...

For various reasons, some of them linked to the evolution of the historiography of Chemistry, many recognized and important chemists in their time – and in ours, because of the legacy they left – are relegated to some degree of oblivion. One of these chemists, dead just over 200 years ago, is Martin Heinrich Klaproth (1743-1817), a key figure in th...

Objectives Centrifugation is a time-consuming step which increases the turnaround time (TAT) in laboratories. A few studies have addressed the effect of altering centrifugation settings on analytical quality for clinical chemistry analytes, and most of these studies have used collection tubes with gel separators. However, gel separator tubes may be...

Realgar is a traditional Chinese medicine that contains arsenic. It has been reported that the abuse of medicine-containing realgar has potential central nervous system (CNS) toxicity, but the toxicity mechanism has not been elucidated. In this study, we established an in vivo realgar exposure model and selected the end product of realgar metabolis...

This review provides an overview of recent advancements in applying graphene-based materials as sorbents for liquid chromatography (LC) analysis. Graphene-based materials are promising for analytical chemistry, including applications as sorbents in liquid chromatography. These sorbents can be functionalized to produce unique extraction or stationar...

Determining the level of contaminants in rice is very important because it is one of the staple foods consumed by most people worldwide. Therefore, the quantity of arsenic in rice has become a health concern because rice cultivars have the property of accumulating arsenic in their grains. As a result, various societies have mandated the measurement...