Science topic

Amino Acids - Science topic

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
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Publications related to Amino Acids (10,000)
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Tuberculosis is a disease with a high level of incidence and mortality. Due to the problems associated with current therapy, it is necessary and urgent to develop new drugs for treatment. Dihydrofolate reductase (DHFR) is a recognized target for the action of several drugs. The 3D structure of the Mycobacterium tuberculosis DHFR (MtDHFR) elucidates...
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Angiotensin-converting enzyme 2 (ACE2) is a well-established functional host receptor for the highly devastating ongoing pandemic of coronavirus disease 2019 (COVID-19). This protein provides the entry point through which COVID-19 hooks and infects human cells. A damaged ACE2 could alter the rate of this viral infection. This study was conducted to...
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Background The pathogenic variation of CASK gene can cause CASK related mental disorders. The main clinical manifestations are microcephaly with pontine and cerebellar hypoplasia, X-linked mental disorders with or without nystagmus and FG syndrome. The main pathogenic mechanism is the loss of function of related protein caused by variant. We report...
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Rationale Multiple myeloma (MM) cells synthesize large amounts of paraproteins, making radiolabeled amino acids promising candidates for PET imaging of MM patients. Methods We compare tumor uptake of the two amino acid analogs [ ¹⁸ F]-fluoroethyltyrosine and [ ¹⁸ F]-FACBC in a MM xenograft model and show the feasibility of PET imaging with [ ¹⁸ F]...
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Background Persistence is a key criterion for the risk assessment of chemicals. In degradation tests, microbial biodegradation of labeled test chemicals leads to the incorporation of the label in microbial biomass, resulting in biogenic non-extractable residues (bioNER), which are not considered as harmful in persistence assessment. The amount of b...
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Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a long time by oral glucose ingestion are uncharacte...
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The aim of this paper is to evaluate improvement in the classification of protein sequence data by introducing clustering as a prepossessing step. Clustering analysis was introduced to discover any possible sub-clusters that might have different patterns within the same protein class. A classification learning algorithm is then applied to each clus...
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Alzheimer's disease (AD) is one of the most common diseases in the elderly, imposing a significant financial and emotional burden on patients and their families. Inhibiting the enzyme cholinesterase is currently one of the main methods of delaying the symptoms of AD. The mulberry extract has good butyrylcholinesterase (BChE) inhibitory activity, bu...
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Before the emergence of plasmid-mediated colistin resistance, colistin was once considered the last drug of choice for infections caused by carbapenem-resistant bacteria. Currently, researchers are relentlessly exploring possible alternative therapies that could efficiently curb the spread of drug resistance. In this study, we aimed to investigate...
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Water deficit (WD) combined with high temperature (HT) is the major factor limiting agriculture worldwide, and it is predicted to become worse according to the current climate change scenario. It is thus important to understand how current cultivated crops respond to these stress conditions. Here we investigated how four soybean cultivars respond t...
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Luminescence chemosensors are one of the most useful tools for the determination and imaging of small biomolecules and ions in situ in real time. Based on the unique photo-physical/-chemical properties of ruthenium(II) (Ru(II)) complexes, the development of Ru(II) complex-based chemosensors has attracted increasing attention in recent years, and th...
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4,4′-Sulfonyl-diphenol (BPS), as a widespread environmental hormone-like micropollutant, is difficult to be degraded in the environment. In this study, the removal of BPS with multi-enzymes extracted from waste sludge and reed sediment was studied at 298 K, 310 K, and 328 K. Results show that BPS could be removed efficiently and was time–temperatur...
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The ability to computationally generate novel yet physically foldable protein structures could lead to new biological discoveries and new treatments targeting yet incurable diseases. Despite recent advances in protein structure prediction, directly generating diverse, novel protein structures from neural networks remains difficult. In this work, we...
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Broad diversity of flowers in Fabaceae provides a good system to investigate development and evolution of floral symmetry in higher plants. Many studies have demonstrated a conserved mechanism controlling development of zygomorphic flower during last decades. However, the molecular basis of how asymmetric flower established is largely unknown. In t...
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Brassinosteroids (BRs) play important roles in plant growth and development, and BR perception is the pivotal process required to trigger BR signaling. In angiosperms, BR insensitive 1 (BRI1) is the essential BR receptor, because its mutants exhibit an extremely dwarf phenotype in Arabidopsis. Two other BR receptors, BRI1-like 1 (BRL1) and BRI1-lik...
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By proposing a numbering of the twenty proteinogenic amino acids deduced from the physicochemical properties of the four coding DNA nucleobases, it is established that this amino acid number, equal to 5x entities, is not arbitrary. Indeed, we demonstrate that many attributes of these twenty amino acids, as a whole, are also 5x in number and that by...
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Triplet repeat diseases (TRDs) refer to a group of diseases caused by three nucleotide repeats elongated beyond a pathologic threshold. TRDs are divided into the following four groups depending on the pathomechanisms, although the pathomechanisms of several diseases remain unelucidated: polyglutamine disorders, caused by a pathologic repeat expansi...
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Background: Rigid dietary controls and pill burden make a very-low protein (0.3–0.4 g/kg body weight per day), vegetarian diet supplemented with ketoanalogues of amino acids (sVLPD) hard to follow in the long-term. This study aimed to evaluate whether a ketoanalogue supplemental low-protein diet (sLPD) (0.6 g/kg body weight per day) could also redu...
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The results of secondary structure prediction methods are widely used in applications in biotechnology and bioinformatics. However, the accuracy limit of these methods could be improved up to 92%. One approach to achieve this goal is to harvest information from the primary structure of the peptide. This study aims to contribute to this goal by inve...
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The classification of protein sequences provides valuable insights into bioinformatics. Most existing methods are based on sequence alignment algorithms, which become time-consuming as the size of the database increases. Therefore, there is a need to develop an improved method for effectively classifying protein sequences. In this paper, we propose...
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In this study, we analyzed the meat quality of Qianhua Mutton Merino sheep (QHMM). QHMM and Small-tail Han sheep (STH) were selected as the test animals. After slaughtering, the longissimus dorsi muscles were tested to determine the nutrient composition, content of amino acid, fatty acid, and muscle fiber diameter. According to the nutrient test re...
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The MID1 protein acts as an E3 ligase in the ubiquitination pathway. The RING and B-Box domains of MID1 both contribute to MID1 E3 ligase activity, however RING has higher E3 activity than B-Box despite having a very similar structure. Therefore, the purpose of this study is to understand what positional amino acid differences make RING have higher...
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Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are elucidated by ¹ H- ² H...
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Asparagus ( Asparagus officinalis L.) has a characteristic flavor and useful components, although the lower stem is not suitable for eating because it has a fibrous skin like wood, being normally discarded. Therefore, to propose drying and roasting as methods for using the hard lower stem of asparagus, usually discarded, useful components in the as...
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The targeted compounds were synthesized by mixing 2-hydroxy-1,2-diarylethanoate with metformin in the presence of ethanol and screened for anti-tubercular activity of novel diaryl imidazole derivatives and predict their affinity against Mycobacterium tuberculosis GlmU. The synthesized imidazole derivatives were determined using Mycobacterium tuberc...
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The main aim of this work was to test the ability of an amino acid (e.g. glycine) to leach cobalt from Li ion batteries (LiBs). The process parameters namely temperature, pulp density and concentration of glycine were optimized for maximizing the leaching efficiency of cobalt from the cathodic material. Response surface methodology (RSM) was applie...
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Creatine is a very popular amino acid widely utilized in the sports world due to its functions mainly related to muscle building and increasing performance. The present work investigates the behavior of creatine aqueous solutions and of creatine aqueous in the presence of trehalose as a function of time changes by means of Infrared spectroscopy. In...
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Myc is a bHLHZip protein involved in growth control and cancer, which does not form a homodimer. Myc operates in a network with its heterodimerization partner Max, the latter of which can form homodimer and heterodimer. Omomyc, a polypeptide, can block Myc to treat cancers because it can both homodimerize as efficiently as Max and heterodimerize wi...
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Molecules reside broadly in the interstellar space and can be detected via spectroscopic observations. To date, more than 271 molecular species have been identified in interstellar medium or circumstellar envelopes. Molecular spectroscopic parameters measured in laboratory make the identification of new species and derivation of physical parameters...
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T cell engager (TCE) antibodies have emerged as promising cancer therapeutics that link cytotoxic T-cells to tumor cells by simultaneously binding to CD3E on T-cells and to a tumor-associated antigen (TAA) expressed by tumor cells. We previously reported a novel bispecific format, the IgG-like Fab x sdAb-Fc (also known as half-IG_VH-h-CH2-CH3), com...
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Two isoforms of beta amyloid peptides, Ab40 and Ab42, differ from each other only in the last two amino acids, IA, at the end of Ab42. They, however, differ significantly in their ability in inducing Alzheimer's disease (AD). The rate curves of fibril growth of Ab40 and Ab42 and the effects of molecular crowding have been measured in in vitro exper...
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In this article codes over lattice valued intuitionistic fuzzy set type-3 (LIFS-3) are defined. Binary block codes and linear codes are constructed over LIFS-3. Hamming distance and related properties of these newly established codes are examined. e research findings are applied to genetic codes. e set L of sixty-four codons is converted into a lat...
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The studies of the meadow-chernozem soil of the Omsk region, showed that biological products are effective when used for spring wheat by seed treatment. When comparing their action, it was noted that a greater effect was obtained from the use of the variants Azotobacterin+Phosphobacterin and Azotobacterin+Phosphobacterin+Humate K. The improvement o...
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There have been at least four types of dengue outbreaks in the past few years. The evolutionary characteristics of dengue viruses have aroused great concerns. The evolutionary characteristics of dengue 4 viruses are studied in the present study based on their base usage patterns and codon usage patterns. The effective number of codons and relative...
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In the present study, we performed in silico analysis on all reported mutations of PRODH in order to investigate their biological significance. 3D models of wildtype and mutant PRODH were predicted using I-TASSER. Protein-protein docking was done with Cluspro, while protein-substrate docking was done with Auto Dock tools. Alignment of 3D models (va...
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Abstract | Field pea (Pisum sativum L.) is one of the leguminous crops that is rich in protein and essential amino acids. A field experiment was conducted during the 2019 cropping season consisting of eight (Bursa, Burkitu, Adi, Herena, Hortu, Letu, T/shaman, and Weyib) improved field pea varietiesand one local variety at west Showa zone Oromia reg...
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afzelia africana is a leguminous tree rich in protein and amino acids, its abundant in the wild with seeds dropping without been exploited but only by wild birds. Inclusion in broiler diets was investigated after toasting to reduce the metabolites on the acceptability and utilization by young chicks.
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Genomic sequencing of many SARS-CoV-2 variants with higher transmission and immune-escape were reported due to point mutations and deletions. Thus, whether a newly sequenced SARS-CoV-2 belongs to Alpha, Beta, Gamma, Delta, or Omicron (BA.1, BA.2, BA.4 and BA.5) variants must be known. We multi-aligned the different Spike, ORF1ab and Nucleocapsid pr...
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Kv1.5 channels conduct the ultra-rapid delayed rectifier potassium current ( I Kur ). Pharmacological blockade of human Kv1.5 (hKv1.5) has been regarded as an effective treatment of re-entrant based atrial fibrillation, because Kv1.5 is highly expressed in human cardiac atria but scarcely in ventricles. The Kv1.5 blockade is also expected to be use...
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Powdery mildew is the most serious fungal disease of Rosa roxburghii in Guizhou Province, China. In this study, the control role of chitosan-assisted pyraclostrobin against powdery mildew of R. roxburghii and its influences on the resistance, photosynthesis, yield, quality and amino acids of R. roxburghii were evaluated. The results indicate that t...
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Although we know something about single-cell neuromuscular junctions, it is still unclear how multiple skeletal muscle cells coordinate to complete intricate spatial curve movement. Here, we hypothesize that skeletal muscle cell populations with action potentials are aligned according to curved manifolds in space (a curved shape in space). When a s...
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The lightweight property of helical composite spring (HCS) applied in the transportation field has attracted more and more attention recently. However, it is difficult to maintain stiffness and fatigue resistance at the same time. Herein, inspired by collagen fibers in bone, a bionic basalt fiber/epoxy resin helical composite spring is manufactured...
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The monomeric catalytic domain (residues 1–199) of SARS-CoV-2 main protease (MPro¹⁻¹⁹⁹) fused to 25 amino acids of its flanking nsp4 region mediates its autoprocessing at the nsp4-MPro¹⁻¹⁹⁹ junction. We report the catalytic activity and the dissociation constants of MPro¹⁻¹⁹⁹ and its analogs with the covalent inhibitors GC373 and nirmatrelvir (NMV)...
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Amino acids (AAs) are well known to be involved in the regulation of glucose metabolism and, in particular, of insulin secretion. However, the effects of different AAs on insulin release and kinetics have not been completely elucidated. The aim of this study was to propose a mathematical model that includes the effect of AAs on insulin kinetics dur...
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Lemon juice vesicles have abundant flavor components that can undergo complex changes during drying. Three drying methods, including integrated freeze-drying (IFD), conventional freeze-drying (CFD), and hot-air drying (AD), were studied to determine their effects on the dynamic changes in the flavor compounds in lemon juice vesicles. Compared with...
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Objective: To increase the thermal stability of sucrose isomerase from Erwinia rhapontici NX-5, we designed a comprehensive strategy that combines different thermostabilizing elements. Results: We identified 19 high B value amino acid residues for site-directed mutagenesis. An in silicoevaluation of the influence of post-translational modifications...
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Alteration in gut microbiota has been associated with COVID-19. However, the underlying mechanisms remain poorly understood. Here, we outlined three potential interconnected mechanistic pathways leading to gut dysbiosis as an adverse outcome following SARS-CoV-2 presence in the gastrointestinal tract. Evidence from the literature and current uncert...
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(1) Background: In order to study the effects of different electric cookers on the nutritional components of millet porridge, five different electric cookers (No. 1–5) were selected to cook millet porridge, then sensory and nutritional components in millet porridge, millet soup, and millet grains were analyzed; (2) Methods: Using principal componen...
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Mechanistic details of the signal recognition particle (SRP)-mediated insertion of membrane proteins have been described from decades of in vitro biochemical studies. However, the dynamics of the pathway inside the living cell remain obscure. By combining in vivo single-molecule tracking with numerical modeling and simulated microscopy, we have con...
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O-GlcNAc transferase (OGT) is an essential glycosylating enzyme that catalyzes the addition of N-acetylglucosamine to serine or threonine residues of nuclear and cytoplasmic proteins. The enzyme glycosylates a broad range of peptide sequences and prediction of glycosylation sites has proven challenging. The lack of an experimentally verified set of...
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IgG3 would play an important role in the immune adaptive response against SARS-CoV-2, and low plasma levels might increase the risk of COVID-19 severity and mortality. The IgG3 hinge sequence has a variable repeat of a 15 amino acid exon with common 4-repeats (M) and 3-repeats (S). This length IGHG3 polymorphism might affect the IgG3 effector funct...
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In this study, we aimed to clarify the taxonomic positions of Anoxybacilluskamchatkensis DSM 14988T and Anoxybacillusayderensis AB04T using whole-genome phylogenetic analysis, biochemical and chemotaxonomic characteristics. In phylogenetic trees drawn using whole-genome sequences and 16S rRNA gene sequences, A. kamchatkensis DSM 14988T and A. ayder...
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Herein, we present the synthesis and utilization of derivatives of 4 H -benzo[ b ][1,4]thiazine-3-carboxylic acid. These benzothiazine compounds were assembled via the coupling of aminothiols and bromopyruvates. Oxidative dimerization of these starting materials was also observed and the corresponding benzothiazine dimers were isolated. Moreover, t...