Ambulatory Monitoring - Science topic

Duchenne muscular dystrophy (DMD) is an X‐linked disease caused by the absence of functional dystrophin in the muscle cells. Recent untargeted metabolomics studies identified amino acid metabolism alterations as biochemical pathways potentially involved in DMD pathogenesis. Here, in a well‐characterised cohort of DMD children and paediatric control...

Introduction Atrial fibrillation (AF), affecting 3% of the US adults, is the most common arrhythmia. While ambulatory electrocardiogram (ECG) monitoring is essential for AF detection, conventional technologies have diagnostic limitations due to AF's sporadic nature. ECG patches offer extended monitoring periods, though their effectiveness is primar...

This review summarizes the current literature on the use of wearable devices for collecting physiological data in pediatric oncology. Searches were conducted in MEDLINE, PubMed and Embase, focusing on pediatric patients (0–25 years) with a cancer diagnosis, and utilizing a wearable device during and/or after treatment. Of the 77 articles that met t...

Aim To assess the clinical staff and patient acceptance of a novel ambulatory monitoring system in general medical and surgical inpatient wards. Design This was a cross‐sectional feasibility study undertaken in a single hospital site. Methods Patients and the nursing staff were asked to provide feedback on a monitoring system via structured quest...

Background Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder caused by the absence of a functional UBE3A gene, leading to developmental, behavioral, and medical challenges. Sleep disturbances, including sleep-disordered breathing, are common in AS. This study, for the first time, investigates nocturnal respiration in individuals...

Falls pose a significant risk, especially among elderly persons. Recently, radar sensors have been explored for fall detection. In this study, an attempt has been made to classify fall detection using multiple radars, machine learning (ML) classifiers. For this, two activity sequences, falling from a stationary position (FandS) and falling while st...

Duchenne Muscular Dystrophy is a progressive neuromuscular disorder characterized by the gradual weakening and deterioration of muscles, leading to loss of ambulation in affected individuals. This decline in mobility can be effectively assessed using the North Star Ambulatory Assessment (NSAA) scores, along with measures such as the 10-m walk time...

Objectives The aim of this study, which was embedded into the ASPIRED randomised controlled trial (ISRCTN10278811), was to explore patient and healthcare professional usability and acceptability of an enhanced (14-day) ambulatory ECG monitoring patch to manage and facilitate discharge of emergency department patients with unexplained syncope. Desi...

The necessity for effective automatic fall detection mechanisms in older adults is driven by the growing demographic of elderly individuals who are at substantial health risk from falls, particularly when residing alone. Despite the existence of numerous fall detection systems (FDSs) that utilize machine learning and predictive modeling, accurately...

Background: Daily ingestion of amphetamines is common, as they are widely prescribed for attention-deficit hyperactivity disorder (ADHD) and other diagnoses. People also use amphetamines recreationally or in an attempt to boost cognitive or athletic performance. Amphetamines have the potential to increase blood pressure, and we do not know if the...

Objectives/Goals: Objectives/Goals (300 characters): Sarcopenia is a progressive skeletal muscle disorder associated with adverse outcomes. There is a gab of having objective measures upon performing interventions in patients with muscular dystrophies. The object of the present study is to describe the severity of sarcopenia in DMD patients in Puer...

Parkinson’s disease (PD) is a neurodegenerative disorder that affects multiple neural pathways, leading to a broad spectrum of motor and non-motor symptoms. Sleep disorders, such as insomnia and excessive daytime sleepiness, are prevalent among PD patients and significantly impact symptomatology and patients’ quality of life. Wearable technology pr...

Background Parkinson disease is a progressive neurodegenerative disorder with complex motor and nonmotor symptoms. To assess these, clinical assessments are completed, providing a snapshot of a person’s experience. Monitoring Parkinson disease using wearable devices can provide continuous and objective data and capture information on movement patte...

Background/Objectives: Previously undiagnosed atrial fibrillation (PUAF) is a significant cause of embolic stroke of undetermined source (ESUS). This study aimed to determine whether early heart rhythm monitoring with a Holter ECG after acute stroke enhances the detection of PUAF compared to standard ambulatory monitoring in ESUS patients, assuming...

Objective Reduced‐channel wearable electroencephalography (EEG) may overcome the accessibility and patient comfort limitations of traditional ambulatory electrographic seizure monitoring during extended‐duration use. Automated algorithms are necessary for review of extended‐duration reduced‐channel EEG, yet current clinical support software is desi...

Background Duchenne Muscular Dystrophy (DMD) is a rare X-linked genetic disorder caused by mutations in the dystrophin gene. The North Star Ambulatory Assessment (NSAA) and Performance of Upper Limb (PUL) are used to measure motor performance in ambulatory and non-ambulatory individuals, respectively. There is limited published qualitative evidence...

Background and Aims Hypertension exacerbates cardiovascular risks in patients with type 1 diabetes mellitus (T1DM), necessitating effective blood pressure (BP) management. Vitamin D deficiency is common in T1DM patients and is associated with an increased risk of cardiovascular diseases. This systematic review aimed to evaluate the impact of vitami...

Background In Duchenne muscular dystrophy (DMD), fibrosis is linked to connective tissue growth factor (CTGF) overexpression. Pamrevlumab, a fully human monoclonal antibody that inhibits CTGF activity, showed promise as a DMD treatment in a phase 2 trial. Objective LELANTOS-2 ( NCT04632940 ) was a global phase 3 study of the safety and efficacy of...

Shift workers have a 40% higher risk for cardiovascular disease (CVD) compared to people who work day shifts. However, the acute impact of shift work on CVD risk factors in free‐living settings remains unclear. We therefore investigated the impact of acute night shift work on factors related to cardiovascular health including blood pressure (BP) an...

This symposium was held at the Muscular Dystrophy Association (MDA) Clinical & Scientific Conference 2025, in Dallas, Texas, USA. Speakers gave an overview of the patient experience and natural history of Becker muscular dystrophy (Becker) and presented the latest Phase I/II clinical data for the novel investigational agent, sevasemten. Becker is a...

Heart rate (HR) and heart rate variability (HRV) are two key measures with significant relevance in psychophysiological studies, and their measurement has become more convenient due to advances in wearable technology. However, photoplethysmography (PPG)-based wearables pose critical validity concerns. In this study, we validated four PPG wearables:...

Atrial fibrillation (AF) is recognized as a developing global epidemic responsible for a significant burden of morbidity and mortality. To counter this public health crisis, the advancement of artificial intelligence (AI)-aided tools and methodologies for the effective detection and monitoring of AF is becoming increasingly apparent. A unified stra...

Objective: Previous research has found that momentary positive affect precedes alcohol use, whereas results have been more mixed for negative affect. Method: This study replicates and builds upon this literature by using a heavy drinking sample, half lesbian, gay, bisexual, trans, queer/questioning, and other minoritized sexual and gender identitie...

Purpose The Daily Phonotrauma Index (DPI) can quantify pathophysiological mechanisms associated with daily voice use in individuals with phonotraumatic vocal hyperfunction (PVH). Since DPI was developed based on weeklong ambulatory voice monitoring, this study investigated if DPI can achieve comparable performance using (a) short laboratory speech...

Objectives Cuffless blood pressure (BP) monitors represent an innovative approach to BP assessment, overcoming the traditional episodic nature of readings obtained from cuff-based, oscillometric modalities. Nonetheless, the comparison of these cuffless devices against their cuff-based counterparts remain debated. Methods This study evaluated BP re...

Background Characterizing dementia risk is difficult with traditional neuropsychological testing. Ecological Momentary Cognitive Testing (EMCT) uses ecological momentary assessment (EMA) methods to sample daily life cognition. The current study examined how daily activities were related to EMCT performance and explored whether associations remained...

The accurate and reliable measurement of human movement stands as a cornerstone in the evaluation of athletic performance, the management of fall risk, the prevention of injury, and the guidance of clinical rehabilitation [...]

Background and Purpose This study was an open-label, dose-escalation, phase 1 clinical trial to determine the safety and dose of EN001 for patients with Duchenne muscular dystrophy (DMD). EN001, developed by ENCell, are allogeneic early-passage Wharton’s jelly-derived mesenchymal stem cells that originate at the umbilical cord, with preclinical stu...

Holter ECG monitoring is a cornerstone in the diagnosis and management of cardiac conditions, offering continuous ambulatory monitoring of the heart's electrical activity. This book, "Ambulatory Holter ECG Monitoring: Practical Insights," provides a detailed and practical exploration of Holter monitoring, tailored for clinicians, cardiologists, and...

Background Duchenne muscular dystrophy (DMD) is the popular kind of muscular dystrophy in childhood characterized by gradual motor decline and respiratory failure which ultimately results in death. Purpose This research sought to determine the impact of bicycle ergometer on ventilatory functions and motor ability in boys with DMD. Design Single-b...

Objective Duchenne muscular dystrophy (DMD) is a rare X-linked neurodegenerative disorder caused by mutations in the DMD gene. This study examined the efficacy and safety of ataluren, the first oral treatment for DMD with nonsense mutations (nmDMD), in patients in the Middle East. Methods This retrospective longitudinal study assessed the outcomes...

Background: Trait perseverative cognition (PC) is associated with inflexible autonomic activity and risk for depressive recurrence. However, the identification of dynamic psychophysiological markers of PC that fluctuate within individuals over time could facilitate the passive detection of moments when PC occurs in daily life. Methods: Using intens...

Introduction/Aims Improved methodologies to monitor the progression of Duchenne muscular dystrophy (DMD) are needed, especially in the context of clinical trials. We report changes in muscle magnetic resonance imaging (MRI) parameters in participants with DMD, including changes in lean muscle volume (LMV), muscle fat fraction (MFF), and muscle fat...

Circadian rhythms develop from an ultradian to a circadian rhythm during a few months in the early human life stage. One of the strong factors in promoting the development of circadian rhythms during infancy is maternal rest-activity rhythms. However, few studies have examined comparing the rest-activity rhythms of parents and infants. This study a...

Background/Objectives: The aim of this study is to shed light on activity-based prospective memory upon the awakening and its association with motor sleep inertia in different phenotypes of insomnia disorder. Methods: To this end, 67 patients with insomnia and 51 healthy controls took part in the study. After enrollment, previously proposed actigra...

Creativity research can robustly predict creative ideation performance from brain physiological data assessed in laboratories. However, physiologically driven prediction models of creative ideation performance in the field are less advanced. The vagus nerve quantified via vagally mediated heart rate variability (vmHRV) signals a brain–heart interac...

Cardiovascular diseases are the leading cause of mortality and early assessment of carotid artery abnormalities with ultrasound is key for effective prevention. Obtaining the carotid diameter waveform is essential for hemodynamic parameter extraction. However, since it is not a trivial task to automate, compact computational models are needed to op...

Background The extreme clinical heterogeneity of children with Becker muscular dystrophy significantly poses a great challenge to accurately assess their disease status. Objective To detect skeletal muscle involvement in children with Becker muscular dystrophy using multiple-parameter quantitative magnetic resonance imaging (qMRI), and to determin...

Cross-cultural translation of the North Star Ambulatory Assessment into Greek. [Poster in Greek]. Purpose: To cross-culturally translate the second (2.1) English version of the NSAA manual and assessment worksheet into Greek, including the accompanying “observed family report worksheet”. Material and Method: After receiving permission from copyrigh...

Duchenne muscular dystrophy (DMD), a rare pediatric disease, presents numerous challenges when designing clinical trials, mainly due to the scarcity of available trial participants and the heterogeneity of disease progression. A quantitative clinical trial simulator (CTS) has been developed based on previously published five disease progression mod...

Objectives To identify suitable patients for glaucoma home monitoring and explore clinicians’ perceptions of the possible benefits and risks of home monitoring within the National Health Service. Design An online survey composed of open-ended and closed-ended questions. Setting Secondary care. Participants Glaucoma specialists registered with th...

Regular health monitoring is essential for maintaining good health, but long hospital queues and the need for ambulatory monitoring in our fast-paced world underscore the necessity for a simple health monitoring system adaptable to various settings. This system addresses the increasing demand for monitoring primary health parameters, particularly a...

The aim of this study was to evaluate the efficacy of olmesartan/amlodipine (OLM/AML) single‐pill combination (SPC) therapy using ambulatory blood pressure monitoring (ABPM) in non‐responders to valsartan or candesartan monotherapy. Isolated systolic hypertension (ISH) is the most prevalent form of hypertension in middle‐aged and elderly individual...

Purpose] This study aimed to assess the motor function status of ambulatory patients with Duchenne muscular dystrophy in 2020, which included a 3-month period of behavioral restriction due to the coronavirus disease of 2019 (COVID-19) pandemic, in comparison to the previous 2 years. [Participants and Methods] A retrospective analysis was conducted...

Background Despite clear associations between arrhythmia burden and cardiovascular risk, clinical risk scores that predict cardiovascular events do not incorporate individual-level arrhythmia characteristics from long-term continuous monitoring (LTCM). Objectives This study evaluated the performance of risk models that use data from LTCM and patie...

Project HERCULES has developed a natural history model (NHM) of disease progression in Duchenne muscular dystrophy (DMD) that comprises eight ordered health states (two ambulatory states, one transfer state indicating increased caregiver burden in which patients cannot walk/run 10m or rise from floor but can still support their own weight, and five...

Growing evidence suggests that abnormal diurnal blood pressure rhythms may be associated with many adverse health outcomes including increased risk of cognitive impairment and dementia. This study evaluates methodological aspects of research on bidirectional associations between ambulatory blood pressure monitoring (ABPM) patterns and cognitive fun...

Background Ambulatory ECG (AECG) monitoring is pivotal to the diagnosis of arrhythmias and can be performed with near “real‐time” notification of abnormalities. There are limited data on the relative benefit of real‐time monitoring compared with traditional Holter monitoring. Methods and Results This is a retrospective observational analysis of Un...

RESUMEN. El trabajo se apoya en las pruebas individuales del monitoreo ambulatorio de la presión arterial realizado a 5,089 cubanos adultos de ambos sexos, atendidos en la consulta de hipertensión arterial del Hospital Provincial Universitario Cardiocentro Ernesto “Che” Guevara de Villa Clara, entre los años 2012 y 2016, con el fin de estimar exper...

Duchenne muscular dystrophy (DMD) is a rare, X-linked neuromuscular disease caused by pathogenic variants in the DMD gene that result in the absence of functional dystrophin, beginning at birth and leading to progressive impaired motor function, loss of ambulation and life-threatening cardiorespiratory complications. Delandistrogene moxeparvovec, a...

The severe mismatch between solid bioelectronics and dynamic biological tissues has posed enduring challenges in the biomonitoring community. Here, we developed a reconfigurable liquid cardiac sensor capable of adapting to dynamic biological tissues, facilitating ambulatory cardiac monitoring unhindered by motion artifacts or interference from othe...

Objectives Affective stress reactivity is a vulnerability factor for mental health. The central mindfulness facets, monitoring and acceptance, are associated with differential patterns of affective stress reactivity. This study investigated whether monitoring amplifies and whether acceptance attenuates affective stress reactivity in daily life. Add...

Objective: The Daily Phonotrauma Index (DPI) can quantify pathophysiological mechanisms associated with daily voice use in individuals with phonotraumatic vocal hyperfunction (PVH). Since DPI was developed based on week-long ambulatory voice monitoring, this study investigated if DPI can achieve comparable performance using (1) short laboratory spe...

Introduction The novel Confirm Rx™ implantable cardiac monitor (ICM) with SharpSense™ technology incorporates a new P‐wave discriminator designed to improve AF detection. This study aimed to evaluate the diagnostic performance of the Confirm Rx™ ICM in detecting AF episodes of varying durations. Methods We conducted a multicenter retrospective ana...

Atrial fibrillation (AF) is common among patients with hypertrophic cardiomyopathy (HCM) with a prevalence greater than 25%. AF in HCM is associated with a high risk of stroke and can be a marker of more advanced cardiomyopathy. Although, it frequently results in cardiac hemodynamic changes which are poorly tolerated, it can be subclinical. Thus, p...

The work is based on individual tests of ambulatory blood pressure monitoring carried out on 5,089 Cuban adults of both sexes, treated in the arterial hypertension consultation of the Provincial University Hospital Cardiocenter Ernesto “Che” Guevara of Villa Clara, between 2012 and 2016, in order to experimentally estimate their individual vulnerab...

Duchenne muscular dystrophy (DMD) results in a progressive loss of functional skeletal muscle mass (MM) and replacement with fibrofatty tissue. Accurate evaluation of MM in DMD patients has not previously been available. Our objective was to measure MM using the D3creatine (D3Cr) dilution method and determine its relationship with strength and func...

With the rise in global life expectancy, ensuring healthier aging experiences for the older population becomes paramount. This scoping review delves into the technologies employed in the remote health monitoring of the elderly over the past 15 years. Exploring the concept of “Healthy Ageing” as proposed by the World Health Organization, this paper...

Monitoring health status at home has garnered increasing interest. Therefore, this study investigated the potential feasibility of using noncontact sensors in actual home settings. We searched PubMed for relevant studies published until February 19, 2024, using the keywords “home-based,” “home,” “monitoring,” “sensor,” and “noncontact.” The studies...

Serum biomarkers are promising minimally invasive outcome measures in clinical studies in Duchenne muscular dystrophy (DMD). However, biomarkers strongly associated with clinical progression and predicting performance decline are lacking. In this study we aimed to identify serum biomarkers associated with clinical performance and able to predict cl...

Background Technology has become an integral part of our everyday life, and its use to manage and study health is no exception. Romantic partners play a critical role in managing chronic health conditions as they tend to be a primary source of support. Objective This study tests the feasibility of using commercial wearables to monitor couples’ uni...

Background/Objectives: Many patients suffering from liver cirrhosis are eventually added to waiting lists for liver transplantation whose priority is established based on scales such as the Child–Pugh score. However, two marker rhythms of the circadian system, motor activity and distal temperature, are not evaluated. Methods: To determine the relat...

Duchenne Muscular Dystrophy (DMD) is an X-linked recessive neuromuscular disorder primarily affecting males, caused by mutations in the dystrophin gene. The absence of dystrophin protein leads to progressive skeletal muscle degeneration. Recent advances in the therapeutic landscape underscore the need to identify appropriate outcome measures to ass...

Chronic disease management and follow-up are vital for realizing sustained patient well-being and optimal health outcomes. Recent advancements in wearable technologies, particularly wrist-worn devices, offer promising solutions for longitudinal patient monitoring, replacing subjective, intermittent self-reporting with objective, continuous monitori...

Background Gastric sensorimotor disorders (functional dyspepsia [FD] and gastroparesis [GP]) are prevalent and burdensome. Prolonged ambulatory recording using a wireless patch may provide novel information in these patients. Methods Consecutive adult patients (age ≥ 18 years) referred for gastric emptying scintigraphy (GES) were eligible for stud...

Research into the detection of human activities from wearable sensors is a highly active field, benefiting numerous applications, from ambulatory monitoring of healthcare patients via fitness coaching to streamlining manual work processes. We present an empirical study that evaluates and contrasts four commonly employed annotation methods in user s...

Evaluations of treatment efficacy in Duchenne muscular dystrophy (DMD), a rare genetic disease that results in progressive muscle wasting, require an understanding of the ‘meaningfulness’ of changes in functional measures. We estimated the minimal detectable change (MDC) for selected motor function measures in ambulatory DMD, i.e., the minimal degr...

Introduction: Sleep habits are related to mood stability and mental health, and adolescence may be an appropriate time to address disturbed sleep patterns because it is a critical period for the onset of psychological problems. Aims: This study had two aims, namely: to explore associations between objectively measured sleep duration and positive an...

Background Transthyretin cardiac amyloidosis (ATTR-CA) is associated with an increased incidence of arrhythmias. We hypothesized that 2-week noninvasive ambulatory cardiac rhythm monitoring of patients with ATTR-CA would detect high rates of atrial fibrillation/atrial flutter (AF/AFL) and nonsustained ventricular tachycardia (NSVT). Objective The...

[Pleaes note: This work is now published in Psychophysiology. Please refer to the open-access, peer-reviewed version of this work at: https://doi.org/10.1111/psyp.70004]. Heart rate (HR) and heart rate variability (HRV) are two key measures with significant relevance in psychophysiological studies, and their measurement has become more convenient...

Globally, the rates of premature baby morbidity and mortality are increasing year. It is essential to use telemedicine and ambulatory monitoring to give these infants the right care at the right time. The strength of the uterine physiological signals limits the practical applicability. The study suggests a lossless compression strategy that combine...

Gottron's carcinoid papillomatosis of the skin is a rare and little-studied disease. The number of available scientific publications does not exceed several dozens, in Ukraine, in the last ten years, 2 works devoted to this pathology have been published. However, in parallel with the increase in diagnostic capabilities in a multidisciplinary hospit...

The use of ambulatory assessments (AAs) as an approach to gather self-reported questionnaires or self-collected biochemical data is constantly increasing to investigate the experiences, states, and behaviors of individuals and their interaction with external situational factors during everyday life. It is often implicitly assumed that data from dif...

Ambulatory assessment (AA) is becoming an increasingly popular research method in the fields of psychology and life science. Nevertheless, knowledge about the effects that design choices, such as questionnaire length (i.e., number of items per questionnaire), have on AA data quality is still surprisingly restricted. Additionally, response styles (R...

Conducting functional assessments remotely can help alleviate the burden of in-person assessment on patients with Duchenne muscular dystrophy and their caregivers. The objective of this study was to evaluate whether scores from remote functional assessment of patients with Duchenne muscular dystrophy correspond to in-person scores on the same funct...

Short-latency somatosensory evoked potentials (SSEPs) serve as a biomarker for recovery of consciousness from coma but often require bulky and time-consuming measurement setups such as scalp-based electroencephalography (EEG), cer-vical recording, or invasive in-vivo electrodes, which limits their deployment to clinical environments. To extend the...

Background: Hypertension is a worldwide condition that occurs in a fourth of the world’s population and it is still rising, posing a threat to public health, with two-thirds living in low- to middle-income countries. One of the procedural treatments to treat resistant hypertension is renal denervation. However, the efficacy of renal denervation wit...

Arterial stiffening is associated with adverse cardiovascular patient outcomes; stiffness may also be associated with postsurgical events and has been suggested to be a fundamental mechanism in the pathogenesis of aortic aneurysms. Although open repair of aneurysms decreases aortic stiffness, implantation of a rigid endograft is associated with inc...

Rheumatoid arthritis (RA) is a global autoimmune disease that requires long-term management. Ambulatory monitoring and treatment of RA favors remission and rehabilitation. Here, we developed a wearable reconfigurable integrated smart device (ISD) for real-time inflammatory monitoring and synergistic therapy of RA. The device establishes an electric...

Premature ventricular complexes (PVCs) are commonly encountered problems in clinical settings. The range of symptoms can be from asymptomatic to palpitations, fatigue, or heart failure symptoms. A higher burden of PVCs is a risk factor for development of PVC-induced cardiomyopathy (PIC). Rhythm evaluation by 12-lead ECG and an ambulatory monitoring...

Introduction Holter-SRA (Stroke Risk Analysis) is an automated analysis of ECG monitoring for Atrial Fibrillation (AF) detection. The aim of this study was to evaluate the rate of AF in undetermined TIA/Rapidly improving stroke symptoms (RISS) patients. Methods Prospective study of undetermined TIA/RISS patients who presented to the emergency depa...