Science topic

Aging - Science topic

The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
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I need to read more about head and neck cancer stem cells and the effect of aging.
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Head and neck cancer management and cancer stem cells implication
Identification and Characterization of Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma Cell Lines
Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications
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Sugar is sweet & loved by all, but doctors campaign not to take it after a certain age. If an octogenarian wanna taste sweetmeat everyday, what to tell her? Again, it's believed that almost all sweeteners are harmful, even carcinogenic!! Your opinion, please.
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The best and safest artificial sweeteners are erythritol, xylitol, stevia leaf extracts, neotame, and monk fruit extract Md Rabiul Alam
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What important information does the shape of dQ/dV curves contains about Lithium-ion batteries?
  • Change in potential (charge/discharge)
  • Height of peaks
  • The shape of peaks during long-term cycling
  • At different C-rates.
In general, they can give information regarding the change in polarization (change in resistance), change in material chemistry (material degradation) etc.
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Dear Umair Nisar
Differential voltage analysis has been applied to various lithium-ion cells, to study degradation reactions (side reactions) as a function of cycle number. Standard cycling data is used to calculate either dQ/dV or dV / dQ, which is then plotted against the voltage. In dQ / dV plots, the peaks represent phase equilibria, whereas, in dV / dQ plots, the peaks represent phase transitions. Differential capacity (dQ/dV) analysis allows you to observe what is happening in a battery (including degradation, failure mechanisms, changes in chemistry) in much greater detail than can be observed using aggregate statistics like capacity, energy, and efficiency per cycle.
Conceptually, dQ/dV describes the incremental capacity going into our out of a device over a given voltage increment (some also prefer to use the inverse, differential voltage, dV/dQ). Differential capacity can be derived from raw time series current and voltage data, or accessed directly using a Battery Intelligence platform such as Energsoft. The differential capacity plot displays dQ/dV on the vertical axis, plotted against potential on the horizontal axis, with the loop in this plot showing one charge-discharge cycle.
dQ/dV Differential capacity curve Where there is a peak on the curve meaning the charge and discharge curves have a voltage platform, and different peaks represent different electrochemical reactions.
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Dear All,
I am thinking about a side experiment where I need to free mouse bone from flesh. Basically to have the skeleton in the end.
The best would be to have a solution which dissolves flesh but not bones. I want to observe bone structure and maybe analyze minerals in the bones.
If you have any solution or a better one than the one I am portraying it would be very nice to hear from you.
Best wishes
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Physical fitness is essential to allow people to carry out everyday activities. It is often particularly low in stroke survivors. It may limit their ability to perform everyday activities and also worsen any stroke-related disability. So, it is recommended that seniors do exercises in order to improve cognitive function, quality of life, and the ability to maintain physical activity. On the other hand, other researchers say that training programs increase the risk of having another stroke.
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Have a look at the following RG links.
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Usually RTFOT instrument is used to measure short term aging for asphaltic binders under standard conditions.
Under what standard conditions, can we use RTFOT instrument to measure long term aging.
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U have to extend the aging duration by using RTFO, and correlate the data to define how long it should be extended.
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I have tried with no success various UV-B stresses but I did not find an increase in beta galactosidase.
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Hi Anthony L, Yes: we often used the DNA-damaging drug etoposide to induce senescence. Soluble in DMSO. 10 uM was often ok, though the best concentration can vary with the cell type -- it gets toxic at higher concentrations (because extensive DNA damage is toxic). It was added to recently plated cells for 48 h, then removed, and the cells were left for 5 days to develop the senescent characteristics -- although this may also vary with cell type. So for a new cell type you might want to try lower and higher concentrations, and different timings. We published this method (used as a positive control) in Cairney CJ et al. 2017, PLoS Genetics. (See Supplementary File 2.)
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I am trying to develop a hybrid physical-data driven model for battery aging estimation. For this aim, I need big data set to train my model. In literature, the biggest data set I found was from Severson's group. I will be grateful if any one can introduce similar data set.
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NASA Ames Prognostics Center of Excellenc :
(published 12 November 2020)
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Hi all
I'm starting to research rating scales to assess symptoms of agitation or anxiety in patients with dementia. If you know any papers or resources Id be very grateful for suggestions
Kind regards
P.J.
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Many thanks for this. This is really useful!
P.J.
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Hi All, I am looking at compiling a wide list of papers or resources on reminiscence therapy for dementia for older people. The positive and negative results, Creative approaches, ICT interventions, standard procedures, etc. I'm interested in perspectives from differing disciplines. All resources/ papers/ leads welcome Thank you!
P.J.
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It feels great to share it. Hope you find it useful P.J. White
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Dr. Caleb Bryce and I have organized a canine science symposium for the Society of Integrative and Comparative Biology (SICB) meeting January 3-7th, 2021 in Washington DC (http://www.sicb.org/meetings/). Attached you may find a poster with a list of the speakers for our symposium which will be held January 7th, 2021.
Abstracts will be due late August to early September 2020. You do not have to be a SICB member to attend this meeting, and you can also register to attend for a single day.
If you cannot attend part or the whole meeting, may I ask that you help us spread the word about it by forwarding this information and poster to potentially interested parties?
Our hope is that dogs take over SICB 2021, hopefully with your help!
Please do let me know if you have any questions.
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The Society for Integrative and Comparative biology is actually taking more abstracts until October 28th, 2020. And, we are still looking for people to participate in the complementary session to our canine science symposium, so your work is still most welcomed!
To submit your abstract, please go here: http://sicb.burkclients.com/meetings/2021/abstracts/late.php
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How to test moderation with a multi-group factor like occupation, education or age. Is there any addon available. For two group group factor like gender or a yes/no question its easy but I cant figure out how to do it for more than three groups.
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Hello Tahir, can you please explain how you tested for occupation etc in AMOS?
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The Greater Cincinnati Well-being Observation Tool developed by Clarissa Rentz (2005).
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My aim is to estimate mortality rates of some eagles on the base of survival tables. The good toll for this is Weibull aging model (see Ricklefs, 2000, page 104 in attachment). According to Ricklefs, the survivorship curve follows the equation
lx = exp( -m0x - (alpha * xbeta + 1)/(beta + 1)),
where x is age, lx is the proportion of population surviving to the age x, m0 is the initial (accidental) mortality, alpha and beta are coefficients connected to the rates of aging.
So, I have to fit 3 parameters of the model: m0, alpha, and beta.
I ask you colleagues to help me with the correct way to do it. So far I've been using NLS (non-linear squares) method in R, and it basically works. However, the model fitting strongly depends on start values of parameters, that's why in some cases the model doesn't converge or comes to singularity.
All this prevents me to make a proper permutation test of my model (after some iterations of the nls function an exception arises and the loop breaks).
Ricklefs himself refers to 'maximum likelihood approaches' which he used to fit the model, but I do not exactly understand what specifically is it in the given context. Could anyone help me with the correct way to fit my data?
Thanks,
Michael
===========
Ricklefs, R.E., 2000. Intrinsic aging-related mortality in birds. Journal of Avian Biology, 31, 103–111.
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Thank you, colleagues! Eventually I managed to fit the model by the algorithm described in the Appendix B to Ricklefs (1998), thanks to my mathematician friend Igor Sizov who made a working example of this tricky thing so that I understood how it is calculated. If you're curious, see the fitted curves in the attachment. Blue colour are males, red colour are females. Solid lines are the curves fitted by NLS (non-linear least squares), dashed lines are the curved fitted by ML (maximum likelihood).
It is clear for me that NLS curves better fit to the data, while ML curves overestimate the lifespan and do not pass through "older" points. Both procedures use unweighed points. If we use weights, both methods fit worse, and begin to ignore right side points since there are fewer number individuals in older age.
So, think that further I will focus on the unweighted NLS method.
Cheers!
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There are several excellent instruments and scales many of which have been validated numerous times. I am going through an exercise in comparing and contrasting the benefits and constraints of each (e.g. Revised Kogan's Attitudes Toward Old People scale (RKATOP), Age Group Evaluation and Description Inventory (AGED Inventory), Sarkisian's Expectations regarding Aging survey) to arrive at my own conclusions, but would also like the input of other researchers.  
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i want to assess the attitude of my young university students attitude towards aging. that is why i am highly interested towards your standardized scale.
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I am studying the cerebral aging in non - human primates, Marmost monkies. The study is conducted on anatomical MRI T1-weighted images. We aim to study the decline of brain and cortical volumes in normal aging.
However, due to the difficulty of extracting (segmenting) some cortical subregions, we would like to rather map the volumetric differences in these regions over years (due to aging / possible atrophy) rather than dileneating and extracting ROIs.
I would appreciate if some one could suggest a method (reference) or an algorithm to start with.
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Maybe this: could be a good entry point for finding the most appropriate way to solve this.
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I have read papers that describe methods for long-term primary neuron culture but I have not seen convincing western blots showing consistent changes in any protein expression with the progress of aging.
I know that aging is a complex process, but I would like to somehow test if my long-term cultures are actually going through an aging-like process.
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Thank you all! I have looked into senescence in cultured cells, and will likely use β-galactosidase (or possibly another factor for which I can borrow an antibody) for my long-term cultures.
I am interested in looking at mTOR signaling eventually, as well. This is very helpful, as I am the only one currently looking at aging in my lab!
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Lifespan development, personality and aging and so on - who is the best now?
My area is age and personality traits change (like personal autonomy for example).
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Yes! That's one of his core areas! And Mathias Alemand (University of Zurich) together with Patrick Hill (Washington University in St. Louis, USA) are co-editing a book which will appear towards summer this year entitled "Personality and Healthy Aging".
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Average weight range.
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I have similar question as Xinyi Cho. What is the reference weight a SD rat should reach to consider obese? Or how many percentage of increase in weight compared to the control rats is considered obese?
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The phrase "geriatric profanity disorder", together with its initialization "GPD", has become somewhat of a meme, being mentioned in TV shows like the Simpsons and receiving an entry in the Urban Dictionary. Is it an actual recognized condition or area of research (perhaps under another name)?
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Any form of disinhibition from drugs or dementia for example will release hitherto suppressed profanities. This is clearly seen nowadays with the phenomenon of the Midnight Tweeter. See my RG question Do drugs release racist comments?
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Age determination of unknown human bodies is important in the setting of a crime investigation or a mass disaster because the age at death, birth date, and year of death as well as gender can guide investigators to the correct identity among a large number of possible matches.
Do you think that this time can be extracted using the ratio of decay of radioactive carbon that turns nitrogen after death?
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I need to measure intracellular NAD (total and NAD+) in human T cells. I see there are several systems (colorimetric and ELISA), and I need a kit that is reliable. I don't want to use HPLC for the moment.
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This may be helpful....
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How to identify neurogenesis in adult human retina? Is there any good non-invasive method? This is an ethical, technical and tricky question which may give rise to important concepts. What techniques should be used to achieve this goal.
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It's a contentious question if consider it in human for which there is almost no evidence. In animal models there are certain reports, especially in Zebrafish. Just a lab have published a preprint about it. https://www.biorxiv.org/content/early/2016/06/08/057893
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We are having difficulty consistently getting DBA/2 mice from the National Institute on Aging.  Can anyone suggest an alternative source for 9+ month old DBA/2 mice and young controls from the same colony?
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Christa,
Well, it's really a problem. I also asked a couple of companies but none of them has old DBA/2.
I'm just thinking probably we could collaborate. I need hematopoietic stem cells from bone marrow which you might not need. Or, if it works for you of course, is it possible that I buy a few aged DBA from you if you don't need them all...?
As you know, it takes time to age them by ourself so we don't really want to do that. I would appreciate it a lot if you can help us!
Daozheng
My email: d.yang@umcg.nl
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WE have the plantations of Eucalyptus camaldulensis. We planted about 400,000 plants of Eucalyptus camaldulensis in 2015, and we want to get first cut in 2019 how much yield can we obtain from these trees. Secondly we want to get some yield again in 2019 from coppice of Eucalyptus camaldulensis then about how much yield we can obtain.
Thanks
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I do really agree with David James views. You question revolves around yield regulation. There are some published works that can provide you some insights. However, its applicability depends upon the edapho-climatic regions of your country.
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NAD is involved in most cellular redox reactions as an oxidant (NAD+) or reductant (NADH) and it changes between both states multiple times in every fraction of second in every cell. But it is still not clear to me the following:
  1. Why is it called dinucleotide when I see only one nucleotide as its component (adenine)? or is it nicotinamide a nucleotide too?
  2. Why it is not so used something like Nicotinamide Guanine Dinucleotide (NGD) instead? or with Cytosine or Thymine? what makes Adenine appropriate for this function?
NAD recently recalled my attention since I read a very interesting article in which the authors managed to decrease age-associated diseases in mice by administration of NAD intermediates:
Mills, Kathryn F., et al. "Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice." Cell metabolism 24.6 (2016): 795-806.
Thanks for your time.
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Hi,
Living systems is a result of thousands of consecutive biological reactions, catalyzed by specific enzymes, in orchasetrated manners. NAD/NADH & NADP/NADPH are very important biological cofactors, participating mainly in numerous cellular oxidation/reduction reactions, as an electron acceptor(to be reduced) or donner(to be oxidized). There is another biological cofactor known as FAD(Flavine Adenine Dinucleotide) also participates in biological reactions. And the particular enzyme involved in each reaction, has strong choice (specificity) for its cofactor of either NAD or NADP or FAD, to catalyze the reaction optimally. This specific choice for cofactors of the catalyzing enzymes, makes other analogues unsuitable for biological reaction. The specificity depends on many factors as three dimensional conformity of the subustrates, enzymes, cocfactors and redox(reduction/oxidation) potential of the reaction & reactants etc.
Although there may be some artificial or synthetic analogues that may somehow support a biological reaction in lab conditions, the reation rate may not be optimum as in biological system. So, if cellular reactions do not run optimally, there must be some traffic congestion, thus making the whole system go-slow or idle (ageing?). All These make NAD/NADP so important. Good luck for you.
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Besides the previously discovered circadian clock (the 24-hour timekeeper) is there another master regulator clock controlling aging and other time scheduled events of life, such as fetal development and puberty (and ultimately over-watching the whole cycle of aging) which are precisely time-dependent, by keeping the track of solar “years” passed?
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Hi Sina,
There is the "DNA methylation clock", named "epigenetic clock": the degree of methylation of few CpG loci reflects the biological age. It keeps track of the "solar years", except for many diseased tissues which appear "epigenetically older" than healthy tissues, and has a different pace in different tissues.
Two reviews about this question: PMID: 25913071; PMID: 25341512. There are many recent papers about the epigenetic clock but not that many reviews. One founding paper: PMID: 24138928.
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Respected Researchers..Can anybode send me a precise paper or suggest me the same for the geochronological aspects of Dalma Formation, East Indian Shield??
Actually the Dalma Formation is composed of meta-sediments and meta-volcanics. The age of the vvolcanics are well reported in Mishra and Johnson, 2004. I need some recent published ages of the metasediments (schists and quartzites).
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Dear Researchers
Thanks for the paper suggestions by you. Went through all of them and also a few more which took me a time of a couple of months to write back to you.
The idea developed from the papers are useful and quite interesting.
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One would expect that due to the protein nature of enzymes, sooner or later the mTOR signaling system would eventually develop an immune dysregulation. This opens the door to hardcore evidence to "The Immunological Theory of Aging" given the close links of mTOR and the aging process. It wouldn't be strange to find high levels of IgM or IgG in patients with progeria. The close relationship between free radicals and aging (Harman, The free radical theory of aging) and mTOR would constitute the thesis, antithesis and synthesis of the molecular biology of aging.
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The mTOR pathway is not related to mechanism of natural aging, therefore it unable to be the basis for elaboration of radical remedy for senescence (see: Trubitsyn A.G. “The Lag of the Proliferative Aging Clock Underlies the Lifespan-Extending Effect of Calorie Restriction” Current Aging Science, 2015, 8, 220-226.) ;� };��Q*G��ȵK�9
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I found a quite old research paper assumes that mental and physical health of aging users can be detected/predicted from the personality he/she hold.
Abstract of that paper says: '' Participants were spouse caregivers of patients diagnosed with Alzheimer's disease. Results showed that neuroticism and optimism were significantly related to mental and physical health. Furthermore, neuroticism had significant direct effects on all of the health outcomes, and substantial indirect effects, through perceived stress, on mental health outcomes. Optimism showed stronger indirect than direct effects on all health outcomes''.
So, can we generalize and carry on further research to answer this question? can we derive from this findings that users who have high neuroticism trait in Facebook could suffer from mental and physical
health outcomes in future?
Many thanks for any redirection.
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The probability depending on the environment which is always diverse will undoubtedly create suspicion/paranoia/ and habit forming points of consumption where gateway and comfort leads to forensic psychology on a clinical and enhanced therapeutic level.
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Hello: Can anyone pls help me to identify an available data set on prostate cancer and birth characteristics (gestational age, birth weight, birth length, time to puberty etc)? 
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I believe there is a genetic component here. I found what I was looking for - thank you!
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Dear researchers,
Here comes a puzzling question. I am having difficulty in explaining a difference in the data of two subcontractors in a scientific way.
as we all know, polymers properties are time temperature and environment dependant. Without giving away names, the two subcontractors are working for the same goal - to extrapolate the master curves of specific medical polymers. When I say master curve, I mean long term behaviour such as yield strength vs. time, so that I can foresee how my material will behave in 10 years time for example...
One subcontractor extrapolates data through testing dog bones in temperature chambers, at standard loads - so various load cases and elevated temperatures. load cases way below the yield strength of the material - the samples take a while to rupture.
They collect data - such as 40C, 200 hours, 14MPa
and 50C, 10 hours, 16MPa
then use TTS (time temperature superposition technique) to draw the final master curve.
Well then I have the other subcontractor, who only ages the dog bones in temperature chambers at different temperatures for various times.
they then take these samples out and do an instantaneous test where they measure initial modulus. so they collect data again such as
1000 hours, 40C, 10MPa
again use TTS method and draw the final master curve
I then take these two mastercurves of the same material and study the difference - and the difference is huge, it is noticeable...
which one do you think is more reliable ?
cause in the first case you need to wait until the material ruptures, which extends the testing time considerably..
Thank you very much for your answers.
Nazli
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Hey Nazli,
It would depend on what polymers you are using but thermoplastics above glass transition temperature will undergo alignment of polymer chains when placed under load. This alignment strengthens and stiffens the material (in the direction of the load) and is used with some polymer threads to improve their mechanical properties. This process may be occuring with your samples with the first contractor.
Mat
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Research scope of psychosocial aspects of ageing and interpersonal acceptance and rejection across culture
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i send you message, and lets start to work on this research,
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I am interested in attempting to increase activity progressively over time throughout the aging process. I expect it is physiologically possible to increase activity but have not been able to identify any animal or human study in the published literature.
Thank you.
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I agree with Ron's assertion that aging is, to some degree, linear. It may nevertheless be possible to progressively increase activity throughout up to a point. Imagine, activity is increased slowly through one's 40s to 80s, e.g. then, life happens and an illness or injury impairs the individual's capacity to remain active and there's a sharp drop-off that persists over the remainder of their life. If that remainder is very brief, then sure, the goal of increasing activity throughout one's life was met. At the very least, it could be shown that activity was progressively increased more than had previously been demonstrated.
Thank you for your contributions.
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As far as I know all countries are currently experiencing gerontogrowth, but not all countries are experiencing population aging. This is the case of Mozambique. Is there anybody investing this difference, besides obviously Gérard- François Dumond, as I acknowledge in a recente paper? see: https://authors.elsevier.com/a/1V4z3,oK5hcTAi
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In many studies conducted across the world using the SF 36 questionnaire as a score for determining physical and mental health, it was found that age was not a predictor of mental health. Why ?? 
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Looking forward to reading your paper Beatrice
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Methods and procedures in order to measure the wear/aging in automotive shock absorbers in real time on the vehicle. What values and parameters can be used for this aim.
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Once the shock absorber seal gets damaged due to longer usage of shock absorber, the oil will come out. Otherwise the shock absorber will have maximum age
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In Alloy 617, in its as-received condition the twins are more prominent, but as aging proceeds twins disappear, Why? Can one measure stacking fault energy (SFE) with TEM?
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dear Aditya,
what are the specific temperatures ? do you apply any stresses? do the twin dislocations disappear at all conditions?
If you observe a significant grain growth it could be the cause for the twin reduction, since also the growth means a total energy reduction. As stale dislocations require a certain volume of material (max. dislocation density) a shrinking grain with a dislocation in it will contribute to further grain growth, respectively cause dislocation silp at some Point when the local energy reaches a certain Level.
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Also if you know a paper where there are tables available with this information it would be nice. I am looking for data with aging data without confounds of dementia.
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Thank you Igor Kurochkin for the database. In this one you can select people without dementia, which is what I want. But you do not have the young people expression unfortunately.
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Tertiary  and mesozoic age related biomarker.
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Biomarkers? There is a rhenium-osmium clock
for bitumen. Carbon dating goes back only
a few thousand years.
Regards,
Joachim
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without counting the ring and cutting the tree stem
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In perennial trees, we usually measure the thickness of both scion and rootstock to see the response to inputs and scion girth just above the bud union will give the age of the trees, which comes through experience , not a concrete method at all...Dr Anshuman Singh ..
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Simple screening tests for frailty like the IANA's FRAIL are now available and validated. There is clear evidence that they predict poor outcomes such as disability and mortality.
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The question is quite old, but the answer for this question is yes. With simple tools the primary care physician may screen for frailty, and it is not very diffucult to perform. When we talk about frailty, we all know that frail older person you may easily recognise. As a nurse, I may point out that not only physician may screen for frailty,it may be done also by other health team members, eg. nurses.
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I want to compare the prevalence of depression in 6 countries using WHO-SAGE data. I calculated with weighted prevalence, but i feel it will be great if i use the standardized prevalence for comparison.  
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Thank you so much!
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i have this article and it is so usefull for my research. for citing your article, i need the citing information. how can i cite your article? is it published?
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I have not seen the article. If well written, it can be publishable, I can only pronounce that if I read it. 
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See details here:
Marie Durand was 123y old in 1883 and had been a widow for 96 years!   Many details are given in a brief summary in Med Times Gaz 1883;2:282, so it should be easy enough for someone in France to check her out.   Did she meet the current record holder, Jeanne Calment?
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145 years:
Oldest Man In History Claims To Be 145 But Wants To Die | IFLScience
Aug 31, 2016 - When you're approaching a century and a half, you can be reasonably pleased with your innings, although at 145 years of age the oldest ...
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In the manufacturing process of poly(vinyl chloride) (PVC) material used in low voltage cables insulation, Calcium Carbonate (CaCO3) and Calcium-Zinc (Ca-Zn) could be used as stabilizers.
During thermal aging process, and at high degradation level of the insulation material, how may the release of these additives affect the electrical properties of the material, mainly the electrical conductivity?  
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Dear Youcef,
In general, the loss of stabilizer due to thermal ageing increases the conductivity of the PVC cable insulation. We had several investigations and publications in this filed. I think the attached is a good summary.
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This paper describes some options and explains why we should be concerned with changes in vasculature when using fMRI to compare neural activity between young and older adults: http://onlinelibrary.wiley.com/doi/10.1002/hbm.22768/epdf  
What do you add or change in your fMRI studies on age-differences? Resting state? Other pulse sequences? 
Any other wisdom (e.g. inclusion/exclusion criteria)?
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You also need to be concerned about the alignment of fMRI data to atlas space. Make sure that you generate a template that is representative of both younger and older adults. You can get group differences simply due to better spatial overlap of the signal in younger adults.
For a paper that touches on spatial overlap.
Another paper on neurovascular coupling
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12 week exercise intervention using power training (20-50% 1RM) or whole body vibration. Complete 3x10 of 4 lower body exercises with 1-3 minutes rest.
Serum collection is early in the morning while fasted using red top vacutainers.
Participants will continue with regular physician care and any prescribed therapy.
All participants are >65 years and long-term care residents.
The presence of comorbidity is common among participants. Diseases range from T2DM, dementia, stroke, hypertension, Alzheimer disease, GERD, and osteoporosis.
Some participants are taking statins.
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The best should be the hs-CRP which brings more information 
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I am working on paddy grain(naturally stored) age assessment and the work is based on the husk color. Please let me know the age intervals (in months) where we can recognize the change in the husk color of stored paddy grains.
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Six months
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I want to setup filed potential recording here in Pakistan where we have very limited resources. I request if someone can guide me following aspects? We have very limited budget for purchasing.
1. Should I got for the in-vivo anesthetized setup or in-vitro setup which needs more instrumentation.
2. Which company can provide us cheap setup. If its a complete unit (including amplifier and simulator) then it will be nice for installation, use and repair.
3. If anyone of you or relevant scientist has some used instruments, I shall request for these. Because this will be great help.
Best Regards,
Touqeer Ahmed PhD
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Hi Touqeer,
Some of the most expensive components of an in vivo and in vitro setup is the anti vibration table. You can avoid buying such system by putting a table, prefereabily a metal one and just the square stuff, over an old big truck tire or over four half tennis balls in the corners. The metal will help because most of the micromanipulator bases can be attached to the table with a magnet, helping to stability and giving flexibility in location. The table should weight enough to provide stability and bend a bit the rubber. This option is used in labs even for single-cell patch clamp recording and should provide stable recording conditions for extracellular field potentials both in vivo and in vitro.
Hope these solutions help!
Kind regards,
Marcel 
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Can anyone recommend a book or other useful resources about images of aging in advertising?
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are we talking about ADs to older consumer or the use of ancient ads, repeated ad nauseum through diverse TV channels? For example, Mars via its Galaxy (Dove) chocolate ad delights in repeating the same old AD over years now. For me, the outcome is a complete turn-off for Galaxy itself, and an annoyance with Mars who do not seem to understand too frequent repetition of the same AD drives customers away from - not toward the brand.
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I'm working on thermo-mechanical precipitate hardening of Aluminum AA7020. Eta phase is detected by EDS. Now I'm trying to calculate the standard free energy of the interphase between MgZn2 particles and the aluminum matrix. I need the terms "chemical energy" and "structure energy" between the phases to calculate the critical diameter of the precipitates in which they start to make an incoherent interface.
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Dear Soheil,
The best way to calculate thermodynamic parameters is TermoCalc software.
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Use of field recording, using DHPG to induce LTD, using Low frequency Paired Pulse. 
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Yes, if you provide the brain region and the protocol of LFS you are using it will be easier to help you. Are you trying to induce LTD chemically and electrically?
Anyway in my experience LTD (I mean electrically, in cortex and in vitro) is not always easy to obtain, you need really a lot of patience....
My LFS protocol is: 900 stimulus pairs of 0.1 msec (50 Hz, i.e. 20 msec interval)  at 1 Hz.
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We introduced a disease-causing mutation in the mouse genome using the CRISPR system. The mice were maintained in a mixed background (B6D2) and these mice were used to evaluate motor performance and body weight. Based on observations, mice show significant variability in disease onset, severity, and body weight. How much of this variability can be attributed to the mixed background? Should backcrossing for at least 6 generations be undertaken before evaluating behavior and body weight? Thank you for your time and consideration.
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I do not disagree with the opinions above, but motor behavior and weight can vary significantly even in inbred strains. Although some favor inbred strains for genetic homogeneity, it may also make results less generalizable and can occasionally produce unusual GxE interactions.. This is why we do clinical trials in humans with diverse genetic backgrounds.  When backcrossing, you may also find that fertility or pup survival suffer greatly.
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I am trying to understand the relationship between the healthy aging process and the development of the blood brain barrier disruption which might lead to several neurodegenerative diseases such as Alzheimer's disease.
Finding a cure for such complicated diseases requires a good understanding of the underlying mechanisms that lead to the development of the disease and a healthy blood brain barrier plays a major role in preventing such diseases.
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Aging and BBB dysfunction is an interesting topic because its a high risk factor for developing neurodegenerative diseases. To my knowledge most of recent studies point at loss of tight junction proteins of the BBB with aging which is likely due to neuroinflammation. Infiltration of circulatory leukocytes and blood borne immunoglobines into the brain is a marker of BBB leakage that happens in aged humans. In aged mice however, only loss of TJ proteins of BBB was observed. I think its not clear which come first, neuroinflammation or BBB leakage. It could be systemic inflammation disrupts the BBB first and lead to infiltration of toxins to the brain that trigger neuroinflammation. Not sure if the brain itself with aging would autonomously initiate inflammation due to certain malfunctioning in metabolic processes and clearance pathways to remove waste byproducts !?.. I would love to here comments from experts in the field..
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Using it with an 83 year old woman following total elbow replacement.  
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Recommended in 18-65 year olds. Not validated in older groups. So there are no normative values.
Smith MV, Calfee RP, Baumgarten KM, Brophy RH, Wright RW. Upper Extremity-Specific Measures of Disability and Outcomes in Orthopaedic Surgery. The Journal of Bone and Joint Surgery American volume. 2012;94(3):277-285. doi:10.2106/JBJS.J.01744.
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We are running a study where we measure grip strength to older patients in acute medical wards to flag up those with low levels who might be at risk of poor healthcare outcomes. We know that grip strength vary according to age, gender, and dominant hand, but I am not aware that there is any research on whether the grip strength of a patient vary when it is being tested before and after meals. It would be helpful if anyone can share their experiences or refer me to any useful references. 
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I can't see the relevance of this study. If the client has the motivation to eat and the skills involved - what is the significance of grip strength after meals? How will your study provide information that is meaningful to clients healthcare outcomes? What are the assumptions/hypotheses underpinning your study?
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I am planning a pilot study to look for the regions in the brain that could develop iron overload in a genetic model of hemochromatosis. The idea is to explore with histology of brain sections and then in identified regions we will quantify iron histologically and biochemically. The question that always remains in my mind is can Perls stain reliably tell the regions of iron deposits. Kindly let me know your inputs. Thanks and regards.
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Perls staining is pretty effective, easey and low cost.  We used it here.  The colour contrast is pretty good for image analysis.
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it is seen that a effective dose imparted to patients during CT examination of brain increase strongly with decreasing age. why? can one explain me?
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Again, I am no expert but the way I understand it is that children are more susceptible to the effects of ionizing radiation.  They are still growing and developing and their cells tend to divide more rapidly.  During cell division there is an increased risk of mutation especially when external influences such as ionizing radiation play a part.  Also, children have longer to develop an accumulative effect than adults. 
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PASE (needs permission)
IPAQ (age 15-69), Can I use IPAQ age over 65?
CHAMPS, YALE, GPAQ ( Is more for vigorous activity? Its need to calculate MET
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 Dear   
Larissa Donatoni da Silva
National University of Ireland, Galway
   I am of the opinion that instead of asking for valid questionnaire it is better to develop it yourself by studying your own problem or project with which you will be dealing. The questionnaire developed can be tested and retested to increase its validity. This is bit laborious but it also trains up you. Yes you can ask for help and many interested and experienced people will do this.
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What are the theories used in analyzing this study and the limitations of this study?
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I haven't published on this, but I have found in my clinical work that older people tend to be more comfortable on the whole with the idea of their own death, though perhaps not of the act of dying. They may fear suffering. They also may be less comfortable as they age with the deaths of friends and other family as their key networks then shrink. Those who live long are "successful" through their long life, but at times find it emotionally difficult to outlive their support systems.  Some evidence below.
Victor Cicirelli has worked in this area for a while.  Two of his publications are:
Cicirelli, V. (2011). Religious and Nonreligious Spirituality in Relation to Death Acceptance or Rejection. Death Studies, 35(2), 124-146.
Cicirelli, V. (2003). Older adults' fear and acceptance of death: A transition model. Ageing International, 28(1), 66-81.
This article below suggests that older people are more comfortable with death:
De Raedt, Rudi, Koster, Ernst H.W., & Ryckewaert, Ruben. (2013). Aging and attentional bias for death related and general threat-related information: Less avoidance in older as compared with middle-aged adults.(Author abstract). The Journals of Gerontology, Series B, 68(1), 41.
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I have FG-NET.
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Hi Rick, can you please share the FG-NET Database with me? and MORPHII if you have. i am doing a research on facial age estimation. thank you.
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Estimation of ageing errors while determining precise age from different ageing structures. How errors are calculated while estimating precise age in fishes.
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You can control systematic error with the proper model of sequence evolution - use some model choice program to help you identify the best model. However, because sequence evolution follows a Poisson process, the random error (standard deviation) with increase with time back to the common ancestor (mean) and will always be quite large (a Poisson mean equals the standard deviation), Nevertheless you do have control over reducing the systematic error so do that at least.
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Keen to hear if anyone has compared how well Horvaths' DNA methylation-based ‘epigenetic clock’ relates to Blackburn's telomere length, as an assessment of the ageing process in different cultures/peoples.
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DNA methylation age and telomere length have only a weak negative correlation after you correct for chronological age. As an aside I mention that it is important to correct for chronological age before one relates DNAm age to telomere length because chronological age confounds the relationship between the two variables.
We correlated DNAm Age with telomere length in *adipose* tissue (Horvath et al 2014, PNAS, Title: Obesity accelerates epigenetic aging of human liver") and only found a weak and insignificant negative correlation between the two variables after correcting for chronological age (e.g., r = −0.28, P = 0.22). We and others have seen similar correlation coefficients in blood tissue but these appear to be unpublished.
Bottom line: the epigenetic clock relates to a biological process that is largely independent of telomere attrition and cellular senescence. 
In the language of multivariate linear models:
if you fit the following regression model:
lm(DNAmAge~AgeAtBloodDraw+TelomereLength)  then TelomereLength will only have a marginally significant p value.
Conversely, if you fit
lm(TelomereLength~AgeAtBloodDraw+DNAmAge) then DNAmAge will only have a marginally significant p-value. Caveat: bmulti-collinearities between the 2 covariates will make the coefficient estimates unstable.
Best,
Steve
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I was thinking the creative thinking of the child from his birth How the observe the things and when they reach up 2 to 3 years of age they start asking of Questions from their parents Like Scientists why,who and how...?And I observe most of children break the toys after playing few days But I can't find the complete answer So I want to try ask the Question from the Researcher for A better Answer And Finding the conclusion...
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Hi Allaudin
Breaking toys after playing with them for few days may not have any hidden psychological predisposition except the 5 to 10 years old's curiosity in exploring the functioning of the toys! beacuse since they have already played with them for few days they might be exploring further possibility and in the process ends up breaking them
regards
Rathish
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I am wondering whether earlier interruption of suckling in mice correlates with insulin resistance or excess adiposity later in life.
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Have you seen this? Ted Garland, 2015. Diet-induced_obesity_resistance_of_adult_female_mice_selectively_bred_for_increased_wheel-running_behavior_is_reversed_by_single_perinatal_exposure_to_a_high-energy_diet?
P.S. I wonder if the question you ask has been addressed using monkeys by anyone, say, at the Oregon Primate Center? They do a lot of work on early nutrition (including prenatal) and diabetes risk. 
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I am a research psychologist exploring the most cutting edge research on aging. Looking for researchers and writers who have ideas, theories or proven information on the topic. Thanks.
Every good wish, -md
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It depends which aspects of aging you're most interested in...
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I would appreciate key reviews/summaries and published/unpublished manuscripts - looking at for example, ageing, expectations, population growth, time-to-death versus inappropriate use of expensive technology, health care practices, etc.
For example, see
Atella, et al. The effect of age and time to death on primary care costs: the Italian experience. Soc Sci Med. 2014;114:10-7. 
Blakely et al. Health system costs by sex, age and proximity to death, and implications for estimation of future expenditure. NZ Med J. 2014;127(1393):12-25.
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Hi Paul,
Like Alan, I think it's a monumental task to come up with a figure - even a range on the impact of demographic change on healthcare spending not least because of the comparability of data even as the OECD try to rectify this matter. There is even debate as to the direction of the impact. Consequently, such an endeavor would be courageous as it would be riveting.
That being said, two references that might be helpful are:
Payne G, Laporte A, Deber R, Coyte PC. Counting backward to health care's future: using time-to-death modeling to identify changes in end-of-life morbidity and the impact of aging on health care expenditures. Milbank Q. 2007 Jun;85(2):213-57.
Reinhardt UE.Does the aging of the population really drive the demand for health care? Health Aff (Millwood). 2003 Nov-Dec;22(6):27-39.
Cheers,
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Do you recommend any papers report the age of mangrove trees, especially for Kandelia obovata ?
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Perhaps the age of Kandelia obovata is about 45 yrs.
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According to WHO, Active ageing is the process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age. It applies to both individuals and population groups.
With the population ageing world wide, Its necessary to carry out different activites to make active ageing to our senior citizens. From this active ageing it will indirectly save the health expenses and other social support related expenses of the family, society, community and of Nations. While sharing the Policy and Action program carried out in your country or region or community people from developed country or other region can also replicate the program which will be useful for the well being of aging society.
I look forward to get lots of theoretical or empirical study results as well as policy related materis will be shared in this forum related with active ageing. Thank you every one for your kind contribution.
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Thank you Jose and Barbara for adding the information.
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The few cancer cells that are immortal activate telomerase reverse transcriptase (TERT), a part of the telomerase enzyme that rebuilds telomeres so they avoid a telomere crisis.  Normally, TERT is active only in sperm or egg cells, so looking for it in a tumour could tell doctors whether the cells are immortal and more likely to spread, helping them decide on the best treatment.
so is it possible to modify mortal cells to immortal cells or control aging by avoiding a telomere crisis?
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Hi,
This question has been posed and answered by many groups. If you are talking about cells in a dish, the answer is definitely yes. Many cell types (not all) can be made immortal by ectopic expression of hTERT alone. Many people have done this on various cell types. Many, but not all cell types in culture can be immortalised by hTERT alone. These cells exhibit normal characteristics and are not transformed (do not grow in soft agar or form tumours in nude mice). Although they are immortal, they still undergo the process of ageing as measured by the epigenetic changes to their genome (epigenetic clock).
If you are asking about making cells in a body immortal, then clearly this has not been done and I doubt will ever be done due to the huge uncertainty of the effect of ectopic expression of hTERT. In any case, it is perhaps not such a bad thing that we do not live forever.
Hope this helps.
Ken
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Good day Friends,
1. Can anyone point me to resources where I could understand in simple terms the difference between these two terms if there is any?
2. If possible, can you give me examples of when one is actively ageing and successfully ageing. 
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There are a special issue of The Gerontologist dedicated to the concept of successful aging (2015). Active aging is a policy framework. 
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What types of experiments or test can be conducted to support/assess this research? I was thinking of employing two groups (Group 1 - Age 40 and above) (Group 2 - Age 40 and below). 
Please Help!
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To begin to answer your question it is necessary to define your terms. Strength if the ability to generate force (usually through the application of a concentric muscle action). Force when exerted against an object produces an acceleration of the object in the direction of the line of action of the applied force. As an individual approaches their maximal strength, the velocity of movement of the resistive body approaches zero (isometric muscle action). This is referred to as the force-velocity relationship of skeletal muscle.
Power is the product of force and velocity. The technical definition of Power is Work divided by Time (W/t); however Work is the product of a Force acting through some distance (actually displacement in accurate terms, since distance is a scalar and displacement is a vector, and in Work the direction of the displacement is quite important). So in mathematical terms Work = Fd; therefore we have (Fd)/t = Power or if we rearrange the variables F(d/t) = Fv = Power.
So, Power is a measure of the Force (generated by the muscle) multiplied by the resultant velocity of the object to which the force is applied. So to measure the Power of an individual compared to another, it would be necessary to give both subjects the same object (a weight) and ask them to move it from point A to point B as rapidly as possible. The weight would provide the value for F and the time it took to move the object across the distance from A to B, divided into the distance, would be the velocity (d/t). The product of F x v would be the power generated by the individual.
As persons age, they lose muscle mass. The loss is greatest in the Type II fiber population. Type II fibers are commonly referred to as "fast twitch" fibers. The loss of Type II fibers affects total strength as well as speed of movement. Therefore the combination of loss of strength and greater loss of that segment of the fiber population with faster speeds of shortening leads to a diminution of the ability to exhibit muscular power, in an older population. However, the loss you are looking at is generally studied in populations above 60 years of age, not 40. There are a large number of papers regarding muscle characteristics in elderly subjects and the trainability of specific aspects of function. If you wish to have me recommend some just let me know. 
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I am interested in the relationship between the use of new technologies and active aging. I would use a good tool (questionnaire) to measure active aging in a sample of older persons.
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Interesting proposals to check. Thanks so much for them.
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I plan to add your study to the metasynthesis that I am currently working on. I see that your findings can contribute well to gerontology.
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Canada
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Malaysia is just ONE of the countries with an aging population; there are other such countries.  "Malaysia's population is ageing at a faster rate than many may have realised. The average life expectancy for women and men in Malaysia is 76 and 73 years, respectively."
At the same time, many young Malaysians are working in distant places: Australia, UK, Europe, and the ASEAN region.  What must be put in place to care for aging relatives in a community, when children, the primary care givers, work far from home?
And, how can we ensure that all older adults receive the care and dignity they need to enhance quality of life in old age? 
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This question is partly triggered in my memory when I read the abstract of Helena's paper.  She has just uploaded the full text for me.  Thanks Helena!
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Any articles/literature in support of the same?
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Dear all,
Is their any datasets for NAFLD which includes non-invasive attributes like liver function tests, symptoms, risk factors, chemical ,markers etc.
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Hi, I am searching for a good protocol to measure the Blood brain barrier permeability in mice model without using the Evans blue dye.
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Sodium fluorescein is often used as a smaller molecular weight tracer. It allows you to do a simple fluorescence assay with your brain homogenate to assess extent (or use a microscope if you want to assess visually) rather than evans blue which you have to score. You could also look up sucrose permeability studies and the wet weight/dry weight method of brain edema