Questions related to Aging
Sugar is sweet & loved by all, but doctors campaign not to take it after a certain age. If an octogenarian wanna taste sweetmeat everyday, what to tell her? Again, it's believed that almost all sweeteners are harmful, even carcinogenic!! Your opinion, please.
What important information does the shape of dQ/dV curves contains about Lithium-ion batteries?
- Change in potential (charge/discharge)
- Height of peaks
- The shape of peaks during long-term cycling
- At different C-rates.
In general, they can give information regarding the change in polarization (change in resistance), change in material chemistry (material degradation) etc.
I am thinking about a side experiment where I need to free mouse bone from flesh. Basically to have the skeleton in the end.
The best would be to have a solution which dissolves flesh but not bones. I want to observe bone structure and maybe analyze minerals in the bones.
If you have any solution or a better one than the one I am portraying it would be very nice to hear from you.
Physical fitness is essential to allow people to carry out everyday activities. It is often particularly low in stroke survivors. It may limit their ability to perform everyday activities and also worsen any stroke-related disability. So, it is recommended that seniors do exercises in order to improve cognitive function, quality of life, and the ability to maintain physical activity. On the other hand, other researchers say that training programs increase the risk of having another stroke.
Usually RTFOT instrument is used to measure short term aging for asphaltic binders under standard conditions.
Under what standard conditions, can we use RTFOT instrument to measure long term aging.
I am trying to develop a hybrid physical-data driven model for battery aging estimation. For this aim, I need big data set to train my model. In literature, the biggest data set I found was from Severson's group. I will be grateful if any one can introduce similar data set.
I'm starting to research rating scales to assess symptoms of agitation or anxiety in patients with dementia. If you know any papers or resources Id be very grateful for suggestions
Hi All, I am looking at compiling a wide list of papers or resources on reminiscence therapy for dementia for older people. The positive and negative results, Creative approaches, ICT interventions, standard procedures, etc. I'm interested in perspectives from differing disciplines. All resources/ papers/ leads welcome Thank you!
Dr. Caleb Bryce and I have organized a canine science symposium for the Society of Integrative and Comparative Biology (SICB) meeting January 3-7th, 2021 in Washington DC (http://www.sicb.org/meetings/). Attached you may find a poster with a list of the speakers for our symposium which will be held January 7th, 2021.
Abstracts will be due late August to early September 2020. You do not have to be a SICB member to attend this meeting, and you can also register to attend for a single day.
If you cannot attend part or the whole meeting, may I ask that you help us spread the word about it by forwarding this information and poster to potentially interested parties?
Our hope is that dogs take over SICB 2021, hopefully with your help!
Please do let me know if you have any questions.
edit: we have a website! Check us out at: https://anagabrielajimenez.wixsite.com/anagjimenez/canine-science-at-sicb-2021
How to test moderation with a multi-group factor like occupation, education or age. Is there any addon available. For two group group factor like gender or a yes/no question its easy but I cant figure out how to do it for more than three groups.
My aim is to estimate mortality rates of some eagles on the base of survival tables. The good toll for this is Weibull aging model (see Ricklefs, 2000, page 104 in attachment). According to Ricklefs, the survivorship curve follows the equation
lx = exp( -m0x - (alpha * xbeta + 1)/(beta + 1)),
where x is age, lx is the proportion of population surviving to the age x, m0 is the initial (accidental) mortality, alpha and beta are coefficients connected to the rates of aging.
So, I have to fit 3 parameters of the model: m0, alpha, and beta.
I ask you colleagues to help me with the correct way to do it. So far I've been using NLS (non-linear squares) method in R, and it basically works. However, the model fitting strongly depends on start values of parameters, that's why in some cases the model doesn't converge or comes to singularity.
All this prevents me to make a proper permutation test of my model (after some iterations of the nls function an exception arises and the loop breaks).
Ricklefs himself refers to 'maximum likelihood approaches' which he used to fit the model, but I do not exactly understand what specifically is it in the given context. Could anyone help me with the correct way to fit my data?
Ricklefs, R.E., 2000. Intrinsic aging-related mortality in birds. Journal of Avian Biology, 31, 103–111.
There are several excellent instruments and scales many of which have been validated numerous times. I am going through an exercise in comparing and contrasting the benefits and constraints of each (e.g. Revised Kogan's Attitudes Toward Old People scale (RKATOP), Age Group Evaluation and Description Inventory (AGED Inventory), Sarkisian's Expectations regarding Aging survey) to arrive at my own conclusions, but would also like the input of other researchers.
I am studying the cerebral aging in non - human primates, Marmost monkies. The study is conducted on anatomical MRI T1-weighted images. We aim to study the decline of brain and cortical volumes in normal aging.
However, due to the difficulty of extracting (segmenting) some cortical subregions, we would like to rather map the volumetric differences in these regions over years (due to aging / possible atrophy) rather than dileneating and extracting ROIs.
I would appreciate if some one could suggest a method (reference) or an algorithm to start with.
I have read papers that describe methods for long-term primary neuron culture but I have not seen convincing western blots showing consistent changes in any protein expression with the progress of aging.
I know that aging is a complex process, but I would like to somehow test if my long-term cultures are actually going through an aging-like process.
Lifespan development, personality and aging and so on - who is the best now?
My area is age and personality traits change (like personal autonomy for example).
The phrase "geriatric profanity disorder", together with its initialization "GPD", has become somewhat of a meme, being mentioned in TV shows like the Simpsons and receiving an entry in the Urban Dictionary. Is it an actual recognized condition or area of research (perhaps under another name)?
Age determination of unknown human bodies is important in the setting of a crime investigation or a mass disaster because the age at death, birth date, and year of death as well as gender can guide investigators to the correct identity among a large number of possible matches.
Do you think that this time can be extracted using the ratio of decay of radioactive carbon that turns nitrogen after death?
I need to measure intracellular NAD (total and NAD+) in human T cells. I see there are several systems (colorimetric and ELISA), and I need a kit that is reliable. I don't want to use HPLC for the moment.
How to identify neurogenesis in adult human retina? Is there any good non-invasive method? This is an ethical, technical and tricky question which may give rise to important concepts. What techniques should be used to achieve this goal.
We are having difficulty consistently getting DBA/2 mice from the National Institute on Aging. Can anyone suggest an alternative source for 9+ month old DBA/2 mice and young controls from the same colony?
WE have the plantations of Eucalyptus camaldulensis. We planted about 400,000 plants of Eucalyptus camaldulensis in 2015, and we want to get first cut in 2019 how much yield can we obtain from these trees. Secondly we want to get some yield again in 2019 from coppice of Eucalyptus camaldulensis then about how much yield we can obtain.
NAD is involved in most cellular redox reactions as an oxidant (NAD+) or reductant (NADH) and it changes between both states multiple times in every fraction of second in every cell. But it is still not clear to me the following:
- Why is it called dinucleotide when I see only one nucleotide as its component (adenine)? or is it nicotinamide a nucleotide too?
- Why it is not so used something like Nicotinamide Guanine Dinucleotide (NGD) instead? or with Cytosine or Thymine? what makes Adenine appropriate for this function?
NAD recently recalled my attention since I read a very interesting article in which the authors managed to decrease age-associated diseases in mice by administration of NAD intermediates:
Mills, Kathryn F., et al. "Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice." Cell metabolism 24.6 (2016): 795-806.
Thanks for your time.
Besides the previously discovered circadian clock (the 24-hour timekeeper) is there another master regulator clock controlling aging and other time scheduled events of life, such as fetal development and puberty (and ultimately over-watching the whole cycle of aging) which are precisely time-dependent, by keeping the track of solar “years” passed?
Respected Researchers..Can anybode send me a precise paper or suggest me the same for the geochronological aspects of Dalma Formation, East Indian Shield??
Actually the Dalma Formation is composed of meta-sediments and meta-volcanics. The age of the vvolcanics are well reported in Mishra and Johnson, 2004. I need some recent published ages of the metasediments (schists and quartzites).
One would expect that due to the protein nature of enzymes, sooner or later the mTOR signaling system would eventually develop an immune dysregulation. This opens the door to hardcore evidence to "The Immunological Theory of Aging" given the close links of mTOR and the aging process. It wouldn't be strange to find high levels of IgM or IgG in patients with progeria. The close relationship between free radicals and aging (Harman, The free radical theory of aging) and mTOR would constitute the thesis, antithesis and synthesis of the molecular biology of aging.
I found a quite old research paper assumes that mental and physical health of aging users can be detected/predicted from the personality he/she hold.
Abstract of that paper says: '' Participants were spouse caregivers of patients diagnosed with Alzheimer's disease. Results showed that neuroticism and optimism were significantly related to mental and physical health. Furthermore, neuroticism had significant direct effects on all of the health outcomes, and substantial indirect effects, through perceived stress, on mental health outcomes. Optimism showed stronger indirect than direct effects on all health outcomes''.
So, can we generalize and carry on further research to answer this question? can we derive from this findings that users who have high neuroticism trait in Facebook could suffer from mental and physical
health outcomes in future?
Many thanks for any redirection.
Hello: Can anyone pls help me to identify an available data set on prostate cancer and birth characteristics (gestational age, birth weight, birth length, time to puberty etc)?
Here comes a puzzling question. I am having difficulty in explaining a difference in the data of two subcontractors in a scientific way.
as we all know, polymers properties are time temperature and environment dependant. Without giving away names, the two subcontractors are working for the same goal - to extrapolate the master curves of specific medical polymers. When I say master curve, I mean long term behaviour such as yield strength vs. time, so that I can foresee how my material will behave in 10 years time for example...
One subcontractor extrapolates data through testing dog bones in temperature chambers, at standard loads - so various load cases and elevated temperatures. load cases way below the yield strength of the material - the samples take a while to rupture.
They collect data - such as 40C, 200 hours, 14MPa
and 50C, 10 hours, 16MPa
then use TTS (time temperature superposition technique) to draw the final master curve.
Well then I have the other subcontractor, who only ages the dog bones in temperature chambers at different temperatures for various times.
they then take these samples out and do an instantaneous test where they measure initial modulus. so they collect data again such as
1000 hours, 40C, 10MPa
again use TTS method and draw the final master curve
I then take these two mastercurves of the same material and study the difference - and the difference is huge, it is noticeable...
which one do you think is more reliable ?
cause in the first case you need to wait until the material ruptures, which extends the testing time considerably..
Thank you very much for your answers.
Research scope of psychosocial aspects of ageing and interpersonal acceptance and rejection across culture
I am interested in attempting to increase activity progressively over time throughout the aging process. I expect it is physiologically possible to increase activity but have not been able to identify any animal or human study in the published literature.
As far as I know all countries are currently experiencing gerontogrowth, but not all countries are experiencing population aging. This is the case of Mozambique. Is there anybody investing this difference, besides obviously Gérard- François Dumond, as I acknowledge in a recente paper? see: https://authors.elsevier.com/a/1V4z3,oK5hcTAi
In many studies conducted across the world using the SF 36 questionnaire as a score for determining physical and mental health, it was found that age was not a predictor of mental health. Why ??
Methods and procedures in order to measure the wear/aging in automotive shock absorbers in real time on the vehicle. What values and parameters can be used for this aim.
In Alloy 617, in its as-received condition the twins are more prominent, but as aging proceeds twins disappear, Why? Can one measure stacking fault energy (SFE) with TEM?
Also if you know a paper where there are tables available with this information it would be nice. I am looking for data with aging data without confounds of dementia.
Simple screening tests for frailty like the IANA's FRAIL are now available and validated. There is clear evidence that they predict poor outcomes such as disability and mortality.
I want to compare the prevalence of depression in 6 countries using WHO-SAGE data. I calculated with weighted prevalence, but i feel it will be great if i use the standardized prevalence for comparison.
i have this article and it is so usefull for my research. for citing your article, i need the citing information. how can i cite your article? is it published?
See details here:
Marie Durand was 123y old in 1883 and had been a widow for 96 years! Many details are given in a brief summary in Med Times Gaz 1883;2:282, so it should be easy enough for someone in France to check her out. Did she meet the current record holder, Jeanne Calment?
In the manufacturing process of poly(vinyl chloride) (PVC) material used in low voltage cables insulation, Calcium Carbonate (CaCO3) and Calcium-Zinc (Ca-Zn) could be used as stabilizers.
During thermal aging process, and at high degradation level of the insulation material, how may the release of these additives affect the electrical properties of the material, mainly the electrical conductivity?
This paper describes some options and explains why we should be concerned with changes in vasculature when using fMRI to compare neural activity between young and older adults: http://onlinelibrary.wiley.com/doi/10.1002/hbm.22768/epdf
What do you add or change in your fMRI studies on age-differences? Resting state? Other pulse sequences?
Any other wisdom (e.g. inclusion/exclusion criteria)?
12 week exercise intervention using power training (20-50% 1RM) or whole body vibration. Complete 3x10 of 4 lower body exercises with 1-3 minutes rest.
Serum collection is early in the morning while fasted using red top vacutainers.
Participants will continue with regular physician care and any prescribed therapy.
All participants are >65 years and long-term care residents.
The presence of comorbidity is common among participants. Diseases range from T2DM, dementia, stroke, hypertension, Alzheimer disease, GERD, and osteoporosis.
Some participants are taking statins.
I am working on paddy grain(naturally stored) age assessment and the work is based on the husk color. Please let me know the age intervals (in months) where we can recognize the change in the husk color of stored paddy grains.
I want to setup filed potential recording here in Pakistan where we have very limited resources. I request if someone can guide me following aspects? We have very limited budget for purchasing.
1. Should I got for the in-vivo anesthetized setup or in-vitro setup which needs more instrumentation.
2. Which company can provide us cheap setup. If its a complete unit (including amplifier and simulator) then it will be nice for installation, use and repair.
3. If anyone of you or relevant scientist has some used instruments, I shall request for these. Because this will be great help.
Touqeer Ahmed PhD
I'm working on thermo-mechanical precipitate hardening of Aluminum AA7020. Eta phase is detected by EDS. Now I'm trying to calculate the standard free energy of the interphase between MgZn2 particles and the aluminum matrix. I need the terms "chemical energy" and "structure energy" between the phases to calculate the critical diameter of the precipitates in which they start to make an incoherent interface.
We introduced a disease-causing mutation in the mouse genome using the CRISPR system. The mice were maintained in a mixed background (B6D2) and these mice were used to evaluate motor performance and body weight. Based on observations, mice show significant variability in disease onset, severity, and body weight. How much of this variability can be attributed to the mixed background? Should backcrossing for at least 6 generations be undertaken before evaluating behavior and body weight? Thank you for your time and consideration.
I am trying to understand the relationship between the healthy aging process and the development of the blood brain barrier disruption which might lead to several neurodegenerative diseases such as Alzheimer's disease.
Finding a cure for such complicated diseases requires a good understanding of the underlying mechanisms that lead to the development of the disease and a healthy blood brain barrier plays a major role in preventing such diseases.
We are running a study where we measure grip strength to older patients in acute medical wards to flag up those with low levels who might be at risk of poor healthcare outcomes. We know that grip strength vary according to age, gender, and dominant hand, but I am not aware that there is any research on whether the grip strength of a patient vary when it is being tested before and after meals. It would be helpful if anyone can share their experiences or refer me to any useful references.
I am planning a pilot study to look for the regions in the brain that could develop iron overload in a genetic model of hemochromatosis. The idea is to explore with histology of brain sections and then in identified regions we will quantify iron histologically and biochemically. The question that always remains in my mind is can Perls stain reliably tell the regions of iron deposits. Kindly let me know your inputs. Thanks and regards.
it is seen that a effective dose imparted to patients during CT examination of brain increase strongly with decreasing age. why? can one explain me?
PASE (needs permission)
IPAQ (age 15-69), Can I use IPAQ age over 65?
CHAMPS, YALE, GPAQ ( Is more for vigorous activity? Its need to calculate MET
Estimation of ageing errors while determining precise age from different ageing structures. How errors are calculated while estimating precise age in fishes.
Keen to hear if anyone has compared how well Horvaths' DNA methylation-based ‘epigenetic clock’ relates to Blackburn's telomere length, as an assessment of the ageing process in different cultures/peoples.
I was thinking the creative thinking of the child from his birth How the observe the things and when they reach up 2 to 3 years of age they start asking of Questions from their parents Like Scientists why,who and how...?And I observe most of children break the toys after playing few days But I can't find the complete answer So I want to try ask the Question from the Researcher for A better Answer And Finding the conclusion...
I am wondering whether earlier interruption of suckling in mice correlates with insulin resistance or excess adiposity later in life.
I am a research psychologist exploring the most cutting edge research on aging. Looking for researchers and writers who have ideas, theories or proven information on the topic. Thanks.
Every good wish, -md
I would appreciate key reviews/summaries and published/unpublished manuscripts - looking at for example, ageing, expectations, population growth, time-to-death versus inappropriate use of expensive technology, health care practices, etc.
For example, see
Atella, et al. The effect of age and time to death on primary care costs: the Italian experience. Soc Sci Med. 2014;114:10-7.
Blakely et al. Health system costs by sex, age and proximity to death, and implications for estimation of future expenditure. NZ Med J. 2014;127(1393):12-25.
According to WHO, Active ageing is the process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age. It applies to both individuals and population groups.
With the population ageing world wide, Its necessary to carry out different activites to make active ageing to our senior citizens. From this active ageing it will indirectly save the health expenses and other social support related expenses of the family, society, community and of Nations. While sharing the Policy and Action program carried out in your country or region or community people from developed country or other region can also replicate the program which will be useful for the well being of aging society.
I look forward to get lots of theoretical or empirical study results as well as policy related materis will be shared in this forum related with active ageing. Thank you every one for your kind contribution.
The few cancer cells that are immortal activate telomerase reverse transcriptase (TERT), a part of the telomerase enzyme that rebuilds telomeres so they avoid a telomere crisis. Normally, TERT is active only in sperm or egg cells, so looking for it in a tumour could tell doctors whether the cells are immortal and more likely to spread, helping them decide on the best treatment.
so is it possible to modify mortal cells to immortal cells or control aging by avoiding a telomere crisis?
Good day Friends,
1. Can anyone point me to resources where I could understand in simple terms the difference between these two terms if there is any?
2. If possible, can you give me examples of when one is actively ageing and successfully ageing.
What types of experiments or test can be conducted to support/assess this research? I was thinking of employing two groups (Group 1 - Age 40 and above) (Group 2 - Age 40 and below).
I am interested in the relationship between the use of new technologies and active aging. I would use a good tool (questionnaire) to measure active aging in a sample of older persons.
I plan to add your study to the metasynthesis that I am currently working on. I see that your findings can contribute well to gerontology.
Malaysia is just ONE of the countries with an aging population; there are other such countries. "Malaysia's population is ageing at a faster rate than many may have realised. The average life expectancy for women and men in Malaysia is 76 and 73 years, respectively."
At the same time, many young Malaysians are working in distant places: Australia, UK, Europe, and the ASEAN region. What must be put in place to care for aging relatives in a community, when children, the primary care givers, work far from home?
And, how can we ensure that all older adults receive the care and dignity they need to enhance quality of life in old age?
Hi, I am searching for a good protocol to measure the Blood brain barrier permeability in mice model without using the Evans blue dye.