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Much like many of the previous writers, I would avoid this combination of medications. There are many other options for augmentation if needed such as lithium, pramipexole, Second or third generation antipsychotics, liiothyronin, ...
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Is there any research on the mental health status of pre- and post-doctoral researchers and/or academic staff with samples from Germany? I have a hard time finding papers on the topic, so if you have any suggestions regarding articles (or even search strings for specific databases or search engines), I'd be very grateful!
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Hello
I want to camparing two Psychiatric groups in their connections .
But, because of our financial limitation , we need the minimum sample size.
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The sample size always depends on the reference population.
Also, you need to clearly set the goals of the analysis.
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"In colleges and universities in the United States, suicide is one of the most common causes of death among students.[1] Each year, approximately 24,000 college students attempt suicide while 1,100 students succeed in their attempt, making suicide the second-leading cause of death among U.S. college students.[2][3] Roughly 12% of college students report the occurrence of suicide ideation during their first four years in college, with 2.6% percent reporting persistent suicide ideation.[3] 65% of college students reported that they knew someone who has either attempted or died by suicide, showing that the majority of students on college campuses are exposed to suicide or suicidal attempts.[4]"
"Why Is Suicide So Common Among College Students?"
"Burnout in College: What Causes It and How to Avoid It"
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There is nothing more tragic than student suicide. iAcademic stress plays a part but there is also being away from home, often too early, disillusionment with both social and academic life, substance abuse, behavioral addictions, broken hearts, competitiveness, loneliness, lack of confidants, mental health problems, medical problems, stigmatization, money problems, bullying, unsympathetic teachers. Large universities are cold, anonymous places and students come unprepared.
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What are the factors that predispose patients to treatment-resistant depression?
What are the advances that predict antidepressant treatment response for depression?
Two articles about prediction of antidepressant treatment response by using artificial intelligence technology and machine learning algorithms:
  • An electroencephalographic signature predicts antidepressant response in major depression (doi:10.1038/s41587-019-0397-3)
  • Brain regulation of emotional conflict predicts antidepressant treatment response for depression (doi:10.1038/s41562-019-0732-1)
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Because it depends on several causes:
-The type and intensity of such Depression
-The one that, in addition, there is also an Anxiety Chart (Mixed Depressive / Anxious Disorder)
-Whoever is male or female
-The type of Antidepressant used: An MAOI is not the same as a Tricyclic type, an SSRI or a Selective Serotonin and Noradrenaline Reuptake Inhibitor or Epinephrine (SSNRI)
-The one who receives a Combined Treatment with, in addition to Antidepressants, Psychotherapy, eminently Cognitive Behavioral.
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As often in medicine animals are ( SADLY) used in experiments .A new study of mice shows there are important links between human and mouse minds in how they function -- and malfunction. Researchers at Washington University School of Medicine in St. Louis devised a rigorous approach to study how hallucinations are produced in the brain, providing a promising entry point to the development of much-needed new therapies for schizophrenia.
The study that was published in the journal Science, lays out a way to probe the biological roots of a defining symptom of psychosis: hallucinations. The researchers trained people and mice to complete a computer-based task that induced them to hear imaginary sounds. By analyzing performance of the task, the researchers were able to objectively measure hallucination-like events in people and mice.
This approach allowed them to study the neural circuits underlying hallucinations, potentially fully opening up the study of mental illness to the kind of scientific studies that have been fruitful for diseases of other parts of the body. My concern is that despite the positives and even if there are similarities, can a study like this be of great value when it comes to humans who has a fundamentally different cognitive ability and brain structure? I agree that we can see tendencies and the study gives an insight, however can this ever fully be transferred to humans? also see other risks as well as grave ethical concerns that applies with all experiments on animals. What are your thoughts?
Best wishes
Henrik
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The comparative study of living organisms is standard laboratory practice, e.g. the knowledge transfer of animal experiments to humans. Concerning psychiatry, this may be the human medicine par excellence, and I personally (and methodically) doubt that, in this case, the results of veterinary medicine can be applied to humans successfully.
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What is your take?
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In my opinion the foundation of personality is inherited, self desires set the direction and environment cause transformation, as seed inherits the type of the plant in it self, a chance to go into the soil is similar to self-desires, while water, sunlight, air and fertilizers are environments. They all have a role to play in the process of a seed becoming a tree.
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The big five personality trait model ( McCrae & Costa) describes 5 bipolar dimensions of personality. The model received some criticism but is still generally accepted and perhaps it is the only descriptive model of personality that is "widely" accepted. What do you think are the strengths and weaknesses of this model? Is it complete or not? If not, what is missing?
Best wishes Henrik
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Dear Dr.Samah Zahran,
Please, add money to your greatest assessment for personality perspective..
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The theories ofthe great Carl Rogers, do you still consider them relevant today? Why? Why not?
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Rogerian psychology create an atmosphere of psychological safety within the counseling relationship which is relevant and applicable today. Rogers believed the therapist should have unconditional positive regard for the client – that is, not judge the client’s character. If the client feels that his/her character is being evaluated, he/she will put on a false front or perhaps leave therapy altogether.
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Let's talk about what is our self else than your memories (if all set of information that we've got is a different type of memories)?
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The self is a complex interaction between memory and attention. In this case memory is facts we know about ourselves (self-knowledge), schematic structures built from our socio-cultural context and autobiographical memory. The Self is how we appraise, use, and prioritize not only information in memory, but also various interests and desires. These actions on memory, interests, and desires require varying degrees of attentional resources. Carolyn Jennings makes this point much better than I in her essay (https://aeon.co/essays/what-is-the-self-if-not-that-which-pays-attention). In sum, there is a bidirectional relationship between our Self and how we appraise, use, and prioritize what’s stored away in memory structures as well as our management of our interests and desires.
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Is its factor structure congruent with that proposed by its author(s) or could be regarded as questionable?
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Selman,
I do not know this scale but an inventory that sounds like that (i.e. as list of symptoms) will rarely be appropriate for factor analysis. Lists of things are aggregate constructs and most often do not reflect a common factor model.
Best,
Holger
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Hello
Request a colleague to do a research paper (Psychology)
Thanks
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Great initiative. I will be happy to provide statistical analysis power and research methods...
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Dear colleagues,
I have been struggling a lot about Ethic Committee. At the moment, I am working on observational studies and I would like to know if investigating suicidal ideation in a specific timeframe (in the last 12 months), and not "at the moment" would make necessary the approval by the Ethic Committee.
Does anyone know anything about it?
Thanks in advance!
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Probably, but it depends which setting you are working in. For example, if you are working in a clinical or educational setting you will certainly need approval. But first of all I would escalate the issue to your own supervisor or in your own institution.
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I am asking this question to prepare for a seminar in the Division of Social and Transcultural Psychiatry at McGill University.
My seminar proposal is attached.
Your thoughts from all disciplines are most welcome.
- Vincenzo Di Nicola
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I agree that there is a social agenda component. One of the goals of effective treatment of severe and persistent mental illness would be to prevent the "downward drift" seen in patients’ socio-economic condition. In a related situation, in advocacy we are often using economic data about days missed at work and lost productivity to try and justify the needed investment in preventing and treating severe and persistent mental illness.
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Particles, such as lithium and ethanol are known for their strong action on CNS. Little diameter of these particles, enables them to migrate and act directly on many cerebral structures. Similarity of lithium to another ions prone to check if high efficacy of lithium treatment is only the result of impaired ion- balance repair...
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I think bipolar disorder is triggered by sleep disorder in persons with unstable circadian rhythms (see my RG question on this).
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I believe while doing research about depression we are doing a huge mistake. We often use screening tools for depression, such a self-reported scale (e.g. EURO-D), and those who are at risk are often called "depressed".
Being at high risk for depression does not mean being depressed.
I often read about incredibly high prevalence of depression in many studies, but then in the methods I see a screening tool was used to measure depressive symptoms.
Depression is not diagnosed in such a way.
Diagnosis of depression can be done only in a clinical setting.
While using scale for screening, we need to talk about "individuals at high risk for depression" or individuals with "high level of depressive symptoms".
It is like if we would refer to those with low tolerance to glucose as diabetic after asking them the value of glucose last time they made a blood test. Actually, this would be even more accurate.
What is your idea?
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I agree with Michael Uebel that PHQ-9 is a useful screening tool, as well as other validated questionnaires (Zung's SDS, CES-D, HADS, Whooley, etc.). However, they are just screening tools, not diagnostic tools. A positive screening indicates that there is a likelihood of having a depressive disorder.
E.g., it is accepted that the operational features (sensitivity, specificity...) of the PHQ9 are sufficiently good to recommend its use as a screening tool, but its predictive positive value (at best: in a population with high prevalence of depression) could be around of 50 % (i. e., 50% of positive results in PHQ 9 do not have depression).
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Psihologija (www.psihologijajournal.org.rs) is a scholarly open access, no fee, peer-reviewed journal published quarterly. It is currently referenced in the Social Sciences Citation Index (SSCI).
As a journal mainly focusing on psychology, neuroscience and psychiatry, Psihologija calls for papers related to all aspects of Internet, digital media, smartphones and other technology use that could lead to potentially detrimental mental health effects. Original research and review articles about specific models and theories, definition, classification, assessment, epidemiology, co-morbidity and treatment options, focusing mainly on, although not limited to:
· Internet gaming
· Internet gambling
· Excessive social media/networks use
· Online dating, cyber-relationships/sex and pornography
· Excessive online information collection
· Cyberbullying
· Smartphones, tablets and other technology use.
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Giovanni Portuesi & Duane A Lundervold great! Definitely good articles are needed! Will be happy to provide more details if needed!
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As aripiprazole, brexpiprazole, and cariprazine are partial-dopamine agonists with potent binding affinities to the D2 receptor, do they prevent augmentation effects (or worsen psychosis) when two or more antipsychotics are combined?
Certainly, there is data suggesting worsening psychosis when aripiprazole has been added to other agents (Takeuchi and Remington, Psychopharmacology 2013). Additionally, the idea of competitive inhibition is supported by the reversal of hyperprolactinemia when aripiprazole is added to another antipsychotic.
I can find no data of this phenomenon occurring yet with brexpiprazole or cariprazine.
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Drugs work best when they are new. Hence the adage, "Be quick to use this new medication before it stops working!"
Problems of low efficacy and adverse effects take time to emerge.
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I would be very grateful if anyone can point out articles on psychiatric education in Africa and Middle East.
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Thank you Dr. Sapkota.
Thank you Dr Ah Gs, but I am looking for materials that cover mainly recent educational programs.
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Dear colleagues,
I am working on a project regarding psychiatric education.
I would be very grateful if anyone can recommend me articles on psychiatric education and/or psychiatric training in South America.
Many thanks in advance.
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Julio:
I recommend you.
Renato D. Alarcón, Manuel Suarez- Richards, Silvana Sarabia.
"Educación Psiquiátrica y componentes culturales en la formación del médico: Perspectivas Latinoamericanas".
Revista Peruana de Medicina Experimental y Salud Pública
(Peruvian Journal of Experimental Medicine and Public Health)
2014 Vol 31 (3).
Best wishes.
Diana from Perú.
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Why or why wouldn't you find the psychological egoist's explanation plausible?
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An egoist will look and treat an altruist wrong. Egoist and altruist , if not diametrically opposite personalities, are completely in different spectrum of behaviors and therefore their value systems and truth to them are completely different.
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Why do you think such links exist?
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Psychology is the result of close observation of many individuals at various mental states, usually those who have a disease or a condition. Hence it can be faulty, though most of the times, it is not. Since each human has some disease in him/her. True religion is close observation of the individual self itself and then progressing above by self cleansing through sadhana/meditation. Book religion is true only for those with open eyes, else it is a poison, coz 'the reading I' becomes the character of the book read
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Do you find their explanation of such phenomena compelling?
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Such situations are bizarre. I am following to learn more though. All forms of sacrifices to save the many of the human family may not necessarily be stupid. Military persons are groomed to prioritize the lives of citizens though. To die for others, its a courageous, selfless and humanly attitude. However, this should be done when that is there is no alternative to save every life!
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A psychiatrist surely is exposed to situations that other people (or physicians) are exposed to, I wondered whether the nature of their work can affect their brains one way or another, and I couldnt find much research done in that field. Why do you think that is? And even if so, what is your opinion on how psychiatry affects the brains of seasoned psychiatrists?
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There have been research on psychiatrist behaviors (prescribing habits, likelihood of addressing primary care needs of psych patients if they don't have a primary care physicians etc). If you are talking about functional imaging or something equally intensive i would imagine it would be difficult to recruit due to relatively small sample size and how much physician time is worth. When i get offers to do surveys on medscape they typically reimburse around $100 per hour for a simple survey. But i'm sure with sufficient funding studying physicians wouldn't be all that difficult.
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For an assignment I need to imaging designing a scale to measure hypomanic symptoms, and write about how this would be done.
Seeing as hypomanic episodes may be present for various periods of time (a few days, a few weeks etc.) is it possible to measure test-retest reliability?
Thanks
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It depends on how the questions are asked. If the scale asks about hypomanic symptom right now, or during the past week, test-retest would not be appropriate. If it ask about the average level, or maximum level, of symptoms during an episode then test-retest reliability is necessary to validate the scale.
Regards,
Simon Young
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As part of our investigations into the current state of psychiatry, I would like to ask how academics and practitioners, researchers and clinicians, and of course professors of psychiatry, see contemporary psychiatry and its future. My colleague Drozdstoj Stoyanov, MD, PhD, and I are writing a book called "Psychiatry in Crisis" (see Research Project on "Psychiatry in Crisis") in which we pose and will try to answer the following question:
Is psychiatry a social science (like psychology or anthropology), is it better understood as part of the humanities (like philosophy, history and linguistics), or is the future of psychiatry best assured as a branch of medicine (privileging genetics and neuroscience)?
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What are the practical implications of classifying Psychiatry into one of the mentioned categories? Would doing so necessarily bring Psychiatry out of the "crisis' mentioned (is it really in a crisis?). My own Psychiatry colleagues used insights from all the disciplines mentioned. For example, several were involved with the issue of euthanasia and the ethical issues involved (philosophy), issues of anthropology were involved (do forms of mental illness manifest themselves differently in different cultures), and neurology and neuro-psychology (are there underlying specific correlations with present diagnostic categories?). An additional issue is that the boundaries between the disciplines mentioned are not fixed. Further, some areas of medicine have changed to be concerned with enhancing human beings rather than just fixing organic problems, will Psychiatry follow this path in the future? I've probably just muddied the water, but I'm not sure why the question needs to be asked.
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I am searching for Psychotherapy Single case Archives (for example the single case archive in Gent)
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There is a Single Case Archive at http://singlecasearchive.com/
Rutgers University has a Pragmatic Case Archives at http://pcsp.libraries.rutgers.edu/index.php/pcsp/issue/archive
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I'm not a psychiatrist, but I wonder if it is possible to reliable identify the presence of hallucinations. And if the method can be translated to the animal models. I would greatly appreciate the variety of opinions.
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Sometimes darting eyes, hands over ears or plugs in ears, loud music on ear phones, head shakes, holding the head, banging the head, talking back, unprovoked smiles or laughs or shouts, frightened looks, looking over one's shoulder, listening attitude, dazed look. Not sure whether any of this applies to lab animals.
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Maybe you can recommend some article?
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Hi Julia,
Here is the link to the ILAE's "Definition and Classification" web page, including a 2016 proposal. They are constantly updating debates in all sorts of topics regarding classification.
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I came across a report that mentions it has been validated in Urdu, but it only includes the authors' names (Taj A., Gambhir S.). Any chance you can provide me with the full citation?
Thank you in advance!
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we used it in our work in Pakistan in multiple projects. I also saw this citation, but authors never responded so we had to get it translated. What is it exactly you are looking for? 
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Im working on a cross-sectional correlation study and I need to measure the agression severity in outpatients. I do not know which scale would be better. Also anybody knows how to rate and interpret this sacales? Thanks
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Thanks you so much!
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Nitrofurantoin (NF)-induced adverse effects have been reported frequently, although NF seems to be a first line treatment for lower urinary infections according to the last E.U. and U.S. guidelines. However its use in psychiatric patients should be reviewed with a great caution. In these cases the use of penicillin is therefore sometimes more appropriate, although the total antibiotic consumption rises. Because of NF use, a dose adjustment because of its adverse events (hallucinations) is also possible and cooperation with clinical pharmacist is beneficial in these cases. What do you think?
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This is true Dr.stuhec
Nitrofurantoin should be avoided in geriatric patients in general not only in psychiatric patients.
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I refer to: tendencies to omnipotent thought; avoidance of otherness; Immediate drive discharge ecc.
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 there is a most excellent tool - severely mistrusted by our evidence-debased friends, apparently - called an analyst.
This "tool" is able to use listening, intelligence, feeling, intuition, compassion and 100 years of psychoanalytic theory to fairly accurately predict and "measure" and to understand the degree and nature of regression in a particular person.
It is an expensive tool - little understood by the evidence-debased CBT-government health-fund alliance - but, it works. And updates are free, but require ongoing genuine interest in the human psyche and the world of the unconscious. To purchase a license requires great patience and curiosity and a mistrust of the usual forms of "evidence".
 That is the shortest answer that I can give.
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Students have to study many diverse subjects in parallel. Is there a research finding
to suggest how many different subjects may be taken by a student with effective
 learning outcomes? A related question is how in modern times with explosion of knowledge and need for combining cross disciplinary fields how should a  course  be designed to optimize depth/ breadth of coverage . 
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Check out Maharishi University of Management (MUM) www.mum.edu and Colorado College https://www.coloradocollege.edu
Both offer the 'Block System' where students take one class at a time for one month to go deeply into one subject at a time. I have worked and taught at MUM and this format has worked very successfully. It is an interesting innovation.
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Dr Charles Nicholson, New York Univ Magazine  Spring 2014
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Agree
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In the subgroup analysis of a meta-analysis no moderator variable is able to explain the high heterogeneity. Is it methodologically correct to proceed to an analysis of sensibility, drawing a study time on each comparison, until homogeneous subgroups?
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I think the answer depends more on other factors about the study itself, and what types of studies you are attempting to pool. Can the high degree of heterogeneity be explained clinically, rather than statistically? Are the outcomes similar between studies? is it just 1-2 studies responsible for the high degree of heterogeneity? How many studies are you pooling, and how many are 'out of line'? The answer to how you handle the analysis depends on these issues as well as others.
There is a possibility that a moderator variable is missing that does in fact explain the heterogeneity (ex. study quality, time of publication, population characteristics, etc) and it is also a possibility that even if you could collect all information on any possibile moderator variable that you will still be unable to statistically explain this heterogeneity.
I wasn't sure I understood the question about 'drawing a study time on each comparison until homogeneous subgroups'. However grouping studies based on similar effect sizes, rather than known characteristics about the study isn't something to consider. It might help you look at the individual studies to learn why they are different, but it is not the subgroup analysis you should be doing. If you are referring to a sensitivity analysis of removing a single study (or a couple studies) to create a homogeneous subgroup, again you should have a very good reason to do so - and not just to create a homogeneous sample.
A possible answer may be to simply report the pooled results using a random effects model and discuss the heterogeneity as a limitation. Real world data is rarely perfect. However if the degree of heterogeneity is really bad, then it could be an indicator of non-uniform study design, various types of publication bias, and so on.  
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I'd like to look at the original videos used in the Bell-Lysaker emotion recognition task, but I've been unable to find them anywhere, even though multiple research groups are using these materials. Could somebody tell me how best to obtain these videos? Thanks!
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Our eyes and ears are the two interfaces between us and the outside world. Whatever we observe and experience in daily life are collected as data and processed by our brain. The outcome of these processes in our brain is our thoughts, beliefs and actions.
This process is similar to that of a computer except that the ability of our brain, in
certain ways, is much more.
Since childhood, our brain is exposed to different observations and incidents. The data collected through teachings by family, society, school, religion and etc. has a direct effect in our present way of thinking and behavior. This data is stored in our memory and is running on the background. If somehow the brain receives a data which is corrupted (through observation of an unpleasant event or other means) the process of this data could have different outcomes depending on how the brain is trained (programmed) in earlier stages. Sometimes the outcome is very tragic.
To stop these kind of data from running in brain the use of medication is recommended by medical doctors. But how effective these medications are and how successfully they can repair the damages to the brain are the questions to be answered by experts.
In a computer system, when a corrupted file is recognized it is either removed by antivirus or manually if the location is known. However such options are not available for human brain yet.
So, as a scientist what can we do for the brains that are not trained or have not the capability of handling all different types of data (observations or events)?
A simple observation shows that listening to a favorite music can temporarily stop the execution of corrupted files in the brain. Therefore an interesting topic of research is "the effect of sound waves on the processes of human brain and how it can permanently remove the corrupted files from the memory".
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Hi Amir,
I think that importance of your study depends on how effective is remove or interrupt "corrupted programs" through sound waves, at least partially. Anyway, I hope this could be helpful for you...
And I agree with you: People do not realize how great could be engineering contribution to biology and medicine!
Best!