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There is a 49 year old patient who started exercising for the first time in her life. She said that she notices that her left half of the face does not sweat at all whereas the right half of the face sweats quite normally. She is unsure whether the same happens on the rest of her body. This symptom is not prominent enough for the others to have noticed it but she has not asked anyone else to specifically look for it. This is not causing her any problems but she is just concerned that this might be a symptom of an underlying problem. She also has a history of idiopathic trigeminal neuralgia 2 years back. She is also a pre-diabetic with well-controlled blood glucose levels. There are no associated symptoms. What do you think it could be? Diabetic autonomic neuropathy? Menopause? Normal variation? Subjective symptom she just noticed because she exercised for the first time in her life? Something else? Thanks in advance for your help!

I would like to get your opinions on a patient that I have recently received. The patient is a 49 year old female. She is a known case of essential tremors for the past 35 years (positive family history of tremors, MRI and CT from a few months back completely normal). In the past four months, she has started experiencing an exacerbation of her tremors, which has started interfering with her activities of daily living. The tremors were originally only in both of her hands, however in the past 4 months, they have involved the entire upper and lower limbs, the head, tongue, lips and she has started having voice tremors as well. Along with this, in the past 2 months she has developed intense proximal muscle weakness (can't stand after sitting, can't climb stairs). When her proximal muscles are supported, the tremors seem to improve considerably and almost become lessened to the condition she was in before the acute exacerbation 4 months. This probably points that her proximal muscle weakness is responsible for some of the exacerbation of the limb tremors but still doesn't explain the head, voice, tongue and lips tremors. She is also a diabetic with well-controlled blood glucose levels, including HbA1c levels and her thyroid function tests are normal. She was started on Propranolol and is currently taking it in doses of 120 mg/day with significant improvement in tremors but not complete resolution. The patient is worried about her continuously worsening whole body tremors and proximal muscle weakness. Her reflexes are normal and power is 4 minus in the limbs. What possible differential diagnoses would you consider and how would you investigate her initially? Could this possibly be a dietary deficiency (since the patient has been trying to lose weight with on and off diet plans for several years)? Would you recommend any immediate treatment steps?

WHat do you think is the correlation? It's impact? and the possible transmission route?

Neurologic Features in Severe SARS-CoV-2 Infection

DOI: 10.1056/NEJMc2008597

Today, I`ve seen a patient who has both MI and CVA at the same time! What are the possible pathophysiologic mechanisms?

what will we investigate?

Does anyone have experience fixing a cannula onto the skull of a 3-week old mouse pup? I have a general protocol for cannula placement, but are there special considerations for the young mouse skull and placement? Is growth a major concern for cannula placement?

Thanks!

What is considered the normal range (in mm Hg) for CSF opening pressure in a lumbar puncture? How serious is CSF opening pressure of 19 mm Hg?

Imagine you're going into a voice meeting with 50 different people, except every one of their voices sound similar, how hard would it be to have a productive meeting? Now imagine learning 50 different subjects from 50 different PDFs that all look similar. This last example, however, is our reality.

What specific structures in communication break down? Will a single sentence form from two people talking in succession? (SEE BELOW)

What would be the implications in terms of neurology, personal distress, memory formation, etc?

It is named after Schrödinger's cat in quantum mechanics - where the cat is considered both dead and alive. Just as the cat's state is unknown, so may be the context of communication within a Schrödinger's Meeting.

The Schrodinger's Meeting example highlights the importance of stimuli distinguishability in our everyday lives. Investigations into this, particularly regarding digital text comprehension, is the novel work of myself and my team. Environmental stimuli distinguishability as it pertains to cognitions for the general public is a massively underexplored area of neurology and information theory. We look forward to hearing other's opinions regarding the effects of a Schrodinger's Meeting.

We try to investigate the vagus nerve activity during exercise and after exercise.

General technique is to place a probe on vagus nerve, but this device is too expensive. So we want to know whether there are some indirect ways to investigate vagus nerve activity. Thanks a lot. 

When is general anaesthesia necessary? Is N2O effective and safe? And what about the Fentanyl Lollipop?

Stroke Research and Treatment

Special Issue on

Stroke in Developing Countries

Call for Papers

Stroke is a major health burden around the world, with general mean yearly rates of 120 per 100’000 inhabitants. It is commonly accepted that stroke is a disease of the elderly in developed countries, with a strong association with risk factors, such as hypertension, diabetes mellitus, cigarette smoking and increased cholesterol. Gender also bears an association, with male predominance, except in the youngest and eldest patients. However, epidemiological data suggest that stroke is also a major issue in emerging and developing countries, including in much younger patients, in association with similar or different risk factors.

We invite authors to submit original research and review articles addressing epidemiological, diagnostic issues, and management in developing countries around the world. This will allow gathering a series of data which will help to understand better this complex problem with critical impact on population health.

Potential topics may include, but without being limited to:

 Prevalence and incidence changes

 Stroke subtyping

 Political medical issues in specific countries

 Diagnostic facilities

 Acute phase therapy

 Stroke prevention strategy and implementation

 Rehabilitation after stroke

 Cultural aspects dealing with mood disorders after stroke

Before submission, authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/srt/guidelines. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:

Manuscript Due November 29, 2013 First Round of Reviews February 21, 2014 Publication Date April 18, 2014

Lead Guest Editor

Julien Bogousslavsky, GSMN Neurocenter, Switzerland; JBOGOUSSLAVSKY@cliniquevalmont.ch

Guest Editors

Bartlomjej Piechowski-Jozwiak, Imperial College London, UK; bpiechowski@gazeta.pl

Alexander Tsiskaridze, University of Tbilisi, Georgia; tsisk@gol.ge

Jacques Joubert, University of Notre Dame Australia, Melbourne, Australia; jacques.joubert@me.com

Abderramane Chahidi, Beni Mellal, Morocco; chahidi12@yahoo.fr

Jorge Moncayo, University of Quito, Ecuador; jmgaete@panchonet.net