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How or where through NIH can you get clozapine-n-oxide (CNO) for free (or at a reduced price)?

Question

Feb 2014

It was mentioned at the optogenetics and chemogenetics short course at SfN that it was possible to attain clozapine-n-oxide (CNO, the DREADD ligand) for free or at a reduced rate through NIH. Is it through BrIDGs at NCATS (http://www.ncats.nih.gov/research/reengineering/bridgs/bridgs.html)? I got the sense at SfN that the program was available for any/most researchers, not just preclinical researchers.

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What TH::Cre rat strain is the best for optogenetics or chemogenetics?

Question

Jan 2016

I am looking to order some TH::Cre rats for a optogenetic and chemogenetic experiment.

I found the Long Evans-Tg(TH-Cre)3.1Deis from RRRC and the Sprague Dawley-Th-Cre from Sage (Horizon), does anyone have any experience with the two? The price tag is quite different 150$ vs 450$.

http://www.rrrc.us/Strain/?x=616&log=yes

https://www.horizondiscovery.com/tyrosine-hydroxylase-th-cre-rat-tgra8400

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