It's a wanderful and helpful translational medicine research!
But nowadays, many studies found expouse after reactivation will gain more robust effect.
"Exposure therapy for patients was derived from early models of extinction learning, and is used widely for anxiety-related disorders. However, as initially suggested by Pavlov, extinction-based procedures do not seem to modify the original memory trace. Instead, they produce a new, separate inhibitory memory that is stored in parallel to the original memory, leaving the original
memory susceptible to the return of behaviour, as shown through the phenomena of spontaneous recovery, re -instatement, and renewal. "
"In 2009, Monfils and colleagues proposed the idea of combining the principles of reconsolidation and extinction to capitalise on their respective strengths. In this so-called retrieval-extinction paradigm, an isolated retrieval trial is presented; then after sufficient time has passed to allow the memory to destabilise, extinction training is introduced. As such, extinction training is thought to update the memory during the reconsolidation window, rather than creating a second memory trace that competes for expression."
Above two sentences was quoted from Marie H Monfils and Emily A Holmes-2018-Lancet Psychiatry- Memory boundaries: opening a window inspired by reconsolidation to treat anxiety, trauma-related, and addiction disorders.
So I want to know would you combine the memory reconsolidation paradigm in this project?