Zoltán Z Nagy's research while affiliated with Semmelweis University and other places

Publications (83)

Article
Full-text available
The aim of the study was to report a case of severe meibomian gland dysfunction (MGD) and conjunctival changes associated with trastuzumab, pertuzumab, and anastrozole therapy in a HER-2 positive breast cancer patient. A 57-year-old white woman was treated with trastuzumab and pertuzumab biological and anastrozole endocrine therapy for metastatic b...
Article
Full-text available
Összefoglaló. Bevezetés: A fejlett országok körében a hátsószegmens-betegségek számítanak a vakság és a gyengénlátás leggyakoribb okának az időskorú lakosság körében. Célkitűzés: Tanulmányunk célja a hátsószegmens-betegségek okozta látásromlás és vakság prevalenciájának meghatározása az 50 éves és annál idősebb korú lakosság körében Magyarországon....
Article
Background and purpose: The aim of our research was to create a scoring system that predicts prognosis and recommends therapeutic options for patients with metastatic spine tumor. Increasing oncological treatment opportunities and prolonged survival have led to a growing need to address clinical symptoms caused by meta-stases of the primary tumor....
Article
Full-text available
Összefoglaló. A varicella zoster vírus (VZV-) fertőzés típusos első megjelenése a bárányhimlő, később a reaktiváció során a herpes zoster. Szemészeti tünet az V/I-es agyideget érintő zoster esetén gyakori. A legrettegettebb szemészeti manifesztáció az akut retinanekrózis, mely fulmináns lefolyású, és súlyos szöveti destrukciót, valamint jelentős fu...
Article
Full-text available
The study aimed at a quantitative evaluation of macular vasculature after primary repair of rhegmatogenous retinal detachment (RRD) in correlation with the elapsed postoperative time. Optical coherence tomography angiography (OCT-A) was performed in 66 eyes of 33 patients in a retrospective case-control study: superficial and deep retinal vessel de...
Article
Full-text available
Purpose: In diabetic subjects, early visual functional alterations such as color vision deficiencies (CVDs) are known to precede clinically apparent diabetic retinopathy. Prominent photoreceptor outer segment degeneration and an increase in the number of retinal dual cones (co-expressing S- and M-opsins simultaneously) have been described in diabe...
Article
Full-text available
A case of a 13-year-old girl after being injured on the left eyeball by a stick from a cage, is presented. Along vitreous haemorrhage, retinal oedema and ischaemia, the disc was replaced by a cavity. Multimodal imaging was performed, which confirmed the optic nerve damage. The eye had no light perception anymore. Our case is a demonstration for com...
Article
Objective: Minimally invasive procedures in spine surgery have undergone significant development in recent times. A demand emerged from both surgeons and patients to develop and perform these types of surgeries in order to prevent biomechanical and surgical complications. Our study aimed to present early clinical results of a biportal endoscopy te...
Article
Background/aims The purpose of this study was to estimate the total healthcare cost associated with diabetic retinopathy (DR) in the population aged 18 years and older in Hungary, and its projection for the year 2045. Methods A cost model was developed based on the standardised rapid assessment of avoidable blindness with the diabetic retinopathy...
Article
Aim: To estimate the prevalence of blindness and visual impairment resulting from cataract in the population aged ≥50y in Hungary, and to assess the cataract surgical services. Methods: A rapid assessment of avoidable blindness (RAAB) was conducted. A total of 3523 eligible people were randomly selected and examined. Each participant underwent s...
Article
Full-text available
Treatment of neovascular age-related macular degeneration (nAMD) with VEGF can be performed with several posologies. The purpose of our cross-sectional study was to analyze retinal vessel density by quantitative OCT-angiography (OCT-A) and to compare treat-and-extend (T&E) and fixed treatment protocols to a control group with dry AMD. Altogether 48...
Article
Purpose: To evaluate and compare the mechanical resistance to tearing of the anterior lens capsule opening after staining with different concentrations of trypan blue in ex vivo porcine eyes. Setting: Semmelweis University, and Budapest University of Technology and Economics, Budapest, Hungary. Design: Experimental study. Methods: The study...
Article
Full-text available
Purpose Remote screening for retinopathy of prematurity by wide-field digital imaging and network telemedicine is increasingly used to prevent blindness without the unnecessary transport of infants. Our purpose was to train and license dedicated neonatal transport nurses to do this in Hungary. Materials and methods We developed a complex, four-ste...
Article
Objectives: Miyazaki syndrome is a cervical myelopathy or radiculopathy caused by cervical epidural venous congestion, due to cerebrospinal fluid over-drainage by an implanted ventricular shunt. The complex pathophysiology includes CSF pressure-changes consistent with the Monro-Kellie doctrine and a non-functional Starling resistor, leading to spi...
Article
Full-text available
Targeting genes to specific neuronal or glial cell types is valuable for both understanding and repairing brain circuits. Adeno-associated viruses (AAVs) are frequently used for gene delivery, but targeting expression to specific cell types is an unsolved problem. We created a library of 230 AAVs, each with a different synthetic promoter designed u...
Article
Purpose: To compare clinical outcomes between two trifocal intraocular lenses (IOLs): the new FineVision POD F GF trifocal IOL made of hydrophobic acrylic glistening-free material, and the FineVision POD F IOL made of hydrophilic acrylic material with 26% water uptake in patients undergoing routine cataract surgery using standard phacoemulsificati...
Article
Full-text available
Background: Despite the significant impact of retinal diseases such as wet age-related macular degeneration (wAMD) and diabetic macular edema (DME), there is a limited understanding of how these conditions are managed in Central and Eastern Europe (CEE). Objectives: To provide a comprehensive overview of the clinical and economic burden of wAMD...
Article
Full-text available
Purpose This study aimed to examine the effectiveness of CO 2 laser-assisted sclerectomy surgery (CLASS) in eyes with primary open-angle glaucoma (POAG) showing progression in spite of maximal local antiglaucomatous therapy. Materials and methods Patients with progressive POAG received CLASS treatment. We performed CLASS on 15 eyes (eight males an...
Article
Introduction:: The purpose of the study was to estimate the number of people with diabetes mellitus, the prevalence of diabetes mellitus and the prevalence of blindness and severe visual impairment among people with diabetes mellitus in Hungary based on our recent national representative survey. Methods:: Altogether 105 clusters of 35 people age...
Article
Purpose: To investigate the differences in biometry data of eyes with unilateral congenital cataract and the contralateral normal eyes in pediatric patients. Setting: Pediatric Ophthalmology Division, Ophthalmology Department, Semmelweis University in Budapest, Hungary. Design: Retrospective case series. Methods: Data of visually significant...
Article
Full-text available
Purpose: To compare the efficacy of perioperative treatment strategies, in addition to topical bromfenac 0.09% and dexamethasone 0.1%, to reduce the risk for developing cystoid macular edema (CME) after uneventful cataract surgery in diabetic patients. Setting: Twelve European study centers. Design: Randomized clinical trial. Methods: Diabet...
Article
Full-text available
Purpose: To describe a large cohort of femtosecond laser-assisted cataract surgeries in terms of baseline characteristics and the related outcomes. Setting: Eighteen cataract surgery clinics in 9 European countries and Australia. Design: Prospective multicenter case series. Methods: Data on consecutive eyes having femtosecond laser-assisted...
Article
Purpose: To evaluate the effect of tear supplementation with preservative free 0.15% zinc-hyaluronate on ocular surface sensations and corneal sensitivity in dry eye patients. Methods: Ocular surface sensations were assessed using the ocular surface disease index (OSDI) questionnaire and by recording ocular sensations during forced blinking in p...
Chapter
Ophthalmology always had a pioneer role in use of lasers (Light Amplification by Stimulated Emission of Radiation). A great variety of lasers have been employed since the first laser appeared within the ophthalmic armamentarium for more than 50 years. The German ophthalmologist Meyer-Schwickerath applied the first laser for photocoagulation in the...
Article
Background/aims The purpose of this study was to estimate the prevalence of diabetes mellitus (DM) and diabetic retinopathy (DR) in the population aged 50 years and older in Hungary, and to assess the coverage of diabetic eye care services. Methods In total, 105 clusters of 35 people aged 50 years or older were randomly selected. The standardised...
Article
Objective: The aim of the article was to analyze extracted patient data from the reported literature and highlight the best treatment option and survival outcome of osteoblastomas in the occipitocervical region. Methods: A systematic literature search method was used to select articles containing information about the demographic features, tumor...
Article
Syphilis is an infectious disease that can cause a wide variety of ocular signs. One of the rarest manifestations of ocular syphilis is acute syphilitic posterior placoid chorioretinitis (ASPPC). We report the case of an immunocompetent 38-year-old woman diagnosed with unilateral, atypical, acute syphilitic posterior placoid chorioretinitis. Fundos...
Article
Purpose: To report on the presence of 4 different structures visualized by confocal microscopy in patients whose clinical presentation suggested infection by Acanthamoeba. Methods: Data and charts of 28 consecutive patients were analyzed in a retrospective study. Four types of structures were recognized by confocal microscopy performed with HRT...
Article
Purpose: To describe the topographic and tomographic characteristics of normal fellow eyes of unilateral keratoconus cases and to evaluate the accuracy of machine learning classifiers in discriminating healthy corneas from the normal fellow corneas. Setting: Department of Ophthalmology, Semmelweis University, Budapest, Hungary. Design: Retrosp...
Article
Full-text available
Aims: To compare postoperative visual performance of a progressive-power diffractive-refractive multifocal and an accommodating intraocular lens in presbyopic patients. Patients and Methods: The OptiVis multifocal IOL (Aaren Scientific, Ontario, CA) (MF group) was implanted into 9 eyes of 5 patients and Crystalens AT-50AO (Bausch & Lomb, Rochester,...
Article
Full-text available
Célkitűzés: A Salzmann-féle noduláris degenerációról való ismereteink összefoglalása, beleértve a kórkép epidemiológiáját, etiológiáját, klinikumát, patolológiáját és kezelését. Módszer: A Salzmann-féle noduláris degenerációval kapcsolatos közlemények áttekintése a szerzők néhány saját esetének illusztrálásával , amelyek alapján a szerzők olyan öss...
Article
Full-text available
Femtosecond laser (FSL) cataract surgery is in its infancy but is rapidly gaining popularity due to the improved consistency and predictability for corneal incisions and anterior capsulorhexis. It enables subsequently less phacoemulsification energy and time to be employed, which has gains in terms of reduced corneal oedema. In addition, the FSL al...
Article
To report the surgical treatment of 3 eyes of 2 patients with bilateral anterior lenticonus due to Alport syndrome using femtosecond laser-assisted cataract surgery (FLACS). Two patients with Alport syndrome presented to our department due to anterior lenticonus in both eyes. We performed FLACS with posterior chamber lens implantation in both eyes...
Article
To evaluate and compare the mechanical properties of anterior capsule opening performed with femtosecond laser capsulotomy at different energy settings in ex vivo porcine anterior lens capsule specimens. Twenty-five fresh porcine eyes per group were included in the study. Femtosecond laser capsulotomy was performed with three different pulse energy...
Article
Purpose: To review the published literature describing the use of the LenSx femtosecond laser technology (Alcon Laboratories, Inc., Fort Worth, TX) in cataract surgery. Methods: Literature review. Results: The LenSx system has been used in more than 200,000 cataract surgery procedures to date. Pre-clinical evaluations have shown that this syst...
Article
Full-text available
Purpose To assess the correlation between keratoconus severity and intereye asymmetry of pachymetric data and posterior elevation values and to evaluate their combined accuracy in discriminating normal corneas from those with keratoconus. Methods This study included 97 patients: 65 subjects with bilateral normal corneas (NC) and 32 with keratoconu...
Article
Purpose: To evaluate and compare the mechanical properties of anterior capsule openings performed with the continuous curvilinear capsulorhexis (CCC) technique and femtosecond laser capsulotomy (FLC) in ex vivo porcine lens capsule specimens. Methods: Fresh porcine eyes were included in the study (CCC group, n = 50; FLC group, n = 30). The capsu...
Article
The mechanical behaviour of zonular fibres greatly affects the accommodation process in mammalian eyes. This paper introduces a detailed measurement procedure for the purpose of obtaining the force-displacement diagram necessary to evaluate the mechanical properties of porcine zonular fibres in situ. It is a complex technique, keeping the integrity...
Article
Purpose: To evaluate femtosecond laser-assisted and manual clear corneal incisions and their effect on surgically induced astigmatism (SIA) and corneal higher-order aberrations (HOAs). Methods: In a prospective randomized study, conventional phacoemulsification with a 2.8-mm clear corneal incision using a disposable keratome was performed in 20...
Article
Full-text available
Femtosecond lasers represent a new frontier in cataract surgery. Since their introduction and first human treatment in 2008, a lot of new developments have been achieved. In this review article, the physical principle of femtolasers is discussed, together with the indications and side effects of the method in cataract surgery. The most important cl...
Article
Full-text available
Purpose: To describe femtosecond laser cataract surgery and discuss the published peer-reviewed articles to have a fair evaluation of this new technology and its comparisons to conventional phacoemulsification surgery. Methods: The technology information released in this article comes from the key individuals in each of the U.S. Food and Drug Ad...
Article
To analyze complications of femtosecond lasers used for cataract surgery. Department of Ophthalmology Semmelweis University, Budapest, Hungary. Retrospective analysis. Intraoperative complications of the first 100 femtosecond laser-assisted (Alcon-Lensx, Inc.) cataract surgeries were collected. Possible complications of femtosecond capsulotomies an...
Article
The aim of this study was to evaluate the balance and changes of corneal higher order aberrations (HOAs) after photorefractive keratectomy (PRK). Myopic and myopic-astigmatic patients (89 eyes of 48 patients) were enrolled in this study. A PRK was performed using an Asclepion Meditec MEL 80 G flying-spot excimer laser. The mean ablation depth and d...
Chapter
Small incision cataract surgery performed using the latest generation of phacoemulsification technology and with implantation of a foldable IOL is highly successful in restoring good levels of best-corrected visual acuity with an acceptable safety profile. However, a comparison of the refractive predictability and complication rates of cataract sur...
Chapter
The development of femtosecond (FS) lasers in ophthalmology has been reviewed elsewhere (Chaps. 3 and 4). Their widespread application in corneal refractive surgery is one of the factors that led to an overall improvement in the clinical results of LASIK during the decade from 1995 to 2005, when rates of postoperative 20/20 UCVA increased from appr...
Article
Full-text available
Analysis of the femtosecond laser refractive lens surgery corneal incision configuration and corneal higher-order aberration (HOA) effect from the first postoperative day. High-resolution anterior segment optical coherence tomography was used to assess 20 eyes undergoing femtosecond laser refractive lens surgery with 2.2-mm minimal incision. The pr...
Article
In recent years femtosecond laser cataract surgery has been an accepted procedure in cataract surgery. In this book chapter the technical aspects of the femtosecond laser systems will be discussed. The most important indications and contraindications of femtolaser cataract surgery will be also described in details. Surgeons might encounter findings...
Article
To report the anterior segment imaging characteristics after femtosecond laser assisted cataract surgery. Cataract surgery was performed with the LenSx femtosecond laser (Alcon-LenSx Inc., Aliso Viejo, CA) in 40 eyes of 40 patients. The laser was programmed to perform a 4.5-mm capsulorhexis, a cross-pattern fragmentation of the nucleus, a 2.8-mm ma...
Article
To evaluate the long-term visual outcome and intraocular (IOL) position parameters with a single-optic accommodating IOL after 5.5- or 6.0-mm femtosecond laser capsulotomy. This prospective, randomized, pilot study comprised 17 eyes from 11 patients (7 men) with a mean age of 65.82±10.64 years (range: 51 to 79 years). All patients received a Crysta...
Article
To compare intraocular lens (IOL) power calculation and refractive outcome between patients who underwent laser refractive cataract surgery with a femtosecond laser and those with conventional cataract surgery. In this prospective study, 77 eyes from 77 patients underwent laser refractive cataract surgery (laser group; Alcon LenSx femtosecond laser...
Article
To evaluate and compare thickness changes in the retinal layers in the macula with optical coherence tomography (OCT) segmentation software after femtosecond laser-assisted phacoemulsification (study group) and conventional phacoemulsification (control group). Department of Ophthalmology, Semmelweis University, Budapest, Hungary. Case-control study...
Article
To compare the effect of conventional phacoemulsification and femtosecond laser-assisted cataract surgery on the cornea using Scheimpflug imaging and noncontact specular microscopy. In each group, 38 eyes (38 patients) underwent cataract surgery using either femtosecond laser-assisted (Alcon LenSx laser) (femtolaser group) or conventional phacoemul...
Article
To compare intraocular lens (IOL) decentration and tilt following a circular capsulotomy created with a femtosecond laser (laser CCC) to a manually performed continuous curvilinear capsulorrhexis (manual CCC). In a prospective, randomized study, a laser CCC (Alcon LenSx Inc) was performed in 20 eyes from 20 patients and a manual CCC was performed i...
Article
Having been very successful in corneal surgery, femtolasers were recently introduced into the surgery of crystalline lens. The most important indications and advantages include: perfectly centered and sized capsulotomy, liquefaction of softer lenses and fragmentation of harder lenses which allows for chopping the nucleus without the use of phaco en...
Article
To compare ocular and internal aberrations after femtosecond laser anterior capsulotomy and continuous curvilinear capsulorrhexis in cataract surgery. In this prospective study, anterior capsulotomy was performed during cataract surgery with an intraocular femtosecond (FS) laser (Alcon LenSx Inc) in 48 eyes. As a control group, continuous curviline...
Article
Full-text available
To compare the effect of conventional and femtosecond laser-assisted (Alcon LenSx Inc) phacoemulsification on the macula using optical coherence tomography (OCT). Twenty eyes of 20 patients underwent uneventful cataract surgery in both study groups: femtosecond laser-assisted (laser group) and conventional phacoemulsification (control group). Macul...
Article
Full-text available
To measure and compare sizing and positioning parameters of femtosecond laser capsulotomy with manual continuous curvilinear capsulorrhexis (CCC). Femtosecond capsulotomies (Alcon-LenSx Lasers Inc) and CCC were carried out in 20 eyes of 20 patients, respectively. Intraocular lens (IOL) decentration, circularity, vertical and horizontal diameters of...
Article
To measure corneal density and evaluate corneal haze in unoperated eyes and in eyes after photorefractive keratectomy (PRK). Forty-nine patients (91 eyes) who underwent PRK and 48 control patients (76 unoperated eyes) were measured with the densitometry program of the Pentacam Scheimpflug imaging system (Oculus Optikgeräte GmbH) (0=no clouding, 100...
Article
To evaluate ocular wavefront aberrations in keratoconus and describe their effect on visual quality. Department of Ophthalmology Semmelweis University, Budapest, Hungary. Case-control study. Ocular aberrations over a 4.5 mm pupil were measured with a Hartmann-Shack sensor in eyes with keratoconus or subclinical keratoconus or of refractive surgery...
Article
To explore the effects of corneal astigmatism and asphericity on posterior elevation values calculated by different reference bodies and to compare their predictive accuracy in the diagnosis of keratoconus. In this prospective observational case series, 44 eyes of 24 patients with keratoconus and 70 eyes of 41 refractive surgery candidates as a con...
Article
To compare anterior chamber parameters in normal eyes and eyes with mild to moderate keratoconus corneas using rotating Scheimpflug imaging and evaluate trends in corneal protrusion progression. Department of Ophthalmology, Semmelweis University, Budapest, Hungary. The anterior chamber depth (ACD) at the corneal center, thinnest point of the cornea...
Article
The human eye is a favored target for laser surgery due to its accessibility via the optically transparent ocular tissue. Femtosecond lasers with confined tissue effects and minimized collateral tissue damage are primary candidates for high precision intraocular surgery. The advent of compact diode-pumped femtosecond lasers, coupled with computer c...
Article
To evaluate femtosecond laser lens fragmentation and anterior capsulotomy in cataract surgery. Anterior capsulotomy and phacofragmentation procedures performed with an intraocular femtosecond laser (LenSx Lasers Inc) were initially evaluated in ex vivo porcine eyes. These procedures were then performed in an initial series of nine patients undergoi...
Article
To evaluate ocular wavefront aberrations owing to keratoconus compared with normal controls and to describe the changes in the axis of line of sight (LoS) among keratoconic patients. Prospective case-control study. Fifty-five eyes of 30 patients with keratoconus and 100 eyes of 50 refractive surgery candidates with normal corneas. Ocular aberration...
Article
The purpose of this study was to evaluate the alteration of keratometric, pachymetric, and elevation parameters of keratoconic and normal corneas with the Pentacam Scheimpflug camera. Pentacam measurements were performed on 41 eyes of 24 patients with keratoconus and 70 eyes of 41 normal subjects. In each eye, keratometric values, central and minim...
Article
To compare central corneal thickness measurements made using two different methods, optical coherence tomography (OCT) and ultrasound pachymetry, applied both in normal eyes and in eyes on which photorefractive keratectomy (PRK) had been performed. A second objective was to assess the intrasession variability of OCT measurements. In this prospectiv...