Zhuolong Wu’s research while affiliated with Shanghai Ocean University and other places

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Publications (4)


Toxic effects of exposure to Polymethyl methacrylate and polyvinyl chloride microplastics in Pacific oysters (Crassostrea gigas )
  • Article

February 2025

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23 Reads

Environmental Pollution

Chunmei Gao

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Zhuolong Wu

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Baogui Liang

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[...]

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In recent years, there has been widespread attention to the toxic effects of microplastics (MPs) on marine mollusks. Therefore, we acclimated and cultured Pacific oysters (Crassostrea gigas) in a 140-liter container, incorporating two types of MPs into their feed: polymethyl methacrylate (PMMA) and polyvinyl chloride (PVC). The concentration of MPs in the water was maintained at 300 μg/L, 600 μg/L, and 900 μg/L, to observe the resulting oxidative stress, DNA damage, and metabolic disorders within their bodies. Under the interference of these pollutants, notable changes were observed in the antioxidant enzyme activities of C. gigas. Specifically, after 30 days of exposure to high concentrations of PMMA, the activity of superoxide dismutase (SOD) in the adductor muscle of C. gigas decreased by 59% compared to the control group, while the activity of catalase (CAT) increased by 67%. In terms of DNA damage, the expression level of NF- κB in the high concentration PMMA group after 30 days reached the highest value in the experimental groups: 2.46. Additionally, enrichment was noted in amino acid and pyrimidine metabolism pathways within the hepatopancreas of the C. gigas. Uridine and methylmalonic acid exhibited low expression levels, whereas glutamic acid and asparagine displayed high expression levels. This study provides fundamental toxicological data to elucidate and quantify the impacts of PMMA and PVC MPs on marine mollusks.