Zhongqi Yang's research while affiliated with Guangzhou University of Chinese Medicine and other places

Publications (24)

Preprint
Background: Tongue diagnosis, as a practical diagnostic approach of traditional Chinese medicine (TCM), reflects physiological functions and pathological conditions in human body. Different features are observed in tongue images including tongue coating and tongue color between chronic heart failure (CHF) patients and healthy controls (HCs), which...
Article
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Nuanxinkang tablet (NXK), a Chinese herbal formula, can improve heart function and quality of life in patients with chronic heart failure (CHF). However, the mechanisms of action of NXK are not fully understood. In this study, we investigated the effects of NXK on inflammation in the CHF mouse model. This model was established by transverse aortic...
Article
New findings: What is the central question of this study? Does the AGEs-RAGE axis mediate myocardial fibrosis in heart failure? What is the main finding and its importance? The AGEs-RAGE axis is involved in the pathogenesis of myocardial fibrosis through CFs activation induced by autophagy in heart failure. Inhibiting AGEs-RAGE axis attenuates dys...
Article
Background Heart failure (HF) is a leading cause of death worldwide. Nuanxinkang (NXK) is an effective Chinese herbal formula used in treating HF, but its underlying potential mechanisms have not been fully elucidated. Purpose To explore the protective activities of NXK in ischemia/reperfusion (IR)-induced HF through modulating the ratio of proinf...
Article
Objective Sepsis is a leading cause of morbidity and mortality after surgery. We aimed to explore the role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sponging microRNA-26a-5p in sepsis-induced myocardial injury by regulating regulator of calcineurin 2 (Rcan2). Methods H9C2 cells were incubated w...
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Endothelial-to-mesenchymal transition (EndMT) has been shown to contribute to cardiac fibrosis and heart failure (HF). Recent studies have demonstrated that EndMT is regulated by autophagy, and we previously showed suppression of excessive autophagy and alleviation of cardiac fibrosis in HF mice with inactivated receptor for advanced glycation end...
Article
Ethnopharmacological relevance Xinyang tablet (XYT) has been traditionally used in the treatment of cardiovascular diseases (CVDs). Our previous study indicated that XYT exhibited protective effects in heart failure (HF). Aim of the study The aim of the present study was to determine the protective effects of XYT in pressure overload induced HF an...
Article
Accumulating evidence has revealed the mechanosensitive ion channel protein Piezo1 is contributing to tumorigenesis. However, its role in hepatocellular carcinoma (HCC) remains unexplored. In this study, we demonstrated that Piezo1 was expressed in the HepG2 cell line and depletion of Piezo1 impaired proliferation and migration, as well as increase...
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Background: Xinyin Tablet (XYT) has been widely used in the treatment of CHF, Which helping to improve the clinical symptoms, enhance exercise, and even may improve the long-term prognosis of patients. However, the exact effectiveness and safety of XYT for CHF has not be comprehensively researched, so we want to generalize the effectiveness and sa...
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Objectives Heart failure (HF) is a common and potentially fatal condition. In 2015, HF affected approximately 40 million people globally. Evidence showing that the use of nitrates can improve clinical outcomes in patients with HF is limited. This study aimed to assess the effect of nitrates on functional capacity and exercise time in patients with...
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Introduction Unstable angina (UA), referred to as acute coronary syndrome (ACS), causes unexpected chest pain. Xueshuantong injection (lyophilised) (XST) is a traditional Chinese herbal injection having the potential to treat ACS. However, no clinical trial has been performed in this field. This clinical trial aims to examine the efficacy and safet...
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Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a member of MAP3K family, is associated with aging, inflammation, oxidative stress, and related diseases, such as CHF. MLK3 has also been reported to play an important role in...
Article
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Patients with heart disease often suffer from ischemia, which can be treated by reperfusion. However, this treatment can lead to the development of ischemia/reperfusion (I/R) injury, an inflammatory condition that can cause further heart damage. Dexmedetomidine (Dex), an α2-adrenoceptor agonist, and the microRNA (miR)-17-3p, have both been suggeste...
Article
Heart failure (HF) is a complex pathology for which single-agent therapy cannot provide comprehensive efficacy. Therefore, effective combination therapies for HF are increasingly emphasized. Multiple-component drugs derived from Chinese herbal formulae provide efficacy and safety when administered to patients with HF. Nuanxinkang (NXK) is a simplif...
Data
Molecular weight markers to gel data and scans in Figure 1C.
Data
(a) PCR Genotyping of RAGE knockout mice. Bands of 380 and 301 bp are derived from the wild-type and knockout alleles, respectively. +/+, wild-type; -/-, homozygous RAGE knockout. (b) Western blot of WT and RAGE KO mice lung tissues using RAGE antibody.
Data
Molecular weight markers to gel data and scans in Figure 5A.
Data
Short axis B-mode of representative echo figure. Scale bars for time and dimensions are listed in lower panel.
Data
Molecular weight markers to gel data and scans in Figure 6A.
Article
Full-text available
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy. However, the role of RAGE in pressure overload-induced HF is not well understood. We found that stimulation of RAGE triggered the death of neonatal rat ventricula...
Article
Full-text available
Objective: Genetic components substantially contribute to the development of myocardial infarction (MI), and R353Q polymorphism (rs6046) in FVII gene has been suspected to be associated with the risk of MI. Methods: A meta-analysis was conducted on the links between R353Q polymorphism and the susceptibility of MI. A comprehensive literature sear...
Article
Full-text available
Situs inversus with dextrocardia is a rare condition, with complete transposition of all the body organs, including the heart. Percutaneous coronary intervention (PCI) in these patients is technically difficult because of the mirror image of organs. Here, we describe a 56-year-old man with coronary heart disease with known situs inversus with dextr...
Article
Ethnopharmacological relevance: Shenmai injection (SMI) is a traditional Chinese herbal medicine extracted from Panax ginseng (Panax ginseng C. A. Mey, steamed and dry) and Ophiopogon japonicus (Ophiopogon japonicus (L. f.) Ker-Gawl, root). It has been widely used for the treatment of chronic heart failure (CHF) in China. However, the evidence sup...
Article
Pressure overload has an important role in heart failure, inducing excessive autophagy in cardiac myocytes that is considered to be pathogenic. Resveratrol has been reported to improve cardiac dysfunction induced by pressure overload, but it has been unclear whether resveratrol ameliorates cardiac dysfunction by regulating autophagy. In this study,...

Citations

... The RAGE axis is involved in rheumatoid arthritis (192), systemic lupus erythematosus (193), amyotrophic lateral sclerosis (194), inflammatory bowel disease (195), depression (196) and other diseases. In addition, RAGE is involved in the fibrotic process in several organs, such as hepatic fibrosis (19), cardiac fibrosis (197), pulmonary fibrosis (198) and renal fibrosis (199) (Figure 2). ...
... MMP2 and MMP9 play an important role in degrading basement membranes, allowing neutrophil (PMN) migration and promoting inflammation [23,24]. In many diseases, MMP2, MMP9, and pyroptosis indicators change in parallel, but it is unclear how they are related to each other [25][26][27][28]. However, whether an association exists between them in LIRI has rarely been studied. ...
... Recent studies have suggested that Piezo1 is involved in regulating many of diseases, including the infectious inflammation and cancer (Nguetse et al., 2020;Choi et al., 2019;Nonomura et al., 2018;Chang et al., 2019;Xie et al., 2022;Kuriyama et al., 2022;O'Callaghan et al., 2022;Liu et al., 2021). Piezo1 modulates macrophage polarization and stiffness sensing, which are related to calcium influx and the promotion of macrophage activation by actin (Atcha et al., 2021). ...
... Using an HF and thrombosis model of zebrafish, Miao Y et al. [66] found that dammarane-type triterpenoids extracted from Rhus Chinensis root improved the cardiac output and heart rate, suppressed inappropriate heart dilatation and excessive venous congestion, preventing thrombosis formation. In a systematic review and meta-analysis, Qingqing L et al. [67] found that the empirical formula of Chinese medicine, Xinyin tablet, consisting of Ginseng, Astragalus, Ophiopogon japonicas, Schisandra, Motherwort, Lex pubescens, and Lepidii semen, improved heart function, myocardial fibrosis, and ventricular remodeling by reducing autophagy and myocardial apoptosis by the regulation of the Akt/AMPK-mTOR signaling pathway and lowering of the serum levels of TNF-α, interleukin-6, endothelin-1, Ang II, and aldosterone. Using a DOX-induced chronic HF Wistar rat model, Fangzhou C et al. [68] showed that the ethanol extract of Crataegus pinnatifida Bunge improved heart function by reducing inflammatory response and oxidative stress via down-regulation of mRNA expression of IL-1β and TNF-α and up-regulation of the mRNA expression of GSH-PX-1 and catalase. ...
... CHF is the final stage of all cardiovascular diseases (CVDs) (Kurlianskaya et al., 2020), and a common and potentially fatal disease. The signs and symptoms of CHF include shortness of breath, excessive fatigue, swelling of the legs (Tendera, 2005), and decreased exercise tolerance, which reduce the ability to engage in normal daily life activities (Long et al., 2020b). In most industrialized countries, the number of CHF patients has been rapidly increasing due to population aging and longer survival after acute myocardial infarction (McMurray and Stewart, 2002). ...
... [46] Heart Oxidative damage MLK3-JNK/p53 pathway-mediated oxidative stress and ferroptosis cause myocardial fibrosis. [111] Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling. [113] Elabela antagonizes ferroptosis by regulating the IL-6/STAT3/GPX4 signaling pathway to prevent adverse myocardial remodeling. ...
... Dexmedetomidine (DEX) is a highly selective α2-adrenergic receptor agonist, which protects against H/R damage and lessens the percentage of apoptotic cells [42]. Reports have claimed that DEX has strong anti-inflammatory properties and is able to reduce I/R-induced cardiomyocyte injury by suppressing inflammatory signaling [43]. Additionally, DEX prevents H/R-induced myocardial injury by improving oxidative stress and apoptosis [33]. ...
... It is composed of Radix ginseng Rubra (Hong Shen) and llex pubescens (Mao DongQing). Our preclinical study showed that NXK has an anti-apoptotic effect against CHF, which is mediated by the AKT signaling pathway (Chen et al., 2019). Another study showed that combination therapy with NXK and basic CHF treatment effectively improved cardiac function in CHF patients compared to basic CHF treatment alone. ...
... Ген, отвечающий за фактор свертывания крови VII, находится на хромосоме 13q34 [13]. Сообщалось о противоречивой связи между полиморфизмами гена фактора свертывания крови VII и ИБС в различных популяциях [14]. Rs6046 F7 был связан с распространенностью ишемического инсульта в популяционном эпидемиологическом генетическом исследовании Olson NC, et al. [15]. ...
... BNIP3/NIX is significantly increased after receiving TAC [126]. Knockout of the RAGE prevented the upregulation of BNIP3 in TAC mice and improved TAC-induced cardiac dysfunction [127]. Another study showed that raloxifene is a novel IL-6 inhibitor that can inhibit IL-6-induced BNIP3 elevation as well as cardiac dysfunction and remodelling caused by pressure overload [128]. ...