Zheng Zhou's research while affiliated with Guangzhou University of Chinese Medicine and other places

Publications (12)

Article
New findings: What is the central question of this study? Does the AGEs-RAGE axis mediate myocardial fibrosis in heart failure? What is the main finding and its importance? The AGEs-RAGE axis is involved in the pathogenesis of myocardial fibrosis through CFs activation induced by autophagy in heart failure. Inhibiting AGEs-RAGE axis attenuates dys...
Article
Aims The goal of our study was to investigate the heterogeneity of cardiac macrophages (CMφs) in mice with transverse aortic constriction (TAC) via single-cell sequencing and identify a subset of macrophages associated with heart injury. Methods and results We selected all CMφs from CD45+ cells using single-cell mRNA sequencing data. Through dimen...
Article
Full-text available
Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a member of MAP3K family, is associated with aging, inflammation, oxidative stress, and related diseases, such as CHF. MLK3 has also been reported to play an important role in...
Article
Full-text available
In this study, we screened potential natural compounds for the treatment of myocardial infarction (MI) and explored the underlying mechanisms. We built three machine learning models to screen the potential compounds. qPCR, flow cytometry, immunohistochemistry, and immunofluorescence analyses were applied to analyze the pharmacological effects of th...
Article
Heart failure (HF) is a complex pathology for which single-agent therapy cannot provide comprehensive efficacy. Therefore, effective combination therapies for HF are increasingly emphasized. Multiple-component drugs derived from Chinese herbal formulae provide efficacy and safety when administered to patients with HF. Nuanxinkang (NXK) is a simplif...
Article
Full-text available
We present the case of a 28 year old patient with an incomplete tear of the tunica albuginea occurred after having sexual intercourse in the female superior position. The diagnostic assessment was performed first clinically, then with CT, owing to its high resolution, allowed to exactly detect the tear location leading to precise preoperative plann...
Data
(a) PCR Genotyping of RAGE knockout mice. Bands of 380 and 301 bp are derived from the wild-type and knockout alleles, respectively. +/+, wild-type; -/-, homozygous RAGE knockout. (b) Western blot of WT and RAGE KO mice lung tissues using RAGE antibody.
Data
Molecular weight markers to gel data and scans in Figure 5A.
Data
Molecular weight markers to gel data and scans in Figure 1C.
Data
Molecular weight markers to gel data and scans in Figure 6A.
Data
Short axis B-mode of representative echo figure. Scale bars for time and dimensions are listed in lower panel.
Article
Full-text available
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy. However, the role of RAGE in pressure overload-induced HF is not well understood. We found that stimulation of RAGE triggered the death of neonatal rat ventricula...

Citations

... Only a small fraction of these alterations can be used to explain the pathogenesis and progression of MI. Single-cell sequencing (SCS) technology is a new technology for the high-throughput sequencing analysis of genome, transcriptome, and epigenome at the single-cell level, and it also plays an important role in the diagnosis and treatment of cardiovascular diseases (6,7). Machine learning plays an important role in screening for hub genes in gene chips. ...
... [46] Heart Oxidative damage MLK3-JNK/p53 pathway-mediated oxidative stress and ferroptosis cause myocardial fibrosis. [111] Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling. [113] Elabela antagonizes ferroptosis by regulating the IL-6/STAT3/GPX4 signaling pathway to prevent adverse myocardial remodeling. ...
... Arctigenin is a lignan derived from A. lappa, shown to have anti-inflammatory and cardioprotective effects (28,98). Yang et al. (28) have evaluated the antiarrhythmic and antioxidant effects of ATG in a rat model of I/R injury. ...
... It is composed of Radix ginseng Rubra (Hong Shen) and llex pubescens (Mao DongQing). Our preclinical study showed that NXK has an anti-apoptotic effect against CHF, which is mediated by the AKT signaling pathway (Chen et al., 2019). Another study showed that combination therapy with NXK and basic CHF treatment effectively improved cardiac function in CHF patients compared to basic CHF treatment alone. ...
... Among these positions, the doggy style position and the position where the woman is on top are the most often described cases [14,[20][21][22]. However, other positions can result in penile fractures as well. ...
... BNIP3/NIX is significantly increased after receiving TAC [126]. Knockout of the RAGE prevented the upregulation of BNIP3 in TAC mice and improved TAC-induced cardiac dysfunction [127]. Another study showed that raloxifene is a novel IL-6 inhibitor that can inhibit IL-6-induced BNIP3 elevation as well as cardiac dysfunction and remodelling caused by pressure overload [128]. ...