Zhen Zhang's research while affiliated with Dalian Medical University and other places

Publications (8)

Article
Objective This present study aims to assess the effect of pirfenidone (PFD) on inhibiting fibroblast proliferation, migration or adhesion in vitro and reducing laminectomy-induced epidural fibrosis in vivo. Methods The effect of PFD on proliferation inhibition was evaluated with flow cytometry, CCK-8, EdU and western-blotting assays. Altered prope...
Article
Post-surgery arthrofibrosis is one of the most restrictive factors in the development of intra-articular surgery and has presented tremendous obstacles for most orthopaedic surgeons. Tanshinone IIA (Tan IIA), a key active ingredient of Den-shen, has been used to treat fibrosis-related diseases, such as pulmonary, hepatic and myocardial fibrosis. In...
Article
Full-text available
Purpose Femoral neck fractures are still unsolved problems nowadays; sliding hip screw (SHS) and cannulated compression screw (CCS) are the most commonly used devices. We evaluated the clinical outcomes and complications in the treatment of femoral neck fractures between SHS and CCS in this meta-analysis to find which is better. Methods We searche...
Article
Aim: To compare the efficacy of 3D printing-assisted surgery with routine surgery in the treatment of distal radius fractures to evaluate whether 3D printing technology has more advantages. Materials & methods: To retrieve all published studies that compared the efficacy of 3D printing-assisted surgery with routine surgery for distal radius fractur...
Article
Objective: To investigate the effects of everolimus (EVE) on postoperative fibrosis in the knee joint and the potentially relevant signaling pathways. Methods: CCK-8 and flow cytometry assays were used to detect the effect of EVE on human fibroblast viability and apoptosis induction. IF and TEM were used to assess fibroblast autophagy. 3-methyla...
Article
Wear debris-induced osteolysis is one of the major reasons for subsequent aseptic loosening after cementless hip arthroplasty. Increasing evidence suggests that receptor activator of nuclear factor kappa-B (NF-κB) ligand-mediated osteoclastogenesis and osteolysis are responsible for wear debris-induced aseptic loosening. In the present study, we ex...
Article
Aseptic periprosthetic osteolysis is a complication induced by wear particles after hip joint replacement, which shortens the service life of prostheses. Although many methods have been applied to prevent this complication, the results were not always successful. In the present study, we explored the prophylactic effect of notoginsenoside R1 (NG-R1...
Article
Aseptic prosthetic loosening is a major complication after hip joint replacement. Wear particle-induced periprosthetic osteolysis plays a key role in aseptic prosthetic loosening. Attempting to modulate receptor activator of nuclear factor-κB (RANKL) mediated signaling pathways is a promising strategy to prevent aseptic prosthetic loosening. In the...

Citations

... Fibrosis is a progressive disease with excessive deposition of extracellular matrix (ECM) composed of fibrillar collagens, EDTA-fibronectin and SMA-stress fiber [27,[36][37][38][39]. Sustained fibroblast proliferation, activation and migration, generally identified as wound healing response, continually happen after tissue injury [40,41]. Healing by epidural fibrosis instead of regeneration may place burden on spinal cord and nerve root after spinal surgery [42]. ...
... Cryptotanshinone inhibited the expression of cyclin D1, and the phosphorylation of Rb in human rhabdomyosarcoma Rh30 cells induced cell cycle arrest at the G0/G1 phase [28]. In addition, previous studies [21,22,29] also showed that tanshinones could inhibit cell migration [30] through a wide range of signaling pathways, i.e., the HIF-1α-EMT pathway [31], STAT3-CCL2-EMT [32], PI3K/AKT signaling [33], and the PI3K and AMPK-mTOR signaling pathway [34]. However, little is still known about the roles and mechanisms of tanshinones, including dihydrotanshinone I in the regulation of cell adhesion and cell migration [33,[35][36][37][38][39]. ...
... This seems reasonable, as the most recently published meta-analysis revealed no differences in overall reoperation rates between the two screw types. There were fewer cases of avascular necrosis when FNF was treated with CCS compared to SHS, particularly in displaced FNF, but CCS was removed more frequently than SHS [9]. The meta-analysis results were heavily weighted toward the largest of the randomized controlled trials (FAITH trial), which included 1,108 patients [10]. ...
... Personalized humerus reconstruction assisted by 3D printing based on radiographic projections using CT data is conducive to an intuitive understanding of fracture types and displacement directions [30]. Then, surgeons select optimal approaches and simulate procedures to reduce operation time with less bleeding and the frequency of use of fluoroscopies [31,32]. Our study demonstrated that 3D printingassisted surgery outperformed conventional operations in these aspects. ...
... RAD001 engages in the regulation of the PI3K/ AKT/mTOR pathway [68][69][70]. Next, we investigated the relationship between RAD001 and RTactivated PI3K/AKT/mTOR pathway by adding RAD001 after RT. The results revealed that treatment of RAD001 diminished the expression levels of PI3K, p-AKT, p-mTOR, p-S6K1, and p62, and elevated the LC3-II/LC3-I ratio and amount of acidic autophagic vesicles in CC cells. ...
... Bisphosphonates are generally recommended for the treatment of osteolysis related bone diseases, which are targeting osteoclast by promoting osteoclast apoptosis and hindering bone resorption. Furthermore, numerous compounds such as amentoflavone [21], anthocyanin [22], enalapril [23], geraniin [24], resveratrol [25], hydrogen sulfide [26], melatonin [27], notoginsenoside R1 [28], and others have been showed their potential in mouse calvarial model. In recent, [29] reported that chitosan-derived carbon dots suppress osteolysis and lipopolysaccharide-induced calvarial bone destruction in mice. ...
... Osteoporosis mainly affects the elderly population and postmenopausal women that 4-6% of people over 50 years in Europe and the United States suffer from osteoporosis, while in Asia, the affected population is more than 15% [2,3]. Remarkably, it has been reported that the prevalence of osteoporosis-related fractures is increasing rapidly with advanced age, from 4% (women aged [50][51][52][53][54][55][56][57][58][59] to 52% (women aged over 80) [4]. In the context of the aging population, osteoporosis will become one of the major public health concerns and thus lead to a considerable economic cost in the foreseeable future. ...
... Scutellarin seems as a safe, effective, and low-cost traditional Chinese medicine, which has a variety of biological activities, such as dilating microvessels, reducing blood viscosity, increasing cerebral blood flow, improving microcirculation, improving lipid metabolism, anti-inflammation, antiapoptosis, antioxidation, and antiallergy [1][2][3]. Recent studies have shown that scutellarin could treat osteoporosis by upregulating BMP2 transcriptional activity and mRNA expression level to induce osteogenic differentiation via activating the BMP pathway and by inhibiting osteoclast differentiation by negatively regulating RANKL-mediated MAPKs and NF-κB signaling pathway [4]. Another study proved that scutellarin could promote the proliferation and differentiation of human osteoblasts in a short time. ...