June 2025
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3 Reads
iScience
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June 2025
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3 Reads
iScience
June 2025
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3 Reads
Journal of Water Process Engineering
May 2025
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23 Reads
The employment of Low Impact Development (LID) facilities is an effective means to alleviate urban flood in the context of climate change and urbanization. Existing methods for evaluating the hydrological reduction and control effect of LID facilities are mostly based on hydrological models, which have inherent shortages in accurate flood process simulation. In this study, a fully‐distributed bidirectional‐coupled hydrodynamic model based on the Finite Volume Coastal Ocean Model (FVCOM) and a one‐dimensional drainage pipe model is used to evaluate the effectiveness of LID facilities combining the Coevolutionary Constrained Multi‐objective Optimization (CCMO) algorithm. The proposed method is applied to investigate the responses of LID facilities effectiveness in hydrological reduction and control to rainfall patterns in the Yuelai New City, Chongqing, China. Results show that the overflow volume and peak overflow under unimodal rainfall are larger than those under other rainfall patterns. The time lag between initial and peak overflow under unimodal rainfall is the shortest, and it is shorter under small rainfall return period. The flood reduction and delay effect of LID facilities under unimodal rainfall is lower than that under bimodal rainfall, and it is the best under uniform rainfall. At low costs, the peak flood reduction effect of combined LID facilities may be lower than that of a single LID facility with strong permeability, but as costs continue to increase, combined LID facilities show its superiority. The proposed optimization‐simulation method is of great significance for environmental managers to seek best solutions in urban flood control.
May 2025
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6 Reads
Journal of Hazardous Materials
May 2025
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3 Reads
Separation and Purification Technology
April 2025
Cell Death and Disease
Malignant glioma is the most common primary malignant tumor of the brain in adults, with glioblastoma (GBM) being the most aggressive subtype. Mesenchymal stem/stromal cells (MSCs) have been shown to fuse with tumor cells in various cancers including glioma, thereby regulating tumor progression. However, there has been no systematic research on the fusion of glioma-associated MSCs (GA-MSCs) with glioma cells. Here, it is shown that GA-MSCs are able to spontaneously fuse with glioma cells both in vitro and in vivo. The hybrid cells display significantly lower levels of N6-methyladenosine (m ⁶ A) modification and can modulate the glioma microenvironment by attracting and inducing M2-like polarization of macrophages. Mechanistically, the demethylase fat mass and obesity-associated protein (FTO) mediates demethylation in hybrids and promotes macrophage colony-stimulating factor (CSF1) secretion by increasing its RNA stability in an m ⁶ A-YTH domain family 2 (YTHDF2)-dependent manner. Our study reveals a novel crosstalk mechanism between glioma cells, GA-MSCs, and macrophages in glioma microenvironment, offering potential new approaches for glioma therapy.
April 2025
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16 Reads
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1 Citation
Molecular Diversity
Farnesoid X receptor (FXR) is a key regulator of bile acid, lipid, and glucose homeostasis, making it a promising target for treating metabolic diseases. FXR antagonists have shown therapeutic potential in cholestasis, metabolic disorders, and certain cancers, while clinically approved FXR antagonists remain unavailable and underrepresented in current treatment strategies. To address this, we developed deep learning models for predicting FXR antagonistic activity (ANTCL) and toxicity (TOXCL). Screening 217,345 compounds from the HMDB database identified eleven human metabolite candidates with significant FXR binding potential. Molecular dynamics simulations and binding free energy calculations revealed five more stable complexes compared to the reference compound Gly-MCA, with HMDB0253354 (Fulvestrant) and HMDB0242367 (ZM 189154) standing out for their binding free energies. Hydrophobic interactions, particularly involving residues MET328, PHE329, and ALA291, contributed to their stability. These results demonstrate the effectiveness of deep learning in FXR antagonist discovery and highlight the potential of HMDB0253354 and HMDB0242367 as promising candidates for metabolic disease treatment. Graphical abstract Developed deep learning models for predicting FXR antagonism and toxicity, screening 11 human metabolites with significant FXR binding potential.
April 2025
Journal of Water Process Engineering
April 2025
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2 Reads
iScience
Glioma-associated mesenchymal stem cells (GA-MSCs), as a critical component of the glioma microenvironment, play an essential role in the development and invasion of glioma. Recent studies have shown that GA-MSCs can differentiate into pericytes under certain conditions, thereby promoting angiogenesis. However, the biological properties and molecular mechanisms underlying this process remain poorly understood. In the glioma microenvironment, our data revealed that the upregulation of Phosducin-like 3 (PDCL3) in GA-MSCs influences the expression of the downstream Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) and pericyte markers, indicating a transformational relationship between GA-MSCs and pericytes. Furthermore, the vascular mimicry ability of co-cultured GA-MSCs and Human Umbilical Vein Endothelial Cells (HUVECs) is also significantly affected. Glioma induces the upregulation of PDCL3 expression in GA-MSCs, facilitating their transformation of GA-MSCs into pericytes and promoting tumor angiogenesis. These findings suggest that PDCL3 in GA-MSCs could serve as a potential target for anti-angiogenesis therapy in glioma.
March 2025
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10 Reads
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2 Citations
Process Safety and Environmental Protection
... Anthraquinones exhibit π-π stacking and a variety of molecular states in extraction solutions due to their π-π conjugated system, planar structure, and strong van der Waals interaction between molecules [24][25][26]. It is unidentified how ultrasonic power, solute concentration, and pH affect π-π stacking in ethanol solution, despite the fact that nanofiltration concentration can improve π-π stacking. ...
February 2025
Journal of Hazardous Materials
... Ofloxacin (OFL), a third-generation fluoroquinolone antibiotic, is extensively used to treat Gram-negative bacterial infections in the respiratory, genitourinary, and dermal systems due to its broad-spectrum antimicrobial activity and high bioavailability [4]. However, the fluorine atoms in its molecular structure enhance chemical stability, resulting in poor biodegradability, high environmental persistence, significant bioaccumulation potential, and ecological toxicity [5]. The mass production and improper disposal of OFL have led to widespread environmental contamination, with detected concentrations ranging from 0.5 ng/L to 30 mg/L in surface water, groundwater, and medical wastewater worldwide [6,7]. ...
February 2025
Chemical Engineering Journal
... Penggunaan simulasi AI didalam arsitektur melibatkan berbagai teknologi, termasuk machine learning seperti algoritma genetik dan reinforcement learning, dimanfaatkan untuk meningkatkan pencahayaan alami, sistem ventilasi, serta insulasi termal pada bangunan, sehingga berdampak pada penurunan penggunaan energi (Saket Maheshwari & Manya Agrawal, 2024). Beberapa model AI yang banyak digunakan dalam simulasi ini meliputi Generative Adversarial Networks (GAN) diterapkan dalam desain arsitektur untuk menyempurnakan alur kerja dengan menciptakan data desain baru melalui proses pelatihan yang bersifat kontradiktif, sehingga mendorong peningkatan dalam proses kreatif (Li et al., 2024). Algoritma ini seperti proses seleksi alam, memungkinkan eksplorasi yang efektif dalam ruang desain yang rumit, suatu hal yang sangat krusial dalam perancangan Teknik (Zou et al., 2024 (Gammal, 2024) Desain generatif yang menggunakan AI dalam BIM tidak hanya membuat proses desain lebih cepat, tetapi juga mendukung pembangunan ramah lingkungan. ...
December 2024
... These foreign scholars have deeply explored the "sustainable" potential of HBIM at the technical level, such as remote access to databases, the establishment of cross-cycle management platforms, the display of interactive icons, and the continuous detection and analysis of heritage structures. Zhang Yunan discussed and pointed out this issue in the article "Domestic HBIM Management Platform and Its Followup Business Expansion" [92], and Zhiwei Zhou also addressed it in the article "Driving Sustainable Cultural Heritage Tourism in China through Heritage Building Information Modeling" [93]. ...
September 2024
... Reprinted from Shengwei et al., Controlling magnetism in 2D CrI3 by electrostatic doping, Nature Nanotechnology 13 (7), 549-553 (2018), with permission from Springer Nature. [185] e) The sample magnetization in bilayer CrI 3 varies with the electric field under external magnetic fields of +0.44T [186] reversible electrical switching between AF and FM states at significantly lower external magnetic fields. [186] Further, (Figure 8i-m,) a colossal and electrically tunable exchange bias (EB) effect in a CrI 3 homotrilayer on a ferroelectric Y-doped HfO 2 (HYO) substrate, achieving a record-high EB field modulation of 0.48 T (ranging from −0.15 T to +0.33 T). ...
September 2024
... The compound that was consistently obtained in the distillation process with various treatments both control and PEF was Benzenethanol (CAS) or phenyl ethyl alcohol. It is a marker in rose essential oil that produces a distinctive aroma of rose flowers in the essential oil produced [38]. One of the largest hydrocarbon compounds in rose essential oil that plays a role in determining the physical characteristics of essential oils is the stearoptenes group, including 1-nonadecene, nanodecene, and octadecene. ...
September 2024
Journal of Food Composition and Analysis
... Despite great efforts to achieve lead optimization, the failure rate of drug development remains very high (~90%) [5,6]. However, overemphasis on drug exposure in plasma and overlooking drug distribution in disease-targeted tissue/normal tissues may mislead the selection of drug candidates for clinical trials [6][7][8][9][10]. ...
September 2024
iScience
... Post-traumatic stress disorder (PTSD) and postpartum depression (PPD) represent critical but often overlooked factors in maternal mortality and morbidity (Liu et al., 2021;Shaik et al., 2023). Although the United Nations Sustainable Development Goals (SDGs) highlight the importance of maternal health, there remains a deficiency in specific interventions that focus on the healing environment within maternal wards, especially in lowresource contexts (Feng et al., 2024;Zuber, et al., 2018;Soman et al., 2024). The existing literature on the impact of healing environments in alleviating maternal psychological distress, especially in developing nations, is quite sparse. ...
August 2024
... In this work we discuss how blockchain may be used to improve the construction waste management process to meet sustainability objectives. In addition, Liu et al. (2024) argue that smart city technology integration with the innovation of business models is a new technology that would facilitate the city infrastructure and Communications on Applied Nonlinear Analysis ISSN: 1074-133X Vol 32 No. 8s (2025) https://internationalpubls.com resource management processes by proposing a new business model using blockchain. ...
June 2024
... A high-fidelity BIM generation of a city level can take years [47]. ...
June 2024