Zeyuan Deng’s research while affiliated with Nanchang University and other places

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Publications (133)


Figure 6. HPLC of bioaccessibility of curcumin (A). Curcumin content in stomach contents of mice (B). Curcumin content in small intestine of mice (C). Curcumin content in rectum of mice (D). Curcumin content in mouse ileum (E). Curcumin content in mouse feces (F). Different lowercase letters and * denotes statistically significant differences * p < 0.05; ** p < 0.01; *** p < 0.001.
First-order kinetic model parameters and half-life of TG-MLP-stabilized Pickering emul- sion under UV, dark, and visible light storage induced by curcumin degradation under different ionic strengths.
First-order kinetic model parameters and half-life of TG-MLP-stabilized Pickering emul- sion under UV, dark, and visible light storage induced by curcumin degradation under different pH conditions.
Enhanced Bioaccessibility and Antioxidant Activity of Curcumin from Transglutaminase Cross-Linked Mulberry Leaf Protein-Stabilized High-Internal-Phase Pickering Emulsion: In Vivo and In Vitro Studies
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  • Full-text available

December 2024

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6 Reads

Foods

Yingshan Xie

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Zeyuan Deng

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The objective of this study was to formulate Pickering emulsions stabilized by transglutaminase cross-linked mulberry leaf protein (TG-MLP) nanoparticles as a delivery system for curcumin (Cur) and to assess its bioaccessibility both in vivo and in vitro. The encapsulation efficiency of curcumin in high-internal-phase Pickering emulsions (HIPEs) prepared at pH 10 with a 20 mg/mL concentration of TG-MLP reached 93%. Compared to Oil-Cur, Cur-HIPEs exhibited superior antioxidant activity. Furthermore, Cur-HIPEs demonstrated enhanced stability against ultraviolet irradiation, storage under dark and visible light, and heating, in contrast to Oil-Cur. Among the various conditions tested, HIPEs stabilized by TG-MLP nanoparticles at an ionic strength of 1000 mM offered the most effective protection for curcumin. Moreover, TG-MLP nanoparticles at pH 8 provided better stability for the formulated HIPEs compared to those at pH 6 and 10. During simulated gastrointestinal digestion, the bioaccessibility of curcumin in Cur-HIPEs was significantly increased to 30.1% compared to Oil-Cur. In murine studies, higher levels of curcumin were detected in the stomach, small intestine, rectum, ileum, and feces following administration of Cur-HIPEs, indicating improved protection, absorption, and potential biological activity during digestion. Consequently, HIPEs offer excellent protection and delivery for curcumin during digestion.

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Preparation and characterization of a new food‐grade Pickering emulsion stabilized by mulberry‐leaf protein nanoparticles

September 2024

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30 Reads

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1 Citation

BACKGROUND Food‐grade Pickering particles, particularly plant proteins, have attracted significant interest due to their bio‐based nature, environmental friendliness, and edibility. Mulberry‐leaf protein (MLP) is a high‐quality protein with rich nutritional value and important functional properties. It has special amphoteric and emulsifying characteristics, making it valuable for use in Pickering emulsions. This study aimed to investigate the feasibility of using MLP nanoparticles as solid particles to stabilize Pickering emulsions. RESULTS The particle size of MLP nanoparticles was less than 300 nm under neutral and alkaline conditions. At pH 9, the zeta potential value reached −34.3 mV, indicating the electrostatic stability of the particles. As ion concentration increased, the particle size of MLP nanoparticles increased, and the zeta potential decreased. Throughout the storage process, no obvious aggregation or precipitation was observed in the dispersion of MLP nanoparticles, indicating strong stability. The particle size of the Pickering emulsion decreased with the increase in protein concentration. When the protein concentration was low, the particles on the oil–water interface became sparse, resulting in poor stability of the prepared emulsion and making it susceptible to aggregation and thus larger particle sizes. Increasing the oil‐phase ratio to 70% (v/v) promotes the formation of Pickering emulsions, which exhibit exceptional stability when MLP nanoparticles are fixed at a concentration of 20 mg mL⁻¹. CONCLUSION The overall findings indicated that MLP nanoparticles have potential as food‐grade materials for Pickering emulsions, marking a novel application of these nanoparticles in the food industry. © 2024 Society of Chemical Industry.


Citations (61)


... Hippocampal tissue is a key structure in the brain that is closely related to learning, memory, and cognitive functions. Its normal operation plays an indispensable role in the exertion of important brain functions [50]. From the perspective of neurobiology, as a key structure in the brain, the hippocampus is deeply involved in multiple key links such as information encoding, storage, and retrieval [51]. ...

Reference:

Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis
Supplementation of 3'-Sialyllactose During the Growth Period Improves Learning and Memory Development in Mice
  • Citing Article
  • October 2024

Journal of Agricultural and Food Chemistry

... Polysaccharides from sources such as Dictyophora indusiate, Deglet Noor, Ganoderma lucidum, and Poria cocos [160,168,169], polyphenols, and alkaloids upregulate the expression of tight junction proteins such as zonulin-1 and occludin [163,164], improving gut barrier integrity. These compounds exhibit significant anti-inflammatory effects by reducing proinflammatory cytokines, including TNF-α, IL-1β, and IL-6. ...

Ganoderma lucidum spore powder after oil extraction alleviates microbiota dysbiosis to improve the intestinal barrier function in mice

... Microencapsulated rice bran (MRB) has been shown to reduce serum lipid levels and hepatic lipid accumulation in hyperlipidemic mice. This is achieved by decreasing the expression of genes related to lipogenesis and increasing those related to lipid catabolism and oxidation [46]. Because rice bran is high in antioxidants, it has the potential as a free radical scavenger. ...

Microencapsulated rice bran alleviates hyperlipidemia induced by high‐fat diet via regulating lipid metabolism and gut microbiota

... Finally, polyphenol content also varied, starting from 0.05 ± 0.01% in P0, rising to 0.47 ± 0.02% in P4, peaking at 2.75 ± 0.29% in P8, and slightly decreasing to 2.23 ± 0.08% in P12. These changes in chemical composition are consistent with trends observed in PCPs processed by the nine-steam-nine-bask method, where total carbohydrate content decreased, protein content increased, and uronic acid content significantly rose (38). In previous studies, the total carbohydrate content in polysaccharides from P. cyrtonema was found to be 70.31% ...

The structure change of polygonatum polysaccharide and the protect effect of Polygonatum crtonema Hua extracts and polysaccharide on cisplatin-induced AKI mice during nine-steam-nine-bask processing
  • Citing Article
  • May 2024

International Journal of Biological Macromolecules

... It can be assessed using techniques like drip loss, cooking loss (CLM), and expressible moisture tests. Myofibril fragmentation index (MFI) assesses the degree of myofibrillar-as primary constituents of skeletal muscle-breakdown, and this condition is directly linked to various aspects of meat quality, including water retention and tenderness (Qaid et al. 2024;Wang et al. 2024). Meat tenderness is linked to myofiber structure, thus, increasing MFI and reducing Warner-Bratzler SF results in more tender meat (Suliman et al. 2021). ...

Shelf life extended: Focus on microbiota identification, nutrition value, color difference and lipid oxidation of puffed bean products
  • Citing Article
  • April 2024

Food Control

... The correlation coefficients between TPC and antioxidant activity (ABTS, DPPH, and FRAP) were strong, ranging from 0.86 to 0.92, with TAC showing an even stronger correlation with FRAP (0.95). These results indicate that, despite significant degradation, the residual polyphenols-particularly anthocyanins-contribute to the antioxidant properties of eggplant peels after thermal processing, highlighting their potential as valuable antioxidant components in food systems [144]. ...

The degradation and antioxidant capacity of anthocyanins from eggplant peels in the context of complex food system under thermal processing
  • Citing Article
  • April 2024

Food Bioscience

... Metabolomic analysis of mice with NAFLD induced by a high-fat diet and treated with tyrosol (supplementation of 0.025%, w/w of high-fat diet) for 16 weeks revealed that improved lipid homeostasis is related to hepatic increase in spermidine, taurine, linoleic acid, malic acid, and eicosapentaenoic acid (EPA) [10]. In tyrosol-treated NAFLD mice, Pparα, Cpt1a, and Acadm genes were upregulated, as well as PPARα and ACOX1 proteins, which were increased with respect to untreated mice, whereas gene expression of Scd1 and Srebp-1c was reduced, confirming previous evidence demonstrating that tyrosol increases hepatic lipid oxidation and inhibits lipogenesis [10]. ...

Tyrosol regulates hepatic lipid metabolism in high-fat diet-induced NAFLD mice
  • Citing Article
  • March 2024

Food & Function

... Compared with conventional procedures, it is more efficient, as it reduces the extraction time and solvent amount and increases the extraction yields. In particular, steam explosion-assisted extraction has been shown to improve the extraction yields of polysaccharides, polyphenols, flavonoids, saponins and alkaloids, etc., from many types of medicinal and edible plants [14][15][16][17][18]. Our previous studies on the SE modification of wheat bran and apple pomace have confirmed that SE can promote the conversion of IDF to SDF and thus increase the extraction yield of SDF [14,15]. ...

Effects of steam explosion on raspberry leaf structure and the release of water-soluble nutrients and phenolics
  • Citing Article
  • February 2024

... In this study, no significant changes were observed in other iron-related transport carriers, which may indicate that FS has unique transport channels. Du et al. found that sucrose calcium chelates enhanced the ability of calcium transport in Caco-2 cells and mouse intestines, which is related to its strong binding to the calcium transport protein PMCA1b located on the cellular basement membrane and its ability to stimulate PMCA1b gene expression [52]. Through in vitro and in vivo studies, Li et al. discovered that zinc sucrose complexes are absorbed by intestinal epithelial cells through active transport, paracellular, and oligosaccharide transport pathways [53]. ...

Structural characterization and calcium absorption‐promoting effect of sucrose‐calcium chelate in Caco‐2 monolayer cells and mice

... This structure facilitates the digestion and absorption of breast milk fat by infants [3]. 1,3-dioleoyl-2-palmitoyltriglyceride (OPO structured lipids) is the most abundant triglyceride in breast milk, playing a crucial role in the digestion and absorption process of infants and young children, and a high-level sn-2 palmitate diet increased calcium absorption from 42% to 57% [4]. As shown in Figure 1, OPO structured lipids with palmitic acid at the sn-2 position and oleic acid at the sn-1 and sn-3 positions, upon hydrolysis by pancreatic lipase in the gastrointestinal tract, release a large amount of free unsaturated fatty acid oleic acid (OA) and sn-2 monopalmitin (sn-2 MAG). ...

1,3-Dioleoyl-2-palmitoyl-glycerol and 1-oleoyl-2-palmitoyl-3-linoleoyl-glycerol: Structure-function relationship, triacylglycerols preparation, nutrition value
  • Citing Article
  • June 2024

Food Chemistry