Zeren Shen's research while affiliated with First Affiliated Hospital of China Medical University and other places

... Intracellular communication via exosomes between melanocytes and fibroblasts plays a key role in forming scars and keloids. Melanocyte-derived exosome miR-7704 facilitates keloid formation by activating the TGF-β/Smad pathway (SHEN et al., 2022). ...

... Our study provides valuable information that MT+IR in breast cancer patients after NAC may bring more short-term 49) yielded reports of a 10.0% postoperative complication rate in the IR group versus 6.1% in the non-IR group. A network meta-analysis of 51 studies revealed that the risk of overall complications and surgical site infection was more significant in the MT+IR group than in the MT group (50). Conversely, other studies found no significant difference in the incidence of complications between the two groups (51,52). ...

... Repeated UVB induced melanocytes into a senescent state, which is typically linked with melanogenesis (Bennett and Medrano 2002;Lin and Fisher 2007;Choi et al. 2018;Martic et al. 2020). Previous work from our group found that repeated UVB radiation induces melanin production of the melanocytes (Shen et al. 2020(Shen et al. , 2022. Thus, we supposed that this model of UVB radiation could also induce senescence of melanocytes, and verified it. ...

... Fibroblasts are the main cellular components of the keloid microenvironment, as well as the main effector cells regulating extracellular matrix (ECM) synthesis and remodeling [19]. Some of the cancer-like behaviors of keloids are their continuous activation of fibroblasts and invasive growth into the normal skin adjacent to the original scars [20]. ...

... 15 A recent metaanalysis also estimated that the meatal stenosis rate was significantly lower with Mathieu than with the TIP technique. 16 Nguyen and Snodgrass correlated meatal stenosis after the use of TIP technique with technical factors, such as too distal tubularization of the urethral plate. 17 Other studies suggest that the natural configuration of the urethral plate plays an important role. ...

... According to the Emery-Little classification, nuclear scleroses grade II or less are often referred to as "soft" cataracts, while nuclear scleroses grade III or higher are known as "hard" cataracts [76,77]. Both of them are quite challenging in PKE. ...

... 86,87 An epidemiological study reports CC incidence rates of 1.9% and 9.6%, respectively. 88 The submuscular placement isolates the implant from the endogenous flora of the glandular tissue. 35,37 It also reduces mechanical friction in the surrounding tissues. ...

... In general, epinephrine injection monotherapy is considered less effective than combined therapy with epinephrine injection and mechanical hemostasis. 47 However, there are complexities to consider in patients with postoperative bleeding due to anatomical changes after surgery and comorbid patient status. The success of endoscopic management was closely related to the type of surgery performed (Table 2). ...

... Different peer-reviewed publications have pointed out that those patients implanted with trifocal models may achieve better intermediate vision than their counterparts implanted with bifocal models, while near and far vision, postoperative refraction or spectacle independence of bifocal models are similar to those of trifocal ones. [3][4][5] Depending on their design properties and the optical technology used, patient outcomes after implantation may vary considerably. Some clinical data suggest that trifocal IOLs led to more photic disturbances (i.e halo and glare) than extended depth-of-focus IOLs 6 since the light distribution between foci can increase these disturbances, but note that objective dysphotopsia is not reduced in extended depth-of-focus IOLs compared to trifocal IOLs. ...

... Artificial tears, physical therapy of meibomian gland dysfunction, punctal plugs and other treatments are used to relieve the symptoms caused by DED after SMILE (3). Nevertheless, according to the literature, dry eye symptoms persist for months or even years in a lot of patients (4). ...