Zbigniew Gadek's research while affiliated with Kyushu University and other places
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Publications (12)
The original article has been published with an error that is corrected below: Under the heading “Mineral waters and medium preparation” in the section of Materials and methods, the sentence “NMWs have the following physical properties: for Hita T. W., pH of 7.29 ± 0.02 and Eh of 410.33 ± 10.41 mV” should be replaced by “NMWs have the following phy...
Insulin-producing cells express limited activities of anti-oxidative enzymes. Therefore, reactive oxygen species (ROS) produced in these cells play a crucial role in cytotoxic effects. Furthermore, diabetes mellitus (DM) development is closely linked to higher ROS levels in insulin-producing cells. Hita Tenryosui Water(®) (Hita T. W., Hita, Japan)...
This prospective observation study examines changes in the relevant tests parameters of 411 diabetes patients drinking natural
reduced water from the “Nordenau Spring”, as well as a correlation of these changes with the fluctuation of the reactive oxygen
species in their blood. The average age of the test persons is 71.5 years and the daily consump...
*The analysis using the DBNBS reduction method and the DCFH-DA intracellular reactive oxygen species (ROS) determination method
revealed that ERW and diseases-improvable natural waters such as Nordenau water in Germany and Hita water in Japan were all
reduced waters (RWs) which could function as active hydrogen donors and intracellular ROS scavenge...
The study examined changes in the relevant tests parameters of 320 diabetes patients (176 female, 144 male) drinking natural reduced water from the "Nordenau Spring" in Nordenau, Germany as well as the correlation of these changes with the fluctuation of the reactive oxygen species concentration in their blood. The average age of the test persons w...
Recent studies have demonstrated that reactive oxygen species9ROS9and the resulting oxidative stress play an important role in apoptosis. Apoptosis is implicated in pathophysiology of diabetes mellitus. Antioxidants can block or delay apoptosis. We have demonstrated that reduced water (RW) such as hydrogen-rich electrolysed-reduced water (ERW) and...
Previous studies showed that reduced water (RW) such as electrolyzed-reduced water (ERW) and natural reduced water (NRW) scavenge reactive oxygen species (ROS), protected DNA from oxidative damage, and stimulated glucose uptake into myotubes and adipocytes. Here, we investigated that the protective mechanism of reduced water (RW) against alloxan-in...
The study examined changes in the tests parameters of 219 diabetes patients (115 female, 104 male) under the influence of what is known as the “Nordenau-Phenomenon”, which attributes a healing effect to an old slate tunnel with an underground spring. The average age of the test persons was 68.6 years; the average duration of their stay in Nordenau...
Reactive oxygen species (ROS) cause irreversible damage to biological macromolecules, resulting in many diseases. Reduced water (RW) such as hydrogen-rich electrolyzed reduced water and natural reduced waters like Hita Tenryosui water in Japan and Nordenau water in Germany that are known to improve various diseases, could protect a hamster pancreat...
The study examined changes in the test parameters of 101 diabetes patients (56 female, 45 male) under the influence of what is known as the “Nordenau Phenomenon”, which attributes a healing effect to an old slate tunnel with an underground spring. The average age of the test persons was 67,9 years; the average duration of their stay in Nordenau was...
Electrolyzed reduced water and natural waters such as Hita Tenryosui water in Japan, Nordenau water in Germany and Tracote water in Mexico, which are known to improve various diseases, were all and- oxidative waters which could scavenge intracellular reactive oxygen species. The and-oxidative waters stimulated not only the glucose uptake of rat myo...
Citations
... In the late 1990s and early 2000s, a few procedural observational studies were performed on hundreds of diabetic patients who drank these claimed natural healing waters. The preliminary reports show that the patients had reduced levels of cholesterol, glucose, glycated hemoglobin (HbA1c), oxidative stress, serum creatinine, blood pressure, and exhibited other physiological health improvements [145][146][147][148][149][150][151]. After the realization that molecular hydrogen had therapeutic effects, it was conjectured that observed benefits from these so-called "curative waters" were due to the natural dissolved hydrogen in these waters [140]. ...
... Most oxygen that humans inhale is converted into water, but 1-2% of the oxygen inhaled is converted into active oxygen [1]. Hydrogen water was found by chance in the experiment of electrolyzing water, and through electrolysis, water is converted into acidic water and alkaline water [2]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/277207952969740-1443102934601_Q64/Takeki-Hamasaki.jpg)
... Both have been implicated in the treatment of diabetes mellitus [5]. Additionally, these waters have been reported to exert antioxidant effects which have protective effects against diseases [12]. In this short communication, we attempt to deduce the superoxide anion radical scavenging activity, water molecule size, active hydrogen, dissolved oxygen and hydrogen peroxide degradation capability of water sourced from Baegunsan mountain in Gyeonggi-go, Korea and compare the results to other sources of healing waters. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/959289007022080-1605723730042_Q64/Deniz-Aki-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272361517744132-1441947454116_Q64/Yoshinori-Katakura.jpg)
... Investigations of some "curative waters" (e.g., Nordenau, Germany; Tlacote, Mexico; Hita Tenryosui, Japan; Nadone, India, etc.) have been reported to indeed exert therapeutic effects [138][139][140]. Intriguingly, there are reports that some of these waters contain small levels of dissolved molecular hydrogen [138,[140][141][142][143][144]. ...
... It has been demonstrated that EW has reactive oxygen species (ROS) scavenging activity and can be used to treat oxidative stress-related diseases [101,102]. Regarding the anti-cancer effect of EW, it has been reported to down-regulate VEGF gene transcription and protein secretion by inactivating ERK, thereby reducing tumor blood vessel generation [8]. It was reported that NEW (pH = 6.6-7.8) ...
... A study on 411 type II diabetes patients whose average age was 71.5 years, who drank natural reduced water from the Nordenau Spring in Germany, up to 2 liters per day over 6 days, showed that 186 (45%) responded positively, with reduced blood glucose, improved cholesterol, LDL, HDL, and serum creatinine levels. 70.6% of a random sample of 136 of the patients also showed a decrease in blood ROS [19]. Recent bioelectrical impedance analysis studies showed that diabetics have a lower ratio of intracellular water (ICW) to extracellular water (ECW). ...
... For instance, Gadek et al. [41] found that the daily drinking of 2 L of alkaline water (Nordenau and Hita Tenryosui water) decreased glucose HbA1c levels in people with type 2 diabetes. Significant changes were observed after just six days, and prolonged use of alkaline water caused a decrease in blood cholesterol and creatinine, as well as an increase in density lipoprotein levels [41,42]. Furthermore, Osada et al. [43] showed that drinking 2 L alkaline water (Hita Tenryosui water) per day for two months significantly decreased blood sugar levels in 89% of diabetes patients. ...
... To achieve this goal, the food and pharmaceutical industries require access to detailed data regarding the levels of antioxidants contained in food to maximize the availability of antioxidants in the body [5 , 6] . Therefore, we have been conducting in vitro and in vivo studies to identify the potential beneficial therapeutic effects of antioxidants present in food and drinking water [7][8][9][10][11][12][13][14][15][16] . ...
... Investigations of some "curative waters" (e.g., Nordenau, Germany; Tlacote, Mexico; Hita Tenryosui, Japan; Nadone, India, etc.) have been reported to indeed exert therapeutic effects [138][139][140]. Intriguingly, there are reports that some of these waters contain small levels of dissolved molecular hydrogen [138,[140][141][142][143][144]. In the late 1990s and early 2000s, a few procedural observational studies were performed on hundreds of diabetic patients who drank these claimed natural healing waters. ...
