Zakiya Zahran Al-Shariqi’s research while affiliated with Sultan Qaboos University and other places

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Publications (1)


1 H NMR (700 MHz) and 13 C NMR (176 MHz) Data for Compound 1 in CDCl 3.
1 H NMR (700 MHz) and 13 C NMR (176 MHz) Data for Compound 2 in CDCl 3.
1 H NMR (400 MHz) and 13 C NMR (100 MHz) Data for Compound 3 in CDCl 3.
Cont.
Isolation and Identification of Phytocompounds from Maytenus dhofarensis and Their Biological Potentials
  • Article
  • Full-text available

August 2023

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147 Reads

Molecules

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Zakiya Zahran Al-Shariqi

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Khalsa S. Al-Shabibi

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Maytenus dhofarensis Sebsebe (Celestraceae) is a naturally growing shrub in Oman. It is not a reputed medicinal plant in Oman, but it is regionally endemic and causes shivering attacks on goats that graze on it. The chemical investigation of the hexane and chloroform extracts of the fruits and stems of M. dhofarensis afforded dihydro-β-agarofuran-type sesquiterpene pyridine alkaloid (1), lupanyl myristoate (2) and lignanolactone (3). Compounds (1–3) are new isolates from M. dhofarensis. The structures of these compounds were assigned through comprehensive IR, NMR, and ESI-MS analyses, and the relative configurations of compounds 1 and 3 were deduced from density function theory (DFT) calculations and NMR experiments. Compound 1 was assayed against the kinase enzyme and showed no inhibition activity for p38 alpha and delta at a 10 µM test concentration. Compound 3 inhibited the 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH) by 69.5%, compared to 70.9% and 78.0% for gallic acid and butylated hydroxyanisole, respectively, which were used as positive controls.

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