Zahra Alamzadeh's research while affiliated with Iran University of Medical Sciences and other places

... Here, NIR activation simultaneously combines thermo-chemotherapy with accelerated drug release. In order to visualize the biodistribution of the graphene-based nanocomposites (NCs) in vivo, gold nanoparticles (AuNPs) and superparamagnetic iron oxide (SPIO) NPs were anchored on GO nanosheet surface to enable computed tomography (CT) [40][41][42][43] and magnetic resonance imaging (MRI) [44][45][46]. The surface of the NCs was also modified with an alginate (Alg) polymer hydrogel to improve their biocompatibility and colloidal stability under physiological conditions [47]. ...

... Many researchers with diverse interests and specialties have been drawn to nanomaterials in order to improve the quality of their study work while using nanomaterials. Many metal oxide Nanoparticles possess numerous advantages and are used in the medical research [1][2][3][4] such as Ag 2 O [5,6], CaO [7,8], CuO [9][10][11], ZnO [12][13][14], SiO 2 [15][16][17], NiO [18,19], CrO [20], Fe 3 O 4 [21][22][23], Fe 2 O 3 [24,25], Al 2 O 3 [26][27][28][29], CdO [30][31][32], and CeO 2 [33,34]. Similarly, MgO nanoparticles have a high potential for use in nanomedical research [35], as well as numerous other applications in agriculture [36][37][38], chemical reaction catalysis [39][40][41], dye removal [42][43][44], and lithium batteries [45][46][47]. ...

... (Hirsch et al. 2003) Among various nanoparticles, gold nanoparticles (AuNPs) have evolved greatly in the fabrication and application of nanomaterials for tumor therapy, owing to their excellent photo-stability and physicochemical properties, high atomic number, low toxicity, and efficient light-to-heat conversion capacity. (Beik et al. 2019(Beik et al. , 2021) Therefore, AuNPs can provide a unique opportunity to cooperate with different treatments at the same time, thus highlighting the value of AuNPs in the synergistic treatment of tumors. Conventional AuNPs are usually prepared by dangerous and complicated chemical methods, and the preparation process is mainly accompanied by high temperature, high pressure, and unnecessary toxicity. ...

... Addition of LDH-palmitate improved the vapor permeability of the washed PCL film. In summary, LDH-palmitate has been shown to be a more nano-additive to obtain harder LDH-PCL composites by improving barrier properties [43][44][45][46][47][48][49]. Shafiei et al. [10] found that tissue engineering scaffolds provide biological and structural support for cell adhesion, proliferation and differentiation. ...

... Fe 3 O 4 @Au HNCs were synthesized according to the method reported in our previous study [23]. Briefly, Fe 3 O 4 NPs were prepared by the co-precipitation method of Massart through adding ammonia to the mixture solution of iron (II) and iron (III) (molar ratio: 1:2). ...

... Results of in vitro experiments indicated that alginate nanoparticles (ALG-NPs) serve as a reliable drug delivery system in breast cancer (Jayapal and Dhanaraj, 2017). In another study, cisplatin was coloaded onto alginate hydrogel and gold NPs for delivery; the combination was found to produce higher levels of tumour inhibition (Mirrahimi, 2020). ...

... 45 Meanwhile, PPH@5Fu@ICG + NIR group showed over-expression of Caspase-3 and low-expression of Ki67 protein, which was due to the great inhibition of tumor growth and low side effect of NIR-induced photothermal chemotherapy. 46 The underlying mechanism of hyperthermia-induced cell death may be that up-regulate of HSP70 gene expression and inhibits caspase-3 activation and down-regulate of Ki67, resulting in mitochondrial instability yielding mitochondrial damage. 47 In summary, PPH@5Fu@ICG nanoparticles achieved an excellent tumor ablation effect with a low dose of 5-Fu and NIR irradiation in vivo, which could be traced by ICG NIR fluorescence imaging. ...

... Depending on the combination of photothermal agent and activating light wavelength utilized, PTT raises the temperature of the tumor microenvironment to 41-48 • C, which causes tissue damage, including damage to cellular architecture, degradation of proteins and nucleic acids (DNA/RNA), and eventually results in apoptosis [14,131,132]. Although both apoptotic and necrotic damage has been reported following PTT, it appears that one or other pathway may be favored, depending upon the hyperthermic temperature achieved during therapy [14,116]. ...

... The murine colon adenocarcinoma cell line CT26 was cultured in RPMI 1640 medium supplemented with 10% FBS, 100 units/mL penicillin, and 100 µg/mL streptomycin at 37 °C in 5% CO 2 . Cells were incubated with 50 µg/mL NCs for 6 h and then examined with TEM (LEO 906; Zeiss) as previously described [49]. To assess cytotoxicity, cells were seeded on 96-well plates at a density of 5×10 3 per well, and then treated with varying concentrations of NCs (0-100 µg /mL), DOX (0-2 µg/mL) and DOX-NC (NC concentration 0-50 µg/mL, DOX concentration: 0-2 µg/mL). ...

... Through the last few years, nanotechnology has widely been considered in development of theranostics [30][31][32][33][34][35][36][37][38][39][40][41][42][43] . In this respect, nanomaterials, as an increasingly trending component of nanotechnology, have left a positive impact on diagnostics, prognostics and therapeutics [44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] . ...