Zahra Alamzadeh's research while affiliated with Iran University of Medical Sciences and other places

Publications (11)

Article
Full-text available
The combination of multiple therapeutic and diagnostic functions is fast becoming a key feature in the area of clinical oncology. The advent of nanotechnology promises multifunctional nanoplatforms with the potential to deliver multiple therapeutics while providing diagnostic information simultaneously. In this study, novel iron oxide-gold core–she...
Article
Recent years have seen considerable progress in the development of nanomedicine by the advent of 2D nanomaterials serving as ideal platforms to integrate multiple theranostic functions. We synthesized multifunctional stimuli-responsive 2D-based smart nanocomposites (NCs), comprising gold nanoparticles (AuNPs) and superparamagnetic iron oxides (SPIO...
Article
Full-text available
In the present study, Fe3O4 (FO) nanoparticles and Au-Fe3O4 (AFO) nanocomposite have been synthesised by using sedimentary method. The samples have been characterised by different techniques including X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), EDX, magnetisation vs applied...
Article
The integration of multiple therapeutic and diagnostic functions into a single nanoplatform for image-guided cancer therapy has been an emerging trend in nanomedicine. We show here that multifunctional theranostic nanostructures consisting of superparamagnetic iron oxide (SPIO) and gold nanoparticles (AuNPs) scaffolded within graphene oxide nanofla...
Article
Background Recent advances in nanotechnology have led to the use of nanomaterials in the diagnosis of cancer by imaging techniques. Objective This study aimed to synthesize fluorescein-conjugated gold nanoparticles and study the parameters affecting the loading of fluorescein on synthesized coated gold nanoparticles with the ability to be used in...
Article
Maximal synergistic effect between photothermal therapy and radiotherapy (RT) may be achieved when the interval between these two modalities is optimal. In this study, we tried to determine the optimal schedule of the combined regime of RT and nano-photothermal therapy (NPTT), based on the cell cycle distribution and kinetics of cell death. To this...
Article
Although multimodal cancer therapy has shown superior antitumor efficacy in comparison to individual therapy due to the potential generation of synergistic interactions among the treatments, its clinical usage is highly hampered by systemic dose-limiting toxicities. Herein, we developed a multi-responsive nanocomplex constructed from alginate hydro...
Article
Multimodal cancer therapy has become a new trend in clinical oncology due to potential generation of synergistic therapeutic effects. Herein, we propose a multifunctional nanoplatform comprising alginate hydrogel co-loaded with cisplatin and gold nanoparticles (abbreviated as ACA) for triple combination of photothermal therapy, chemotherapy and rad...
Article
We have recently reported the synthesis and characterization of gold-coated iron oxide nanoparticle and demonstrated such a nanoparticle (Au@Fe2O3 NP) was able to significantly enhance the lethal effects of photo-thermo-radiotherapy. The purpose of this study was to determine the mechanisms behind such an enhancement by investigating the changes in...
Article
Objectives To investigate the effects of Au@Fe2O3 core–shell nanoparticle (NP), with and without conjugation to folic acid (FA) as a targeting ligand, on radiosensitization of both cancer and healthy cells. Methods Au@Fe2O3 NPs were first synthesized, then modified with FA, and finally characterized. Radiation dose enhancement studies were perform...

Citations

... Here, NIR activation simultaneously combines thermo-chemotherapy with accelerated drug release. In order to visualize the biodistribution of the graphene-based nanocomposites (NCs) in vivo, gold nanoparticles (AuNPs) and superparamagnetic iron oxide (SPIO) NPs were anchored on GO nanosheet surface to enable computed tomography (CT) [40][41][42][43] and magnetic resonance imaging (MRI) [44][45][46]. The surface of the NCs was also modified with an alginate (Alg) polymer hydrogel to improve their biocompatibility and colloidal stability under physiological conditions [47]. ...
... Many researchers with diverse interests and specialties have been drawn to nanomaterials in order to improve the quality of their study work while using nanomaterials. Many metal oxide Nanoparticles possess numerous advantages and are used in the medical research [1][2][3][4] such as Ag 2 O [5,6], CaO [7,8], CuO [9][10][11], ZnO [12][13][14], SiO 2 [15][16][17], NiO [18,19], CrO [20], Fe 3 O 4 [21][22][23], Fe 2 O 3 [24,25], Al 2 O 3 [26][27][28][29], CdO [30][31][32], and CeO 2 [33,34]. Similarly, MgO nanoparticles have a high potential for use in nanomedical research [35], as well as numerous other applications in agriculture [36][37][38], chemical reaction catalysis [39][40][41], dye removal [42][43][44], and lithium batteries [45][46][47]. ...
... (Hirsch et al. 2003) Among various nanoparticles, gold nanoparticles (AuNPs) have evolved greatly in the fabrication and application of nanomaterials for tumor therapy, owing to their excellent photo-stability and physicochemical properties, high atomic number, low toxicity, and efficient light-to-heat conversion capacity. (Beik et al. 2019(Beik et al. , 2021) Therefore, AuNPs can provide a unique opportunity to cooperate with different treatments at the same time, thus highlighting the value of AuNPs in the synergistic treatment of tumors. Conventional AuNPs are usually prepared by dangerous and complicated chemical methods, and the preparation process is mainly accompanied by high temperature, high pressure, and unnecessary toxicity. ...
... Addition of LDH-palmitate improved the vapor permeability of the washed PCL film. In summary, LDH-palmitate has been shown to be a more nano-additive to obtain harder LDH-PCL composites by improving barrier properties [43][44][45][46][47][48][49]. Shafiei et al. [10] found that tissue engineering scaffolds provide biological and structural support for cell adhesion, proliferation and differentiation. ...
... Fe 3 O 4 @Au HNCs were synthesized according to the method reported in our previous study [23]. Briefly, Fe 3 O 4 NPs were prepared by the co-precipitation method of Massart through adding ammonia to the mixture solution of iron (II) and iron (III) (molar ratio: 1:2). ...
... Results of in vitro experiments indicated that alginate nanoparticles (ALG-NPs) serve as a reliable drug delivery system in breast cancer (Jayapal and Dhanaraj, 2017). In another study, cisplatin was coloaded onto alginate hydrogel and gold NPs for delivery; the combination was found to produce higher levels of tumour inhibition (Mirrahimi, 2020). ...
... 45 Meanwhile, PPH@5Fu@ICG + NIR group showed over-expression of Caspase-3 and low-expression of Ki67 protein, which was due to the great inhibition of tumor growth and low side effect of NIR-induced photothermal chemotherapy. 46 The underlying mechanism of hyperthermia-induced cell death may be that up-regulate of HSP70 gene expression and inhibits caspase-3 activation and down-regulate of Ki67, resulting in mitochondrial instability yielding mitochondrial damage. 47 In summary, PPH@5Fu@ICG nanoparticles achieved an excellent tumor ablation effect with a low dose of 5-Fu and NIR irradiation in vivo, which could be traced by ICG NIR fluorescence imaging. ...
... Depending on the combination of photothermal agent and activating light wavelength utilized, PTT raises the temperature of the tumor microenvironment to 41-48 • C, which causes tissue damage, including damage to cellular architecture, degradation of proteins and nucleic acids (DNA/RNA), and eventually results in apoptosis [14,131,132]. Although both apoptotic and necrotic damage has been reported following PTT, it appears that one or other pathway may be favored, depending upon the hyperthermic temperature achieved during therapy [14,116]. ...
... The murine colon adenocarcinoma cell line CT26 was cultured in RPMI 1640 medium supplemented with 10% FBS, 100 units/mL penicillin, and 100 µg/mL streptomycin at 37 °C in 5% CO 2 . Cells were incubated with 50 µg/mL NCs for 6 h and then examined with TEM (LEO 906; Zeiss) as previously described [49]. To assess cytotoxicity, cells were seeded on 96-well plates at a density of 5×10 3 per well, and then treated with varying concentrations of NCs (0-100 µg /mL), DOX (0-2 µg/mL) and DOX-NC (NC concentration 0-50 µg/mL, DOX concentration: 0-2 µg/mL). ...
... Through the last few years, nanotechnology has widely been considered in development of theranostics [30][31][32][33][34][35][36][37][38][39][40][41][42][43] . In this respect, nanomaterials, as an increasingly trending component of nanotechnology, have left a positive impact on diagnostics, prognostics and therapeutics [44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] . ...