Zachary Compton's research while affiliated with Arizona State University and other places
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Publications (5)
Cancer is a disease that affects nearly all multicellular life, including birds. However, little is known about what factors explain the variance in cancer prevalence among species. Litter size is positively correlated with cancer prevalence in managed species of mammals, and larger body size, but not incubation or nestling period, is linked to tum...
Chimerism is a widespread phenomenon across the tree of life. It is defined as a multicellular organism composed of cells from other genetically distinct entities. This ability to ‘tolerate’ non-self cells may be linked to susceptibility to diseases like cancer. Here we test whether chimerism is associated with cancers across obligately multicellul...
Cancer cells possess a nearly universal set of characteristics termed the hallmarks of cancer, including replicative immortality and resisting cell death. Dysregulated differentiation is present in virtually all cancers yet has not yet been described as a cancer hallmark. Like other hallmarks, dysregulated differentiation involves a breakdown of th...
The ecology in which species live and evolve likely affects their health and vulnerability to diseases including cancer. Using 14,267 necropsy records across 244 vertebrate species, we tested if animals in low productivity habitats, with large habitat range, high body temperature and weight-inferred estimates of metabolic rates, and in high trophic...
Cancer has a significant impact on morbidity and mortality worldwide, with estimates reaching 18.1 million cases in 2018 alone. This chapter reviews the contributions of evolutionary medicine and palaeopathology to oncological research and addresses how these disciplines can conjointly develop models that evaluate how biological, ecological and soc...
Citations
... Evolutionary biology has also been an important component of cancer research over the last 50 years 3,7 . The ecological conditions under which organisms evolved have shaped their responses to various diseases, including cancer 8,9 . Understanding why organisms differ in their ability to suppress cancer, as well as how they respond to neoplastic expansion, is a central question in comparative cancer research. ...
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... This paradigm was extended and made widely popular by Niko Tinbergen, who added developmental processes and evolutionary history to the existing paradigm [36,37]. Often called "Tinbergen's four questions", this perspective can provide a fuller picture cancer biology and human vulnerability to the disease [38][39][40] by understanding the proximate causes (i.e., mutations), developmental processes (i.e., accumulation of mutations through aging), evolutionary history (i.e., evolution of multicellular species), and adaptive significance (i.e., how fitness is impacted). These perspectives address different (but not mutually exclusive) needs in cancer research. ...
