Yung-Yi Cheng's research while affiliated with University of North Carolina at Chapel Hill and other places

Publications (21)

Article
Full-text available
Exposure to ultraviolet B (UVB) leads to the overproduction of reactive oxygen species (ROS), causing higher risks of skin disorders. Luteolin (Lut) is a naturally occurring antioxidant that can absorb a broad range of ultraviolet light, but its water solubility and skin permeability are limited and insufficient. The aim of the current study was to...
Article
Full-text available
Background The optimal procedure for combining radiotherapy (RT) with tamoxifen treatment is controversial as RT may alter the pharmacokinetics and biotransformation of tamoxifen. The present study investigated this potential interaction by assessing the pharmacokinetics of tamoxifen during concurrent and sequential RT. Method Plasma tamoxifen con...
Article
Tamoxifen, a widely prescribed medication in premenopausal women diagnosed with hormone-dependent breast cancer, is potentially co-prescribed with Hedyotis diffusa (H. diffusa), particularly in Taiwan. However, no related report has investigated the drug-herb interaction of H. diffusa on the pharmacokinetics of tamoxifen and its metabolites. In the...
Article
Full-text available
Sorafenib is one of the most effective target therapeutic agents for patients with late-stage hepatocellular carcinoma. To seek possible alternative adjuvant agents to enhance the efficacy and improve the side effect of sorafenib, Hedyotis diffusa, one of the most prescribed phytomedicines for treating liver cancer patients in Taiwan, was evaluated...
Article
Full-text available
Ginsenosides, which contain one triterpene and one or more sugar moieties, are the major bioactive compounds of ginseng. The aim of this study was to develop and optimize a specific and reliable ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the analysis of twelve different resources of ginseng. The six mar...
Article
The Asian plant Kalimeris shimadai has been used as food and ethnologic medicine for over a thousand years. In this study, we isolated and identified one new lignan, kalshiolin A (1), and 12 known lignans (2–13). The structures were characterized by the comprehensive analyses of spectroscopic data (HR-ESI-MS, IR, 1D, and 2D-NMR) and the absolute co...
Article
Background: Multidrug resistance (MDR) in cancer is one of the main obstacles in treatment with chemotherapy. Drug efflux through P-glycoprotein is the major mechanism involved in MDR. A potential strategy to provide the best possible clinical outcomes is to develop P-glycoprotein (P-gp) inhibitors from natural products. Purpose: The present stu...
Article
Full-text available
Erectile dysfunction (ED) is a disorder found in males throughout the world, which negatively affects relationships with partners with advancing age. Hence, in this study, we tested a combined novel treatment of electro-acupuncture (EA) and sildenafil citrate against ED. In addition to EA therapy, the sildenafil citrate, a phosphodiesterase 5 inhib...
Article
The hypothesis of this study is that fisetin and phase II conjugated forms of fisetin may partly undergo biliary excretion. To investigate this hypothesis, the male Sprague-Dawley rats were used for the experiment and the bile duct was cannulated with polyethylene tubes for bile sampling. The pharmacokinetic results demonstrated that the average ar...
Article
Full-text available
With an increasing number of cancer patients seeking an improved quality of life, complementary and alternative therapies are becoming more common ways to achieve such improvements. The potential risks of concurrent administration are serious and must be addressed. However, comprehensive evidence for the risks and benefits of combining anticancer d...
Article
Full-text available
Schisandra chinensis has been used as an important component in various prescriptions in traditional Chinese medicine and, more recently, in Western-based medicine for its anti-hepatotoxic effect. The aim of this study was to develop a selective, rapid, and sensitive ultra-performance liquid chromatography-tandem mass spectrometry method for pharma...
Article
Full-text available
Background: Xiang-Sha-Liu-Jun-Zi-Tang (XSLJZT) is the most common traditional formula given to colorectal and breast cancer patients in Taiwan, according to a statistical study of the National Health Insurance Research Database. 5-Fluorouracil (5-FU) is widely used as the first line of treatment for colorectal cancer. Thus, the aim of study is to...
Article
Full-text available
Background: Commercial pharmaceutical herbal products have enabled people to take traditional Chinese medicine (TCM) in a convenient and accessible form. However, the quantity and quality should be additionally inspected. To address the issue, a combination of chemical and physical inspection methods were developed to evaluate the amount of an her...
Article
Rhodamine dyes have been banned as food additives due to their potential tumorigenicity. Rhodamine 110 is illegal as a food additive, although its pharmacokinetics have not been characterized, and no accurate bioanalytical methods are available to quantify rhodamine 110. The aim of this study was to develop and validate a fast, stable, sensitive me...
Article
Full-text available
Sorafenib has been used as a standard therapy for advanced hepatocellular carcinoma (HCC). In Asia, patients with HCC are potentially treated with the combination of sorafenib and Chinese herbal medicines to improve the efficiency and reduce the side effects of sorafenib. However, limited information about the herb-drug interactions is available. W...
Article
The purpose of this study was to investigate the pharmacokinetics of the polymethoxylated flavonoids kumatakenin, pachypodol and retusin, which contain two, three or four methoxy substitutions, using a validated ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method in rats. The pharmacokinetic results demonstrat...
Article
The International Agency for Research on Cancer (IARC) demonstrated rhodamine B as a potential carcinogen in 1978. Nevertheless, rhodamine B has been illegally used as a colorant in food in many countries. Few pharmacokinetic and toxicological investigations have been performed since the first pharmacokinetic study on rhodamine B in 1961. The aims...
Article
Full-text available
Sheng-Mai-San is a multi-component traditional Chinese herbal preparation. Due to the fact granulated additives, such as starch, carboxymethyl cellulose, lactose and raw herbal powder may alter the content of the bioactive markers in the herbal products, a developed ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS)...
Article
Rhodamine B is an illegal and potentially carcinogenic food dye. The aim of this study was to develop a convenient, rapid, and sensitive UHPLC-MS/MS method for pharmacokinetic studies in rats. Rat plasma samples were deproteinized with acetonitrile and separated by UHPLC on a reverse-phase C18e column (100mm×2.1mm, 2μm) using a mobile phase consist...
Article
Full-text available
The herbal decoction process is generally inconvenient and unpleasant. To avoid using herbal medicine decoctions, various high-quality industrial and pharmaceutical herbal decoction products have been used in clinical applications for more than ten years in Taiwan. However, the consistency and standardization of the quality of these herbal medicine...

Citations

... Plasma drug levels are probably below the lowest detectable concentration of quantification, given that the bioavailability of tamoxifen was approximately 20% (23). The tamoxifen dosage orally administered in the present study is consistent with our previous work (24). Experimental animals were randomized into five groups: group 1 (sham group): tamoxifen 10 mg/kg, p.o. plus 0 Gy; two concurrent tamoxifen with single-fraction irradiation; group 2: tamoxifen 10 mg/kg, p.o. plus RT 0.5 Gy (RT 0.5Gy ); group 3: tamoxifen 10 mg/kg, p.o. plus RT 2.0 Gy (RT 2Gy ); sequential tamoxifen with single-fraction irradiation; group 4: tamoxifen 10 mg/kg, p.o. plus RT 0.5 Gy (RT 0.5Gy ), and group 5: tamoxifen 10 mg/kg, p.o. plus RT 2.0 Gy (RT 2Gy ). ...
... The study found that both quinolone saponin components significantly improved the humoral and cellular immune responses to ovalbumin (OVA) in mice, with obvious immune adjuvant properties [107]. In another study, the sources of 12 kinds of ginseng were assessed to analyze the development trend of ginseng varieties; assessments were completed with fast and accurate UPLC-tandem MS [108]. Another study identified and determined the content of six steroidal glycosides and one aglycone in pangolin and yam using the efficient and reliable UPLC-Q-TOF-MS. ...
... Most of these natural compounds have the capability to modulate the outflow, inhibit ATPase activity, and reduce the expression of the gene that encodes for P-gp at the same time. A large number of natural products were re-ported to be P-gp inhibitors by blocking the ATPase activity through nucleotide binding pocket or ATP binding pocket (NBP) which is their major binding site [9,10]. For these reasons, these compounds are considered to be fourth-generation inhibitors and their use is a promising alternative to overcome the numerous side effects and the drug resistance associated with anticancer drugs. ...
... e combined application of acupuncture with PDE5Is has also achieved initial results in certain basic studies. Huang et al. showed pharmacokinetic results, demonstrating that low-frequency EA may elevate sildenafil (10 mg/kg, i.v.) concentration in rat plasma, whereas pharmacodynamic investigation revealed that the combined treatment of sildenafil and low-frequency EA enhanced penile circulation in rats [31]. ...
... An IP administration of 223 mg/kg of FIS to mice showed a C max of 2.5 µg/mL at 15 min and a T 1/2~3 h [98]. A 3 mg/kg IV dose of FIS in rats showed an AUC of 276 mg/kg, C max~7 4 µg/mL, Vd 935 mL and clearance of 111 mL/min [99]. ...
... Plantderived anticancer drugs have both preventative and therapeutic potentials (Iqbal et al., 2017). Because of the toxicity profile of existing therapies, as well as the significant danger of initiating uncontrollable inflammatory responses caused by deceased cancerous cells, a variety of natural phytochemicals are employed as alternative or complementary therapies (Cheng et al., 2018). ...
... The bioavailability studies of S. chinensis products were mainly performed in animals. A maximum concentration of schisandrin of 0.08 ± 0.07 and 0.15 ± 0.09 μg/mL was achieved after oral administration of 3 g/kg and 10 g/kg of S. chinensis fruit extract in rats [15]. In a parallel study, schisandrin (10 mg/kg, administered intravenously (i.v.) or orally (p.o.)) and the herbal extract of S. chinensis (3 g/kg and 10 g/kg, p.o.) were given individually to rats [15]. ...
... After the introduction 5-FU as a chemotherapeutic drug, it has maintained a considerable clinical relevance. Certain tumor types, including colorectal, breast, esophageal, and head and neck tumors, are managed with 5-FU-based palliative chemotherapy Liu et al. (2017). An essential restriction of 5-FU use is its toxicity on normal growing body cells of various organs and tissues Al-Asmari et al. (2016). ...
... In line XSLJZT is a herbal formula that contains a high polyphenol content. Liu et al. reported that glycyrrhizin and liquiritin from Glycyrrhiza uralensis (Gan Cao), quercetrin, and hesperidin from Citrus reticulata (Chen Pi), ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 from Panax ginseng (Ren Shen), 6-gingerol and 6-shogaol from Zingiber officinale, and costunolide and dehydrocostus lactone from Aucklandia lappa (Mu Xiang) could be detected in XSLJZT using HPLC-MS (Liu et al., 2017). Polyphenols can potentially influence the cytotoxicity of chemotherapeutic drugs either by additive or synergistic effects, which can result in toxicity (Mahbub et al., 2015;Klimaszewska-Wisniewska et al., 2016). ...
... We then tested our collection of acyl rhodamine profluorophores with both untransfected and PLE-expressing HEK293 cells. [18] As shown in Figure 3a, addition of 3 μm 1 c to PLE-expressing HEK293 cells in a 384-well assay plate produced a rapid increase in fluorescence demonstrating that the pro-fluorophore readily enters into the cells. After the 6 min time point a modest decrease in fluorescence is noted, possibly as a result of photobleaching. ...